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The map label for this gene is uvrC

Identifier: 57234009

GI number: 57234009

Start: 1115562

End: 1117385

Strand: Direct

Name: uvrC

Synonym: DET1216

Alternate gene names: 57234009

Gene position: 1115562-1117385 (Clockwise)

Preceding gene: 57234022

Following gene: 57234008

Centisome position: 75.9

GC content: 52.08

Gene sequence:

>1824_bases
ATGCCAAGCGAAACCCTGCAAAACCAGATAGCCAGTTTACCCGAAAACCCCGGCGTTTACCTGATGAAAAACGCCCAGGG
AGAAATCATTTATGTAGGCAAAGCAGCTGTTTTAAAAGACAGGGTCAAATCGTACTTTGTACCCCCATCCCGCCTTGAAC
CCAAAACCCGTCAGCTGGTCAGCCAGATAAACGAACTAGAATACCTGATAACCGGGTCTGAACAGGAAGCTTTGATACTG
GAACTGAACCTGATAAAGAGGCACCGCCCCTATTTCAATGTCCGCCTGAAGGACGATAAGGGTTTTCCGTACCTGAAAAT
AACTTTAAATGAAAAATGGCCGCGTATATATATAACCCGTAGTATGGCAGATGACGGCGGCAGGTATTTCGGCCCGTTTG
CCAGCACCCGTTCCGTCCGCCATACCCTGCAGGTGCTAAAAGAGCTTTTCCGTTTCCGCTCCTGCAACCGCACCGAACCG
GAAAAACGCAGCCGCCCCTGTCTGGAATACGATATCCACCAGTGCCTTTCGCCCTGCACCGGCAAAATAAGCAAGCAGGA
TTATGACCACCTTATCTCACAGGCCATACTCTTTCTGGAGGGCAAACAGGATAAGGTGCTGAAGCTGCTTGCCAAACTTA
TGAACGAAGCCTCAGCCCGGCTGGATTATGAAACCGCCGCCCTGCGCCGTGACCAGATATCATCTATAAAAGAGGTGATT
GAAGGACAGCAGCTGGCCGCCAGGGTAAGCGGCGAACAGGACGCCATTGCCTTTGCCCAGGAAGGAGACCTGTCCATGGT
GCAGGTTTTCTTTATCCGGCGGGGCAAACTTATCGGGCGGGAAAGCTTCAGCCTTCAGGGTACCCGCGAAGAAAAACCGG
GGGATATCCTTTCTGAATTTGTAAAACAGTTTTACCACTCCTCCACCCAGATACCGCCAAAAATAGTTACCCAGTACCCG
CTTTCAGACCGCGAAATACTGGAAAAGTGGCTGTCTGAAAGGCGGGGTGGCAAAGTGCAGATAACGGCGGGGCTTCGCGG
ACAGCCCAAAGACCTTATAAATATAGTAGCCGAAAATGCCAGGGAACAGCTGAAACAGGCACGGATAAAAAACCTGTCTT
CCGCCGCTACCCTGACAGATGCGCTGGAGGAACTGCAAACCGCGCTGGGACTGCCCCTGCCGCCGCAGCGGATAGAAGGC
TACGATATATCCAATATACAGGGCACCAATGCCGTAGGCAGCATGGTGGTTTTTGAAAACGGCAAACCCCAGAAAGCTCA
TTACCGCCGTTTCCGCATTAAGACCGTAAAGGGCGCGGATGATTTTTCCATGCTCAAAGAAGTCATCAGCCGCCGCTTCG
GCAGGCTAAACAAAGACAATGCCGGCGAAAGTTTTGCCCGGCGGCCTTCACTCATGCTGATAGACGGCGGCAAAGGTCAA
TTAAGCTCGGTCAAAGAAACATTAGACACCCTGGGGCTTGAGGGGCAGGCTGTAATAGGTCTGGCAAAAGAATTTGAAGA
AATCTATCTGCCCGGAAAATCCGAACCCATCAGGCTTATGGCCAACTCCCCCGCCCTTCAGCTGCTTCAGCGGGTGCGAG
ACGAAGCCCACCGCTTTGCGCTGGGGTATCACCTGAATATCCGCCATAAATCAGGGCTGACTTCGGCACTGGACGGGATT
CCCGGAATCGGCCCAAGCCGCCGCCGCCTGCTTATCAAAACATTCGGTTCGGTTTCAGGTATCCGTCAGGCCAGCCTTGA
TGAGCTTTTACAGGTAAAGGGTATAAATCAGGCACTTGCCCTGTCTATTAAGGAACTACTCTAA

Upstream 100 bases:

>100_bases
TACGCCCGAAAATTATTTAGCTTTATTTCCCCTCCGAAAAAAATATATCGTTTTTTACTGCCCCTTTGCTTACCTGAGCT
GCGGTTGCTACAATTTATCT

Downstream 100 bases:

>100_bases
ACAAAGGTTGCCACAAGCAGGCAATCAACTACCTGATAGTGGTATAATAGGTTTCAATCTAACGGTAAGAGGTTTATATG
CTGGAAATACGTACTCAAAC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MPSETLQNQIASLPENPGVYLMKNAQGEIIYVGKAAVLKDRVKSYFVPPSRLEPKTRQLVSQINELEYLITGSEQEALIL
ELNLIKRHRPYFNVRLKDDKGFPYLKITLNEKWPRIYITRSMADDGGRYFGPFASTRSVRHTLQVLKELFRFRSCNRTEP
EKRSRPCLEYDIHQCLSPCTGKISKQDYDHLISQAILFLEGKQDKVLKLLAKLMNEASARLDYETAALRRDQISSIKEVI
EGQQLAARVSGEQDAIAFAQEGDLSMVQVFFIRRGKLIGRESFSLQGTREEKPGDILSEFVKQFYHSSTQIPPKIVTQYP
LSDREILEKWLSERRGGKVQITAGLRGQPKDLINIVAENAREQLKQARIKNLSSAATLTDALEELQTALGLPLPPQRIEG
YDISNIQGTNAVGSMVVFENGKPQKAHYRRFRIKTVKGADDFSMLKEVISRRFGRLNKDNAGESFARRPSLMLIDGGKGQ
LSSVKETLDTLGLEGQAVIGLAKEFEEIYLPGKSEPIRLMANSPALQLLQRVRDEAHRFALGYHLNIRHKSGLTSALDGI
PGIGPSRRRLLIKTFGSVSGIRQASLDELLQVKGINQALALSIKELL

Sequences:

>Translated_607_residues
MPSETLQNQIASLPENPGVYLMKNAQGEIIYVGKAAVLKDRVKSYFVPPSRLEPKTRQLVSQINELEYLITGSEQEALIL
ELNLIKRHRPYFNVRLKDDKGFPYLKITLNEKWPRIYITRSMADDGGRYFGPFASTRSVRHTLQVLKELFRFRSCNRTEP
EKRSRPCLEYDIHQCLSPCTGKISKQDYDHLISQAILFLEGKQDKVLKLLAKLMNEASARLDYETAALRRDQISSIKEVI
EGQQLAARVSGEQDAIAFAQEGDLSMVQVFFIRRGKLIGRESFSLQGTREEKPGDILSEFVKQFYHSSTQIPPKIVTQYP
LSDREILEKWLSERRGGKVQITAGLRGQPKDLINIVAENAREQLKQARIKNLSSAATLTDALEELQTALGLPLPPQRIEG
YDISNIQGTNAVGSMVVFENGKPQKAHYRRFRIKTVKGADDFSMLKEVISRRFGRLNKDNAGESFARRPSLMLIDGGKGQ
LSSVKETLDTLGLEGQAVIGLAKEFEEIYLPGKSEPIRLMANSPALQLLQRVRDEAHRFALGYHLNIRHKSGLTSALDGI
PGIGPSRRRLLIKTFGSVSGIRQASLDELLQVKGINQALALSIKELL
>Mature_606_residues
PSETLQNQIASLPENPGVYLMKNAQGEIIYVGKAAVLKDRVKSYFVPPSRLEPKTRQLVSQINELEYLITGSEQEALILE
LNLIKRHRPYFNVRLKDDKGFPYLKITLNEKWPRIYITRSMADDGGRYFGPFASTRSVRHTLQVLKELFRFRSCNRTEPE
KRSRPCLEYDIHQCLSPCTGKISKQDYDHLISQAILFLEGKQDKVLKLLAKLMNEASARLDYETAALRRDQISSIKEVIE
GQQLAARVSGEQDAIAFAQEGDLSMVQVFFIRRGKLIGRESFSLQGTREEKPGDILSEFVKQFYHSSTQIPPKIVTQYPL
SDREILEKWLSERRGGKVQITAGLRGQPKDLINIVAENAREQLKQARIKNLSSAATLTDALEELQTALGLPLPPQRIEGY
DISNIQGTNAVGSMVVFENGKPQKAHYRRFRIKTVKGADDFSMLKEVISRRFGRLNKDNAGESFARRPSLMLIDGGKGQL
SSVKETLDTLGLEGQAVIGLAKEFEEIYLPGKSEPIRLMANSPALQLLQRVRDEAHRFALGYHLNIRHKSGLTSALDGIP
GIGPSRRRLLIKTFGSVSGIRQASLDELLQVKGINQALALSIKELL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=36.4532019704434, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1788037, Length=200, Percent_Identity=29, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_DEHE1 (Q3Z770)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181929.1
- ProteinModelPortal:   Q3Z770
- STRING:   Q3Z770
- GeneID:   3229475
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1216
- NMPDR:   fig|243164.3.peg.1118
- TIGR:   DET1216
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q3Z770
- ProtClustDB:   PRK00558
- BioCyc:   DETH243164:DET_1216-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68325; Mature: 68194

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSETLQNQIASLPENPGVYLMKNAQGEIIYVGKAAVLKDRVKSYFVPPSRLEPKTRQLV
CCCHHHHHHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHH
SQINELEYLITGSEQEALILELNLIKRHRPYFNVRLKDDKGFPYLKITLNEKWPRIYITR
HHHHHHEEEEECCCCCEEEEEEHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCEEEEEE
SMADDGGRYFGPFASTRSVRHTLQVLKELFRFRSCNRTEPEKRSRPCLEYDIHQCLSPCT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHC
GKISKQDYDHLISQAILFLEGKQDKVLKLLAKLMNEASARLDYETAALRRDQISSIKEVI
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EGQQLAARVSGEQDAIAFAQEGDLSMVQVFFIRRGKLIGRESFSLQGTREEKPGDILSEF
CCHHHHHHHCCCCHHEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHH
VKQFYHSSTQIPPKIVTQYPLSDREILEKWLSERRGGKVQITAGLRGQPKDLINIVAENA
HHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
REQLKQARIKNLSSAATLTDALEELQTALGLPLPPQRIEGYDISNIQGTNAVGSMVVFEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEC
GKPQKAHYRRFRIKTVKGADDFSMLKEVISRRFGRLNKDNAGESFARRPSLMLIDGGKGQ
CCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEECCCCC
LSSVKETLDTLGLEGQAVIGLAKEFEEIYLPGKSEPIRLMANSPALQLLQRVRDEAHRFA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHEE
LGYHLNIRHKSGLTSALDGIPGIGPSRRRLLIKTFGSVSGIRQASLDELLQVKGINQALA
EEEEEEEECCCCCHHHHCCCCCCCCHHHEEHHHHHHCHHHHHHHHHHHHHHHCCCCHHHH
LSIKELL
HHHHHHC
>Mature Secondary Structure 
PSETLQNQIASLPENPGVYLMKNAQGEIIYVGKAAVLKDRVKSYFVPPSRLEPKTRQLV
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHH
SQINELEYLITGSEQEALILELNLIKRHRPYFNVRLKDDKGFPYLKITLNEKWPRIYITR
HHHHHHEEEEECCCCCEEEEEEHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCEEEEEE
SMADDGGRYFGPFASTRSVRHTLQVLKELFRFRSCNRTEPEKRSRPCLEYDIHQCLSPCT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHC
GKISKQDYDHLISQAILFLEGKQDKVLKLLAKLMNEASARLDYETAALRRDQISSIKEVI
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EGQQLAARVSGEQDAIAFAQEGDLSMVQVFFIRRGKLIGRESFSLQGTREEKPGDILSEF
CCHHHHHHHCCCCHHEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCCHHHHHHH
VKQFYHSSTQIPPKIVTQYPLSDREILEKWLSERRGGKVQITAGLRGQPKDLINIVAENA
HHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
REQLKQARIKNLSSAATLTDALEELQTALGLPLPPQRIEGYDISNIQGTNAVGSMVVFEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEC
GKPQKAHYRRFRIKTVKGADDFSMLKEVISRRFGRLNKDNAGESFARRPSLMLIDGGKGQ
CCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEECCCCC
LSSVKETLDTLGLEGQAVIGLAKEFEEIYLPGKSEPIRLMANSPALQLLQRVRDEAHRFA
HHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHEE
LGYHLNIRHKSGLTSALDGIPGIGPSRRRLLIKTFGSVSGIRQASLDELLQVKGINQALA
EEEEEEEECCCCCHHHHCCCCCCCCHHHEEHHHHHHCHHHHHHHHHHHHHHHCCCCHHHH
LSIKELL
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA