Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 57234404

GI number: 57234404

Start: 770363

End: 771277

Strand: Direct

Name: purC [H]

Synonym: DET0841

Alternate gene names: 57234404

Gene position: 770363-771277 (Clockwise)

Preceding gene: 57234405

Following gene: 57234390

Centisome position: 52.42

GC content: 47.54

Gene sequence:

>915_bases
ATGACTGATAACAAAGTACTCATGGAAACCGCCCTGCCGCTGCCTTCTTTTATTAAGGGTAAGGTGCGGGATACTTATCT
GCTGGGTGATAAACTGCTTATCATTGCCAGTGACCGTATTTCAGCTTTTGATGTAATATTGCCTGGCGGTATACCCGGCA
AAGGGCGGGTGCTTAACCGTATCTCCTCATTCTGGTTTGAAAAAACCGCCCGCATAATACCCAATCATGTTATAGAGCTG
GTTGAAGATGTAAGCTGTCTGGATAAATATTTGCCCCCGGAAGAACGCTTTCGTTACCCAGAATATTTGAGCGGCAGAAG
CATGGTGGTCAAAAGGGTAAAGCGGGTTTCGGTGGAATGTGTGGTACGGGGTTACATTGCCGGCTCAGCCTGGAGTGAAT
ATAAAAAGACGGGTACGGTAAATGGTATGCCCATGCCCAAAGGTCTTTTACAAAGCCAGGAGCTGCCCGAACCTATATTT
ACTCCTACTACCAAAGGTGAGGGCGAACATGACCATCCTATGACCATTGCCGAACTGGAAGCTATGGTTGGCAAAGAGCT
GGCTGATAAACTGGCTGAAAAAAGCTTGGCACTTTATAAACTTGGGCGGGAATATGCCCGCCAAAGGGGTATTATTATAG
CTGACACCAAGTTTGAGTTTGGTCTGGACGGCTCAGAGCTTATCCTTATTGACGAAGCCCTTACCCCGGATTCCAGCCGT
TTCTGGGATGAAAAGACTTATAGAGTAGGCGAAGCCCAGGATAGCTATGACAAACAGCCCGTGAGAGATTATCTGGAAGC
TATCGGCTGGGATAAAGAGCCTCCAGGCCCGGTATTGCCGGATGAGGTTATCAAATCAACTACCCGCCGGTATGAATACG
CGTATGAAAGAATAACCGGTATCAAACTGGTCTAG

Upstream 100 bases:

>100_bases
CATAGATGATATATTCAGACGGGTAGGGCTGACTAATTCCCAGTGGAAGAAAGGCGGGGATGCCTCCTCTGACGAAGGAC
TGGCCCCCAGAGCTATATAA

Downstream 100 bases:

>100_bases
CTGGGTTTCACATATCCAAAATAAAAAAGGGGCTTTTCGCCCCTTTTTTATTCTATAAACTATTTAAATCAGTTTTCCAG
CATGCCTTTGGTGCTGGGGG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTDNKVLMETALPLPSFIKGKVRDTYLLGDKLLIIASDRISAFDVILPGGIPGKGRVLNRISSFWFEKTARIIPNHVIEL
VEDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVECVVRGYIAGSAWSEYKKTGTVNGMPMPKGLLQSQELPEPIF
TPTTKGEGEHDHPMTIAELEAMVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSR
FWDEKTYRVGEAQDSYDKQPVRDYLEAIGWDKEPPGPVLPDEVIKSTTRRYEYAYERITGIKLV

Sequences:

>Translated_304_residues
MTDNKVLMETALPLPSFIKGKVRDTYLLGDKLLIIASDRISAFDVILPGGIPGKGRVLNRISSFWFEKTARIIPNHVIEL
VEDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVECVVRGYIAGSAWSEYKKTGTVNGMPMPKGLLQSQELPEPIF
TPTTKGEGEHDHPMTIAELEAMVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSR
FWDEKTYRVGEAQDSYDKQPVRDYLEAIGWDKEPPGPVLPDEVIKSTTRRYEYAYERITGIKLV
>Mature_303_residues
TDNKVLMETALPLPSFIKGKVRDTYLLGDKLLIIASDRISAFDVILPGGIPGKGRVLNRISSFWFEKTARIIPNHVIELV
EDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVECVVRGYIAGSAWSEYKKTGTVNGMPMPKGLLQSQELPEPIFT
PTTKGEGEHDHPMTIAELEAMVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSRF
WDEKTYRVGEAQDSYDKQPVRDYLEAIGWDKEPPGPVLPDEVIKSTTRRYEYAYERITGIKLV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Escherichia coli, GI1788820, Length=212, Percent_Identity=30.6603773584906, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319326, Length=307, Percent_Identity=46.5798045602606, Blast_Score=269, Evalue=4e-73,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 34380; Mature: 34249

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDNKVLMETALPLPSFIKGKVRDTYLLGDKLLIIASDRISAFDVILPGGIPGKGRVLNR
CCCCCEEHHHHCCCHHHHHCCCCCEEEECCEEEEEECCCCCEEEEEECCCCCCCHHHHHH
ISSFWFEKTARIIPNHVIELVEDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHCCHHHHHHHHHHHHHHH
VVRGYIAGSAWSEYKKTGTVNGMPMPKGLLQSQELPEPIFTPTTKGEGEHDHPMTIAELE
HHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
AMVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCEEEEEECCCCCCCHH
FWDEKTYRVGEAQDSYDKQPVRDYLEAIGWDKEPPGPVLPDEVIKSTTRRYEYAYERITG
HCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
IKLV
CCCC
>Mature Secondary Structure 
TDNKVLMETALPLPSFIKGKVRDTYLLGDKLLIIASDRISAFDVILPGGIPGKGRVLNR
CCCCEEHHHHCCCHHHHHCCCCCEEEECCEEEEEECCCCCEEEEEECCCCCCCHHHHHH
ISSFWFEKTARIIPNHVIELVEDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHCCHHHHHHHHHHHHHHH
VVRGYIAGSAWSEYKKTGTVNGMPMPKGLLQSQELPEPIFTPTTKGEGEHDHPMTIAELE
HHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHH
AMVGKELADKLAEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCEEECCCCCEEEEEECCCCCCCHH
FWDEKTYRVGEAQDSYDKQPVRDYLEAIGWDKEPPGPVLPDEVIKSTTRRYEYAYERITG
HCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
IKLV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA