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The map label for this gene is pyrC [H]

Identifier: 57234049

GI number: 57234049

Start: 1095090

End: 1096373

Strand: Direct

Name: pyrC [H]

Synonym: DET1200

Alternate gene names: 57234049

Gene position: 1095090-1096373 (Clockwise)

Preceding gene: 57234050

Following gene: 57234040

Centisome position: 74.51

GC content: 54.28

Gene sequence:

>1284_bases
ATGAAAATACTGATTAAAAACGGGCGCATCATAGACCCTGCCGGAGGCACAGATAAAGTGGCAGACCTGCTGCTGGAAAA
CGGGCTGGTTGCCGGAATAAACAGTAATATACCTTCAGATAAAGCTGATGAAGTTATAGATGCCGAAGGCAAAGTGGTTT
GCCCCGGTTTTATAGACCTGCACGTACACCTGCGTGAGCCGGGTTTTGAAGGCAAAGAGACTATTGAAAGCGGCTGCAAG
GCCGCCGCAGCCGGAGGGTTCACTACCATCTGCCCCATGCCTAATACCAATCCCGCAGCGGATAATCTGCCGGTGATAGA
CTTTGTTAGAAACACCGCCGCCAAGGTTTCGCCCATACGGGTGCTGCCCATAGCCGCCATTACCAAAGGGCGCAAAGGAC
AGGAGCTTTCCCCCATGGGAGAGCTGGCCGAAGCAGGAGTGGCCGGTTTTTCAGATGACGGTGACTACGTGTCAAACAGC
TCCATGCTCCTCCATGCCCTGCTTTACAGCCGCACTTTTGGCCTGCCCGTTATGGAGCACTGCGAAGAGCCGTGCCTGGC
GGAAGGCGGGGTAATGAACGAAGGTCTTTTAGCCTGCCGTTTGGGATTAAAGGGCATACCTGATGCCGCTGAAGAAATTG
CCCTGAGCCGGGATATTGCCCTGGCCAAAGAAAGCGGCGGGCAGCTGCACCTTTGCCATATCAGTACGGCCGGTTCGGTG
GAACTGGTACGCAGAGCCAAAGCCGCAGGCATACAGGTAAGCGCGGAGGTTACCCCCCACCACCTGACCCTGACCGAAGC
TGAAGTAAGCGGCTACAACACAAATGCCAAAGTCAACCCGCCGCTTCGCACCCAGAGTGATATTGAGGCATTAATAAAAG
GGCTGAAAGACGGCACTATAGATGCCATTGCCACAGACCATGCCCCCCACACTGCCAATGACAAACTGTGTGAATTCGGT
CTGGCCGCAAACGGCATTTCGGGGCTGGAAACCGCATTTGCCAGCCTGATGGGGCTGGTACACTCAGGCTCTATCAGCCT
AAGCCTGCTTATAGAAAAGCTGACCGCCGGCCCCCGGCAGGTACTGGGTGAAAAACACAAAAACATCGGCAATTTGAAAC
CAGGCTCCAGTGCAGATGTGGTTATATTTGACCCTGACGAAGAATGGACGGTGGATACCGCCAGATTCTTCTCCAAGGGC
AAAAATACTCCCCTTGAGGGACGCAGGCTGAAAGGCAGGGTAAAAACCACCATTGCCTGCGGCCGGATAGCATACCGGGA
ATAA

Upstream 100 bases:

>100_bases
TGCACGGAGAGCAGTCTGTCATAAACGAACAGGTAAAAAACGGGGTAGCCATCCGCATGGCCCTCTTTTACCTGTGCAGC
GGAAGCAAGGAAATATAGAT

Downstream 100 bases:

>100_bases
CAGACTTGCCAGTTTAGAAAGTGAGAAGGATAGATTAAATGACAAATACAGCATACCTGGTACTGGAGGACGGAACAGTA
TTCAGCGGCAAAAGCTTCGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKILIKNGRIIDPAGGTDKVADLLLENGLVAGINSNIPSDKADEVIDAEGKVVCPGFIDLHVHLREPGFEGKETIESGCK
AAAAGGFTTICPMPNTNPAADNLPVIDFVRNTAAKVSPIRVLPIAAITKGRKGQELSPMGELAEAGVAGFSDDGDYVSNS
SMLLHALLYSRTFGLPVMEHCEEPCLAEGGVMNEGLLACRLGLKGIPDAAEEIALSRDIALAKESGGQLHLCHISTAGSV
ELVRRAKAAGIQVSAEVTPHHLTLTEAEVSGYNTNAKVNPPLRTQSDIEALIKGLKDGTIDAIATDHAPHTANDKLCEFG
LAANGISGLETAFASLMGLVHSGSISLSLLIEKLTAGPRQVLGEKHKNIGNLKPGSSADVVIFDPDEEWTVDTARFFSKG
KNTPLEGRRLKGRVKTTIACGRIAYRE

Sequences:

>Translated_427_residues
MKILIKNGRIIDPAGGTDKVADLLLENGLVAGINSNIPSDKADEVIDAEGKVVCPGFIDLHVHLREPGFEGKETIESGCK
AAAAGGFTTICPMPNTNPAADNLPVIDFVRNTAAKVSPIRVLPIAAITKGRKGQELSPMGELAEAGVAGFSDDGDYVSNS
SMLLHALLYSRTFGLPVMEHCEEPCLAEGGVMNEGLLACRLGLKGIPDAAEEIALSRDIALAKESGGQLHLCHISTAGSV
ELVRRAKAAGIQVSAEVTPHHLTLTEAEVSGYNTNAKVNPPLRTQSDIEALIKGLKDGTIDAIATDHAPHTANDKLCEFG
LAANGISGLETAFASLMGLVHSGSISLSLLIEKLTAGPRQVLGEKHKNIGNLKPGSSADVVIFDPDEEWTVDTARFFSKG
KNTPLEGRRLKGRVKTTIACGRIAYRE
>Mature_427_residues
MKILIKNGRIIDPAGGTDKVADLLLENGLVAGINSNIPSDKADEVIDAEGKVVCPGFIDLHVHLREPGFEGKETIESGCK
AAAAGGFTTICPMPNTNPAADNLPVIDFVRNTAAKVSPIRVLPIAAITKGRKGQELSPMGELAEAGVAGFSDDGDYVSNS
SMLLHALLYSRTFGLPVMEHCEEPCLAEGGVMNEGLLACRLGLKGIPDAAEEIALSRDIALAKESGGQLHLCHISTAGSV
ELVRRAKAAGIQVSAEVTPHHLTLTEAEVSGYNTNAKVNPPLRTQSDIEALIKGLKDGTIDAIATDHAPHTANDKLCEFG
LAANGISGLETAFASLMGLVHSGSISLSLLIEKLTAGPRQVLGEKHKNIGNLKPGSSADVVIFDPDEEWTVDTARFFSKG
KNTPLEGRRLKGRVKTTIACGRIAYRE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=28.6821705426357, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI19923821, Length=448, Percent_Identity=26.1160714285714, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=22.7373068432671, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=22.7373068432671, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4503377, Length=443, Percent_Identity=22.7990970654628, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786722, Length=447, Percent_Identity=29.7539149888143, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082175, Length=443, Percent_Identity=28.2167042889391, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193204318, Length=375, Percent_Identity=30.1333333333333, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI86575075, Length=448, Percent_Identity=24.3303571428571, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539558, Length=456, Percent_Identity=25.6578947368421, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=26.8170426065163, Blast_Score=120, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24642586, Length=412, Percent_Identity=30.5825242718447, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI18859883, Length=451, Percent_Identity=27.4944567627494, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17137462, Length=450, Percent_Identity=26.2222222222222, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221377917, Length=454, Percent_Identity=25.9911894273128, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44958; Mature: 44958

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIKNGRIIDPAGGTDKVADLLLENGLVAGINSNIPSDKADEVIDAEGKVVCPGFIDL
CEEEEECCEEECCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCCCEECCCEEEE
HVHLREPGFEGKETIESGCKAAAAGGFTTICPMPNTNPAADNLPVIDFVRNTAAKVSPIR
EEEEECCCCCCHHHHHHHHCCHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEE
VLPIAAITKGRKGQELSPMGELAEAGVAGFSDDGDYVSNSSMLLHALLYSRTFGLPVMEH
EEEEHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
CEEPCLAEGGVMNEGLLACRLGLKGIPDAAEEIALSRDIALAKESGGQLHLCHISTAGSV
CCCCCHHCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHEEEECCCCEEEEEEECCCCHH
ELVRRAKAAGIQVSAEVTPHHLTLTEAEVSGYNTNAKVNPPLRTQSDIEALIKGLKDGTI
HHHHHHHHCCEEEEEECCCCEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCCE
DAIATDHAPHTANDKLCEFGLAANGISGLETAFASLMGLVHSGSISLSLLIEKLTAGPRQ
EEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHH
VLGEKHKNIGNLKPGSSADVVIFDPDEEWTVDTARFFSKGKNTPLEGRRLKGRVKTTIAC
HHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEE
GRIAYRE
CEEECCC
>Mature Secondary Structure
MKILIKNGRIIDPAGGTDKVADLLLENGLVAGINSNIPSDKADEVIDAEGKVVCPGFIDL
CEEEEECCEEECCCCCHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCCCCEECCCEEEE
HVHLREPGFEGKETIESGCKAAAAGGFTTICPMPNTNPAADNLPVIDFVRNTAAKVSPIR
EEEEECCCCCCHHHHHHHHCCHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCEE
VLPIAAITKGRKGQELSPMGELAEAGVAGFSDDGDYVSNSSMLLHALLYSRTFGLPVMEH
EEEEHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHH
CEEPCLAEGGVMNEGLLACRLGLKGIPDAAEEIALSRDIALAKESGGQLHLCHISTAGSV
CCCCCHHCCCCCCCCHHHEECCCCCCCCHHHHHHHHHHHEEEECCCCEEEEEEECCCCHH
ELVRRAKAAGIQVSAEVTPHHLTLTEAEVSGYNTNAKVNPPLRTQSDIEALIKGLKDGTI
HHHHHHHHCCEEEEEECCCCEEEEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCCCCCE
DAIATDHAPHTANDKLCEFGLAANGISGLETAFASLMGLVHSGSISLSLLIEKLTAGPRQ
EEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHH
VLGEKHKNIGNLKPGSSADVVIFDPDEEWTVDTARFFSKGKNTPLEGRRLKGRVKTTIAC
HHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEEE
GRIAYRE
CEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]