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The map label for this gene is argH

Identifier: 57233964

GI number: 57233964

Start: 1148088

End: 1149473

Strand: Direct

Name: argH

Synonym: DET1261

Alternate gene names: 57233964

Gene position: 1148088-1149473 (Clockwise)

Preceding gene: 57233965

Following gene: 57233962

Centisome position: 78.12

GC content: 51.23

Gene sequence:

>1386_bases
ATGAGCCATATCCGCAGCCGCTTTTCAAAACCGGCAGATGAACTTGTGGTCAGATATACCACCTCGCTGCCGTTTGACTG
GCGCTTATACCAGGAAGATATAAAATGCTCAACCGCCCATGCCCGCATGCTGGGTAAGCAGAGCATTATCTCCGCTGGGG
ACAGCCAGTCCATCATAAACGGGCTTTCGGATATCCTGACAGAGATTGAAACCGGCAGTTTTGTGTTTAAACCCGAAATG
GAAGATATCCATATGGCCATAGAGGGGCGTCTTTTTGAACTTATCGGCGAGGCGGCCGGCAGACTGCACACCGCCCGCAG
CCGGAATGACCAGGTAGCCACCGATGTACACCTGTTTGTAAAAAACACCTGTACCAGCACTATCAATAAAATACGCACCC
TTCAGGGGGCTTTGCTGAAACAGGCGGAAGCCCACCAGCAAACCGCTTTGCCCGGTTATACCCATTTGCAGGTAGCCCAG
CCGGTGCTTCTTTCACACCACCTGCTGGCTTATTTTGAAATGCTGGAGCGTGACTGCGGGCGTTTTACAGACGCAAAAAA
ACGCTCAGATGTGATGCCTCTGGGCAGCGGGGCTTTGGCTGGCGTACCTTATCCGCTTGACCGCAAAATGGTAGCCGAAG
AGCTGGGTTTTACGGCTATCAGCCAGAACTCGCTGGATGCCGTTTCAGAGCGGGACTTTGTACTGGAATACCTTTCAGAC
GCCGCTATCTGCCAGATGCACCTCTCCAGACTGAGTGAGGAAATGGTGATATGGTCTTCGGCGGAATATGCCTTTGTAGA
GCTTGATGATGCCTATACCACCGGCTCAAGCATTATGCCCCAGAAGAAAAACCCTGACGTAGCCGAGCTTTGCCGCGGCA
AGACCGGGCGGGTATACGGTTCTCTAAATACCATGCTGACTGTCATGAAGGGTCTGCCCCTTTCCTATAACCGTGACCTT
CAGGAAGATAAAGAACCTCTGTTTGAATGCGCAGATACTCTGGGTGACAGCCTTGAGGTATTTGCCGGTATGATAAAAAC
CGCCACGTTCAAACCCGAACGTATGCTCCGGGCTTTGGAAAAAGGATACGTGCTGGCAACCGATATTGCCGACTATCTGG
TGGGCAAAGGTGAAAGTTTCCGCAGTTCCCACGGCATAGTAGCCCGTCTGGTGAGCTACGCCATCTCCCAAAATAAAACC
TTTGGCGAGCTGAGCCTTGAGGAATACCGCCAGTTTTCAAACCTGTTTGGAAACGATATTTATGCAGTAGATATAAAGTC
TGCTTTAAACGCCCGCAACCTGACCGGCGGAACTGCCCCAAAACAAATAGCCCAGGCAATTGCCCGGGCTAAGAAAATAC
TGGCTGAAGCTGGAGTTAAAAACTAA

Upstream 100 bases:

>100_bases
GTCTTCGGCAGTGGGTTTCATAACCCTGTGGGGACTTCAGGCCAAACTGCAGGCCCAGCTCCAGCCTATTCTGGAAGAAG
AAAAGGGGAATAAATCCTAG

Downstream 100 bases:

>100_bases
ATGTCTGTATTAGGCAGTTTTAGCAAGCTTGGCCTGAGAGCGGATGCAACGGGTGCAGAGCTTCATACGAACCTCAGCGC
CGTTGACTGTAACCTTGGCG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MSHIRSRFSKPADELVVRYTTSLPFDWRLYQEDIKCSTAHARMLGKQSIISAGDSQSIINGLSDILTEIETGSFVFKPEM
EDIHMAIEGRLFELIGEAAGRLHTARSRNDQVATDVHLFVKNTCTSTINKIRTLQGALLKQAEAHQQTALPGYTHLQVAQ
PVLLSHHLLAYFEMLERDCGRFTDAKKRSDVMPLGSGALAGVPYPLDRKMVAEELGFTAISQNSLDAVSERDFVLEYLSD
AAICQMHLSRLSEEMVIWSSAEYAFVELDDAYTTGSSIMPQKKNPDVAELCRGKTGRVYGSLNTMLTVMKGLPLSYNRDL
QEDKEPLFECADTLGDSLEVFAGMIKTATFKPERMLRALEKGYVLATDIADYLVGKGESFRSSHGIVARLVSYAISQNKT
FGELSLEEYRQFSNLFGNDIYAVDIKSALNARNLTGGTAPKQIAQAIARAKKILAEAGVKN

Sequences:

>Translated_461_residues
MSHIRSRFSKPADELVVRYTTSLPFDWRLYQEDIKCSTAHARMLGKQSIISAGDSQSIINGLSDILTEIETGSFVFKPEM
EDIHMAIEGRLFELIGEAAGRLHTARSRNDQVATDVHLFVKNTCTSTINKIRTLQGALLKQAEAHQQTALPGYTHLQVAQ
PVLLSHHLLAYFEMLERDCGRFTDAKKRSDVMPLGSGALAGVPYPLDRKMVAEELGFTAISQNSLDAVSERDFVLEYLSD
AAICQMHLSRLSEEMVIWSSAEYAFVELDDAYTTGSSIMPQKKNPDVAELCRGKTGRVYGSLNTMLTVMKGLPLSYNRDL
QEDKEPLFECADTLGDSLEVFAGMIKTATFKPERMLRALEKGYVLATDIADYLVGKGESFRSSHGIVARLVSYAISQNKT
FGELSLEEYRQFSNLFGNDIYAVDIKSALNARNLTGGTAPKQIAQAIARAKKILAEAGVKN
>Mature_460_residues
SHIRSRFSKPADELVVRYTTSLPFDWRLYQEDIKCSTAHARMLGKQSIISAGDSQSIINGLSDILTEIETGSFVFKPEME
DIHMAIEGRLFELIGEAAGRLHTARSRNDQVATDVHLFVKNTCTSTINKIRTLQGALLKQAEAHQQTALPGYTHLQVAQP
VLLSHHLLAYFEMLERDCGRFTDAKKRSDVMPLGSGALAGVPYPLDRKMVAEELGFTAISQNSLDAVSERDFVLEYLSDA
AICQMHLSRLSEEMVIWSSAEYAFVELDDAYTTGSSIMPQKKNPDVAELCRGKTGRVYGSLNTMLTVMKGLPLSYNRDLQ
EDKEPLFECADTLGDSLEVFAGMIKTATFKPERMLRALEKGYVLATDIADYLVGKGESFRSSHGIVARLVSYAISQNKTF
GELSLEEYRQFSNLFGNDIYAVDIKSALNARNLTGGTAPKQIAQAIARAKKILAEAGVKN

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=449, Percent_Identity=42.5389755011136, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI68303542, Length=449, Percent_Identity=42.5389755011136, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI68303547, Length=449, Percent_Identity=40.3118040089087, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI68303549, Length=449, Percent_Identity=40.3118040089087, Blast_Score=338, Evalue=9e-93,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=45.3947368421053, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321806, Length=452, Percent_Identity=41.1504424778761, Blast_Score=348, Evalue=7e-97,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=40.0447427293065, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=40.0447427293065, Blast_Score=337, Evalue=1e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_DEHE1 (Q3Z726)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_181973.1
- ProteinModelPortal:   Q3Z726
- SMR:   Q3Z726
- STRING:   Q3Z726
- GeneID:   3229429
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1261
- NMPDR:   fig|243164.3.peg.1254
- TIGR:   DET1261
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q3Z726
- ProtClustDB:   PRK00855
- BioCyc:   DETH243164:DET_1261-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51045; Mature: 50914

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHIRSRFSKPADELVVRYTTSLPFDWRLYQEDIKCSTAHARMLGKQSIISAGDSQSIIN
CCHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GLSDILTEIETGSFVFKPEMEDIHMAIEGRLFELIGEAAGRLHTARSRNDQVATDVHLFV
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KNTCTSTINKIRTLQGALLKQAEAHQQTALPGYTHLQVAQPVLLSHHLLAYFEMLERDCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RFTDAKKRSDVMPLGSGALAGVPYPLDRKMVAEELGFTAISQNSLDAVSERDFVLEYLSD
CCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AAICQMHLSRLSEEMVIWSSAEYAFVELDDAYTTGSSIMPQKKNPDVAELCRGKTGRVYG
HHHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEE
SLNTMLTVMKGLPLSYNRDLQEDKEPLFECADTLGDSLEVFAGMIKTATFKPERMLRALE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
KGYVLATDIADYLVGKGESFRSSHGIVARLVSYAISQNKTFGELSLEEYRQFSNLFGNDI
CCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCE
YAVDIKSALNARNLTGGTAPKQIAQAIARAKKILAEAGVKN
EEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHIRSRFSKPADELVVRYTTSLPFDWRLYQEDIKCSTAHARMLGKQSIISAGDSQSIIN
CHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GLSDILTEIETGSFVFKPEMEDIHMAIEGRLFELIGEAAGRLHTARSRNDQVATDVHLFV
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
KNTCTSTINKIRTLQGALLKQAEAHQQTALPGYTHLQVAQPVLLSHHLLAYFEMLERDCG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
RFTDAKKRSDVMPLGSGALAGVPYPLDRKMVAEELGFTAISQNSLDAVSERDFVLEYLSD
CCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AAICQMHLSRLSEEMVIWSSAEYAFVELDDAYTTGSSIMPQKKNPDVAELCRGKTGRVYG
HHHHHHHHHHHHHHHEEEECCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEE
SLNTMLTVMKGLPLSYNRDLQEDKEPLFECADTLGDSLEVFAGMIKTATFKPERMLRALE
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHH
KGYVLATDIADYLVGKGESFRSSHGIVARLVSYAISQNKTFGELSLEEYRQFSNLFGNDI
CCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCE
YAVDIKSALNARNLTGGTAPKQIAQAIARAKKILAEAGVKN
EEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA