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The map label for this gene is liaR [H]

Identifier: 57233544

GI number: 57233544

Start: 88814

End: 89524

Strand: Direct

Name: liaR [H]

Synonym: DET0092

Alternate gene names: 57233544

Gene position: 88814-89524 (Clockwise)

Preceding gene: 57233545

Following gene: 57233542

Centisome position: 6.04

GC content: 42.33

Gene sequence:

>711_bases
ATGGAAACCCTAGATTGTCCTAATAAGATTGATACAAACCTAGACGGCTACATTATAAGCGTTGTCATAATAGATGATCA
TGAAATAGTACGGCAGGGCTTGATGGCTATGCTCAGGCGGGAAGATGGGCTTTGCCTGGTCGGTGATGCATCTGATGCTG
TTACCGGACTAAAGTTGATTGATGCTACCAATCCGGATGTAGTTTTGCTGGATATACAGCTAAATAATTCGGATATGGAC
GGATTTTCGCTGGCGAAACAGATTAAGAGTAAATCACCGGATAAAATAGTAATAATGCTGACTGGTTTTGATTCGGCGCT
TTACTTGATAGAATCACTCAGAACTAGACTGGATGGGTTCGTTCTAAAGGAGCAATCCGGCGCTATCATAGCCGGTGCAA
TTAGAATGGCATATGCGGGTGTAGGCGCTTGGGATACACGGATTTTGCACCGGGCACTTGTAAACCGGCTGAAAGCGCAT
ACCGGGGACACTATTGATAATTTAGGTATTAAGGCTGATATAGACCTTAATGATAAAGAACGGATGGTTTTCAATCTTCT
GGCGCGGGGGTATTCAAATAAAGACATTGAAAGTACGTTAAAATATACTGCCAGTACAGTCAAAAAATATGTGTACACCT
GTATGAAAAAATTCGGGGTTTCCAACCGCACGCAATTGGCTCTTATAGCTAACAGTACCGGAGTAAAATAA

Upstream 100 bases:

>100_bases
GAAATAAGGCAGGGAGCGGCTGGCCATAATTGGTTGACTTAACGTAACGTAATAATTATATTGGTCACGTTTCATAAACT
GGAAAGGTGATGACCCGTAA

Downstream 100 bases:

>100_bases
ATTTATACAATCAGTCCGGTTTGGGCTTACGGCTAAAGGCAGATGTGCCTTTGAAGCATATCATAAAGCCATAAATAAGG
TATCGGACGGGATAAATGAT

Product: LuxR family DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
METLDCPNKIDTNLDGYIISVVIIDDHEIVRQGLMAMLRREDGLCLVGDASDAVTGLKLIDATNPDVVLLDIQLNNSDMD
GFSLAKQIKSKSPDKIVIMLTGFDSALYLIESLRTRLDGFVLKEQSGAIIAGAIRMAYAGVGAWDTRILHRALVNRLKAH
TGDTIDNLGIKADIDLNDKERMVFNLLARGYSNKDIESTLKYTASTVKKYVYTCMKKFGVSNRTQLALIANSTGVK

Sequences:

>Translated_236_residues
METLDCPNKIDTNLDGYIISVVIIDDHEIVRQGLMAMLRREDGLCLVGDASDAVTGLKLIDATNPDVVLLDIQLNNSDMD
GFSLAKQIKSKSPDKIVIMLTGFDSALYLIESLRTRLDGFVLKEQSGAIIAGAIRMAYAGVGAWDTRILHRALVNRLKAH
TGDTIDNLGIKADIDLNDKERMVFNLLARGYSNKDIESTLKYTASTVKKYVYTCMKKFGVSNRTQLALIANSTGVK
>Mature_236_residues
METLDCPNKIDTNLDGYIISVVIIDDHEIVRQGLMAMLRREDGLCLVGDASDAVTGLKLIDATNPDVVLLDIQLNNSDMD
GFSLAKQIKSKSPDKIVIMLTGFDSALYLIESLRTRLDGFVLKEQSGAIIAGAIRMAYAGVGAWDTRILHRALVNRLKAH
TGDTIDNLGIKADIDLNDKERMVFNLLARGYSNKDIESTLKYTASTVKKYVYTCMKKFGVSNRTQLALIANSTGVK

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=27.1844660194175, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=22.4770642201835, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25945; Mature: 25945

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLDCPNKIDTNLDGYIISVVIIDDHEIVRQGLMAMLRREDGLCLVGDASDAVTGLKLI
CCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCHHHCEEEE
DATNPDVVLLDIQLNNSDMDGFSLAKQIKSKSPDKIVIMLTGFDSALYLIESLRTRLDGF
ECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCE
VLKEQSGAIIAGAIRMAYAGVGAWDTRILHRALVNRLKAHTGDTIDNLGIKADIDLNDKE
EEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCCCHH
RMVFNLLARGYSNKDIESTLKYTASTVKKYVYTCMKKFGVSNRTQLALIANSTGVK
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
>Mature Secondary Structure
METLDCPNKIDTNLDGYIISVVIIDDHEIVRQGLMAMLRREDGLCLVGDASDAVTGLKLI
CCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCCHHHCEEEE
DATNPDVVLLDIQLNNSDMDGFSLAKQIKSKSPDKIVIMLTGFDSALYLIESLRTRLDGF
ECCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCE
VLKEQSGAIIAGAIRMAYAGVGAWDTRILHRALVNRLKAHTGDTIDNLGIKADIDLNDKE
EEECCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCCCHH
RMVFNLLARGYSNKDIESTLKYTASTVKKYVYTCMKKFGVSNRTQLALIANSTGVK
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]