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The map label for this gene is htpX [H]

Identifier: 57233651

GI number: 57233651

Start: 1425255

End: 1426448

Strand: Direct

Name: htpX [H]

Synonym: DET1587

Alternate gene names: 57233651

Gene position: 1425255-1426448 (Clockwise)

Preceding gene: 57233652

Following gene: 57233620

Centisome position: 96.97

GC content: 53.94

Gene sequence:

>1194_bases
ATGTGGGAACAGATACAATCCAATAGAACCCGTTCCATTATGCTGGTTATCGGCATGGGGCTTATTCTGGTAGCCCTGGG
CTACGCTTTAGGCATGGCCTTTACCGATAACGGGCTGGTGGGACTGGTAATTGCTCTTGTCCTGTGGGGAATTATGAATC
TGGTAGCCCTAACCCAGGGTGACAGTATTCTTCTGGGCATGGCTAATGCCAAGGAAATAAAACCGGCTGACCATCCGCGC
CTTTACAACGTGGTGGAGGAAATGAAGATTGCCTCCGGGCTGGATACCATGCCCAAGGTTTATATTATTGACGACCCCGC
CTTAAACGCCTTTGCCACCGGACGGGACAAAAACCATATTTCAGTTGCCATTACTTCCGGACTGCTGCAGAAGCTGAACC
GTGATGAACTGCAGGGTGTGATAGGGCATGAAATGGCCCATATCAAAAACCGGGATGTCTCACTGATGGTGTGGTGCAGT
ATCCTTTTGGGGACTATAGTTATTTTAGCCCAGTACGGCTCACGGATGTTTATTTTCGGCGGAGGGTCACGCCGTTCTTC
CTCAAACGAAGGGGGCGGCGGCGGGGCTCAGGCTATCTTGATGGTGGCGGCACTGCTGCTTATTATACTGGCACCCTTGT
TTGCCCAGCTGATATATTTTGCCATCTCACGCAAACGCGAATATCTGGCAGATGCGTCATCTGCCCAGTATACCCGTTAC
CCGGAGGGGCTGGCTTCCGCCCTTGAAAAGCTGGGGGCTTCTACCGCACAGCTGCGCTCAGCCAACCAGGCTACCGCCCC
CATGTATATAATTAACCCCTTCAGAGCCAAAGGCAAAGCCGCCGCTGACCTGACTTCCACCCATCCCCCCATAAGCGAGC
GGATACGGATTCTGCGGTCTATGAACGGGGCTTCCTACCACAACTATGACGAGGCCTTTAAACAGGTGAAAGGCGGGCAT
GTTATACCGCCTACCGCTATCAAGCTTGACCACGCCGAGACTATACGGGAGGCTTCGGACGAAGGGCCTTTGGCTACTGA
AATCGGCCGCGCCCGCGAAACCTCAAACGCCCTCTGGAATATGAATAAATACCAGACGGTAGATTGTGACTGCGGGGTCA
GGCTGCGTGTCCCACCCGGCTTAAAGGGGCAGGAGGTCAGTTGCCCGCACTGCGGCAAAACCCACCAGACCTGA

Upstream 100 bases:

>100_bases
CCGGTATAGCTAATTTCAAGGCCAGCGAATTTTTTGAGCTTAAAGTAGAAGAGGAACGCCAGGCTCCCAAGGTAAAGTTT
TAAACAGGATTTAGACCGAT

Downstream 100 bases:

>100_bases
TATATAAGCTGTTAGACCGAAATATTAAAGGGGCGTAAAACCGCCCCTTTTTGTTATATCCGCAAAATCCATTTTAAAAA
GTCAGAGGTTAAACTCTTTC

Product: M28 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MWEQIQSNRTRSIMLVIGMGLILVALGYALGMAFTDNGLVGLVIALVLWGIMNLVALTQGDSILLGMANAKEIKPADHPR
LYNVVEEMKIASGLDTMPKVYIIDDPALNAFATGRDKNHISVAITSGLLQKLNRDELQGVIGHEMAHIKNRDVSLMVWCS
ILLGTIVILAQYGSRMFIFGGGSRRSSSNEGGGGGAQAILMVAALLLIILAPLFAQLIYFAISRKREYLADASSAQYTRY
PEGLASALEKLGASTAQLRSANQATAPMYIINPFRAKGKAAADLTSTHPPISERIRILRSMNGASYHNYDEAFKQVKGGH
VIPPTAIKLDHAETIREASDEGPLATEIGRARETSNALWNMNKYQTVDCDCGVRLRVPPGLKGQEVSCPHCGKTHQT

Sequences:

>Translated_397_residues
MWEQIQSNRTRSIMLVIGMGLILVALGYALGMAFTDNGLVGLVIALVLWGIMNLVALTQGDSILLGMANAKEIKPADHPR
LYNVVEEMKIASGLDTMPKVYIIDDPALNAFATGRDKNHISVAITSGLLQKLNRDELQGVIGHEMAHIKNRDVSLMVWCS
ILLGTIVILAQYGSRMFIFGGGSRRSSSNEGGGGGAQAILMVAALLLIILAPLFAQLIYFAISRKREYLADASSAQYTRY
PEGLASALEKLGASTAQLRSANQATAPMYIINPFRAKGKAAADLTSTHPPISERIRILRSMNGASYHNYDEAFKQVKGGH
VIPPTAIKLDHAETIREASDEGPLATEIGRARETSNALWNMNKYQTVDCDCGVRLRVPPGLKGQEVSCPHCGKTHQT
>Mature_397_residues
MWEQIQSNRTRSIMLVIGMGLILVALGYALGMAFTDNGLVGLVIALVLWGIMNLVALTQGDSILLGMANAKEIKPADHPR
LYNVVEEMKIASGLDTMPKVYIIDDPALNAFATGRDKNHISVAITSGLLQKLNRDELQGVIGHEMAHIKNRDVSLMVWCS
ILLGTIVILAQYGSRMFIFGGGSRRSSSNEGGGGGAQAILMVAALLLIILAPLFAQLIYFAISRKREYLADASSAQYTRY
PEGLASALEKLGASTAQLRSANQATAPMYIINPFRAKGKAAADLTSTHPPISERIRILRSMNGASYHNYDEAFKQVKGGH
VIPPTAIKLDHAETIREASDEGPLATEIGRARETSNALWNMNKYQTVDCDCGVRLRVPPGLKGQEVSCPHCGKTHQT

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Escherichia coli, GI1788133, Length=289, Percent_Identity=30.7958477508651, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022919
- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 42998; Mature: 42998

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWEQIQSNRTRSIMLVIGMGLILVALGYALGMAFTDNGLVGLVIALVLWGIMNLVALTQG
CCCCHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
DSILLGMANAKEIKPADHPRLYNVVEEMKIASGLDTMPKVYIIDDPALNAFATGRDKNHI
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCCCCE
SVAITSGLLQKLNRDELQGVIGHEMAHIKNRDVSLMVWCSILLGTIVILAQYGSRMFIFG
EEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
GGSRRSSSNEGGGGGAQAILMVAALLLIILAPLFAQLIYFAISRKREYLADASSAQYTRY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PEGLASALEKLGASTAQLRSANQATAPMYIINPFRAKGKAAADLTSTHPPISERIRILRS
HHHHHHHHHHHCCCHHHHHCCCCCCCCEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHH
MNGASYHNYDEAFKQVKGGHVIPPTAIKLDHAETIREASDEGPLATEIGRARETSNALWN
CCCCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
MNKYQTVDCDCGVRLRVPPGLKGQEVSCPHCGKTHQT
CCCCEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MWEQIQSNRTRSIMLVIGMGLILVALGYALGMAFTDNGLVGLVIALVLWGIMNLVALTQG
CCCCHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
DSILLGMANAKEIKPADHPRLYNVVEEMKIASGLDTMPKVYIIDDPALNAFATGRDKNHI
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEECCCCCCCE
SVAITSGLLQKLNRDELQGVIGHEMAHIKNRDVSLMVWCSILLGTIVILAQYGSRMFIFG
EEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEE
GGSRRSSSNEGGGGGAQAILMVAALLLIILAPLFAQLIYFAISRKREYLADASSAQYTRY
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
PEGLASALEKLGASTAQLRSANQATAPMYIINPFRAKGKAAADLTSTHPPISERIRILRS
HHHHHHHHHHHCCCHHHHHCCCCCCCCEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHH
MNGASYHNYDEAFKQVKGGHVIPPTAIKLDHAETIREASDEGPLATEIGRARETSNALWN
CCCCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
MNKYQTVDCDCGVRLRVPPGLKGQEVSCPHCGKTHQT
CCCCEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]