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The map label for this gene is nrd-2 [H]

Identifier: 57234895

GI number: 57234895

Start: 329593

End: 331878

Strand: Direct

Name: nrd-2 [H]

Synonym: DET0345

Alternate gene names: 57234895

Gene position: 329593-331878 (Clockwise)

Preceding gene: 57234896

Following gene: 57234894

Centisome position: 22.43

GC content: 50.7

Gene sequence:

>2286_bases
ATGCCGGTAAAAGTACAAGTTAAATCTGAAATTAAGGCTGATGCCAAAACTGAGGGGCTGAAGCTTACAGATAATGCCAT
GTGCGTGCTGGAACGCCGCTATCTGAAAAAAGACAAGCAGGGGAAACCCTCTGAAACAGTGGAAGATATGTTCCGCAGGG
TTGCCCGCACTATTGCCATGGGTGAGCTTATTTATAACCCCAAGGCAGACGTAAGAAGCCGCGAGGATGAGTTTTATAAT
ATTATGACCCGGCTGGAGTTTTTGCCCAATTCCCCCACCCTTATGAATGCCGGACGTGAACTGGGTCAGCTTTCGGCCTG
TTTCGTGCTGCCGGTAGATGATTCCATAGAGTCTATTTTTGATGCCGTAAAGCATACTGCCATGATACATAAAAGCGGCG
GCGGCACCGGCTTTTCGTTTTCCCGCCTGCGTCCCGAACAGGACCGGGTGGGCACTACCGGAGGGGTGGCCAGCGGGCCT
GTATCCTTCATGCGTGCCTTTGACGTGGCAACTGATGTTATCAAGCAGGGCGGCACCAGACGGGGCGCCAATATGGCTAT
CTTGAGTATTGACCACCCGGACATCATGAAATTTATCCATGCCAAAGATAAGGCCGGGGTGCTGACAAACTTTAATTTGT
CGGTGGCTATTACTGATAAATTTATGCAGGCGGTCAAAGACGGGGTTGATTATGATTTGCTTAATCCCCACAACGGCGAG
GTGGTTTCCCGCCTGAATGCTACCGAGGTGTTTAACAAGATTGTCCACATGGCCTGGAAGACGGGTGACCCCGGTATTGT
GTTTATAGACCGCATAAATGCTTATAATCCCACTCCCCAGCTGGGGCGGATTGAAAGCACTAATCCCTGCGGTGAACAGC
CTCTGCTGCCTTATGAGTCATGCAATCTGGGGTCTATAAACCTGTCCCGCATGGTGACCGTAAGCGGCGGCCAAGCGGTG
GTTGATTATAAAAAGCTCAGCCGGGTTGTAAAGAGTGCGGTCCGTTTCCTGGATAATGTTATTGATGTTAATAAATTTCC
CCTGCCCCAGATTGAGGAGATGACCAAGAAAAGCCGCAAGATTGGTCTGGGGGTAATGGGTTTTGCGGATATGCTTTTGG
AACTGGGCATACCTTACAATTCGGAAAACTCTATCAAGCTGGCAGAAGAGATAATGTGCTTTGTAAATGAGGAAGCCCAC
AAGTTCTCTTCAGAGCTGGCGGTGGAGAGGGGGGTGTTCCCGGCTTATCGCGGGAGTATTTATGAAAAGAGCGGCCGCCC
CATGCGGAATGCTTCCTGCACAACCATTGCACCCACCGGTACTTTGTCTATTATAGCCGGCTGTTCTTCGGGTATTGAGC
CCCATTTTGCCCTGTGCTTCACCCGCAATATACTGGACGGTACCAAGATGATAGAGGTTAACCCGTATTTTGAGCGGGCG
GCTAAAGAAGGCGGGTATTATTCCGAGGAGCTTATTAAATCTTTGGCGGAAGGGGCTCATCTGGACGAAGCTGATGTGCC
GGCCGAAGCCAAAGAATTGTTCGTAACTGCCCACCAGATTGTGCCGGAGTGGCATGTTCGTATTCAGGCAGCCTTTCAGA
AGTGCACTGATAACGCTGTGTCCAAGACAGTAAACTTCTCGCGTGAGGCGGTTGAAGGTGACGTAGCTGAGGTTTACAAG
ATGGCTCATGACAGCAACCTTAAGGGCATTACCATCTACCGTGACGGCAGCCGTGAAGACCAGCCTATGTCTACCGGCAA
GGCTGAAAATAAAATTGAGACCCCGGCGGCGGTTGTTAACCCCAATTTGGCACCGCGCAAACGTTCCAAAGTAACCCAGG
GTATTACCGAAAGGGTCACGACGGGTTGCGGATATATTTACGTTACTGTAAACTCTGACGAGCATGGAATTTGTGAGGTA
TTTTCCTCGCTGGGCAAAGCGGGAGGCTGTGCCTCTGCCCAGCTGGAATCTACCTGCCGGCTTATTTCGCTGGCTTTGCG
TTCCGGTATGGAAGTGGCTTCGGTGGTTAAACAGCTTAGAGGTATCCGCTGCCCATCCATTGCCTGGGATGACAGCAAAG
CTGTGTTAAGCTGTGCTGATGCTATTGCCAGCGTGCTGGAAAAACATGTGGATGGTTATACCCAGCCGGTGGCAGGTTCG
GCAAAGACCGTAAGCGCTAATGCTCTGGTTCGGAATATAGCCGGGCAATGTCCGGAATGCGGCAGTATTCTGGTGTATCA
GGAAGGGTGTTTTATTTGTCCCGGTTGCGGTTATACTAAATGCTAA

Upstream 100 bases:

>100_bases
CACCGATGACGAAATAGATTTAATGGTCAAAGAGGTGCTGGAGGAAGGCGGCAAGGACAGGCAAGCCCAAAATAATACCC
AAGCCAAGGAGGAAGAACCA

Downstream 100 bases:

>100_bases
AAAATAATGGAGGAATATAAAATGGAAAACGTTAAGGATATGCTGGCTCTGGTACTGGTGGCTGCTGGATTTATGTATCT
TATGATAGTCATGGTAGCCG

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 761; Mature: 760

Protein sequence:

>761_residues
MPVKVQVKSEIKADAKTEGLKLTDNAMCVLERRYLKKDKQGKPSETVEDMFRRVARTIAMGELIYNPKADVRSREDEFYN
IMTRLEFLPNSPTLMNAGRELGQLSACFVLPVDDSIESIFDAVKHTAMIHKSGGGTGFSFSRLRPEQDRVGTTGGVASGP
VSFMRAFDVATDVIKQGGTRRGANMAILSIDHPDIMKFIHAKDKAGVLTNFNLSVAITDKFMQAVKDGVDYDLLNPHNGE
VVSRLNATEVFNKIVHMAWKTGDPGIVFIDRINAYNPTPQLGRIESTNPCGEQPLLPYESCNLGSINLSRMVTVSGGQAV
VDYKKLSRVVKSAVRFLDNVIDVNKFPLPQIEEMTKKSRKIGLGVMGFADMLLELGIPYNSENSIKLAEEIMCFVNEEAH
KFSSELAVERGVFPAYRGSIYEKSGRPMRNASCTTIAPTGTLSIIAGCSSGIEPHFALCFTRNILDGTKMIEVNPYFERA
AKEGGYYSEELIKSLAEGAHLDEADVPAEAKELFVTAHQIVPEWHVRIQAAFQKCTDNAVSKTVNFSREAVEGDVAEVYK
MAHDSNLKGITIYRDGSREDQPMSTGKAENKIETPAAVVNPNLAPRKRSKVTQGITERVTTGCGYIYVTVNSDEHGICEV
FSSLGKAGGCASAQLESTCRLISLALRSGMEVASVVKQLRGIRCPSIAWDDSKAVLSCADAIASVLEKHVDGYTQPVAGS
AKTVSANALVRNIAGQCPECGSILVYQEGCFICPGCGYTKC

Sequences:

>Translated_761_residues
MPVKVQVKSEIKADAKTEGLKLTDNAMCVLERRYLKKDKQGKPSETVEDMFRRVARTIAMGELIYNPKADVRSREDEFYN
IMTRLEFLPNSPTLMNAGRELGQLSACFVLPVDDSIESIFDAVKHTAMIHKSGGGTGFSFSRLRPEQDRVGTTGGVASGP
VSFMRAFDVATDVIKQGGTRRGANMAILSIDHPDIMKFIHAKDKAGVLTNFNLSVAITDKFMQAVKDGVDYDLLNPHNGE
VVSRLNATEVFNKIVHMAWKTGDPGIVFIDRINAYNPTPQLGRIESTNPCGEQPLLPYESCNLGSINLSRMVTVSGGQAV
VDYKKLSRVVKSAVRFLDNVIDVNKFPLPQIEEMTKKSRKIGLGVMGFADMLLELGIPYNSENSIKLAEEIMCFVNEEAH
KFSSELAVERGVFPAYRGSIYEKSGRPMRNASCTTIAPTGTLSIIAGCSSGIEPHFALCFTRNILDGTKMIEVNPYFERA
AKEGGYYSEELIKSLAEGAHLDEADVPAEAKELFVTAHQIVPEWHVRIQAAFQKCTDNAVSKTVNFSREAVEGDVAEVYK
MAHDSNLKGITIYRDGSREDQPMSTGKAENKIETPAAVVNPNLAPRKRSKVTQGITERVTTGCGYIYVTVNSDEHGICEV
FSSLGKAGGCASAQLESTCRLISLALRSGMEVASVVKQLRGIRCPSIAWDDSKAVLSCADAIASVLEKHVDGYTQPVAGS
AKTVSANALVRNIAGQCPECGSILVYQEGCFICPGCGYTKC
>Mature_760_residues
PVKVQVKSEIKADAKTEGLKLTDNAMCVLERRYLKKDKQGKPSETVEDMFRRVARTIAMGELIYNPKADVRSREDEFYNI
MTRLEFLPNSPTLMNAGRELGQLSACFVLPVDDSIESIFDAVKHTAMIHKSGGGTGFSFSRLRPEQDRVGTTGGVASGPV
SFMRAFDVATDVIKQGGTRRGANMAILSIDHPDIMKFIHAKDKAGVLTNFNLSVAITDKFMQAVKDGVDYDLLNPHNGEV
VSRLNATEVFNKIVHMAWKTGDPGIVFIDRINAYNPTPQLGRIESTNPCGEQPLLPYESCNLGSINLSRMVTVSGGQAVV
DYKKLSRVVKSAVRFLDNVIDVNKFPLPQIEEMTKKSRKIGLGVMGFADMLLELGIPYNSENSIKLAEEIMCFVNEEAHK
FSSELAVERGVFPAYRGSIYEKSGRPMRNASCTTIAPTGTLSIIAGCSSGIEPHFALCFTRNILDGTKMIEVNPYFERAA
KEGGYYSEELIKSLAEGAHLDEADVPAEAKELFVTAHQIVPEWHVRIQAAFQKCTDNAVSKTVNFSREAVEGDVAEVYKM
AHDSNLKGITIYRDGSREDQPMSTGKAENKIETPAAVVNPNLAPRKRSKVTQGITERVTTGCGYIYVTVNSDEHGICEVF
SSLGKAGGCASAQLESTCRLISLALRSGMEVASVVKQLRGIRCPSIAWDDSKAVLSCADAIASVLEKHVDGYTQPVAGSA
KTVSANALVRNIAGQCPECGSILVYQEGCFICPGCGYTKC

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=552, Percent_Identity=29.7101449275362, Blast_Score=209, Evalue=8e-54,
Organism=Escherichia coli, GI1789030, Length=459, Percent_Identity=26.5795206971678, Blast_Score=139, Evalue=9e-34,
Organism=Escherichia coli, GI2367133, Length=496, Percent_Identity=21.9758064516129, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555242, Length=585, Percent_Identity=27.1794871794872, Blast_Score=188, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6322123, Length=555, Percent_Identity=29.009009009009, Blast_Score=193, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6320914, Length=555, Percent_Identity=27.5675675675676, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17352481, Length=570, Percent_Identity=28.0701754385965, Blast_Score=196, Evalue=7e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 82978; Mature: 82847

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVQVKSEIKADAKTEGLKLTDNAMCVLERRYLKKDKQGKPSETVEDMFRRVARTIAM
CCEEEEEHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
GELIYNPKADVRSREDEFYNIMTRLEFLPNSPTLMNAGRELGQLSACFVLPVDDSIESIF
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCEEEEEEECCHHHHHHH
DAVKHTAMIHKSGGGTGFSFSRLRPEQDRVGTTGGVASGPVSFMRAFDVATDVIKQGGTR
HHHHHHHEEEECCCCCCCCHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RGANMAILSIDHPDIMKFIHAKDKAGVLTNFNLSVAITDKFMQAVKDGVDYDLLNPHNGE
CCCCEEEEECCCHHHHHHHHCCCCCCEEEECCEEEEEHHHHHHHHHCCCCEECCCCCCCH
VVSRLNATEVFNKIVHMAWKTGDPGIVFIDRINAYNPTPQLGRIESTNPCGEQPLLPYES
HHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
CNLGSINLSRMVTVSGGQAVVDYKKLSRVVKSAVRFLDNVIDVNKFPLPQIEEMTKKSRK
CCCCCEEHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IGLGVMGFADMLLELGIPYNSENSIKLAEEIMCFVNEEAHKFSSELAVERGVFPAYRGSI
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
YEKSGRPMRNASCTTIAPTGTLSIIAGCSSGIEPHFALCFTRNILDGTKMIEVNPYFERA
CCCCCCCCCCCCCCEECCCCCCCEEECCCCCCCCCEEHEEHHHHCCCCEEEEECHHHHHH
AKEGGYYSEELIKSLAEGAHLDEADVPAEAKELFVTAHQIVPEWHVRIQAAFQKCTDNAV
HHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SKTVNFSREAVEGDVAEVYKMAHDSNLKGITIYRDGSREDQPMSTGKAENKIETPAAVVN
HHHHHCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHCC
PNLAPRKRSKVTQGITERVTTGCGYIYVTVNSDEHGICEVFSSLGKAGGCASAQLESTCR
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
LISLALRSGMEVASVVKQLRGIRCPSIAWDDSKAVLSCADAIASVLEKHVDGYTQPVAGS
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AKTVSANALVRNIAGQCPECGSILVYQEGCFICPGCGYTKC
CCEEHHHHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCCC
>Mature Secondary Structure 
PVKVQVKSEIKADAKTEGLKLTDNAMCVLERRYLKKDKQGKPSETVEDMFRRVARTIAM
CEEEEEHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
GELIYNPKADVRSREDEFYNIMTRLEFLPNSPTLMNAGRELGQLSACFVLPVDDSIESIF
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCHHHCCCEEEEEEECCHHHHHHH
DAVKHTAMIHKSGGGTGFSFSRLRPEQDRVGTTGGVASGPVSFMRAFDVATDVIKQGGTR
HHHHHHHEEEECCCCCCCCHHCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
RGANMAILSIDHPDIMKFIHAKDKAGVLTNFNLSVAITDKFMQAVKDGVDYDLLNPHNGE
CCCCEEEEECCCHHHHHHHHCCCCCCEEEECCEEEEEHHHHHHHHHCCCCEECCCCCCCH
VVSRLNATEVFNKIVHMAWKTGDPGIVFIDRINAYNPTPQLGRIESTNPCGEQPLLPYES
HHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
CNLGSINLSRMVTVSGGQAVVDYKKLSRVVKSAVRFLDNVIDVNKFPLPQIEEMTKKSRK
CCCCCEEHEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
IGLGVMGFADMLLELGIPYNSENSIKLAEEIMCFVNEEAHKFSSELAVERGVFPAYRGSI
CCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
YEKSGRPMRNASCTTIAPTGTLSIIAGCSSGIEPHFALCFTRNILDGTKMIEVNPYFERA
CCCCCCCCCCCCCCEECCCCCCCEEECCCCCCCCCEEHEEHHHHCCCCEEEEECHHHHHH
AKEGGYYSEELIKSLAEGAHLDEADVPAEAKELFVTAHQIVPEWHVRIQAAFQKCTDNAV
HHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
SKTVNFSREAVEGDVAEVYKMAHDSNLKGITIYRDGSREDQPMSTGKAENKIETPAAVVN
HHHHHCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHCC
PNLAPRKRSKVTQGITERVTTGCGYIYVTVNSDEHGICEVFSSLGKAGGCASAQLESTCR
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHH
LISLALRSGMEVASVVKQLRGIRCPSIAWDDSKAVLSCADAIASVLEKHVDGYTQPVAGS
HHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AKTVSANALVRNIAGQCPECGSILVYQEGCFICPGCGYTKC
CCEEHHHHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]