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The map label for this gene is liaS [H]

Identifier: 57233740

GI number: 57233740

Start: 1381804

End: 1382379

Strand: Direct

Name: liaS [H]

Synonym: DET1530

Alternate gene names: 57233740

Gene position: 1381804-1382379 (Clockwise)

Preceding gene: 57233741

Following gene: 57233739

Centisome position: 94.02

GC content: 46.88

Gene sequence:

>576_bases
GTGCATGACCGGGTAATCCAGCTTCTGATTAGTTCCTGCCGGCTGATTGAAAGTACCAAACAGGCCGGCACCGATTCACC
CCAAATGAATAAATCCCTGAACGAAATAAACGACACAATCTTAAAAACTATCGCCGAATGCCGCCTGATAACCAAACAGC
TATACCCGTCTGTATTATCAGAAGGCGGACTGGTTTCGGTTATAACCGAAGAGCTAAGTGCCTTGAAACTAACCGGCATG
TCAGCCGAACTGACAACCGATAAAACCGCCCCTATACCCAAACCGGTTGCCGAGGTACTTTACAGGATATTCCATGAGGC
TATCTGGAATGCCCAGAGACATTCCAAGGCCAGCCATATTGATGTTATACTAAAAATAGTGGAAAACGGCGTAAGACTGG
CGGTTATTGATGACGGATGCGGGTTCAATCTGTACAAATCCCTGCAATCCGGCAAATTTGGCGGGCTGAAAAGTATGCGC
AGACGGGCCGAACTGATGGGCGGCAGTTTCAATATAGAAAGTGAGATAGGTAAAGGTACATCTATCGAAGTTTTTATCCC
GTTTTCGGTAGGGTAG

Upstream 100 bases:

>100_bases
AACTTGAACGTGAGCTCAAAAAAATAAAACCCAGCTTAAAGAGCTGGCTTCAGCCTATGTAAGTTCACAGGAAAACGAAA
GGGAGCTGATTGCTTGCGAG

Downstream 100 bases:

>100_bases
GGAAAATGCTTGAGAGTAAGATAAAAGTACTGATATGTGATGACCATGACATAGTTTGTCAGGGGTTAGTAAATATTATT
TCCTGCGAAGCTGATTTGGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MHDRVIQLLISSCRLIESTKQAGTDSPQMNKSLNEINDTILKTIAECRLITKQLYPSVLSEGGLVSVITEELSALKLTGM
SAELTTDKTAPIPKPVAEVLYRIFHEAIWNAQRHSKASHIDVILKIVENGVRLAVIDDGCGFNLYKSLQSGKFGGLKSMR
RRAELMGGSFNIESEIGKGTSIEVFIPFSVG

Sequences:

>Translated_191_residues
MHDRVIQLLISSCRLIESTKQAGTDSPQMNKSLNEINDTILKTIAECRLITKQLYPSVLSEGGLVSVITEELSALKLTGM
SAELTTDKTAPIPKPVAEVLYRIFHEAIWNAQRHSKASHIDVILKIVENGVRLAVIDDGCGFNLYKSLQSGKFGGLKSMR
RRAELMGGSFNIESEIGKGTSIEVFIPFSVG
>Mature_191_residues
MHDRVIQLLISSCRLIESTKQAGTDSPQMNKSLNEINDTILKTIAECRLITKQLYPSVLSEGGLVSVITEELSALKLTGM
SAELTTDKTAPIPKPVAEVLYRIFHEAIWNAQRHSKASHIDVILKIVENGVRLAVIDDGCGFNLYKSLQSGKFGGLKSMR
RRAELMGGSFNIESEIGKGTSIEVFIPFSVG

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 20934; Mature: 20934

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDRVIQLLISSCRLIESTKQAGTDSPQMNKSLNEINDTILKTIAECRLITKQLYPSVLS
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGGLVSVITEELSALKLTGMSAELTTDKTAPIPKPVAEVLYRIFHEAIWNAQRHSKASHI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHH
DVILKIVENGVRLAVIDDGCGFNLYKSLQSGKFGGLKSMRRRAELMGGSFNIESEIGKGT
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCC
SIEVFIPFSVG
EEEEEEECCCC
>Mature Secondary Structure
MHDRVIQLLISSCRLIESTKQAGTDSPQMNKSLNEINDTILKTIAECRLITKQLYPSVLS
CHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EGGLVSVITEELSALKLTGMSAELTTDKTAPIPKPVAEVLYRIFHEAIWNAQRHSKASHI
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHCCHHHH
DVILKIVENGVRLAVIDDGCGFNLYKSLQSGKFGGLKSMRRRAELMGGSFNIESEIGKGT
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHCCCCC
SIEVFIPFSVG
EEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]