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The map label for this gene is cobQ

Identifier: 57234286

GI number: 57234286

Start: 857033

End: 858553

Strand: Direct

Name: cobQ

Synonym: DET0936

Alternate gene names: 57234286

Gene position: 857033-858553 (Clockwise)

Preceding gene: 57234288

Following gene: 57234285

Centisome position: 58.31

GC content: 49.57

Gene sequence:

>1521_bases
ATGAACGCCATGGCGAAATTGATAATGGTTCAGGGCACTTCTTCTAATGTGGGCAAGAGCATACTGGTCACTGCGCTCTG
CCGGATATTCAAACAGGACGGCTACAAAGTAGCCCCGTTCAAGTCCCAAAATATGGCGCTGAACGCTTTTGTCACCCAAG
AGGGCGGTGAAATCGGCCGGGCACAGGCTGTTCAGGCAGAAGCCTGCGGCATTGCCCCCAGTGTAGATATGAACCCTATT
CTGATGAAGCCCGAAGCAGATTCCAAAAGCCAGATTGTTGTAAACGGCAAAGTGGACCGCACCATTTCTGCCCGTGAATA
TTATGAATATGCACCCCTGCTGCTGGATACCGCTCTGGCGGCACTTAACCGTCTGCGGGAGCAAAATGATATTGTGGTCA
TAGAAGGGGCAGGCAGCCCGGCTGAGATAAACCTGAGGCAGCGGGAGATTGTAAATATGCGGATTGCCAAAACCGCCGGT
GCGCCGGTGCTTCTGGCCGGAGACATAGACCGGGGCGGCGTTTTTGCTTCTTTGATTGGCACTATAGACCTTTTAGAGCC
TGAAGAACGCAGTTATGTAAAGGGCTATCTGATAAATAAATTCCGGGGGGATGCCAGTTTACTTAAACCAGCCATAGATG
TACTGGAAGACCGCACCTCCATACCGGTACTGGGCATTATCCCCTATCTGCGGAATATGGCCATTGCCCAGGAAGATTCG
GTATACCTGGACGAATGTAAAAGCGGTCTGGGTGAAACCGACCTTGATATTGCGGTAATACGTCTGCCCCGCATATCCAA
CTACGACGATTTTGACGCTTTAGCCACAGACGGGGCATCAGTCAGGTTTGTATCTAAAACCGGTGAGATTGGCAACCCTG
ATTTGATAATAATTCCGGGTACCAAATCCACCATACCTGACATGGAATATCTGTGGCAAAACGGTCTGGCGGAAACTATC
ATCAAAAAAGCCGGAAAAGGCACCCATGTTTTAGGCGTCTGCGGCGGCTATCAGATTTTGGGAAAGATGATATACGACCC
CCACAAGACTGAGTCTGAAACCACCGAATTAAAGGGTCTGGGTTTGCTGGATACCGAAACAACCTTTGAAAAAGAAAAAT
CCACCACACAGGTAAGCGGCCAGGTCAGGTTTAATAACGGGCTGCTTGCAGATATGGCCGGTTGTGAAGTGGGCGGCTAT
GAAATCCACATGGGAAGGACCCGCTTATTTACTGCCCAGCCTGCCTTCCAGATTACCAAAACCCCCAAAGGCCCGGCTGA
TTATCTGGACGGGGCATCCAATGCCGAAGGTACGGTGCTGGGTACATATATACACGGAATATTTGAAAGTGACTCTTTCC
GCCGCGGCTTCTTAAATGCAATCCGCCGTTACAAGGGCATCCCTGAGCGGCAGGCAGGCTATTTTGACCGTGACAAAGAA
TATGATAAACTGGCAGATATAGTCAGGGCAAGCATAGACATGAACAAGATTTATGATATTTTGAACGAGGGAATAAGATG
A

Upstream 100 bases:

>100_bases
AGTTGGGAAACATTATACATCAAAGATTTTCAAGGCAGAACACGCTATAAATCAAAATAAGTTGTCCTTTTTCTACTCTA
CTTAAATAAAAACTGGTATA

Downstream 100 bases:

>100_bases
CACACCCTGATGCTGAAGAAAATATTAAGCTTCTGCATGAAAAAAGCCGCACTGAACCTGCCCTGAATTTTCTGGGCATA
AAAATACTGGAATTGAAACC

Product: cobyric acid synthase CobQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNAMAKLIMVQGTSSNVGKSILVTALCRIFKQDGYKVAPFKSQNMALNAFVTQEGGEIGRAQAVQAEACGIAPSVDMNPI
LMKPEADSKSQIVVNGKVDRTISAREYYEYAPLLLDTALAALNRLREQNDIVVIEGAGSPAEINLRQREIVNMRIAKTAG
APVLLAGDIDRGGVFASLIGTIDLLEPEERSYVKGYLINKFRGDASLLKPAIDVLEDRTSIPVLGIIPYLRNMAIAQEDS
VYLDECKSGLGETDLDIAVIRLPRISNYDDFDALATDGASVRFVSKTGEIGNPDLIIIPGTKSTIPDMEYLWQNGLAETI
IKKAGKGTHVLGVCGGYQILGKMIYDPHKTESETTELKGLGLLDTETTFEKEKSTTQVSGQVRFNNGLLADMAGCEVGGY
EIHMGRTRLFTAQPAFQITKTPKGPADYLDGASNAEGTVLGTYIHGIFESDSFRRGFLNAIRRYKGIPERQAGYFDRDKE
YDKLADIVRASIDMNKIYDILNEGIR

Sequences:

>Translated_506_residues
MNAMAKLIMVQGTSSNVGKSILVTALCRIFKQDGYKVAPFKSQNMALNAFVTQEGGEIGRAQAVQAEACGIAPSVDMNPI
LMKPEADSKSQIVVNGKVDRTISAREYYEYAPLLLDTALAALNRLREQNDIVVIEGAGSPAEINLRQREIVNMRIAKTAG
APVLLAGDIDRGGVFASLIGTIDLLEPEERSYVKGYLINKFRGDASLLKPAIDVLEDRTSIPVLGIIPYLRNMAIAQEDS
VYLDECKSGLGETDLDIAVIRLPRISNYDDFDALATDGASVRFVSKTGEIGNPDLIIIPGTKSTIPDMEYLWQNGLAETI
IKKAGKGTHVLGVCGGYQILGKMIYDPHKTESETTELKGLGLLDTETTFEKEKSTTQVSGQVRFNNGLLADMAGCEVGGY
EIHMGRTRLFTAQPAFQITKTPKGPADYLDGASNAEGTVLGTYIHGIFESDSFRRGFLNAIRRYKGIPERQAGYFDRDKE
YDKLADIVRASIDMNKIYDILNEGIR
>Mature_506_residues
MNAMAKLIMVQGTSSNVGKSILVTALCRIFKQDGYKVAPFKSQNMALNAFVTQEGGEIGRAQAVQAEACGIAPSVDMNPI
LMKPEADSKSQIVVNGKVDRTISAREYYEYAPLLLDTALAALNRLREQNDIVVIEGAGSPAEINLRQREIVNMRIAKTAG
APVLLAGDIDRGGVFASLIGTIDLLEPEERSYVKGYLINKFRGDASLLKPAIDVLEDRTSIPVLGIIPYLRNMAIAQEDS
VYLDECKSGLGETDLDIAVIRLPRISNYDDFDALATDGASVRFVSKTGEIGNPDLIIIPGTKSTIPDMEYLWQNGLAETI
IKKAGKGTHVLGVCGGYQILGKMIYDPHKTESETTELKGLGLLDTETTFEKEKSTTQVSGQVRFNNGLLADMAGCEVGGY
EIHMGRTRLFTAQPAFQITKTPKGPADYLDGASNAEGTVLGTYIHGIFESDSFRRGFLNAIRRYKGIPERQAGYFDRDKE
YDKLADIVRASIDMNKIYDILNEGIR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_DEHE1 (Q3Z7Y8)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181661.1
- ProteinModelPortal:   Q3Z7Y8
- STRING:   Q3Z7Y8
- GeneID:   3229753
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET0936
- NMPDR:   fig|243164.3.peg.1235
- TIGR:   DET0936
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   CLSK837187
- BioCyc:   DETH243164:DET_0936-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: NA

Molecular weight: Translated: 55256; Mature: 55256

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 334-334 ACT_SITE 445-445

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAMAKLIMVQGTSSNVGKSILVTALCRIFKQDGYKVAPFKSQNMALNAFVTQEGGEIGR
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEECCCCCCCC
AQAVQAEACGIAPSVDMNPILMKPEADSKSQIVVNGKVDRTISAREYYEYAPLLLDTALA
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHH
ALNRLREQNDIVVIEGAGSPAEINLRQREIVNMRIAKTAGAPVLLAGDIDRGGVFASLIG
HHHHHHCCCCEEEEECCCCCCEEEEHHHHHHEEEEECCCCCCEEEECCCCCCCHHHHHHH
TIDLLEPEERSYVKGYLINKFRGDASLLKPAIDVLEDRTSIPVLGIIPYLRNMAIAQEDS
HHHCCCCCHHHHHHHHHHEHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
VYLDECKSGLGETDLDIAVIRLPRISNYDDFDALATDGASVRFVSKTGEIGNPDLIIIPG
CHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCEEEECC
TKSTIPDMEYLWQNGLAETIIKKAGKGTHVLGVCGGYQILGKMIYDPHKTESETTELKGL
CCCCCCCHHHHHHCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHHCCC
GLLDTETTFEKEKSTTQVSGQVRFNNGLLADMAGCEVGGYEIHMGRTRLFTAQPAFQITK
EEECCCCHHHHCCCCEEEEEEEEECCCEEEECCCCCCCCEEEEECCEEEEECCCCEEEEC
TPKGPADYLDGASNAEGTVLGTYIHGIFESDSFRRGFLNAIRRYKGIPERQAGYFDRDKE
CCCCCHHHCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCHHCCCCCCCCH
YDKLADIVRASIDMNKIYDILNEGIR
HHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNAMAKLIMVQGTSSNVGKSILVTALCRIFKQDGYKVAPFKSQNMALNAFVTQEGGEIGR
CCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEECCCCCCCC
AQAVQAEACGIAPSVDMNPILMKPEADSKSQIVVNGKVDRTISAREYYEYAPLLLDTALA
HHHHHHHHCCCCCCCCCCCEEECCCCCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHHH
ALNRLREQNDIVVIEGAGSPAEINLRQREIVNMRIAKTAGAPVLLAGDIDRGGVFASLIG
HHHHHHCCCCEEEEECCCCCCEEEEHHHHHHEEEEECCCCCCEEEECCCCCCCHHHHHHH
TIDLLEPEERSYVKGYLINKFRGDASLLKPAIDVLEDRTSIPVLGIIPYLRNMAIAQEDS
HHHCCCCCHHHHHHHHHHEHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCC
VYLDECKSGLGETDLDIAVIRLPRISNYDDFDALATDGASVRFVSKTGEIGNPDLIIIPG
CHHHHHHCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCEEEECC
TKSTIPDMEYLWQNGLAETIIKKAGKGTHVLGVCGGYQILGKMIYDPHKTESETTELKGL
CCCCCCCHHHHHHCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHHCCC
GLLDTETTFEKEKSTTQVSGQVRFNNGLLADMAGCEVGGYEIHMGRTRLFTAQPAFQITK
EEECCCCHHHHCCCCEEEEEEEEECCCEEEECCCCCCCCEEEEECCEEEEECCCCEEEEC
TPKGPADYLDGASNAEGTVLGTYIHGIFESDSFRRGFLNAIRRYKGIPERQAGYFDRDKE
CCCCCHHHCCCCCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCCHHCCCCCCCCH
YDKLADIVRASIDMNKIYDILNEGIR
HHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA