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The map label for this gene is guaA

Identifier: 57234409

GI number: 57234409

Start: 765339

End: 766940

Strand: Direct

Name: guaA

Synonym: DET0836

Alternate gene names: 57234409

Gene position: 765339-766940 (Clockwise)

Preceding gene: 57234436

Following gene: 57234408

Centisome position: 52.07

GC content: 47.82

Gene sequence:

>1602_bases
TTGGAAATTGCCAAGGAAAAGTCCGGCGCCAAACCGGAGTTTATTGATAACGAAGATGAAAGCCTGCGTGAATCAATAGT
AATCTTTGATTTCGGTTCTCAATACAGCTTACTTATTGCCCGCCGTATACGTGAGATGCATGTTTATTGCGAGCTGGTTT
CGCACGATACCCCTTGGGAGAAAATAGCCCACTTAAATCCCCGCGGGTTTATTCTTTCCGGCGGGCCTTCCAGTGTCTAC
GAAGCAGGAGCGCCTTTGGCCCCTGCTTATATATTTGAAAGTAAATTGCCGGTTTTGGGTATTTGCTACGGTATGCAGGC
TATCACCCACCAGCTTGGGGGGGTAGTTGAGCACAGTGAAAAACGCGAATACGGCCATGCCTTACTCCACTCAAGCGTGG
CAAATTCCGACCTCCTGTCGGATATGCCCGAACCCTCTCCCGTTTGGATGAGCCACGGAGACCGTATTGAGAAAATGCCG
GCCGGGTTTACGGCGCTGGCTTACACTGAAAACTGCCCGGTGGCGGTTATGGGTAACGAAGCGGACATTTACGGTTTGCA
GTTTCACCCCGAAGTTGTCCATTCCCCTAACGGCAAAATCATTCTTAAAAACTTTGTTTTCAATATTTGTAAATGTCATG
CCAACTGGACTATGGGCAACTATATTCAGGAAAGCATTCATAATATACGCGAACAGGTCGGAGACGGTCAGGTTATCTGT
GCCCTTTCCGGCGGGGTTGATTCGGCGGTAGTGGCTTCTCTTATCCACAAGGCCATTGGTGACCAGCTGACCTGCATATA
TGTAAATAACGGTCTTCTCCGGCGTGAGGAGGCTGACCGCACCCTGCATGTTTTCAAAAACCATATGGGTATGAAAATAA
TATATGTAGATGCGGTTGACCGTTTCCTTGATAGCCTTAGCGGAGTTACCGACCCCGAACAGAAACGCAAGGTTATCGGC
AGTGAATTTATTAAAGTATTTGAAGATGAAGCCTGTAAGCTTGGCAAGATTGATTTTCTGGCTCAGGGGACACTTTACCC
TGACGTCATAGAAAGCGTTTCTTCCGTATCTAAAGCTTCCGCCAAAATAAAAAGCCATCATAACGTGGGCGGCCTGCCTG
CCCATATGAAGTTAAAACTTATAGAGCCTTTGCGCTATCTCTTTAAAGATGAAGTGCGGCTGCTGGGCAAAGAGCTGGGT
TTGCCGGACGAAATGATTTGGCGTCAGCCCTTCCCCGGCCCCGGTCTGGCAATACGCATTATCGGTGAAGTTACCCGTGA
AAAGCTGGAAATCCTCCGCGCGGCGGACTGGATTGTAATGAGCGAAATTAAAAAAGCCAAAATGTATCACCAGGTATGGC
AAAGCTTTGCCATATTGACTGATGTTAAGTCTGTGGGTGTTATGGGTGATTTCCGCACCTACGGTTATCTGGTTGCAATC
AGGGCTGTCACCAGCGAAGACGCCATGACGGCGGACTGGGCTAAACTGCCTTATGATTTGCTTTCAGTTATATCCAACCG
GATTGTTAACGAGGTTAAAGAAGTGAACAGGGTGGTTTATGATATAAGCTCCAAACCGCCTTCCACTATTGAATGGGAGT
AA

Upstream 100 bases:

>100_bases
CTAAGCTACCATCAAGAAAATGATGAGCGAAATGAATAATATACAAACCACTGAAAGCCTGCGGGTTGCCACTAGCGGAG
ACATTGAGGTCTCTACTTAT

Downstream 100 bases:

>100_bases
GGTATTATGACCGGCGGTTATATCATGGGCAGAGGCTACACACCCGAAACCTGTCTGGATGAAGTTAAAAAAGCGCTGAC
AGATTTGGGGGGGAGGGCTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MEIAKEKSGAKPEFIDNEDESLRESIVIFDFGSQYSLLIARRIREMHVYCELVSHDTPWEKIAHLNPRGFILSGGPSSVY
EAGAPLAPAYIFESKLPVLGICYGMQAITHQLGGVVEHSEKREYGHALLHSSVANSDLLSDMPEPSPVWMSHGDRIEKMP
AGFTALAYTENCPVAVMGNEADIYGLQFHPEVVHSPNGKIILKNFVFNICKCHANWTMGNYIQESIHNIREQVGDGQVIC
ALSGGVDSAVVASLIHKAIGDQLTCIYVNNGLLRREEADRTLHVFKNHMGMKIIYVDAVDRFLDSLSGVTDPEQKRKVIG
SEFIKVFEDEACKLGKIDFLAQGTLYPDVIESVSSVSKASAKIKSHHNVGGLPAHMKLKLIEPLRYLFKDEVRLLGKELG
LPDEMIWRQPFPGPGLAIRIIGEVTREKLEILRAADWIVMSEIKKAKMYHQVWQSFAILTDVKSVGVMGDFRTYGYLVAI
RAVTSEDAMTADWAKLPYDLLSVISNRIVNEVKEVNRVVYDISSKPPSTIEWE

Sequences:

>Translated_533_residues
MEIAKEKSGAKPEFIDNEDESLRESIVIFDFGSQYSLLIARRIREMHVYCELVSHDTPWEKIAHLNPRGFILSGGPSSVY
EAGAPLAPAYIFESKLPVLGICYGMQAITHQLGGVVEHSEKREYGHALLHSSVANSDLLSDMPEPSPVWMSHGDRIEKMP
AGFTALAYTENCPVAVMGNEADIYGLQFHPEVVHSPNGKIILKNFVFNICKCHANWTMGNYIQESIHNIREQVGDGQVIC
ALSGGVDSAVVASLIHKAIGDQLTCIYVNNGLLRREEADRTLHVFKNHMGMKIIYVDAVDRFLDSLSGVTDPEQKRKVIG
SEFIKVFEDEACKLGKIDFLAQGTLYPDVIESVSSVSKASAKIKSHHNVGGLPAHMKLKLIEPLRYLFKDEVRLLGKELG
LPDEMIWRQPFPGPGLAIRIIGEVTREKLEILRAADWIVMSEIKKAKMYHQVWQSFAILTDVKSVGVMGDFRTYGYLVAI
RAVTSEDAMTADWAKLPYDLLSVISNRIVNEVKEVNRVVYDISSKPPSTIEWE
>Mature_533_residues
MEIAKEKSGAKPEFIDNEDESLRESIVIFDFGSQYSLLIARRIREMHVYCELVSHDTPWEKIAHLNPRGFILSGGPSSVY
EAGAPLAPAYIFESKLPVLGICYGMQAITHQLGGVVEHSEKREYGHALLHSSVANSDLLSDMPEPSPVWMSHGDRIEKMP
AGFTALAYTENCPVAVMGNEADIYGLQFHPEVVHSPNGKIILKNFVFNICKCHANWTMGNYIQESIHNIREQVGDGQVIC
ALSGGVDSAVVASLIHKAIGDQLTCIYVNNGLLRREEADRTLHVFKNHMGMKIIYVDAVDRFLDSLSGVTDPEQKRKVIG
SEFIKVFEDEACKLGKIDFLAQGTLYPDVIESVSSVSKASAKIKSHHNVGGLPAHMKLKLIEPLRYLFKDEVRLLGKELG
LPDEMIWRQPFPGPGLAIRIIGEVTREKLEILRAADWIVMSEIKKAKMYHQVWQSFAILTDVKSVGVMGDFRTYGYLVAI
RAVTSEDAMTADWAKLPYDLLSVISNRIVNEVKEVNRVVYDISSKPPSTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=565, Percent_Identity=34.6902654867257, Blast_Score=307, Evalue=1e-83,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=53.1669865642994, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1789760, Length=150, Percent_Identity=30, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787517, Length=185, Percent_Identity=27.5675675675676, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992717, Length=589, Percent_Identity=34.46519524618, Blast_Score=291, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI133901714, Length=589, Percent_Identity=34.46519524618, Blast_Score=291, Evalue=7e-79,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=34.7368421052632, Blast_Score=290, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=522, Percent_Identity=51.7241379310345, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI281365319, Length=559, Percent_Identity=35.9570661896243, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_DEHE1 (Q3Z886)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181563.1
- ProteinModelPortal:   Q3Z886
- SMR:   Q3Z886
- STRING:   Q3Z886
- GeneID:   3229876
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0836
- NMPDR:   fig|243164.3.peg.935
- TIGR:   DET0836
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- PhylomeDB:   Q3Z886
- ProtClustDB:   PRK00074
- BioCyc:   DETH243164:DET_0836-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 59511; Mature: 59511

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 102-102 ACT_SITE 189-189 ACT_SITE 191-191

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIAKEKSGAKPEFIDNEDESLRESIVIFDFGSQYSLLIARRIREMHVYCELVSHDTPWE
CCCCCCCCCCCCCCCCCCCHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
KIAHLNPRGFILSGGPSSVYEAGAPLAPAYIFESKLPVLGICYGMQAITHQLGGVVEHSE
HHHCCCCCCEEEECCCCHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHH
KREYGHALLHSSVANSDLLSDMPEPSPVWMSHGDRIEKMPAGFTALAYTENCPVAVMGNE
HHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCEEEECCC
ADIYGLQFHPEVVHSPNGKIILKNFVFNICKCHANWTMGNYIQESIHNIREQVGDGQVIC
CEEEEEEECCHHEECCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE
ALSGGVDSAVVASLIHKAIGDQLTCIYVNNGLLRREEADRTLHVFKNHMGMKIIYVDAVD
EECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEHHHHHHHHHHHHHCCCEEEEEHHHHH
RFLDSLSGVTDPEQKRKVIGSEFIKVFEDEACKLGKIDFLAQGTLYPDVIESVSSVSKAS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
AKIKSHHNVGGLPAHMKLKLIEPLRYLFKDEVRLLGKELGLPDEMIWRQPFPGPGLAIRI
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEH
IGEVTREKLEILRAADWIVMSEIKKAKMYHQVWQSFAILTDVKSVGVMGDFRTYGYLVAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEE
RAVTSEDAMTADWAKLPYDLLSVISNRIVNEVKEVNRVVYDISSKPPSTIEWE
EEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MEIAKEKSGAKPEFIDNEDESLRESIVIFDFGSQYSLLIARRIREMHVYCELVSHDTPWE
CCCCCCCCCCCCCCCCCCCHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHH
KIAHLNPRGFILSGGPSSVYEAGAPLAPAYIFESKLPVLGICYGMQAITHQLGGVVEHSE
HHHCCCCCCEEEECCCCHHHHCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHH
KREYGHALLHSSVANSDLLSDMPEPSPVWMSHGDRIEKMPAGFTALAYTENCPVAVMGNE
HHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCHHHHCCCCCEEEEEECCCCEEEECCC
ADIYGLQFHPEVVHSPNGKIILKNFVFNICKCHANWTMGNYIQESIHNIREQVGDGQVIC
CEEEEEEECCHHEECCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEE
ALSGGVDSAVVASLIHKAIGDQLTCIYVNNGLLRREEADRTLHVFKNHMGMKIIYVDAVD
EECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEHHHHHHHHHHHHHCCCEEEEEHHHHH
RFLDSLSGVTDPEQKRKVIGSEFIKVFEDEACKLGKIDFLAQGTLYPDVIESVSSVSKAS
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
AKIKSHHNVGGLPAHMKLKLIEPLRYLFKDEVRLLGKELGLPDEMIWRQPFPGPGLAIRI
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCEEEH
IGEVTREKLEILRAADWIVMSEIKKAKMYHQVWQSFAILTDVKSVGVMGDFRTYGYLVAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEEEEEE
RAVTSEDAMTADWAKLPYDLLSVISNRIVNEVKEVNRVVYDISSKPPSTIEWE
EEECCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA