Click here to switch to the map view.

The map label for this gene is lspA

Identifier: 57233861

GI number: 57233861

Start: 1241512

End: 1241994

Strand: Direct

Name: lspA

Synonym: DET1374

Alternate gene names: 57233861

Gene position: 1241512-1241994 (Clockwise)

Preceding gene: 57233862

Following gene: 57233860

Centisome position: 84.47

GC content: 51.14

Gene sequence:

>483_bases
ATGACCAGGGGATTAGTATTTTTTGTCAGCGCCGCTTGCGGCGTTCTGGCTGACCAGCTAAGCAAATTTATTATTGCCGC
TAACCTTACCCCGGGCACAGCCATACCGGAAAGCGGTTTCTTCCAGATTGTCCACGTTCATAATACCGGCGCGGCTTTCA
GTATTTTCAGGGGGCACACCGAGTGGCTTATTGCCGCCAGCTGTCTGGGAGTAATACTGGCCCTGACCGCTTTCTTCTTA
AGGAAAAAACTGCCGTTTTTGGATACCCGCCCCGGTGTAGCCGCTTTGGGAATTATCCTGGCAGGTACGATAGGCAACCT
GATTGACCGGGTGCGGCTGGGTTATGTTACTGACTTTATACAGGTAGGGAATTTCCCTACTTTCAATATGGCTGATTCCT
GCCTGACGCTGGGCATTATCTGGCTGGTGCTCTTATACCTGACATCTTCCCATTCGGGAGGAGATGCCAGTGAAAACGCG
TAA

Upstream 100 bases:

>100_bases
CCTGCCAGACTTGAAGCTTTGCCGCAGGCCAGACTGTGTATGCAGTGCAAGTCTAAAGCAGCCAAGTCTTACTAAATCAG
CTTGAAAAGGGTTGGGGTTA

Downstream 100 bases:

>100_bases
ACTGGTTGCCGAATCTGACGGTGAGCGGCTGGATAAATACATAACCCAAAAGGAAACTGACCTTTCCCGCAGTTTTATAC
AGGAACTGGTGGAAGCAGGC

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MTRGLVFFVSAACGVLADQLSKFIIAANLTPGTAIPESGFFQIVHVHNTGAAFSIFRGHTEWLIAASCLGVILALTAFFL
RKKLPFLDTRPGVAALGIILAGTIGNLIDRVRLGYVTDFIQVGNFPTFNMADSCLTLGIIWLVLLYLTSSHSGGDASENA

Sequences:

>Translated_160_residues
MTRGLVFFVSAACGVLADQLSKFIIAANLTPGTAIPESGFFQIVHVHNTGAAFSIFRGHTEWLIAASCLGVILALTAFFL
RKKLPFLDTRPGVAALGIILAGTIGNLIDRVRLGYVTDFIQVGNFPTFNMADSCLTLGIIWLVLLYLTSSHSGGDASENA
>Mature_159_residues
TRGLVFFVSAACGVLADQLSKFIIAANLTPGTAIPESGFFQIVHVHNTGAAFSIFRGHTEWLIAASCLGVILALTAFFLR
KKLPFLDTRPGVAALGIILAGTIGNLIDRVRLGYVTDFIQVGNFPTFNMADSCLTLGIIWLVLLYLTSSHSGGDASENA

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_DEHE1 (Q3Z6R4)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_182085.1
- STRING:   Q3Z6R4
- MEROPS:   A08.001
- GeneID:   3229325
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1374
- NMPDR:   fig|243164.3.peg.1329
- TIGR:   DET1374
- eggNOG:   COG0597
- HOGENOM:   HBG724422
- OMA:   SGFFQIV
- ProtClustDB:   PRK14784
- BioCyc:   DETH243164:DET_1374-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17032; Mature: 16901

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 109-109 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

HASH(0xe0637dc)-; HASH(0xe68a11c)-; HASH(0xdf6a470)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGLVFFVSAACGVLADQLSKFIIAANLTPGTAIPESGFFQIVHVHNTGAAFSIFRGHT
CCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEEEECCCCEEHHHCCCH
EWLIAASCLGVILALTAFFLRKKLPFLDTRPGVAALGIILAGTIGNLIDRVRLGYVTDFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVGNFPTFNMADSCLTLGIIWLVLLYLTSSHSGGDASENA
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
>Mature Secondary Structure 
TRGLVFFVSAACGVLADQLSKFIIAANLTPGTAIPESGFFQIVHVHNTGAAFSIFRGHT
CCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCEEEEEEECCCCEEHHHCCCH
EWLIAASCLGVILALTAFFLRKKLPFLDTRPGVAALGIILAGTIGNLIDRVRLGYVTDFI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVGNFPTFNMADSCLTLGIIWLVLLYLTSSHSGGDASENA
HHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA