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The map label for this gene is map [H]

Identifier: 57234757

GI number: 57234757

Start: 456533

End: 457288

Strand: Direct

Name: map [H]

Synonym: DET0496

Alternate gene names: 57234757

Gene position: 456533-457288 (Clockwise)

Preceding gene: 57234758

Following gene: 57234756

Centisome position: 31.06

GC content: 51.98

Gene sequence:

>756_bases
ATGACCATAATACTGAAAACCGAAAAAGAGATTGCTATAATGCGGCGGGCCGGTCATATACTGGCAGCTGCTTTAGAAGA
AGTTAAGAAGAATGTCAGACCGGGGGTAACTACCCGGGAGCTGGACGAGATAGCCGAGAGGGAACTGCGGCGCAGGGGGA
CAACTCCTTCGTTCAAAGGTTACCAGGGCTTCCCGGCCAGTCTTTGTGCGTCTGTAAACGAAGAGATTGTTCACGGCATA
CCCGGTGGCCGGGTATTAAAAGAAGGCGACATAATATCGCTGGATATAGGCAATATATTAGAAGGATTCCAGGCGGATAT
GGCTGTGACAGTGGGGGTGGGTGAAATATCTCCCGCGGCCACGCGGCTTTTATCTGCTACTCAGGCCTCACTGGTGGCCG
GGATTGCTCAAGCCAGGGCAGGCGGGCATCTGGGTGACATAGGTGCGGTAGTTGAGGAATATGCCCAAAGCAGAGGGTAT
GGGGTAGTCAGGGATTATACCGGACACGGTATAGGCCGGGATATGCACGAAGACCCCCAGATACCGAACTTTGGCCGCCG
GGGTAAAGGCCCGGAATTAAAAAAGGGTATGACACTGGCTATAGAGCCAATGTTAAATCTGGGCACTGAAAAGACAAGAG
TAGCCCCTGACTGCTGGACAGTGTATACTGCGGATGGCAGTTTGTCGGCTCATTTTGAACATACAGTTGCCATTACCGAT
GGTGAGCCGGAAATACTCACCGTGATAGAAGGATAG

Upstream 100 bases:

>100_bases
CGCTCAAAGGGCAAGCTGAGTGAGATTGATGGTATGGCTGAGATAACAGAGGTGACCAAGCGGATTGTATCAGCTATAAA
GTGCGGTAAATAACCGGTTT

Downstream 100 bases:

>100_bases
CGGGGATTTATGCCTAAAAAAGATGCAATAGAAGTTGAAGCGACAGTGCTGGAGGCTTTGCCCAGTGCCGCTTTTCGTGT
TCAGCTTTCAAACGGGCATG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTIILKTEKEIAIMRRAGHILAAALEEVKKNVRPGVTTRELDEIAERELRRRGTTPSFKGYQGFPASLCASVNEEIVHGI
PGGRVLKEGDIISLDIGNILEGFQADMAVTVGVGEISPAATRLLSATQASLVAGIAQARAGGHLGDIGAVVEEYAQSRGY
GVVRDYTGHGIGRDMHEDPQIPNFGRRGKGPELKKGMTLAIEPMLNLGTEKTRVAPDCWTVYTADGSLSAHFEHTVAITD
GEPEILTVIEG

Sequences:

>Translated_251_residues
MTIILKTEKEIAIMRRAGHILAAALEEVKKNVRPGVTTRELDEIAERELRRRGTTPSFKGYQGFPASLCASVNEEIVHGI
PGGRVLKEGDIISLDIGNILEGFQADMAVTVGVGEISPAATRLLSATQASLVAGIAQARAGGHLGDIGAVVEEYAQSRGY
GVVRDYTGHGIGRDMHEDPQIPNFGRRGKGPELKKGMTLAIEPMLNLGTEKTRVAPDCWTVYTADGSLSAHFEHTVAITD
GEPEILTVIEG
>Mature_250_residues
TIILKTEKEIAIMRRAGHILAAALEEVKKNVRPGVTTRELDEIAERELRRRGTTPSFKGYQGFPASLCASVNEEIVHGIP
GGRVLKEGDIISLDIGNILEGFQADMAVTVGVGEISPAATRLLSATQASLVAGIAQARAGGHLGDIGAVVEEYAQSRGYG
VVRDYTGHGIGRDMHEDPQIPNFGRRGKGPELKKGMTLAIEPMLNLGTEKTRVAPDCWTVYTADGSLSAHFEHTVAITDG
EPEILTVIEG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=245, Percent_Identity=37.1428571428571, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=34.1463414634146, Blast_Score=154, Evalue=9e-38,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=41.6, Blast_Score=203, Evalue=9e-54,
Organism=Escherichia coli, GI1788728, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=250, Percent_Identity=37.2, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6323273, Length=247, Percent_Identity=41.2955465587045, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI21355531, Length=240, Percent_Identity=38.75, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=35.3909465020576, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI19920384, Length=237, Percent_Identity=21.9409282700422, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26837; Mature: 26706

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIILKTEKEIAIMRRAGHILAAALEEVKKNVRPGVTTRELDEIAERELRRRGTTPSFKG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
YQGFPASLCASVNEEIVHGIPGGRVLKEGDIISLDIGNILEGFQADMAVTVGVGEISPAA
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEHHHHHHHHCCCEEEEEECCCCCHHH
TRLLSATQASLVAGIAQARAGGHLGDIGAVVEEYAQSRGYGVVRDYTGHGIGRDMHEDPQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
IPNFGRRGKGPELKKGMTLAIEPMLNLGTEKTRVAPDCWTVYTADGSLSAHFEHTVAITD
CCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEEC
GEPEILTVIEG
CCCCEEEEECC
>Mature Secondary Structure 
TIILKTEKEIAIMRRAGHILAAALEEVKKNVRPGVTTRELDEIAERELRRRGTTPSFKG
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
YQGFPASLCASVNEEIVHGIPGGRVLKEGDIISLDIGNILEGFQADMAVTVGVGEISPAA
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEHHHHHHHHCCCEEEEEECCCCCHHH
TRLLSATQASLVAGIAQARAGGHLGDIGAVVEEYAQSRGYGVVRDYTGHGIGRDMHEDPQ
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCC
IPNFGRRGKGPELKKGMTLAIEPMLNLGTEKTRVAPDCWTVYTADGSLSAHFEHTVAITD
CCCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEEC
GEPEILTVIEG
CCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]