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The map label for this gene is 57233600

Identifier: 57233600

GI number: 57233600

Start: 1447241

End: 1447732

Strand: Direct

Name: 57233600

Synonym: DET1615

Alternate gene names: NA

Gene position: 1447241-1447732 (Clockwise)

Preceding gene: 57233604

Following gene: 57233591

Centisome position: 98.47

GC content: 49.8

Gene sequence:

>492_bases
ATGGATAATTTATGGGCACCCTGGCGGGCAAAATACATAGAAAAGGCAGTCAAAAACGAAGATAGCGGCTGTATATTCTG
CACTTTTCCGGCCGCAAGCGAAGACCAGAAAAACCTGATACTTTTCCGCGGCCAATACAACTTTGTTATCTTAAATGCTT
TTCCTTACAATGCCGGGCACCTTATGGTTGTACCCTTCCGCCATACTTCCGCTTTGGAGGAGCTTCCCGAAGAAGAACGC
AACGAGCATTACCGTCTGGTCTGCCGGGCGGTTGCCGTACTTAAAAATGAATACAAACCTGAAGGCTTTAATATAGGTAT
GAATCTGGGACGGGTGGGCGGTGCCGGTATAGACAAACACATCCACACCCATATTGTGCCCCGCTGGAACGGGGATACCA
ACTTCATGCCGGTTATAGGCCAGACCAAGGTTCAGAACGAAGCCCCGGCAGATACCTACCGCCGCCTTAAGCCCTGCTTC
CAGTCCGTTTAA

Upstream 100 bases:

>100_bases
CCCACAAACCCTTGCGGTTTCTTTCTCTGTTTTAACATCCAAAAACCCTTTGACTTGGGGGCTTTTTACGTTTAAAATCA
TAAACAGACAAGGAGCTGGC

Downstream 100 bases:

>100_bases
ATAAGCCCGTTTTTGTCTTTGCCAGCCTTTCAGAAACTTTATTTGCAAAACCCGCCTGCAGGGTCTTGCCTTTTAGTAAT
ACTTGTTATACTATTCATAC

Product: HIT domain-containing protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MDNLWAPWRAKYIEKAVKNEDSGCIFCTFPAASEDQKNLILFRGQYNFVILNAFPYNAGHLMVVPFRHTSALEELPEEER
NEHYRLVCRAVAVLKNEYKPEGFNIGMNLGRVGGAGIDKHIHTHIVPRWNGDTNFMPVIGQTKVQNEAPADTYRRLKPCF
QSV

Sequences:

>Translated_163_residues
MDNLWAPWRAKYIEKAVKNEDSGCIFCTFPAASEDQKNLILFRGQYNFVILNAFPYNAGHLMVVPFRHTSALEELPEEER
NEHYRLVCRAVAVLKNEYKPEGFNIGMNLGRVGGAGIDKHIHTHIVPRWNGDTNFMPVIGQTKVQNEAPADTYRRLKPCF
QSV
>Mature_163_residues
MDNLWAPWRAKYIEKAVKNEDSGCIFCTFPAASEDQKNLILFRGQYNFVILNAFPYNAGHLMVVPFRHTSALEELPEEER
NEHYRLVCRAVAVLKNEYKPEGFNIGMNLGRVGGAGIDKHIHTHIVPRWNGDTNFMPVIGQTKVQNEAPADTYRRLKPCF
QSV

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18651; Mature: 18651

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNLWAPWRAKYIEKAVKNEDSGCIFCTFPAASEDQKNLILFRGQYNFVILNAFPYNAGH
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCC
LMVVPFRHTSALEELPEEERNEHYRLVCRAVAVLKNEYKPEGFNIGMNLGRVGGAGIDKH
EEEEEECCHHHHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCC
IHTHIVPRWNGDTNFMPVIGQTKVQNEAPADTYRRLKPCFQSV
EEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDNLWAPWRAKYIEKAVKNEDSGCIFCTFPAASEDQKNLILFRGQYNFVILNAFPYNAGH
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEEEECCCCCCC
LMVVPFRHTSALEELPEEERNEHYRLVCRAVAVLKNEYKPEGFNIGMNLGRVGGAGIDKH
EEEEEECCHHHHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCC
IHTHIVPRWNGDTNFMPVIGQTKVQNEAPADTYRRLKPCFQSV
EEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]