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The map label for this gene is glmU [H]

Identifier: 57234693

GI number: 57234693

Start: 482106

End: 483308

Strand: Direct

Name: glmU [H]

Synonym: DET0529

Alternate gene names: 57234693

Gene position: 482106-483308 (Clockwise)

Preceding gene: 57234694

Following gene: 57234692

Centisome position: 32.8

GC content: 53.37

Gene sequence:

>1203_bases
ATGAAGGCAGTCATATTGGCAGCGGGCGAAGGCAGCCGCATGCGTCCGCTTACATTTACCCGCCCCAAGGTTATGCTGCC
CATTGCGGGCAAGCCTATTTTGGAGCACCTCTTACTGGAGGTCAGCGCTGCCGGTATCACGGAGTTTATACTGGTGGTGG
GTTACCGTGATGAACAGGTGCGTTCGTATTTTGCAGACGGTGCCAGGTGGGGGTTGAAAATCAGCTATTGCCAGCAGACC
CGTCAGCTGGGTACCGCCCACGCCTTAAAGCAGCTTGAAAAGCAGCTGCAGGCTGATTTTCTGGTTATGAACGGGGATAT
ACTGGCAAAATCAGCTGATATCGCCGCTCTGGCGGCATCTTCCGAAACTACACTGGGTGTTTTTGAAGCATCAGACCCAC
GCCGCCTGGGGGTGCTTGAAACAGACGGCAGCCGGGTAAAACGTATCCATGAAAAATCCGCAAATCCCCCCACCAATCTG
GCAAATGCCGGTTTGTATTTCTTTACCCCACGTATATTTGCCGCCATAAACAATACCCCGCTGTCACTTAGGGGCGAATA
TGAAATAACCGCATCTATCCAGATGCTTATTGACAGCGGCCTGGCGGTGGGTTACCGCCCGCTTACTTACTGGCAGGACG
TCAGCTACCCGTGGGATTTGCTTGACCTGAATGCCTCCATGCTTAAAAGCCTTAGCCAACGTATTTGCGGCCAGGTAGAG
GAAAATGCGGTTATCAGGGGGGCGGTGGAAATAGGCGAAGGCAGCCGTGTTCGTTCGGGGGCGTATCTGGAAGGGCCGGT
GATAATAGGCAAAAACTGTGACATAGGCCCGAATTGTTATATCCGTCCGGCTACCTCCATAGGGGATAACTGCCGGGTTG
GGGCTTCGGTTGAGATAAAAAACTCTATTATTATGGATAATACCAAAATACCTCACCTGAATTATGTGGGGGATAGTGTT
ATCGGGCAAAACTGCAATCTGGGGGCCGGAACCAAGCTGGCAAACCTGCGTTTTGACGGCGCGGATATTACAGCCGGGGG
TGTCAATACCCGCCGCCGCAAGCTGGGTGCGGTCTTGGGGGATGGGGTTGAGACCGGTATTAACGTAAGCCTTAATCCGG
GCGTCCTTATAGGCGCAGGCAGCCGTATAGGGCCCGGTGCGGTTGTGAGCGGTGTTATTGAACCGAACTCATACATCGGC
TAA

Upstream 100 bases:

>100_bases
ATCCGCCTGACGGCCGAAGCCAGAACACCGGAGTACTGTGAGACTATTTACCAAACCGGGCTTAAGTGCCTGAAGAGCTG
TCTTTCCCGGGAGAAATAAA

Downstream 100 bases:

>100_bases
GGCGGGGAGTGAAATATGAAACAGGCAGTTATACTGGCGGCCGGTGAAGGACAGCGTCTTAGGCCTTTTACCTCAAGCAA
GTCAAAGGTTATGTTGTCTA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKAVILAAGEGSRMRPLTFTRPKVMLPIAGKPILEHLLLEVSAAGITEFILVVGYRDEQVRSYFADGARWGLKISYCQQT
RQLGTAHALKQLEKQLQADFLVMNGDILAKSADIAALAASSETTLGVFEASDPRRLGVLETDGSRVKRIHEKSANPPTNL
ANAGLYFFTPRIFAAINNTPLSLRGEYEITASIQMLIDSGLAVGYRPLTYWQDVSYPWDLLDLNASMLKSLSQRICGQVE
ENAVIRGAVEIGEGSRVRSGAYLEGPVIIGKNCDIGPNCYIRPATSIGDNCRVGASVEIKNSIIMDNTKIPHLNYVGDSV
IGQNCNLGAGTKLANLRFDGADITAGGVNTRRRKLGAVLGDGVETGINVSLNPGVLIGAGSRIGPGAVVSGVIEPNSYIG

Sequences:

>Translated_400_residues
MKAVILAAGEGSRMRPLTFTRPKVMLPIAGKPILEHLLLEVSAAGITEFILVVGYRDEQVRSYFADGARWGLKISYCQQT
RQLGTAHALKQLEKQLQADFLVMNGDILAKSADIAALAASSETTLGVFEASDPRRLGVLETDGSRVKRIHEKSANPPTNL
ANAGLYFFTPRIFAAINNTPLSLRGEYEITASIQMLIDSGLAVGYRPLTYWQDVSYPWDLLDLNASMLKSLSQRICGQVE
ENAVIRGAVEIGEGSRVRSGAYLEGPVIIGKNCDIGPNCYIRPATSIGDNCRVGASVEIKNSIIMDNTKIPHLNYVGDSV
IGQNCNLGAGTKLANLRFDGADITAGGVNTRRRKLGAVLGDGVETGINVSLNPGVLIGAGSRIGPGAVVSGVIEPNSYIG
>Mature_400_residues
MKAVILAAGEGSRMRPLTFTRPKVMLPIAGKPILEHLLLEVSAAGITEFILVVGYRDEQVRSYFADGARWGLKISYCQQT
RQLGTAHALKQLEKQLQADFLVMNGDILAKSADIAALAASSETTLGVFEASDPRRLGVLETDGSRVKRIHEKSANPPTNL
ANAGLYFFTPRIFAAINNTPLSLRGEYEITASIQMLIDSGLAVGYRPLTYWQDVSYPWDLLDLNASMLKSLSQRICGQVE
ENAVIRGAVEIGEGSRVRSGAYLEGPVIIGKNCDIGPNCYIRPATSIGDNCRVGASVEIKNSIIMDNTKIPHLNYVGDSV
IGQNCNLGAGTKLANLRFDGADITAGGVNTRRRKLGAVLGDGVETGINVSLNPGVLIGAGSRIGPGAVVSGVIEPNSYIG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=353, Percent_Identity=27.1954674220963, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI11761619, Length=343, Percent_Identity=27.4052478134111, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI31881779, Length=357, Percent_Identity=23.5294117647059, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI45447090, Length=357, Percent_Identity=23.5294117647059, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1790224, Length=211, Percent_Identity=32.7014218009479, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788351, Length=267, Percent_Identity=29.5880149812734, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790168, Length=471, Percent_Identity=23.3545647558386, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=354, Percent_Identity=28.5310734463277, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17509979, Length=358, Percent_Identity=25.1396648044693, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17509981, Length=345, Percent_Identity=24.3478260869565, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=355, Percent_Identity=27.3239436619718, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21355443, Length=351, Percent_Identity=26.4957264957265, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24644084, Length=351, Percent_Identity=26.4957264957265, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653912, Length=380, Percent_Identity=25, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 42728; Mature: 42728

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVILAAGEGSRMRPLTFTRPKVMLPIAGKPILEHLLLEVSAAGITEFILVVGYRDEQV
CCEEEEECCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCHHHH
RSYFADGARWGLKISYCQQTRQLGTAHALKQLEKQLQADFLVMNGDILAKSADIAALAAS
HHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCEEEEECC
SETTLGVFEASDPRRLGVLETDGSRVKRIHEKSANPPTNLANAGLYFFTPRIFAAINNTP
CCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHCCCEEEECCEEEEEECCCC
LSLRGEYEITASIQMLIDSGLAVGYRPLTYWQDVSYPWDLLDLNASMLKSLSQRICGQVE
EEEECCEEEEEEEEEEHHCCCCCCEECCEEEECCCCCCCEEECCHHHHHHHHHHHCCCCC
ENAVIRGAVEIGEGSRVRSGAYLEGPVIIGKNCDIGPNCYIRPATSIGDNCRVGASVEIK
CCEEEEEEEEECCCCEECCCCEEECCEEECCCCCCCCCCEEEECCCCCCCCEECCEEEEC
NSIIMDNTKIPHLNYVGDSVIGQNCNLGAGTKLANLRFDGADITAGGVNTRRRKLGAVLG
CEEEECCCCCCEEECCCCHHCCCCCCCCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHC
DGVETGINVSLNPGVLIGAGSRIGPGAVVSGVIEPNSYIG
CCCCCCEEEEECCCEEEECCCCCCCCHHEEEEECCCCCCC
>Mature Secondary Structure
MKAVILAAGEGSRMRPLTFTRPKVMLPIAGKPILEHLLLEVSAAGITEFILVVGYRDEQV
CCEEEEECCCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCHHHH
RSYFADGARWGLKISYCQQTRQLGTAHALKQLEKQLQADFLVMNGDILAKSADIAALAAS
HHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCEEEEECC
SETTLGVFEASDPRRLGVLETDGSRVKRIHEKSANPPTNLANAGLYFFTPRIFAAINNTP
CCCEEEEEECCCCCEEEEEECCCHHHHHHHHHCCCCCCCHHCCCEEEECCEEEEEECCCC
LSLRGEYEITASIQMLIDSGLAVGYRPLTYWQDVSYPWDLLDLNASMLKSLSQRICGQVE
EEEECCEEEEEEEEEEHHCCCCCCEECCEEEECCCCCCCEEECCHHHHHHHHHHHCCCCC
ENAVIRGAVEIGEGSRVRSGAYLEGPVIIGKNCDIGPNCYIRPATSIGDNCRVGASVEIK
CCEEEEEEEEECCCCEECCCCEEECCEEECCCCCCCCCCEEEECCCCCCCCEECCEEEEC
NSIIMDNTKIPHLNYVGDSVIGQNCNLGAGTKLANLRFDGADITAGGVNTRRRKLGAVLG
CEEEECCCCCCEEECCCCHHCCCCCCCCCCCEEEEEEECCCEEEECCCCHHHHHHHHHHC
DGVETGINVSLNPGVLIGAGSRIGPGAVVSGVIEPNSYIG
CCCCCCEEEEECCCEEEECCCCCCCCHHEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]