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The map label for this gene is clpC [H]

Identifier: 57233578

GI number: 57233578

Start: 51068

End: 53542

Strand: Direct

Name: clpC [H]

Synonym: DET0057

Alternate gene names: 57233578

Gene position: 51068-53542 (Clockwise)

Preceding gene: 57233579

Following gene: 57233577

Centisome position: 3.47

GC content: 52.16

Gene sequence:

>2475_bases
ATGTCTAGCAGATTTGATAAATTTTCTGAAAGAGCGCGCCGGGTTCTTACCTATGCACAGGAGGAAGCCCAAAGCCTTAA
CCATAACTATATCGGCACTGAGCATATTCTGCTGGGGCTGGTTAGGGAAGAAGAAGGCGTGGCCGCCCGCGTACTGGTGA
ATATGGACGTAAACCTGGCCAAGGTACGTTCGGCTGTTGAGTTTATACTGGGGCGGGGCGAACACCCGGCCACCTCTGAA
ACTGGTCTTACCTCCAGAGCCAAAAAGGTAATAGAACTGGGCATTGATGAGGCCCGGAATCTGGGTCACAACTATATCGG
CACTGAACACCTGCTTTTAGGTTTACTGCGTGAAGGCGAAGGGGCGGCTGCCGGTGTCCTTGAGAGTTTCGGGGTTACTG
TTGAAAAGGTACGCACCGAAGTAGGGCGTATTTTGAATCAGGGCTTAAATAAACCTAAAGCCGGCCGGGCAACTCCCAGC
CGCACTCCCCAGCTTGACCAGCTGGGCTTTGACCTGACGGCCGCTGCCAGAACCGGCAAACTTGACCCGGTTATCGGGCG
TGCCAAAGAAATAGAGCGGGTTGTCCAGATTCTTTCCCGCCGTACCAAAAATAACCCTGCCCTTATCGGCGAACCCGGTG
TCGGCAAAACCTCCATTGTGGAGGGGCTGGCCCAGCGGATTGTTTCGGGTGACGTGCCGGAAACTCTGGAACAGAAACAT
ATAATTTCGCTGGACGTGGCCTCACTGGTAGCCGGTACTAAATACCGGGGTGAATTTGAAGAACGGCTCAAGAAAGTTAT
TGAAGAGATTAAAACCGCAGGTAATATAATCCTGTTTATAGACGAATTCCATACCATGGTGGGTGCCGGTGCCGCCGAGG
GTGCGGTAGATGCCGCCAATATCCTCAAGCCTTCGCTGGCCAGAGGTGAGGTACAGGTAATAGGGGCAACCACCCTGGAT
GACTTCCGCAAATATGTTGAGCGGGATGCCGCATTTGAGCGGCGTTTCCAGCCGGTGCTGGTGGAAGAACCGGCCATAGA
AGATACCCTGAGTATACTTCGGGGCATAAAAGAGCGCTACGAAGAGCATCATAAGCTTATCATCAGCGAAGAAGCTATTG
TCGCTGCCGCCAATATGGCTGCCAGATATATACCTGACCGCTTTTTGCCGGATAAGGCTATAGATTTAGTTGATGAAGCC
GCTTCACGGGTGCGGATAAAGAAACGCACCAAGCCGGTCTCTTTGAAAGAGATGAAAGCCATAGAAGACAGCTACCGCCG
GGATAAAGAAGCCGCTTTGGCTACCCAGCAGTATGATTATGCCTCCGAATTGCGTGAGCGTGAGCTTCAGATAGCTGAAA
AGATACGCCGCATGGAAGACGAATGGCAGAACGAACAGGCCATGGATAAGCCGGTGGTGGGCGAAGAAGATATTGCCCAG
GTAGTCAGCATGTGGACGGGTGTGCCGCTGGTACAGCTTACCGGTGACGAAACCGAACGTCTTTTACATATGGAAGAAGC
CCTGCATGAGCGGATTATCGGCCAGGAAGAGGCCATTGTTACCATATCCAAGGCTGTCAGACGGGCACGGGCAGGTCTTA
AAGATCCCCGCCATCCCATCGGCAACTTTGTCTTCCTGGGGCCCACCGGCGTAGGTAAAACCGAGCTGGCACGGGCGCTT
GCCCAGTTTATGTTCGGTTCAGAAGACGCTTTAGTGCGGCTGGATATGTCCGAATTTATGGAAAAGTTTGCCGTATCCCG
TCTGGTGGGTGCGCCCCCCGGATATGTGGGCTATGACGAGGGCGGCCAGTTGACTGAAGCTGTTCGCCGCAAGTCTTATT
GCCTGATACTGCTGGACGAAATAGAAAAAGCTCATCCTGACGTTTTCAATATTCTTCTGCAGATATTTGATGACGGCCAC
CTGACAGATACCAAGGGCAGACGGGTGGACTTTCGGAATACCATTATTATTATGACCTCAAACATCGGGGCGGAGCTTAT
CCGCAAGGGCAGCGGAACTATCGGTTTTGCTACCCAGACAGATGAATCAAAGGCTCAGCAGACCAACTTTGAGCATATGA
AAGACAAGCTGCTGGGTGAGCTTAAGAAGAGCTTCCGCCCGGAGTTCCTGAACCGTATTGACAGTGTGGTGGTCTTCCAC
TCACTTAATAAAGAGCAGATTCGCAGTATTGTTGACCTGATGCTTAAGAGTGTTATCAAGCAGATGTCTGAAAAGGGTAT
CGGGCTTGAAGTGACTGACTCTGCCAAAGACTTGCTGGGCAAGAAGGGTTATGACGAGGTTTATGGTGCAAGGCCGCTGC
GCCGCACTATCCAGACCATGCTGGAGGACAGGCTGTCCGAGGACCTGCTGCGGGCTAAATTTGAAGCCGGGGATAAAGTG
ATAGTGGATACTGCCGAAGACGAAATAATTGTCCGTCTGGCAGAGCCGGCCGAACTTAGCCAGGCCACTTCATAA

Upstream 100 bases:

>100_bases
GCCTTTTTTTTATTTCAAAGCTGATACCCCCTGTTTGCTTTACACTTTCTTTTTAGCTGAGCTATAATAAGATTACTAAC
CTAGTGAAAGTAAAAAAATT

Downstream 100 bases:

>100_bases
AGGCGGGGCAGGGTATAACTGGTTGTTTTAAGGGGAGTTTTAAAAACTCCCCTTTTTATTTGGTCAGAACACGAGGTCAG
GGCGGAAACGCCTTTACGAT

Product: ATP-dependent Clp protease, ATP-binding subunit ClpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MSSRFDKFSERARRVLTYAQEEAQSLNHNYIGTEHILLGLVREEEGVAARVLVNMDVNLAKVRSAVEFILGRGEHPATSE
TGLTSRAKKVIELGIDEARNLGHNYIGTEHLLLGLLREGEGAAAGVLESFGVTVEKVRTEVGRILNQGLNKPKAGRATPS
RTPQLDQLGFDLTAAARTGKLDPVIGRAKEIERVVQILSRRTKNNPALIGEPGVGKTSIVEGLAQRIVSGDVPETLEQKH
IISLDVASLVAGTKYRGEFEERLKKVIEEIKTAGNIILFIDEFHTMVGAGAAEGAVDAANILKPSLARGEVQVIGATTLD
DFRKYVERDAAFERRFQPVLVEEPAIEDTLSILRGIKERYEEHHKLIISEEAIVAAANMAARYIPDRFLPDKAIDLVDEA
ASRVRIKKRTKPVSLKEMKAIEDSYRRDKEAALATQQYDYASELRERELQIAEKIRRMEDEWQNEQAMDKPVVGEEDIAQ
VVSMWTGVPLVQLTGDETERLLHMEEALHERIIGQEEAIVTISKAVRRARAGLKDPRHPIGNFVFLGPTGVGKTELARAL
AQFMFGSEDALVRLDMSEFMEKFAVSRLVGAPPGYVGYDEGGQLTEAVRRKSYCLILLDEIEKAHPDVFNILLQIFDDGH
LTDTKGRRVDFRNTIIIMTSNIGAELIRKGSGTIGFATQTDESKAQQTNFEHMKDKLLGELKKSFRPEFLNRIDSVVVFH
SLNKEQIRSIVDLMLKSVIKQMSEKGIGLEVTDSAKDLLGKKGYDEVYGARPLRRTIQTMLEDRLSEDLLRAKFEAGDKV
IVDTAEDEIIVRLAEPAELSQATS

Sequences:

>Translated_824_residues
MSSRFDKFSERARRVLTYAQEEAQSLNHNYIGTEHILLGLVREEEGVAARVLVNMDVNLAKVRSAVEFILGRGEHPATSE
TGLTSRAKKVIELGIDEARNLGHNYIGTEHLLLGLLREGEGAAAGVLESFGVTVEKVRTEVGRILNQGLNKPKAGRATPS
RTPQLDQLGFDLTAAARTGKLDPVIGRAKEIERVVQILSRRTKNNPALIGEPGVGKTSIVEGLAQRIVSGDVPETLEQKH
IISLDVASLVAGTKYRGEFEERLKKVIEEIKTAGNIILFIDEFHTMVGAGAAEGAVDAANILKPSLARGEVQVIGATTLD
DFRKYVERDAAFERRFQPVLVEEPAIEDTLSILRGIKERYEEHHKLIISEEAIVAAANMAARYIPDRFLPDKAIDLVDEA
ASRVRIKKRTKPVSLKEMKAIEDSYRRDKEAALATQQYDYASELRERELQIAEKIRRMEDEWQNEQAMDKPVVGEEDIAQ
VVSMWTGVPLVQLTGDETERLLHMEEALHERIIGQEEAIVTISKAVRRARAGLKDPRHPIGNFVFLGPTGVGKTELARAL
AQFMFGSEDALVRLDMSEFMEKFAVSRLVGAPPGYVGYDEGGQLTEAVRRKSYCLILLDEIEKAHPDVFNILLQIFDDGH
LTDTKGRRVDFRNTIIIMTSNIGAELIRKGSGTIGFATQTDESKAQQTNFEHMKDKLLGELKKSFRPEFLNRIDSVVVFH
SLNKEQIRSIVDLMLKSVIKQMSEKGIGLEVTDSAKDLLGKKGYDEVYGARPLRRTIQTMLEDRLSEDLLRAKFEAGDKV
IVDTAEDEIIVRLAEPAELSQATS
>Mature_823_residues
SSRFDKFSERARRVLTYAQEEAQSLNHNYIGTEHILLGLVREEEGVAARVLVNMDVNLAKVRSAVEFILGRGEHPATSET
GLTSRAKKVIELGIDEARNLGHNYIGTEHLLLGLLREGEGAAAGVLESFGVTVEKVRTEVGRILNQGLNKPKAGRATPSR
TPQLDQLGFDLTAAARTGKLDPVIGRAKEIERVVQILSRRTKNNPALIGEPGVGKTSIVEGLAQRIVSGDVPETLEQKHI
ISLDVASLVAGTKYRGEFEERLKKVIEEIKTAGNIILFIDEFHTMVGAGAAEGAVDAANILKPSLARGEVQVIGATTLDD
FRKYVERDAAFERRFQPVLVEEPAIEDTLSILRGIKERYEEHHKLIISEEAIVAAANMAARYIPDRFLPDKAIDLVDEAA
SRVRIKKRTKPVSLKEMKAIEDSYRRDKEAALATQQYDYASELRERELQIAEKIRRMEDEWQNEQAMDKPVVGEEDIAQV
VSMWTGVPLVQLTGDETERLLHMEEALHERIIGQEEAIVTISKAVRRARAGLKDPRHPIGNFVFLGPTGVGKTELARALA
QFMFGSEDALVRLDMSEFMEKFAVSRLVGAPPGYVGYDEGGQLTEAVRRKSYCLILLDEIEKAHPDVFNILLQIFDDGHL
TDTKGRRVDFRNTIIIMTSNIGAELIRKGSGTIGFATQTDESKAQQTNFEHMKDKLLGELKKSFRPEFLNRIDSVVVFHS
LNKEQIRSIVDLMLKSVIKQMSEKGIGLEVTDSAKDLLGKKGYDEVYGARPLRRTIQTMLEDRLSEDLLRAKFEAGDKVI
VDTAEDEIIVRLAEPAELSQATS

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=335, Percent_Identity=35.5223880597015, Blast_Score=191, Evalue=3e-48,
Organism=Escherichia coli, GI1788943, Length=879, Percent_Identity=44.9374288964733, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=804, Percent_Identity=37.1890547263682, Blast_Score=495, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6320464, Length=727, Percent_Identity=46.6299862448418, Blast_Score=628, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6323002, Length=876, Percent_Identity=37.8995433789954, Blast_Score=563, Evalue=1e-161,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 91713; Mature: 91582

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRFDKFSERARRVLTYAQEEAQSLNHNYIGTEHILLGLVREEEGVAARVLVNMDVNLA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHH
KVRSAVEFILGRGEHPATSETGLTSRAKKVIELGIDEARNLGHNYIGTEHLLLGLLREGE
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
GAAAGVLESFGVTVEKVRTEVGRILNQGLNKPKAGRATPSRTPQLDQLGFDLTAAARTGK
CHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCC
LDPVIGRAKEIERVVQILSRRTKNNPALIGEPGVGKTSIVEGLAQRIVSGDVPETLEQKH
CCHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
IISLDVASLVAGTKYRGEFEERLKKVIEEIKTAGNIILFIDEFHTMVGAGAAEGAVDAAN
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCHHHH
ILKPSLARGEVQVIGATTLDDFRKYVERDAAFERRFQPVLVEEPAIEDTLSILRGIKERY
HHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHH
EEHHKLIISEEAIVAAANMAARYIPDRFLPDKAIDLVDEAASRVRIKKRTKPVSLKEMKA
HHHHHEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IEDSYRRDKEAALATQQYDYASELRERELQIAEKIRRMEDEWQNEQAMDKPVVGEEDIAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHH
VVSMWTGVPLVQLTGDETERLLHMEEALHERIIGQEEAIVTISKAVRRARAGLKDPRHPI
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GNFVFLGPTGVGKTELARALAQFMFGSEDALVRLDMSEFMEKFAVSRLVGAPPGYVGYDE
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRKSYCLILLDEIEKAHPDVFNILLQIFDDGHLTDTKGRRVDFRNTIIIMTS
CCHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEECCCEEEEEEC
NIGAELIRKGSGTIGFATQTDESKAQQTNFEHMKDKLLGELKKSFRPEFLNRIDSVVVFH
CCCHHHHHCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SLNKEQIRSIVDLMLKSVIKQMSEKGIGLEVTDSAKDLLGKKGYDEVYGARPLRRTIQTM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCHHHHCCCHHHHHHHHH
LEDRLSEDLLRAKFEAGDKVIVDTAEDEIIVRLAEPAELSQATS
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCHHHHCCCC
>Mature Secondary Structure 
SSRFDKFSERARRVLTYAQEEAQSLNHNYIGTEHILLGLVREEEGVAARVLVNMDVNLA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHH
KVRSAVEFILGRGEHPATSETGLTSRAKKVIELGIDEARNLGHNYIGTEHLLLGLLREGE
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
GAAAGVLESFGVTVEKVRTEVGRILNQGLNKPKAGRATPSRTPQLDQLGFDLTAAARTGK
CHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHCCC
LDPVIGRAKEIERVVQILSRRTKNNPALIGEPGVGKTSIVEGLAQRIVSGDVPETLEQKH
CCHHHCCHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
IISLDVASLVAGTKYRGEFEERLKKVIEEIKTAGNIILFIDEFHTMVGAGAAEGAVDAAN
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCCCHHHH
ILKPSLARGEVQVIGATTLDDFRKYVERDAAFERRFQPVLVEEPAIEDTLSILRGIKERY
HHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHH
EEHHKLIISEEAIVAAANMAARYIPDRFLPDKAIDLVDEAASRVRIKKRTKPVSLKEMKA
HHHHHEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IEDSYRRDKEAALATQQYDYASELRERELQIAEKIRRMEDEWQNEQAMDKPVVGEEDIAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCHHHHHH
VVSMWTGVPLVQLTGDETERLLHMEEALHERIIGQEEAIVTISKAVRRARAGLKDPRHPI
HHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCC
GNFVFLGPTGVGKTELARALAQFMFGSEDALVRLDMSEFMEKFAVSRLVGAPPGYVGYDE
CCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCC
GGQLTEAVRRKSYCLILLDEIEKAHPDVFNILLQIFDDGHLTDTKGRRVDFRNTIIIMTS
CCHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHHHHHCCCCEECCCCCEEECCCEEEEEEC
NIGAELIRKGSGTIGFATQTDESKAQQTNFEHMKDKLLGELKKSFRPEFLNRIDSVVVFH
CCCHHHHHCCCCCEEEEECCCHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
SLNKEQIRSIVDLMLKSVIKQMSEKGIGLEVTDSAKDLLGKKGYDEVYGARPLRRTIQTM
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCCCHHHHCCCHHHHHHHHH
LEDRLSEDLLRAKFEAGDKVIVDTAEDEIIVRLAEPAELSQATS
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]