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The map label for this gene is mpg1 [H]

Identifier: 57234025

GI number: 57234025

Start: 1106216

End: 1107301

Strand: Direct

Name: mpg1 [H]

Synonym: DET1208

Alternate gene names: 57234025

Gene position: 1106216-1107301 (Clockwise)

Preceding gene: 57234038

Following gene: 57234024

Centisome position: 75.27

GC content: 51.93

Gene sequence:

>1086_bases
ATGAAAGCTATTATTCTGGTCGGCGGGCAGGGCACAAGGCTTCGGCCGCTAAGTATAAACACGCCCAAATCCATGGTTCC
GGTACTTAACGTACCTTTCTTAAGCCATGTTTTGCGTTACCTGTCTTCCTGCGGCATCAAAGATATTATCCTTACCCAGG
GGCATCTGGCCGCCCCCATTGAGCAGTATTTCGGCAATGGCCAAAGCCTGGGTGTAAACCTGGTATATTCGGTTGAACAC
GAGGCTTTAGGCACAGCCGGGGCTATCAAAAATGCCGAACGCTACCTTGATGACACTTTCATTACTTTGAACGGGGATAT
ATTTACCCATCTGGATTTGTCTGCCATGCTGCGCGCCCACCGGGATAAAAAAGCGCTGGTCAGCATAGCCCTGACACCGG
TAGATGACCCCACCAAATACGGGCTGGTTGAAACCGCAGACGGCGGCAGGGTAAGCCGCTTTCTGGAAAAGCCTTCACCC
GCCCAGATAACAACCAACATGATAAATGCCGGCACGTATATCATTGAGCCCGAAGTACTCAAATACATACCTGCGGGTGA
AAACCACAGCTTTGAAAGACAGCTTTTCCCCCGCCTGCTGAATGAATGTCAGGCGGTTTATGCCTACCCGTCCAGTGCGT
ACTGGATAGACATTGGCAGCCCCGAAAAATACTCCCAGCTAAACAGGGATTTACTCTGCGGCGAGGGCGGAGATTTTGGT
TTCAGCCGGGGTAATGAGATAGTCATTGGCCGCGGTTGCCAGCTTCACCCCACAGCCCGAATCAGCGGGCCGGTACTGGT
GGGAGAAAACTGCATTATAGGCGCAAATGCCTGTATTGCAGGGCCAGTAGTTATCGGCGCGGAATGCCGGATTGAAGATG
AGGCTACCCTTACCGAATCTGTTATCTGGCAAAATGTGACCATAGGAGCCGAATGCAAAGTTGTTTCGTCCATCATTGCC
AATCATTGCCACCTGAAGGCAGGCGGCAAATATGAGAATGTGGTGTTGGGAGACAATGTGACCGCCGAATGCGGTTGCGC
GCCGGAACCCGGCAGCAAAATCAGCCCGGGTATCCTTATGATCTAA

Upstream 100 bases:

>100_bases
AAGTCCTCATTGCTAATATATACTTATCCGTCTGTGATTCATTTTCCTGTACCCTATCCCTCTTAGCTTGTAGAATTTGC
TCAGAAGAGAACAAGAACCT

Downstream 100 bases:

>100_bases
TCAGATACAAGAGGAGGAAAAGACATGAGTACCGAAGAAAAGAAGTTTGAAACCCAGAATCTGCCTACCAAAACTTATTT
CTGGCCATTAAAAAGATACC

Product: nucleotidyltransferase family protein

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKAIILVGGQGTRLRPLSINTPKSMVPVLNVPFLSHVLRYLSSCGIKDIILTQGHLAAPIEQYFGNGQSLGVNLVYSVEH
EALGTAGAIKNAERYLDDTFITLNGDIFTHLDLSAMLRAHRDKKALVSIALTPVDDPTKYGLVETADGGRVSRFLEKPSP
AQITTNMINAGTYIIEPEVLKYIPAGENHSFERQLFPRLLNECQAVYAYPSSAYWIDIGSPEKYSQLNRDLLCGEGGDFG
FSRGNEIVIGRGCQLHPTARISGPVLVGENCIIGANACIAGPVVIGAECRIEDEATLTESVIWQNVTIGAECKVVSSIIA
NHCHLKAGGKYENVVLGDNVTAECGCAPEPGSKISPGILMI

Sequences:

>Translated_361_residues
MKAIILVGGQGTRLRPLSINTPKSMVPVLNVPFLSHVLRYLSSCGIKDIILTQGHLAAPIEQYFGNGQSLGVNLVYSVEH
EALGTAGAIKNAERYLDDTFITLNGDIFTHLDLSAMLRAHRDKKALVSIALTPVDDPTKYGLVETADGGRVSRFLEKPSP
AQITTNMINAGTYIIEPEVLKYIPAGENHSFERQLFPRLLNECQAVYAYPSSAYWIDIGSPEKYSQLNRDLLCGEGGDFG
FSRGNEIVIGRGCQLHPTARISGPVLVGENCIIGANACIAGPVVIGAECRIEDEATLTESVIWQNVTIGAECKVVSSIIA
NHCHLKAGGKYENVVLGDNVTAECGCAPEPGSKISPGILMI
>Mature_361_residues
MKAIILVGGQGTRLRPLSINTPKSMVPVLNVPFLSHVLRYLSSCGIKDIILTQGHLAAPIEQYFGNGQSLGVNLVYSVEH
EALGTAGAIKNAERYLDDTFITLNGDIFTHLDLSAMLRAHRDKKALVSIALTPVDDPTKYGLVETADGGRVSRFLEKPSP
AQITTNMINAGTYIIEPEVLKYIPAGENHSFERQLFPRLLNECQAVYAYPSSAYWIDIGSPEKYSQLNRDLLCGEGGDFG
FSRGNEIVIGRGCQLHPTARISGPVLVGENCIIGANACIAGPVVIGAECRIEDEATLTESVIWQNVTIGAECKVVSSIIA
NHCHLKAGGKYENVVLGDNVTAECGCAPEPGSKISPGILMI

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=357, Percent_Identity=35.0140056022409, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI11761619, Length=367, Percent_Identity=34.0599455040872, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI31881779, Length=365, Percent_Identity=26.027397260274, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI45447090, Length=365, Percent_Identity=26.027397260274, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1788351, Length=183, Percent_Identity=31.1475409836066, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790224, Length=185, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789837, Length=392, Percent_Identity=23.7244897959184, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=350, Percent_Identity=34.5714285714286, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17509979, Length=332, Percent_Identity=26.8072289156627, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17509981, Length=319, Percent_Identity=25.705329153605, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=350, Percent_Identity=33.7142857142857, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355443, Length=351, Percent_Identity=31.6239316239316, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24644084, Length=351, Percent_Identity=31.6239316239316, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24653912, Length=376, Percent_Identity=25.7978723404255, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 38791; Mature: 38791

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIILVGGQGTRLRPLSINTPKSMVPVLNVPFLSHVLRYLSSCGIKDIILTQGHLAAPI
CEEEEEECCCCCEEEEEECCCCHHHCCEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCH
EQYFGNGQSLGVNLVYSVEHEALGTAGAIKNAERYLDDTFITLNGDIFTHLDLSAMLRAH
HHHCCCCCEEEEEEEEEECHHHCCCHHHHHHHHHHHCCEEEEECCCEEEEECHHHHHHHC
RDKKALVSIALTPVDDPTKYGLVETADGGRVSRFLEKPSPAQITTNMINAGTYIIEPEVL
CCCCEEEEEEEECCCCCCCCCEEEECCCCHHHHHHCCCCCCEEEEEEECCCEEEECHHHH
KYIPAGENHSFERQLFPRLLNECQAVYAYPSSAYWIDIGSPEKYSQLNRDLLCGEGGDFG
HCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCEEEEECCCCHHHHHCCCCEEECCCCCCC
FSRGNEIVIGRGCQLHPTARISGPVLVGENCIIGANACIAGPVVIGAECRIEDEATLTES
CCCCCEEEEECCCEECCCCCCCCCEEECCCEEEECCCCCCCCEEECCEEEECCCCHHHHH
VIWQNVTIGAECKVVSSIIANHCHLKAGGKYENVVLGDNVTAECGCAPEPGSKISPGILM
HHHCCEEECCHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEE
I
C
>Mature Secondary Structure
MKAIILVGGQGTRLRPLSINTPKSMVPVLNVPFLSHVLRYLSSCGIKDIILTQGHLAAPI
CEEEEEECCCCCEEEEEECCCCHHHCCEECCHHHHHHHHHHHHCCCCEEEEECCCCCCCH
EQYFGNGQSLGVNLVYSVEHEALGTAGAIKNAERYLDDTFITLNGDIFTHLDLSAMLRAH
HHHCCCCCEEEEEEEEEECHHHCCCHHHHHHHHHHHCCEEEEECCCEEEEECHHHHHHHC
RDKKALVSIALTPVDDPTKYGLVETADGGRVSRFLEKPSPAQITTNMINAGTYIIEPEVL
CCCCEEEEEEEECCCCCCCCCEEEECCCCHHHHHHCCCCCCEEEEEEECCCEEEECHHHH
KYIPAGENHSFERQLFPRLLNECQAVYAYPSSAYWIDIGSPEKYSQLNRDLLCGEGGDFG
HCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCEEEEECCCCHHHHHCCCCEEECCCCCCC
FSRGNEIVIGRGCQLHPTARISGPVLVGENCIIGANACIAGPVVIGAECRIEDEATLTES
CCCCCEEEEECCCEECCCCCCCCCEEECCCEEEECCCCCCCCEEECCEEEECCCCHHHHH
VIWQNVTIGAECKVVSSIIANHCHLKAGGKYENVVLGDNVTAECGCAPEPGSKISPGILM
HHHCCEEECCHHHHHHHHHHCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEE
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]