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The map label for this gene is panC

Identifier: 38234891

GI number: 38234891

Start: 2463154

End: 2464014

Strand: Direct

Name: panC

Synonym: DIP2357

Alternate gene names: 38234891

Gene position: 2463154-2464014 (Clockwise)

Preceding gene: 38234890

Following gene: 38234893

Centisome position: 98.98

GC content: 57.49

Gene sequence:

>861_bases
ATGACCTCGATCACGCACACCATCAGCGAAATCCAAAAACTTACCCGCCAAGCCATCTCCGACGCCCGCCCCGTCGTCTT
AATTCCCACCATGGGAGCCCTCCACGAAGGCCATCTTTCGCTCGTGGATACCGCCTATTCTTTAGAGCTCGACAATCCCT
TCGTGATCATGAGCATCTTTGTTAACCCCCTCCAATTTGCAGCAGGGGAGGATCTGGATTCCTACCCGCGCACTCTTGAT
GCCGATGCCGCAAAGCTTGCCACACACAACCATCAGGTTCACGCCATCTTCGCTCCCAGCCCAGCCGAGATGTACCCCCT
AGGTCCACGCACCACCATCACACCAGGTGCTGCGGCACTTCGTTTTGAGGGCGCTACTCGCCCCACGCACTTCGCGGGTG
TCCTCACCGTGGTGAACAAACTCTTCCAGATCACGCAGTGCCAGCACGCCATCTTCGGCGAAAAGGACTTCCAACAGCTC
GCCCTGATCCGTCAGATGGTGGCGGATTTCAACCTTCCTGTCCACGTACACGGCAGCCCCCTCATGCGCGACCACGATGG
GGTGGCGCTCAGTTCCCGCAACGCTTATCTCAGCGATACCGAGCGCGTTGAGGCGCGACGTATCTCAGCAGCTCTACGCC
AAGCCGCAATGTTTCACGTGAAACATGACATTATTGCAGCCGCCATCAACGCAATGGCCGGAATGGACATCGACTACATC
GATGTTGTCGCACCCGATTTCAGCGAGCCCACAGCAGGCAATGAACTCTACGGCGACGCGCGAATCATCACCGCCGTCAA
GGTAGGAAGCACCCGACTGCTAGACAACATGGCGGTGAACGTCGAAAAGCCCAACGCTTAG

Upstream 100 bases:

>100_bases
ATATCACCCTCGAGACAATCATTCCCGCCATCGTGTTGCCTCTCATGGCTTGTGTAGCAACTCTCCATATTTCGCGGATG
AATCCCGCTATGGTTGAGGA

Downstream 100 bases:

>100_bases
AACGTGTGCTCCTCAGCGGGGAAGCGACGTGCCTCCACATCCTTTCGATAGAACCGCGCCGCGCAAGTAAGCTGCGAACC
AACCTCTGCATACGTCTTAA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MTSITHTISEIQKLTRQAISDARPVVLIPTMGALHEGHLSLVDTAYSLELDNPFVIMSIFVNPLQFAAGEDLDSYPRTLD
ADAAKLATHNHQVHAIFAPSPAEMYPLGPRTTITPGAAALRFEGATRPTHFAGVLTVVNKLFQITQCQHAIFGEKDFQQL
ALIRQMVADFNLPVHVHGSPLMRDHDGVALSSRNAYLSDTERVEARRISAALRQAAMFHVKHDIIAAAINAMAGMDIDYI
DVVAPDFSEPTAGNELYGDARIITAVKVGSTRLLDNMAVNVEKPNA

Sequences:

>Translated_286_residues
MTSITHTISEIQKLTRQAISDARPVVLIPTMGALHEGHLSLVDTAYSLELDNPFVIMSIFVNPLQFAAGEDLDSYPRTLD
ADAAKLATHNHQVHAIFAPSPAEMYPLGPRTTITPGAAALRFEGATRPTHFAGVLTVVNKLFQITQCQHAIFGEKDFQQL
ALIRQMVADFNLPVHVHGSPLMRDHDGVALSSRNAYLSDTERVEARRISAALRQAAMFHVKHDIIAAAINAMAGMDIDYI
DVVAPDFSEPTAGNELYGDARIITAVKVGSTRLLDNMAVNVEKPNA
>Mature_285_residues
TSITHTISEIQKLTRQAISDARPVVLIPTMGALHEGHLSLVDTAYSLELDNPFVIMSIFVNPLQFAAGEDLDSYPRTLDA
DAAKLATHNHQVHAIFAPSPAEMYPLGPRTTITPGAAALRFEGATRPTHFAGVLTVVNKLFQITQCQHAIFGEKDFQQLA
LIRQMVADFNLPVHVHGSPLMRDHDGVALSSRNAYLSDTERVEARRISAALRQAAMFHVKHDIIAAAINAMAGMDIDYID
VVAPDFSEPTAGNELYGDARIITAVKVGSTRLLDNMAVNVEKPNA

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=291, Percent_Identity=40.2061855670103, Blast_Score=186, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322046, Length=226, Percent_Identity=38.4955752212389, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_CORDI (Q6NEB8)

Other databases:

- EMBL:   BX248361
- RefSeq:   NP_940658.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q6NEB8
- SMR:   Q6NEB8
- GeneID:   2649180
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP2357
- NMPDR:   fig|257309.1.peg.2249
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- PhylomeDB:   Q6NEB8
- BioCyc:   CDIP257309:DIP2357-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31128; Mature: 30997

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: ACT_SITE 38-38 BINDING 65-65 BINDING 65-65 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSITHTISEIQKLTRQAISDARPVVLIPTMGALHEGHLSLVDTAYSLELDNPFVIMSIF
CCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEEEEH
VNPLQFAAGEDLDSYPRTLDADAAKLATHNHQVHAIFAPSPAEMYPLGPRTTITPGAAAL
HHHHHHHCCCCCHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCEECCCCEEE
RFEGATRPTHFAGVLTVVNKLFQITQCQHAIFGEKDFQQLALIRQMVADFNLPVHVHGSP
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCC
LMRDHDGVALSSRNAYLSDTERVEARRISAALRQAAMFHVKHDIIAAAINAMAGMDIDYI
CEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
DVVAPDFSEPTAGNELYGDARIITAVKVGSTRLLDNMAVNVEKPNA
EEECCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHCEEEEEECCCC
>Mature Secondary Structure 
TSITHTISEIQKLTRQAISDARPVVLIPTMGALHEGHLSLVDTAYSLELDNPFVIMSIF
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEEEEECCCCEEEEEEH
VNPLQFAAGEDLDSYPRTLDADAAKLATHNHQVHAIFAPSPAEMYPLGPRTTITPGAAAL
HHHHHHHCCCCCHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCCEECCCCEEE
RFEGATRPTHFAGVLTVVNKLFQITQCQHAIFGEKDFQQLALIRQMVADFNLPVHVHGSP
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCC
LMRDHDGVALSSRNAYLSDTERVEARRISAALRQAAMFHVKHDIIAAAINAMAGMDIDYI
CEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
DVVAPDFSEPTAGNELYGDARIITAVKVGSTRLLDNMAVNVEKPNA
EEECCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910