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The map label for this gene is hypA

Identifier: 57233778

GI number: 57233778

Start: 1301433

End: 1301792

Strand: Direct

Name: hypA

Synonym: DET1430

Alternate gene names: 57233778

Gene position: 1301433-1301792 (Clockwise)

Preceding gene: 57233780

Following gene: 57233777

Centisome position: 88.55

GC content: 47.22

Gene sequence:

>360_bases
ATGCACGAACTATCCATAACCGAAGAACTGCTAAAAACAATTGTAGCCAAGGCTGAAGAAGCCAAAGCCCGTAAAATCAG
CCGGATAAATCTGGTGATAGGCGAATATGCAGGCGTGGTGGAAGACAGCGTAAAAATGTGTTTTGATATACTCAGCCAGG
ACACTATGGCCAAGGGGGCGCTTTTAGAATTTAAGCGCATACCCGCCGAATTCCGCTGCCGTTTGTGCGGCCATACCTTC
CCTTCAGGGCAGCATGCACTGGTCTGCCCCAAATGTCAGGGCTGGAATGCCGAAGTGATAGCCGGCAACGAATTTTTTAT
TGAAAGCATTGAGGTAGATGATGAAAGTCAAAGTTCTTAA

Upstream 100 bases:

>100_bases
ACCTCGCTTCTTTCTGAATAATAAACACAGCCTTAAAAGGTGTCAAATACCCCCCGAATTAGACACCCAAGCGGGTCTGC
CTTATAATTAAATAAGAATT

Downstream 100 bases:

>100_bases
AAATATTACCGACATGAATGACCAGCTGGCTGCCAGAAACAAGGATATGTTTGCCGGAAAAGGCATACTGGTGATAAATG
TCATGTCTTCACCCGGCGCC

Product: hydrogenase nickel insertion protein HypA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 119; Mature: 119

Protein sequence:

>119_residues
MHELSITEELLKTIVAKAEEAKARKISRINLVIGEYAGVVEDSVKMCFDILSQDTMAKGALLEFKRIPAEFRCRLCGHTF
PSGQHALVCPKCQGWNAEVIAGNEFFIESIEVDDESQSS

Sequences:

>Translated_119_residues
MHELSITEELLKTIVAKAEEAKARKISRINLVIGEYAGVVEDSVKMCFDILSQDTMAKGALLEFKRIPAEFRCRLCGHTF
PSGQHALVCPKCQGWNAEVIAGNEFFIESIEVDDESQSS
>Mature_119_residues
MHELSITEELLKTIVAKAEEAKARKISRINLVIGEYAGVVEDSVKMCFDILSQDTMAKGALLEFKRIPAEFRCRLCGHTF
PSGQHALVCPKCQGWNAEVIAGNEFFIESIEVDDESQSS

Specific function: Probably plays a role in an hydrogenase nickel cofactor insertion step

COG id: COG0375

COG function: function code R; Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hypA/hybF family

Homologues:

Organism=Escherichia coli, GI1789365, Length=113, Percent_Identity=31.858407079646, Blast_Score=67, Evalue=3e-13,
Organism=Escherichia coli, GI1789081, Length=116, Percent_Identity=28.448275862069, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYPA_DEHE1 (Q3Z6L1)

Other databases:

- EMBL:   CP000027
- RefSeq:   YP_182138.1
- STRING:   Q3Z6L1
- GeneID:   3229241
- GenomeReviews:   CP000027_GR
- KEGG:   det:DET1430
- NMPDR:   fig|243164.3.peg.1398
- TIGR:   DET1430
- eggNOG:   COG0375
- HOGENOM:   HBG688671
- OMA:   IAGNEFF
- PhylomeDB:   Q3Z6L1
- ProtClustDB:   CLSK836881
- BioCyc:   DETH243164:DET_1430-MONOMER
- HAMAP:   MF_00213
- InterPro:   IPR000688
- InterPro:   IPR020538
- InterPro:   IPR004039
- Gene3D:   G3DSA:2.20.28.10
- TIGRFAMs:   TIGR00100

Pfam domain/function: PF01155 HypA

EC number: NA

Molecular weight: Translated: 13219; Mature: 13219

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS01249 HYPA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHELSITEELLKTIVAKAEEAKARKISRINLVIGEYAGVVEDSVKMCFDILSQDTMAKGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEFKRIPAEFRCRLCGHTFPSGQHALVCPKCQGWNAEVIAGNEFFIESIEVDDESQSS
HHHHHHCCHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MHELSITEELLKTIVAKAEEAKARKISRINLVIGEYAGVVEDSVKMCFDILSQDTMAKGA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLEFKRIPAEFRCRLCGHTFPSGQHALVCPKCQGWNAEVIAGNEFFIESIEVDDESQSS
HHHHHHCCHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEECCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA