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The map label for this gene is accC [H]

Identifier: 57235052

GI number: 57235052

Start: 118589

End: 120085

Strand: Direct

Name: accC [H]

Synonym: DET0120

Alternate gene names: 57235052

Gene position: 118589-120085 (Clockwise)

Preceding gene: 57235060

Following gene: 57235050

Centisome position: 8.07

GC content: 50.9

Gene sequence:

>1497_bases
ATGCTAAATAAAATACTGGTTGCCAACAGGGGTGAGATAGCCATACGTATTATGCGCGCCTGCCGTGAGCTGGGCATAAA
GACTGTTGCCGTTTATTCCGATGCTGACAAAGGCGCTCTTTTTGTAAAGTATGCAGACGAAGCTTATCATATTGGCCCTT
CCCAGCTGTCTGAGAGCTATCTGAATATAAAAAAGATAGTCTCGGCTGCCAAAAAAGCGGGGGTAGACGGGGTTCACCCC
GGATACGGTTTTTTATCTGAAAACCCCGGTTTTGCACTGGCTCTGGAAAAGGCCGGCATCAAGTTTATAGGCCCCAGCAG
CCGGGTTATAGAGCTGATGGGCAACAAGATTGCCGCCAGACGTGAAATGAAAAAAGCGGGTGTGCCGGTACTGCCCGGTA
CCGAGGGCTGTGTTTCCGGTATTGAGCAGGCCACCGAAGCGGCCGCGGCTATCGGTTACCCGGTTATTATCAAACCCAGC
GGCGGCGGCGGCGGTATCGGTATGCGGGTGGCAAACGGCCCGGACGAGCTTAAAGATGCCATAGAATCCTCCCAGAAAGT
AGCCGGAAATACCTTTGGTCTGGCCGAAGTCTATATTGAAAAATACATATCCAATCCCCGCCATATAGAGATACAGATAA
TGGGTGATTCACAGGGGAATGTGGTTTATCTGGGTGAGAGGGAATGTTCTATCCAGCGGCGTTATCAGAAACTTATTGAA
GAAGCCCCTTCACCGGTCATCACCCCCGAACTCCGCAAGAAAATGGGCGAAGTGGCTATCAAGGCCGGCAAGTGGGTTAA
CTATGAGGGTGCCGGTACTATTGAATTTATCTTTTCAAACGGCCAGTTTTACTTCCTTGAGGCCAATACCCGGGTGCAGG
TGGAACACCCTGTTACCGAAATGGTTACCGGCATAGATATAGTCAAAGAACAGATAATGGTAGCCTCCGGAGATGAGCTT
TCTTTCAAACAGGAAGACGTCCAGATGCGGGGTTGGGCTATAGAGTGCCGCATAAACGCCGAAGACCCCTTGAATGAGTT
TGCCCCCTCGGCGGCCAAACTAAAGGGTTACCGTTCACCCGGCGGTATCGGGGTGCGGGTGGACAGCGGCGTTCATACCC
GCTATAACATACCTTACCTGTATGACCCCATGATATCCAAGCTGATTGTCTGGGGACGTACCCGCGAAGAAGCCATAGCC
CGTATGCGGCGCGCCCTTTACGAATACATTATAGTAGGGGTGAAGACCAATATCCCCTTCCACAAGGCGGTTCTGGTTAA
TCCCAATTTTGTGGCCGGGAATTTGCATACCCATTTCATTGAAAAAGAAACCACCCTGCTTGATGAGATGAAGCGTATCA
TGAGTGAAGAACAGCCGCTGGAAGAGAAGCTGTCCGAAATATTTGACGATACCCGGAGGATTGCCGCTATTGCGGCGGTT
GCCGCTCTGACCCAGCTTCCGGCTGAAATTGATGAAGATGAGATAACCGGCGTTTAA

Upstream 100 bases:

>100_bases
AACGATGTTACCGCCGCTGTCAGCGGGGTAGTTTCAGAGATATATGCTTATGAGGGCGAAGTGGTGGGCAGCAAAGACGT
AATTATGGTGATTGAGCCAG

Downstream 100 bases:

>100_bases
AGGTTTTTCTTTAAACGCCCAATCTCTTTCTGGATTTCCTTGTTTTCCCAGTCACTTTCGTCACGCATGAAGCCGAAAAC
ACTCAGGAAGTGAAAAATCA

Product: pyruvate carboxylase subunit A

Products: NA

Alternate protein names: Pyruvic carboxylase A [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MLNKILVANRGEIAIRIMRACRELGIKTVAVYSDADKGALFVKYADEAYHIGPSQLSESYLNIKKIVSAAKKAGVDGVHP
GYGFLSENPGFALALEKAGIKFIGPSSRVIELMGNKIAARREMKKAGVPVLPGTEGCVSGIEQATEAAAAIGYPVIIKPS
GGGGGIGMRVANGPDELKDAIESSQKVAGNTFGLAEVYIEKYISNPRHIEIQIMGDSQGNVVYLGERECSIQRRYQKLIE
EAPSPVITPELRKKMGEVAIKAGKWVNYEGAGTIEFIFSNGQFYFLEANTRVQVEHPVTEMVTGIDIVKEQIMVASGDEL
SFKQEDVQMRGWAIECRINAEDPLNEFAPSAAKLKGYRSPGGIGVRVDSGVHTRYNIPYLYDPMISKLIVWGRTREEAIA
RMRRALYEYIIVGVKTNIPFHKAVLVNPNFVAGNLHTHFIEKETTLLDEMKRIMSEEQPLEEKLSEIFDDTRRIAAIAAV
AALTQLPAEIDEDEITGV

Sequences:

>Translated_498_residues
MLNKILVANRGEIAIRIMRACRELGIKTVAVYSDADKGALFVKYADEAYHIGPSQLSESYLNIKKIVSAAKKAGVDGVHP
GYGFLSENPGFALALEKAGIKFIGPSSRVIELMGNKIAARREMKKAGVPVLPGTEGCVSGIEQATEAAAAIGYPVIIKPS
GGGGGIGMRVANGPDELKDAIESSQKVAGNTFGLAEVYIEKYISNPRHIEIQIMGDSQGNVVYLGERECSIQRRYQKLIE
EAPSPVITPELRKKMGEVAIKAGKWVNYEGAGTIEFIFSNGQFYFLEANTRVQVEHPVTEMVTGIDIVKEQIMVASGDEL
SFKQEDVQMRGWAIECRINAEDPLNEFAPSAAKLKGYRSPGGIGVRVDSGVHTRYNIPYLYDPMISKLIVWGRTREEAIA
RMRRALYEYIIVGVKTNIPFHKAVLVNPNFVAGNLHTHFIEKETTLLDEMKRIMSEEQPLEEKLSEIFDDTRRIAAIAAV
AALTQLPAEIDEDEITGV
>Mature_498_residues
MLNKILVANRGEIAIRIMRACRELGIKTVAVYSDADKGALFVKYADEAYHIGPSQLSESYLNIKKIVSAAKKAGVDGVHP
GYGFLSENPGFALALEKAGIKFIGPSSRVIELMGNKIAARREMKKAGVPVLPGTEGCVSGIEQATEAAAAIGYPVIIKPS
GGGGGIGMRVANGPDELKDAIESSQKVAGNTFGLAEVYIEKYISNPRHIEIQIMGDSQGNVVYLGERECSIQRRYQKLIE
EAPSPVITPELRKKMGEVAIKAGKWVNYEGAGTIEFIFSNGQFYFLEANTRVQVEHPVTEMVTGIDIVKEQIMVASGDEL
SFKQEDVQMRGWAIECRINAEDPLNEFAPSAAKLKGYRSPGGIGVRVDSGVHTRYNIPYLYDPMISKLIVWGRTREEAIA
RMRRALYEYIIVGVKTNIPFHKAVLVNPNFVAGNLHTHFIEKETTLLDEMKRIMSEEQPLEEKLSEIFDDTRRIAAIAAV
AALTQLPAEIDEDEITGV

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=51.131221719457, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=51.131221719457, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=51.131221719457, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI116805327, Length=471, Percent_Identity=45.6475583864119, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI106049528, Length=477, Percent_Identity=43.6058700209644, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=477, Percent_Identity=43.6058700209644, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=477, Percent_Identity=43.6058700209644, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38679977, Length=511, Percent_Identity=31.5068493150685, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679967, Length=511, Percent_Identity=31.5068493150685, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679974, Length=511, Percent_Identity=31.5068493150685, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679960, Length=511, Percent_Identity=31.5068493150685, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679971, Length=511, Percent_Identity=31.5068493150685, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=30.5283757338552, Blast_Score=225, Evalue=7e-59,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=54.1387024608501, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1786216, Length=317, Percent_Identity=23.6593059936909, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.9638009049774, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=481, Percent_Identity=45.5301455301455, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17562816, Length=473, Percent_Identity=42.7061310782241, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=28.3673469387755, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=443, Percent_Identity=30.2483069977427, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=443, Percent_Identity=30.2483069977427, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319695, Length=473, Percent_Identity=44.1860465116279, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=41.1764705882353, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=473, Percent_Identity=44.6088794926004, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323863, Length=491, Percent_Identity=30.5498981670061, Blast_Score=220, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324343, Length=530, Percent_Identity=29.2452830188679, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322331, Length=299, Percent_Identity=22.4080267558528, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=44.543429844098, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652212, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=474, Percent_Identity=46.4135021097046, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651759, Length=411, Percent_Identity=43.5523114355231, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=29.9009900990099, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=29.9009900990099, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=29.9009900990099, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=29.9009900990099, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 54647; Mature: 54647

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKILVANRGEIAIRIMRACRELGIKTVAVYSDADKGALFVKYADEAYHIGPSQLSESY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEECCHHHHHHHH
LNIKKIVSAAKKAGVDGVHPGYGFLSENPGFALALEKAGIKFIGPSSRVIELMGNKIAAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHCCHHHHH
REMKKAGVPVLPGTEGCVSGIEQATEAAAAIGYPVIIKPSGGGGGIGMRVANGPDELKDA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCHHHHHHH
IESSQKVAGNTFGLAEVYIEKYISNPRHIEIQIMGDSQGNVVYLGERECSIQRRYQKLIE
HHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
EAPSPVITPELRKKMGEVAIKAGKWVNYEGAGTIEFIFSNGQFYFLEANTRVQVEHPVTE
HCCCCCCCHHHHHHHHHHEEECCCEEEECCCCEEEEEEECCEEEEEECCCEEEECCCHHH
MVTGIDIVKEQIMVASGDELSFKQEDVQMRGWAIECRINAEDPLNEFAPSAAKLKGYRSP
HHHHHHHHHHHHEEECCCCCCCCCCCCEECCEEEEEEECCCCCHHHHCCCHHHHCCCCCC
GGIGVRVDSGVHTRYNIPYLYDPMISKLIVWGRTREEAIARMRRALYEYIIVGVKTNIPF
CCEEEEECCCCCEEECCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCE
HKAVLVNPNFVAGNLHTHFIEKETTLLDEMKRIMSEEQPLEEKLSEIFDDTRRIAAIAAV
EEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AALTQLPAEIDEDEITGV
HHHHHCCCCCCCHHCCCC
>Mature Secondary Structure
MLNKILVANRGEIAIRIMRACRELGIKTVAVYSDADKGALFVKYADEAYHIGPSQLSESY
CCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCCEECCHHHHHHHH
LNIKKIVSAAKKAGVDGVHPGYGFLSENPGFALALEKAGIKFIGPSSRVIELMGNKIAAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHCCHHHHH
REMKKAGVPVLPGTEGCVSGIEQATEAAAAIGYPVIIKPSGGGGGIGMRVANGPDELKDA
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEECCCHHHHHHH
IESSQKVAGNTFGLAEVYIEKYISNPRHIEIQIMGDSQGNVVYLGERECSIQRRYQKLIE
HHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
EAPSPVITPELRKKMGEVAIKAGKWVNYEGAGTIEFIFSNGQFYFLEANTRVQVEHPVTE
HCCCCCCCHHHHHHHHHHEEECCCEEEECCCCEEEEEEECCEEEEEECCCEEEECCCHHH
MVTGIDIVKEQIMVASGDELSFKQEDVQMRGWAIECRINAEDPLNEFAPSAAKLKGYRSP
HHHHHHHHHHHHEEECCCCCCCCCCCCEECCEEEEEEECCCCCHHHHCCCHHHHCCCCCC
GGIGVRVDSGVHTRYNIPYLYDPMISKLIVWGRTREEAIARMRRALYEYIIVGVKTNIPF
CCEEEEECCCCCEEECCCEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEECCCCE
HKAVLVNPNFVAGNLHTHFIEKETTLLDEMKRIMSEEQPLEEKLSEIFDDTRRIAAIAAV
EEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AALTQLPAEIDEDEITGV
HHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 9478969 [H]