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The map label for this gene is nrd-3 [H]

Identifier: 57234550

GI number: 57234550

Start: 575110

End: 576909

Strand: Direct

Name: nrd-3 [H]

Synonym: DET0623

Alternate gene names: 57234550

Gene position: 575110-576909 (Clockwise)

Preceding gene: 57234551

Following gene: 57234546

Centisome position: 39.13

GC content: 49.89

Gene sequence:

>1800_bases
ATGACAGTAGAATTCGGCAGGCAATCAGTTCTGGCAGATGTACGCTTATCTACTACCGCCAAGAGGGTACTAGAAAAACG
TTATCTAAAGAAAGATGCCAACGGGCGGGTGATTGAAACGCCGGAGGATATGTTTCGCCGGGTTGCCAGAGTAGTGGCAT
CTGCCGAATGCAAATATGCACCAGGGGCGGATACCAGCCGGATAGAAGATGAATTTTATCAGGCTATGTCCCGCCTGGAG
TTTCTGCCGAATTCGCCCACTCTGTTAAATGCCGGGCGGCAGGTGGGGCAGCTTTCGGCCTGTTTTGTACTGCCGGTAGA
GGATTCTATTGAGTCTATTTTTGATGCGGTCAAGCAGACAGCTCTTATTCATAAAAGCGGGGGCGGTACCGGATTTTCCT
TTTCAAATCTCAGGCCTGCCGGAGACAAAGTAGGGGAATTAACAGAAGTAGCCGGAGGGCCGGTTTCTGTCATAAACATA
TTTTCCGCAGCAGCAGATTATGTGCGCCAGGGCGGGGTACGCCGCGGGTGTAATGCCGCTATTTTAGACGTAACCCATCC
TGATATTCTCAAGTTTATATCCTGCAAGGGTGACCCTAATGCACTGACCAATTTCTACATTTCGGTTGTGGTCACCAGAG
AGTTTATGACTAAAGTCCGCAGCGGTGAAGATTACGATATTATCAACCCTCATACCGGCGAAGTAGTCCAGCGGCTCAAT
GCCGCCTGTGTGTTTGACTGTATTGTGGACCAGGCCTGGAAAACAGGTGACCCCGGTCTGGTATTTATAGACCGGATAAA
TGATGATAACCCCACCCCGGAATTAGGCCGTATCAGGCATGTGAGCGGCTGTGGTGAGCAGACCCTTTTGCCGTATGAAT
CCTGCAATCTGGGTTCAATCTCCCTGCCCCGTATGCTTAAGCGTGACGGTGAGAGGGTAGTAGTAGACTATGAAAAACTG
GGACGGACAGTCAAAATGGCTATCCGCTTTTTGGATAATGTAATAGATGTAAATAGATTCCCCACCCCTGAGATTGAAAA
AGCCACCTTGCGTAACCGCAAGATAGGCTTGGGGGTGATGGGCTTTGCCGATATGCTGGTTTTGATGGGTATACCATATA
ATTCCGAAGAGGCTATATTTCAGGCTGACCAGATAATGGAGTTTATCAAGGAAACCTCCCACCGTGCTTCGTCCAAACTG
GCCGAAGCCAGAGGCTCTTTCCCTGCTTATGAGGGCAGTATTTATGACGTACCCGGCGGACGCCCCATGAGGAACGCCAC
CTGTACCAGTATAGCCCCCACCGGCACCCTTTCCATTATCGCCGGGGTTTCTTCGGGCATAGAGCCTTCTTTCGCTATGG
TATTCGTCAGGAATATTCTGGATGGTGAAAATCTGCTGGAGATAAACCCCTATTTTGAGGAAATGGCCAGACGTGAGGGT
TTTCATTCCAAAGAGCTGTTTGAAAAGCTGGTTTCGTCAAACCATCTGCATGATATGGAGTGTGTGCCGGACTGGCTGAA
ACGGCTGCTGGTTACCGCTCACCGCATTCGCCCCGAATGGCATATCCGCATTCAGGCGGCTTTCCAAAAGTATACTGACA
ATGCTGTTTCCAAGACGGTAAATTTCTCCCATGAAGCTACCCGTGAGGATATGGCCAATGTGTTTAATCTGGCCTACGAC
AAGGGTCTTAAAGGGATAACGGTTTACCGTGACGGAAGCCGGGCAGCCCAGCCTTTATGCACCAGTGAATCCGGCGTCAA
GCTGGTAGACCAGTATCTGGATAACTGCTCTTGCCATTAG

Upstream 100 bases:

>100_bases
GGAAGAAGCCGCTGAGGCTGCCCGTAAGTATTTGAATAATGTGGTGGTGCTTACCCTGGATATGAAACGAATCGGTGATA
AGGCCATTAAGGTTTTTTAA

Downstream 100 bases:

>100_bases
GTATTGTTGTTTACACGGGAAAAAACAGCTAAAATCTCCGGGTCAAACTGTGTGCCTGAACATCTCTTCAGTTCTTCCCA
GGCTTCTTTATCTGTCATTG

Product: ribonucleotide reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTVEFGRQSVLADVRLSTTAKRVLEKRYLKKDANGRVIETPEDMFRRVARVVASAECKYAPGADTSRIEDEFYQAMSRLE
FLPNSPTLLNAGRQVGQLSACFVLPVEDSIESIFDAVKQTALIHKSGGGTGFSFSNLRPAGDKVGELTEVAGGPVSVINI
FSAAADYVRQGGVRRGCNAAILDVTHPDILKFISCKGDPNALTNFYISVVVTREFMTKVRSGEDYDIINPHTGEVVQRLN
AACVFDCIVDQAWKTGDPGLVFIDRINDDNPTPELGRIRHVSGCGEQTLLPYESCNLGSISLPRMLKRDGERVVVDYEKL
GRTVKMAIRFLDNVIDVNRFPTPEIEKATLRNRKIGLGVMGFADMLVLMGIPYNSEEAIFQADQIMEFIKETSHRASSKL
AEARGSFPAYEGSIYDVPGGRPMRNATCTSIAPTGTLSIIAGVSSGIEPSFAMVFVRNILDGENLLEINPYFEEMARREG
FHSKELFEKLVSSNHLHDMECVPDWLKRLLVTAHRIRPEWHIRIQAAFQKYTDNAVSKTVNFSHEATREDMANVFNLAYD
KGLKGITVYRDGSRAAQPLCTSESGVKLVDQYLDNCSCH

Sequences:

>Translated_599_residues
MTVEFGRQSVLADVRLSTTAKRVLEKRYLKKDANGRVIETPEDMFRRVARVVASAECKYAPGADTSRIEDEFYQAMSRLE
FLPNSPTLLNAGRQVGQLSACFVLPVEDSIESIFDAVKQTALIHKSGGGTGFSFSNLRPAGDKVGELTEVAGGPVSVINI
FSAAADYVRQGGVRRGCNAAILDVTHPDILKFISCKGDPNALTNFYISVVVTREFMTKVRSGEDYDIINPHTGEVVQRLN
AACVFDCIVDQAWKTGDPGLVFIDRINDDNPTPELGRIRHVSGCGEQTLLPYESCNLGSISLPRMLKRDGERVVVDYEKL
GRTVKMAIRFLDNVIDVNRFPTPEIEKATLRNRKIGLGVMGFADMLVLMGIPYNSEEAIFQADQIMEFIKETSHRASSKL
AEARGSFPAYEGSIYDVPGGRPMRNATCTSIAPTGTLSIIAGVSSGIEPSFAMVFVRNILDGENLLEINPYFEEMARREG
FHSKELFEKLVSSNHLHDMECVPDWLKRLLVTAHRIRPEWHIRIQAAFQKYTDNAVSKTVNFSHEATREDMANVFNLAYD
KGLKGITVYRDGSRAAQPLCTSESGVKLVDQYLDNCSCH
>Mature_598_residues
TVEFGRQSVLADVRLSTTAKRVLEKRYLKKDANGRVIETPEDMFRRVARVVASAECKYAPGADTSRIEDEFYQAMSRLEF
LPNSPTLLNAGRQVGQLSACFVLPVEDSIESIFDAVKQTALIHKSGGGTGFSFSNLRPAGDKVGELTEVAGGPVSVINIF
SAAADYVRQGGVRRGCNAAILDVTHPDILKFISCKGDPNALTNFYISVVVTREFMTKVRSGEDYDIINPHTGEVVQRLNA
ACVFDCIVDQAWKTGDPGLVFIDRINDDNPTPELGRIRHVSGCGEQTLLPYESCNLGSISLPRMLKRDGERVVVDYEKLG
RTVKMAIRFLDNVIDVNRFPTPEIEKATLRNRKIGLGVMGFADMLVLMGIPYNSEEAIFQADQIMEFIKETSHRASSKLA
EARGSFPAYEGSIYDVPGGRPMRNATCTSIAPTGTLSIIAGVSSGIEPSFAMVFVRNILDGENLLEINPYFEEMARREGF
HSKELFEKLVSSNHLHDMECVPDWLKRLLVTAHRIRPEWHIRIQAAFQKYTDNAVSKTVNFSHEATREDMANVFNLAYDK
GLKGITVYRDGSRAAQPLCTSESGVKLVDQYLDNCSCH

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=617, Percent_Identity=27.8768233387358, Blast_Score=228, Evalue=9e-60,
Organism=Escherichia coli, GI1789030, Length=581, Percent_Identity=25.8175559380379, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI2367133, Length=661, Percent_Identity=20.2723146747353, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17555242, Length=607, Percent_Identity=27.5123558484349, Blast_Score=212, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320914, Length=643, Percent_Identity=27.8382581648523, Blast_Score=218, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322123, Length=608, Percent_Identity=27.4671052631579, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI17352481, Length=616, Percent_Identity=26.7857142857143, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 66406; Mature: 66275

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEFGRQSVLADVRLSTTAKRVLEKRYLKKDANGRVIETPEDMFRRVARVVASAECKYA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHCCCCCC
PGADTSRIEDEFYQAMSRLEFLPNSPTLLNAGRQVGQLSACFVLPVEDSIESIFDAVKQT
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHCCCEEEEEEECHHHHHHHHHHHHHH
ALIHKSGGGTGFSFSNLRPAGDKVGELTEVAGGPVSVINIFSAAADYVRQGGVRRGCNAA
HHEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
ILDVTHPDILKFISCKGDPNALTNFYISVVVTREFMTKVRSGEDYDIINPHTGEVVQRLN
EEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AACVFDCIVDQAWKTGDPGLVFIDRINDDNPTPELGRIRHVSGCGEQTLLPYESCNLGSI
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHCEEECCCCCCCCCCCCCCCCCCCC
SLPRMLKRDGERVVVDYEKLGRTVKMAIRFLDNVIDVNRFPTPEIEKATLRNRKIGLGVM
CHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHH
GFADMLVLMGIPYNSEEAIFQADQIMEFIKETSHRASSKLAEARGSFPAYEGSIYDVPGG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
RPMRNATCTSIAPTGTLSIIAGVSSGIEPSFAMVFVRNILDGENLLEINPYFEEMARREG
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCC
FHSKELFEKLVSSNHLHDMECVPDWLKRLLVTAHRIRPEWHIRIQAAFQKYTDNAVSKTV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHC
NFSHEATREDMANVFNLAYDKGLKGITVYRDGSRAAQPLCTSESGVKLVDQYLDNCSCH
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
TVEFGRQSVLADVRLSTTAKRVLEKRYLKKDANGRVIETPEDMFRRVARVVASAECKYA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHCCCCCC
PGADTSRIEDEFYQAMSRLEFLPNSPTLLNAGRQVGQLSACFVLPVEDSIESIFDAVKQT
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHCCCEEEEEEECHHHHHHHHHHHHHH
ALIHKSGGGTGFSFSNLRPAGDKVGELTEVAGGPVSVINIFSAAADYVRQGGVRRGCNAA
HHEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
ILDVTHPDILKFISCKGDPNALTNFYISVVVTREFMTKVRSGEDYDIINPHTGEVVQRLN
EEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AACVFDCIVDQAWKTGDPGLVFIDRINDDNPTPELGRIRHVSGCGEQTLLPYESCNLGSI
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHCEEECCCCCCCCCCCCCCCCCCCC
SLPRMLKRDGERVVVDYEKLGRTVKMAIRFLDNVIDVNRFPTPEIEKATLRNRKIGLGVM
CHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCHH
GFADMLVLMGIPYNSEEAIFQADQIMEFIKETSHRASSKLAEARGSFPAYEGSIYDVPGG
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
RPMRNATCTSIAPTGTLSIIAGVSSGIEPSFAMVFVRNILDGENLLEINPYFEEMARREG
CCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHHHHCC
FHSKELFEKLVSSNHLHDMECVPDWLKRLLVTAHRIRPEWHIRIQAAFQKYTDNAVSKTV
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHC
NFSHEATREDMANVFNLAYDKGLKGITVYRDGSRAAQPLCTSESGVKLVDQYLDNCSCH
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]