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The map label for this gene is clpP

Identifier: 57234482

GI number: 57234482

Start: 657199

End: 657801

Strand: Direct

Name: clpP

Synonym: DET0710

Alternate gene names: 57234482

Gene position: 657199-657801 (Clockwise)

Preceding gene: 57234483

Following gene: 57234465

Centisome position: 44.72

GC content: 48.92

Gene sequence:

>603_bases
ATGATAAGCCCTGAAAACGTAGTACCTATGGTTATTGAAAGCAGCGCCAGAGGCGAACGCGCCTTTGACATTTATTCTCT
GCTGCTAAAGGAAAGGATTATCTTTCTGGGTTCGCAAATAAATGACCAGGTAGCCAATCTGGTTATTGCCCAGCTATTGT
TTCTTGACCGTGAAGACCCTGACAAGGACATAAGCCTTTATATTCACAGCCCCGGCGGCGTAATATCTGCCGGCCTTGCC
ATGTATGATACCATGCAGCTTATCCGGCCCAAAGTGTCCACCATTTGCGTGGGTGTGGCGGCTTCCATGGCTACAGTTTT
GCTGTGTGCCGGTGCTAAGGGGAAACGCTATGCTCTGCCCAATGCCACCATCCATATGCATCAGGCTATGGGGGGTGCTC
AGGGACAGGCCTCAGATATTGAAATTGCCGCCCGTGAGATTATGCGCCAGCAGGATATCCTCAGGAATATCCTGGTAAAA
CACACTGGCCAGCCTATGGAAAAAATTATCCATGACAGTGACCGTGATTATTACCTGAATGCCCAGCAGGCTGTGGAATA
CGGCCTGATAGATGAGATTTTGCAGAAACCCGAAAACAAATAG

Upstream 100 bases:

>100_bases
GTAAGACCATGGCCTTTATAGATGAAATAGCCCTCCAGCCAGCTCTTGAGGCTGTTGAACCTAAATCTGATGAAGGTGAA
AAAACAGAGGAGGCAGATAA

Downstream 100 bases:

>100_bases
TTAATAACCGGTTGTTTCGTATCTAAAAGAAAAACGCCCCTTCGTAACAGAGGGGGCGTTTTTCTTTCAGCCAGATAATG
AATCAGCTGGTAAAATAGTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDPDKDISLYIHSPGGVISAGLA
MYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALPNATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVK
HTGQPMEKIIHDSDRDYYLNAQQAVEYGLIDEILQKPENK

Sequences:

>Translated_200_residues
MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDPDKDISLYIHSPGGVISAGLA
MYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALPNATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVK
HTGQPMEKIIHDSDRDYYLNAQQAVEYGLIDEILQKPENK
>Mature_200_residues
MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDPDKDISLYIHSPGGVISAGLA
MYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALPNATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVK
HTGQPMEKIIHDSDRDYYLNAQQAVEYGLIDEILQKPENK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=52.3560209424084, Blast_Score=204, Evalue=6e-53,
Organism=Escherichia coli, GI1786641, Length=188, Percent_Identity=60.6382978723404, Blast_Score=251, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=50, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=52.6041666666667, Blast_Score=211, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_DEHE1 (Q3Z8J8)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181451.1
- ProteinModelPortal:   Q3Z8J8
- SMR:   Q3Z8J8
- STRING:   Q3Z8J8
- MEROPS:   S14.001
- GeneID:   3229949
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0710
- NMPDR:   fig|243164.3.peg.817
- TIGR:   DET0710
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   LPNASIM
- ProtClustDB:   PRK00277
- BioCyc:   DETH243164:DET_0710-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22091; Mature: 22091

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 102-102 ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDP
CCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
DKDISLYIHSPGGVISAGLAMYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALP
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
NATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVKHTGQPMEKIIHDSDRDYYLN
CCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEC
AQQAVEYGLIDEILQKPENK
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDP
CCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCC
DKDISLYIHSPGGVISAGLAMYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALP
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECC
NATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVKHTGQPMEKIIHDSDRDYYLN
CCEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEC
AQQAVEYGLIDEILQKPENK
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA