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The map label for this gene is lpd [H]

Identifier: 57234504

GI number: 57234504

Start: 674884

End: 676353

Strand: Direct

Name: lpd [H]

Synonym: DET0732

Alternate gene names: 57234504

Gene position: 674884-676353 (Clockwise)

Preceding gene: 57234505

Following gene: 57234503

Centisome position: 45.92

GC content: 46.26

Gene sequence:

>1470_bases
ATGAAATATCAATATGATTTGGTGGTTATCGGTGGCGGGCTGGCTGGATTTACTGCCGCTGTTTTTGCAAATGGTCTTGG
CAAAAAAGTGGCCATAGTGGAGAAGGGTAAGCTGGGCGGGGCTTGTACCTGGAATGCCTGCGTGCCGTCTAAGGCTTTAC
TCCAGCTGGGTCTGCGTATCCGTCAATTAAACAACTATAACCGCAGCGGTACCAAACTGGCCAGCGTAAACTTGCAAACA
GAAAATGTTATGCCATACCTGCACTCGGTGCTGGAAAATATTTCCCGGATTGATGATTTTGCAAGTTTAGTAAACACGGG
CATAGATATATTAAATGGTGAGGCGGTATTCAACGGCCGGCATCAGGTAAGTCTAAACGGACAGCTTATATCTGCCAAGC
ACTTTATTATTGCAACCGGCTCAAGCCCGGCAATTCCCCCAGTAGAAGGACTGTCTGATATACCCTATTATACTAATGAG
ACTGTCTTTGACATAAAGGCTATACCATCTTCTATGATAGTGTTAGGCGGGGGTCCGGCCGGTATTGAGTTGGGGCTGGC
TTTTGCCTGGCTGGGCTGCAAAGTAGATATCATTGAAATGGCAGACCGTATATTGCCGAAGGACGATACCGAACTAAGTG
CCTTGTTACTGGAATACCTGAATGCTGAAGAAAACTTAAATATTCATATATCCACTAAAGCTGTTCGCTTTCAAAGTCAG
ACTGATGGCAGTCTGAAACTTGAAATGCAGACGCGTGAAGGCAAGATTAGTGAAATATCTTCCGAGACGGTGCTGGTAGC
AGTAGGCAGACGGGCAAATGTAGCCGGTCTTGCACTGGAAAAAGCTGGTGTTAAGTATACCCCCCGGGGTATCAGTATCA
ATAACAGGCTTCAAACCAGCTCTTCAAACATCTTTGCAGCCGGTGATGTGGCCGGACCTATCCAACTGGGTATGATGGCT
GAAAAACAGGCTATTTTGGCGGCAAGTAACGCCTGCTTGCCGTTTAAGCAGAGCATTAGGTATGAAGATGTGGCTTGGGT
AACATATTCCGAACCTCAAATGGCTCATATCGGTTTAACCGAGGATGAAGCCCGGCGGAAATATGGTAATAATGTGCGGG
TTATCCGCTATCCGCTTACTAAAGTGCGCCGGGCGGTTATGGACCATGATACCCGCGGTCTGTGTAAATTTATACTTGAT
AAAAATGACAGGCTGATAGGGGCACATCTGCTGTGTTCTCATGCCGAAAACCTTGTCCATGAACTGCAAATAGTAAAGTG
CCTGAATAAGCCGCTTTCAAAACTGCATACCATTCCCCATATTTATCCTACTTATGAAGAAGGGATAATAAAACGGGCAG
CGGATATCAGCTATACAATAAAAATGCAGCGCAATCCATTTGTCAGGCTGGTACTGCGCTACTGGCCTGGTTATAAGGAC
AGGCTGGATACAGTGATAAGCCGGCTGTAA

Upstream 100 bases:

>100_bases
ATATAAAGATTGGTTCGCTGATATAGAGTGTGAACGGGGTGGGGGAGGGATTAGATTCTGTGTTGGGTTAAGAGATTTGC
CAGGCAGAAAGAGAACAGAT

Downstream 100 bases:

>100_bases
GGCTTTCAGTTAGATATATAAACAGGGGGAAAGTATGGAGCGGGAGACGGGGCTCGAACCCGCGACAGCCTGCTTGGAAG
GCAGGAACTCTACCACTGAG

Product: mercuric reductase, putative

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MKYQYDLVVIGGGLAGFTAAVFANGLGKKVAIVEKGKLGGACTWNACVPSKALLQLGLRIRQLNNYNRSGTKLASVNLQT
ENVMPYLHSVLENISRIDDFASLVNTGIDILNGEAVFNGRHQVSLNGQLISAKHFIIATGSSPAIPPVEGLSDIPYYTNE
TVFDIKAIPSSMIVLGGGPAGIELGLAFAWLGCKVDIIEMADRILPKDDTELSALLLEYLNAEENLNIHISTKAVRFQSQ
TDGSLKLEMQTREGKISEISSETVLVAVGRRANVAGLALEKAGVKYTPRGISINNRLQTSSSNIFAAGDVAGPIQLGMMA
EKQAILAASNACLPFKQSIRYEDVAWVTYSEPQMAHIGLTEDEARRKYGNNVRVIRYPLTKVRRAVMDHDTRGLCKFILD
KNDRLIGAHLLCSHAENLVHELQIVKCLNKPLSKLHTIPHIYPTYEEGIIKRAADISYTIKMQRNPFVRLVLRYWPGYKD
RLDTVISRL

Sequences:

>Translated_489_residues
MKYQYDLVVIGGGLAGFTAAVFANGLGKKVAIVEKGKLGGACTWNACVPSKALLQLGLRIRQLNNYNRSGTKLASVNLQT
ENVMPYLHSVLENISRIDDFASLVNTGIDILNGEAVFNGRHQVSLNGQLISAKHFIIATGSSPAIPPVEGLSDIPYYTNE
TVFDIKAIPSSMIVLGGGPAGIELGLAFAWLGCKVDIIEMADRILPKDDTELSALLLEYLNAEENLNIHISTKAVRFQSQ
TDGSLKLEMQTREGKISEISSETVLVAVGRRANVAGLALEKAGVKYTPRGISINNRLQTSSSNIFAAGDVAGPIQLGMMA
EKQAILAASNACLPFKQSIRYEDVAWVTYSEPQMAHIGLTEDEARRKYGNNVRVIRYPLTKVRRAVMDHDTRGLCKFILD
KNDRLIGAHLLCSHAENLVHELQIVKCLNKPLSKLHTIPHIYPTYEEGIIKRAADISYTIKMQRNPFVRLVLRYWPGYKD
RLDTVISRL
>Mature_489_residues
MKYQYDLVVIGGGLAGFTAAVFANGLGKKVAIVEKGKLGGACTWNACVPSKALLQLGLRIRQLNNYNRSGTKLASVNLQT
ENVMPYLHSVLENISRIDDFASLVNTGIDILNGEAVFNGRHQVSLNGQLISAKHFIIATGSSPAIPPVEGLSDIPYYTNE
TVFDIKAIPSSMIVLGGGPAGIELGLAFAWLGCKVDIIEMADRILPKDDTELSALLLEYLNAEENLNIHISTKAVRFQSQ
TDGSLKLEMQTREGKISEISSETVLVAVGRRANVAGLALEKAGVKYTPRGISINNRLQTSSSNIFAAGDVAGPIQLGMMA
EKQAILAASNACLPFKQSIRYEDVAWVTYSEPQMAHIGLTEDEARRKYGNNVRVIRYPLTKVRRAVMDHDTRGLCKFILD
KNDRLIGAHLLCSHAENLVHELQIVKCLNKPLSKLHTIPHIYPTYEEGIIKRAADISYTIKMQRNPFVRLVLRYWPGYKD
RLDTVISRL

Specific function: Has chromate reductase activity [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=456, Percent_Identity=28.9473684210526, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI50301238, Length=471, Percent_Identity=25.2653927813163, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI22035672, Length=483, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI33519430, Length=441, Percent_Identity=24.9433106575964, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI33519428, Length=441, Percent_Identity=24.9433106575964, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI33519426, Length=441, Percent_Identity=24.9433106575964, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI148277065, Length=441, Percent_Identity=24.9433106575964, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI148277071, Length=441, Percent_Identity=24.9433106575964, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI291045266, Length=485, Percent_Identity=25.979381443299, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI291045268, Length=334, Percent_Identity=27.2455089820359, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=26.7094017094017, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=27.3522975929978, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789915, Length=470, Percent_Identity=27.6595744680851, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082354, Length=435, Percent_Identity=25.7471264367816, Blast_Score=125, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI32565766, Length=464, Percent_Identity=29.3103448275862, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983419, Length=441, Percent_Identity=25.6235827664399, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71983429, Length=441, Percent_Identity=25.6235827664399, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17557007, Length=482, Percent_Identity=23.6514522821577, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=23.5908141962422, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=28.8747346072187, Blast_Score=157, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=25.1063829787234, Blast_Score=120, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6325166, Length=467, Percent_Identity=24.4111349036403, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21358499, Length=476, Percent_Identity=26.4705882352941, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24640553, Length=395, Percent_Identity=25.8227848101266, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24640549, Length=395, Percent_Identity=25.8227848101266, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24640551, Length=395, Percent_Identity=25.8227848101266, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17737741, Length=399, Percent_Identity=25.5639097744361, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 53772; Mature: 53772

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYQYDLVVIGGGLAGFTAAVFANGLGKKVAIVEKGKLGGACTWNACVPSKALLQLGLRI
CCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
RQLNNYNRSGTKLASVNLQTENVMPYLHSVLENISRIDDFASLVNTGIDILNGEAVFNGR
HHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCC
HQVSLNGQLISAKHFIIATGSSPAIPPVEGLSDIPYYTNETVFDIKAIPSSMIVLGGGPA
EEEEECCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCCC
GIELGLAFAWLGCKVDIIEMADRILPKDDTELSALLLEYLNAEENLNIHISTKAVRFQSQ
CHHHHHEEHHHCCEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEECC
TDGSLKLEMQTREGKISEISSETVLVAVGRRANVAGLALEKAGVKYTPRGISINNRLQTS
CCCEEEEEEECCCCCCHHCCCCEEEEEECCCCCEEEEEEECCCCEECCCCCCCCCCEECC
SSNIFAAGDVAGPIQLGMMAEKQAILAASNACLPFKQSIRYEDVAWVTYSEPQMAHIGLT
CCCEEEECCCCCCHHCCHHHHHHHHEEECCCCCCHHHCCCCCEEEEEEECCCCEEEECCC
EDEARRKYGNNVRVIRYPLTKVRRAVMDHDTRGLCKFILDKNDRLIGAHLLCSHAENLVH
HHHHHHHHCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
ELQIVKCLNKPLSKLHTIPHIYPTYEEGIIKRAADISYTIKMQRNPFVRLVLRYWPGYKD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCHHH
RLDTVISRL
HHHHHHHCC
>Mature Secondary Structure
MKYQYDLVVIGGGLAGFTAAVFANGLGKKVAIVEKGKLGGACTWNACVPSKALLQLGLRI
CCEEEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
RQLNNYNRSGTKLASVNLQTENVMPYLHSVLENISRIDDFASLVNTGIDILNGEAVFNGR
HHHCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCC
HQVSLNGQLISAKHFIIATGSSPAIPPVEGLSDIPYYTNETVFDIKAIPSSMIVLGGGPA
EEEEECCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEECCCCC
GIELGLAFAWLGCKVDIIEMADRILPKDDTELSALLLEYLNAEENLNIHISTKAVRFQSQ
CHHHHHEEHHHCCEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEECC
TDGSLKLEMQTREGKISEISSETVLVAVGRRANVAGLALEKAGVKYTPRGISINNRLQTS
CCCEEEEEEECCCCCCHHCCCCEEEEEECCCCCEEEEEEECCCCEECCCCCCCCCCEECC
SSNIFAAGDVAGPIQLGMMAEKQAILAASNACLPFKQSIRYEDVAWVTYSEPQMAHIGLT
CCCEEEECCCCCCHHCCHHHHHHHHEEECCCCCCHHHCCCCCEEEEEEECCCCEEEECCC
EDEARRKYGNNVRVIRYPLTKVRRAVMDHDTRGLCKFILDKNDRLIGAHLLCSHAENLVH
HHHHHHHHCCCEEEEEECHHHHHHHHHCCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
ELQIVKCLNKPLSKLHTIPHIYPTYEEGIIKRAADISYTIKMQRNPFVRLVLRYWPGYKD
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCHHH
RLDTVISRL
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA