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The map label for this gene is napA [H]

Identifier: 57234518

GI number: 57234518

Start: 666888

End: 668171

Strand: Direct

Name: napA [H]

Synonym: DET0722

Alternate gene names: 57234518

Gene position: 666888-668171 (Clockwise)

Preceding gene: 57234465

Following gene: 57234517

Centisome position: 45.38

GC content: 47.35

Gene sequence:

>1284_bases
GTGACTGGTATGGAAACAGAAATCTATTTTAAATTTATACTCTCTTTTGGGCTTATTTTGCTTGTTGCCCGTTTGGGCGG
AGCCTTTGCAGAACGCTTTCTGAAACAACCGGCAGTTATCGGTGAACTTTTGGCCGGTATTATCATCTCACCCTTTCTGC
TGGGGCATTTCCTTTTTGCCAATGACCCGGTTATTTTGAACTTTGCCCTTATTGACGGGGTATTCAGCCAGAATGGTGAA
CATCTGAGCGAATTTGCCCCTATGGAAATTATTTCGCAGATAGCGGTTGTGGTTTTGCTGTTTGTGGCGGGTCTGGAAAC
AAACGTGGCCTCATTTATTAAAAACAGCTTTACCGGCGCTATGGTAGCCATTGGCGGGGTTGTTGTACCCTTTGCTTTGG
GTGTCTTTGGCGCCATGTACTTTTTCCCTGATTTGCATATTGCCGGATGGCTCTTTATCGGTGCTATTCTGACTGCCACC
AGCATCGGTATCACGGTACGCATACTAATGGATATGGGTAAACTCAGTTCCCGTGAGGGCACTATTATTCTGGTTGCCGC
CGTGGTGGATGATATTATCGGTCTGGTCATTTTGTCTGTGGTTATTTCCATGGCTCAGAGCGGCAGTATCAATGCCTTAA
GTGCTATAGGCACCGGTGTTATCGGCTTTGCAGTCTGGCTGGGTATACTTTTGCTGGGTGTGTACGGCCACAAATATATT
TCAAAATATATACTTACCCCGTTTAAGGCCTCCGGCACTATGCCAGTCATGGCCTTGATTGTGGGTCTGTTGGTTTCCTA
TATGGTCACGCTGGTGGGTCTGCATCCGGTAGTTGGTGCTTATGTAGCCGGGCTTATGTTTGCTTCCACCGCGGAAAAAG
AAGAAATACTCCATCAAACCCGCCCGATAATGCTTTTTATTGCCCCGTTCTTCTTTGCTTACCTGGGTATGCAGGTGGAT
TTGAAGGAAGTCTGGGCAGTAATTGTTCCGGCGCTGGTTATAGTTGTGCTGGCCATTATCGGCAAGATTATCGGCTGTTA
TTTTCCCGCCCGGTTTGTGGGCAAGACCAGTCATAAAGGTGCTTTGATTGTCGGTGTAGGTATGGTACCTAGAGGTGAAG
TGGGTCTTATCGTAGCCGGGGCGGGACTTATTGCCGGGGCTATCACCCGTGACCTTTTCGGCATTGCGGTAGCTGTCAGT
ATTTTGACTACCCTCGTTATGCCCCTTATGATAAAACCTTTATTCAAACCTAAAGCTGAAGCTAACGGCAAAGAGCTTCC
TTGA

Upstream 100 bases:

>100_bases
ATTCTTCTAAAATATATTTCCCTTTGGTTATTCTGCAATAGCAGCTCATAAATTAGATTATCAGCCGTATTTTTGCTAAA
ATAGATCAAATTATTCTTAA

Downstream 100 bases:

>100_bases
GTAAAAACATAGCTTAAGGTAAAATTGGGTACTATGCCTCTGTAGCTCAGTGGATAGAGCACCAGCCTCCGAAGCTGGTG
GCGAGAGTTCGAGTCTCTCC

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTGMETEIYFKFILSFGLILLVARLGGAFAERFLKQPAVIGELLAGIIISPFLLGHFLFANDPVILNFALIDGVFSQNGE
HLSEFAPMEIISQIAVVVLLFVAGLETNVASFIKNSFTGAMVAIGGVVVPFALGVFGAMYFFPDLHIAGWLFIGAILTAT
SIGITVRILMDMGKLSSREGTIILVAAVVDDIIGLVILSVVISMAQSGSINALSAIGTGVIGFAVWLGILLLGVYGHKYI
SKYILTPFKASGTMPVMALIVGLLVSYMVTLVGLHPVVGAYVAGLMFASTAEKEEILHQTRPIMLFIAPFFFAYLGMQVD
LKEVWAVIVPALVIVVLAIIGKIIGCYFPARFVGKTSHKGALIVGVGMVPRGEVGLIVAGAGLIAGAITRDLFGIAVAVS
ILTTLVMPLMIKPLFKPKAEANGKELP

Sequences:

>Translated_427_residues
MTGMETEIYFKFILSFGLILLVARLGGAFAERFLKQPAVIGELLAGIIISPFLLGHFLFANDPVILNFALIDGVFSQNGE
HLSEFAPMEIISQIAVVVLLFVAGLETNVASFIKNSFTGAMVAIGGVVVPFALGVFGAMYFFPDLHIAGWLFIGAILTAT
SIGITVRILMDMGKLSSREGTIILVAAVVDDIIGLVILSVVISMAQSGSINALSAIGTGVIGFAVWLGILLLGVYGHKYI
SKYILTPFKASGTMPVMALIVGLLVSYMVTLVGLHPVVGAYVAGLMFASTAEKEEILHQTRPIMLFIAPFFFAYLGMQVD
LKEVWAVIVPALVIVVLAIIGKIIGCYFPARFVGKTSHKGALIVGVGMVPRGEVGLIVAGAGLIAGAITRDLFGIAVAVS
ILTTLVMPLMIKPLFKPKAEANGKELP
>Mature_426_residues
TGMETEIYFKFILSFGLILLVARLGGAFAERFLKQPAVIGELLAGIIISPFLLGHFLFANDPVILNFALIDGVFSQNGEH
LSEFAPMEIISQIAVVVLLFVAGLETNVASFIKNSFTGAMVAIGGVVVPFALGVFGAMYFFPDLHIAGWLFIGAILTATS
IGITVRILMDMGKLSSREGTIILVAAVVDDIIGLVILSVVISMAQSGSINALSAIGTGVIGFAVWLGILLLGVYGHKYIS
KYILTPFKASGTMPVMALIVGLLVSYMVTLVGLHPVVGAYVAGLMFASTAEKEEILHQTRPIMLFIAPFFFAYLGMQVDL
KEVWAVIVPALVIVVLAIIGKIIGCYFPARFVGKTSHKGALIVGVGMVPRGEVGLIVAGAGLIAGAITRDLFGIAVAVSI
LTTLVMPLMIKPLFKPKAEANGKELP

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=446, Percent_Identity=27.1300448430493, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 45186; Mature: 45055

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGMETEIYFKFILSFGLILLVARLGGAFAERFLKQPAVIGELLAGIIISPFLLGHFLFA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
NDPVILNFALIDGVFSQNGEHLSEFAPMEIISQIAVVVLLFVAGLETNVASFIKNSFTGA
CCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHH
MVAIGGVVVPFALGVFGAMYFFPDLHIAGWLFIGAILTATSIGITVRILMDMGKLSSREG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TIILVAAVVDDIIGLVILSVVISMAQSGSINALSAIGTGVIGFAVWLGILLLGVYGHKYI
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKYILTPFKASGTMPVMALIVGLLVSYMVTLVGLHPVVGAYVAGLMFASTAEKEEILHQT
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHC
RPIMLFIAPFFFAYLGMQVDLKEVWAVIVPALVIVVLAIIGKIIGCYFPARFVGKTSHKG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ALIVGVGMVPRGEVGLIVAGAGLIAGAITRDLFGIAVAVSILTTLVMPLMIKPLFKPKAE
EEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ANGKELP
CCCCCCC
>Mature Secondary Structure 
TGMETEIYFKFILSFGLILLVARLGGAFAERFLKQPAVIGELLAGIIISPFLLGHFLFA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHC
NDPVILNFALIDGVFSQNGEHLSEFAPMEIISQIAVVVLLFVAGLETNVASFIKNSFTGA
CCCEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHH
MVAIGGVVVPFALGVFGAMYFFPDLHIAGWLFIGAILTATSIGITVRILMDMGKLSSREG
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TIILVAAVVDDIIGLVILSVVISMAQSGSINALSAIGTGVIGFAVWLGILLLGVYGHKYI
CEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKYILTPFKASGTMPVMALIVGLLVSYMVTLVGLHPVVGAYVAGLMFASTAEKEEILHQT
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHC
RPIMLFIAPFFFAYLGMQVDLKEVWAVIVPALVIVVLAIIGKIIGCYFPARFVGKTSHKG
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ALIVGVGMVPRGEVGLIVAGAGLIAGAITRDLFGIAVAVSILTTLVMPLMIKPLFKPKAE
EEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ANGKELP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]