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The map label for this gene is folP [H]

Identifier: 57233620

GI number: 57233620

Start: 1437031

End: 1437879

Strand: Direct

Name: folP [H]

Synonym: DET1603

Alternate gene names: 57233620

Gene position: 1437031-1437879 (Clockwise)

Preceding gene: 57233651

Following gene: 57233619

Centisome position: 97.78

GC content: 54.42

Gene sequence:

>849_bases
ATGGATTTACCCGCAAAAAAACCTGTAGAAAGCCTCTTCGGCTCAAAACAATTCGGCTGGGGAGAGCGTACCTACATAAT
GGGTATAGTCAATGTCACCGCTGACTCATTTTCAGGTGACGGACTGGGTGCTAACCCCGAAGCCGCTCTGGAACAGGCCC
GCCGTTTTGCTCTGGAAGGGGCAGATATACTGGATATAGGCGGTGAAAGCACCCGCCCGGGCAGCCAGCCGGTAAACACC
CGGGAAGAACTGGACAGGGTCATACCGGCGGTTAGGCTTATTTCCCGAAATCTGGATATACCCGTAAGCGTAGATACCTA
CCGGCGAGAAGTGGCGGAAGAAGCCCTGAAAGCCGGCGCCTGCATAATAAATGATGTCTGGGGGTTAAAAAAAGACCCTT
CCCTTTTTGAGCTGGCAGCCAAAAGGCCTGCCGGCTGGGTGATAACCTCCAACCAGCGGGAAAACCCGGCGGAAGATATA
ATGGCGGCAGTCACCAGCGAACTGAGGGAAACTGCCCTGAGGCTGCTTGGCTTGGGTGTACCCGCCCGAAATATTATTAT
TGACCCCGGAGTGGGGTTCGGCAAAACCCTGGAGCAAAATCTGGAAATTGTCCGCCGTTTGTCAGAACTGAAAACCCTAA
ATCTGCCTATACTGCTGGGCACTTCCCGCAAATCCCTTATCGGGCAGGTGCTGGACACCCCGCCGGGCGAAAGGCTGGAA
GGGACGGCCGCCACGGTTGCCCTGGGGATAGGGGGCGGGGCGGATATTGTAAGGGTGCATGATGTAGCCTATATGAAACG
GGTCTGCCGGATGAGTGATGCTGTTGTAAGGGGTAAAATATGGAAATAA

Upstream 100 bases:

>100_bases
TTGATTAAGCCCTTTTAAGCTTGGAAATGACGGCCGGGCGGCAGTATTTGCTTGCTCCTTTTATCATTTGCTGAGATAAT
CATCACAGAGGGGAAAGTTA

Downstream 100 bases:

>100_bases
TCTACCTGGGGCTGGGGTCAAACACGGGTGAGCGTGAACAGAACCTGAAAGATGCCCAGAGCCGCCTTTCAGAGAAAATC
AGTATTAGCGGCCTTTCTAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MDLPAKKPVESLFGSKQFGWGERTYIMGIVNVTADSFSGDGLGANPEAALEQARRFALEGADILDIGGESTRPGSQPVNT
REELDRVIPAVRLISRNLDIPVSVDTYRREVAEEALKAGACIINDVWGLKKDPSLFELAAKRPAGWVITSNQRENPAEDI
MAAVTSELRETALRLLGLGVPARNIIIDPGVGFGKTLEQNLEIVRRLSELKTLNLPILLGTSRKSLIGQVLDTPPGERLE
GTAATVALGIGGGADIVRVHDVAYMKRVCRMSDAVVRGKIWK

Sequences:

>Translated_282_residues
MDLPAKKPVESLFGSKQFGWGERTYIMGIVNVTADSFSGDGLGANPEAALEQARRFALEGADILDIGGESTRPGSQPVNT
REELDRVIPAVRLISRNLDIPVSVDTYRREVAEEALKAGACIINDVWGLKKDPSLFELAAKRPAGWVITSNQRENPAEDI
MAAVTSELRETALRLLGLGVPARNIIIDPGVGFGKTLEQNLEIVRRLSELKTLNLPILLGTSRKSLIGQVLDTPPGERLE
GTAATVALGIGGGADIVRVHDVAYMKRVCRMSDAVVRGKIWK
>Mature_282_residues
MDLPAKKPVESLFGSKQFGWGERTYIMGIVNVTADSFSGDGLGANPEAALEQARRFALEGADILDIGGESTRPGSQPVNT
REELDRVIPAVRLISRNLDIPVSVDTYRREVAEEALKAGACIINDVWGLKKDPSLFELAAKRPAGWVITSNQRENPAEDI
MAAVTSELRETALRLLGLGVPARNIIIDPGVGFGKTLEQNLEIVRRLSELKTLNLPILLGTSRKSLIGQVLDTPPGERLE
GTAATVALGIGGGADIVRVHDVAYMKRVCRMSDAVVRGKIWK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=40.0763358778626, Blast_Score=183, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=34.4827586206897, Blast_Score=150, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30489; Mature: 30489

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLPAKKPVESLFGSKQFGWGERTYIMGIVNVTADSFSGDGLGANPEAALEQARRFALEG
CCCCCCCCHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
ADILDIGGESTRPGSQPVNTREELDRVIPAVRLISRNLDIPVSVDTYRREVAEEALKAGA
CCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
CIINDVWGLKKDPSLFELAAKRPAGWVITSNQRENPAEDIMAAVTSELRETALRLLGLGV
CEEHHHCCCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PARNIIIDPGVGFGKTLEQNLEIVRRLSELKTLNLPILLGTSRKSLIGQVLDTPPGERLE
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCC
GTAATVALGIGGGADIVRVHDVAYMKRVCRMSDAVVRGKIWK
CCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDLPAKKPVESLFGSKQFGWGERTYIMGIVNVTADSFSGDGLGANPEAALEQARRFALEG
CCCCCCCCHHHHHCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCC
ADILDIGGESTRPGSQPVNTREELDRVIPAVRLISRNLDIPVSVDTYRREVAEEALKAGA
CCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
CIINDVWGLKKDPSLFELAAKRPAGWVITSNQRENPAEDIMAAVTSELRETALRLLGLGV
CEEHHHCCCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
PARNIIIDPGVGFGKTLEQNLEIVRRLSELKTLNLPILLGTSRKSLIGQVLDTPPGERLE
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCCC
GTAATVALGIGGGADIVRVHDVAYMKRVCRMSDAVVRGKIWK
CCEEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]