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The map label for this gene is folK [H]

Identifier: 57233619

GI number: 57233619

Start: 1437870

End: 1438400

Strand: Direct

Name: folK [H]

Synonym: DET1604

Alternate gene names: 57233619

Gene position: 1437870-1438400 (Clockwise)

Preceding gene: 57233620

Following gene: 57233618

Centisome position: 97.83

GC content: 52.35

Gene sequence:

>531_bases
ATGGAAATAATCTACCTGGGGCTGGGGTCAAACACGGGTGAGCGTGAACAGAACCTGAAAGATGCCCAGAGCCGCCTTTC
AGAGAAAATCAGTATTAGCGGCCTTTCTACAATTTATGAAACCAAGCCGCTTAACTGCCCGGCTCAACCCGACTTTTTAA
ATATGGTGCTGGAAGCCCGCACCGAACTTTCACCCCAAGACCTGCTTGCGTTTACCCAAAAGGTAGAGCAGGATATGGGA
CGAAGCCCAAGCAGCCATAACCAGCCCCGCATAATAGATATTGATATCCTGCTGTACGGACAGAAGCGCTTGAATACACC
CGCCCTGACTATACCTCACCCCGGCCTGACTGAAAGGGCTTTTGTAATGCTGCCTCTTGTGGAACTGGCAGCTGATTTTA
TCTATCCGGGCAGCCGCTTAAGTTTGTCAGAGCTGCTTGAAGAACTGCCGCCCGGCCAGTCTATCCGCCCGTTTTCCCGC
CTGCCGCAAAGCGGCGAAGATACAGCGGAAGATGACGAGGAGGACGAGTAA

Upstream 100 bases:

>100_bases
CCCTGGGGATAGGGGGCGGGGCGGATATTGTAAGGGTGCATGATGTAGCCTATATGAAACGGGTCTGCCGGATGAGTGAT
GCTGTTGTAAGGGGTAAAAT

Downstream 100 bases:

>100_bases
TGTACTACCTGAGTGTAAAAAAACATTTTGAAGCCGCCCATTTCCTGCGGGGATATAAAGGCAAGTGCGAAAACCTGCAC
GGCCACCGCTATGAAGTAGC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MEIIYLGLGSNTGEREQNLKDAQSRLSEKISISGLSTIYETKPLNCPAQPDFLNMVLEARTELSPQDLLAFTQKVEQDMG
RSPSSHNQPRIIDIDILLYGQKRLNTPALTIPHPGLTERAFVMLPLVELAADFIYPGSRLSLSELLEELPPGQSIRPFSR
LPQSGEDTAEDDEEDE

Sequences:

>Translated_176_residues
MEIIYLGLGSNTGEREQNLKDAQSRLSEKISISGLSTIYETKPLNCPAQPDFLNMVLEARTELSPQDLLAFTQKVEQDMG
RSPSSHNQPRIIDIDILLYGQKRLNTPALTIPHPGLTERAFVMLPLVELAADFIYPGSRLSLSELLEELPPGQSIRPFSR
LPQSGEDTAEDDEEDE
>Mature_176_residues
MEIIYLGLGSNTGEREQNLKDAQSRLSEKISISGLSTIYETKPLNCPAQPDFLNMVLEARTELSPQDLLAFTQKVEQDMG
RSPSSHNQPRIIDIDILLYGQKRLNTPALTIPHPGLTERAFVMLPLVELAADFIYPGSRLSLSELLEELPPGQSIRPFSR
LPQSGEDTAEDDEEDE

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=139, Percent_Identity=34.5323741007194, Blast_Score=93, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324073, Length=135, Percent_Identity=34.8148148148148, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19621; Mature: 19621

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIYLGLGSNTGEREQNLKDAQSRLSEKISISGLSTIYETKPLNCPAQPDFLNMVLEAR
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
TELSPQDLLAFTQKVEQDMGRSPSSHNQPRIIDIDILLYGQKRLNTPALTIPHPGLTERA
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCHHCCCCEEECCCCCCCCHH
FVMLPLVELAADFIYPGSRLSLSELLEELPPGQSIRPFSRLPQSGEDTAEDDEEDE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEIIYLGLGSNTGEREQNLKDAQSRLSEKISISGLSTIYETKPLNCPAQPDFLNMVLEAR
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
TELSPQDLLAFTQKVEQDMGRSPSSHNQPRIIDIDILLYGQKRLNTPALTIPHPGLTERA
HCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCHHCCCCEEECCCCCCCCHH
FVMLPLVELAADFIYPGSRLSLSELLEELPPGQSIRPFSRLPQSGEDTAEDDEEDE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]