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The map label for this gene is betT [H]

Identifier: 38234742

GI number: 38234742

Start: 2286982

End: 2289207

Strand: Reverse

Name: betT [H]

Synonym: DIP2201

Alternate gene names: 38234742

Gene position: 2289207-2286982 (Counterclockwise)

Preceding gene: 38234744

Following gene: 38234741

Centisome position: 91.99

GC content: 57.82

Gene sequence:

>2226_bases
GTGAAAGAAGATGCTCACACAGATGGTGACGCGTCCTCGGTGGACGCATCAACCTCACATGGGGGTAAAACGCAGGGGGT
AAAGGAAGCCGCGCCAAAAGTTTTGGTCGGTTCATATAAAGCCGGTGCGGGGGGAGTTGTCGGTGAGAGTTCCGCAGGCG
GAAATGACATCCCCGAACCCACCACCAACTGGCCCGTATTCGGTGCATCCGCAGTGGGCATTATTGCGCTGACCCTTTGG
GCATTCTTCGCGCGTGAAAAAGCAGCCACGGCACTCGGTGCTGTCACCGAGTGGATCTCTACCAACCTAGGTTGGTTCTA
TATCCTCACCGCCACCGTGGTGATCGTCTTTGTTATCGGTGTCGCCGTCACTAGAACTGGCAGCATCCGCCTAGGTCCCG
ATCACTCCCGCCCACAGTTCAAACTCTTCTCGTGGTCGGCCATGCTGTTTGCCGCCGGCATTGGCGTGGATCTTATGTTC
TTCTCCGTCGCAGAACCAGTGGCCCAGTACTATGGCCCGCCTGTTGGCCAGGGTGAAACGCGTGAGGCTGCGGAACAAGC
CGTGGTGTGGGCACTGTTCCACTACGGCATGACCGGCTGGGCGTTGTACTGCCTCATGGGCATGGCCTTCGGCTACTACG
CCTACCGCTTGAACATGCCACTGGCGATCCGCTCGGCACTATATCCGTTGATCGGCAAGCGCATTCACGGTGCGGTGGGT
AACTGCGTAGACATTGCCGCCATGCTGGGTACCGTCTTCGGTATCGCAGCCTCGCTGGGTATCGGCGTGGTGCAGTTGAA
TTACGGTATGAAAGTACTCTTCGGAGTAGAAGAAGGCCTTACTTGGCAGATCATCCTTGTGGTGGTATCGGTGGCCGTCG
CAACGCTCTCTGCGGTATCCGGCGTGGATAAGGGCATCAAAGTGCTCAGTGAAATCAACGTGTTGCTCGCCATCGCCCTC
ATGATCTACGTGGTCATCGCGGGTAAAACCGCTTTCTTGCTCGACGGTCTTGTGATGAATATCGGCGACTACGTGTCCTC
CCTACCGGGGATGACCATGGACACCTACGCGTTTTCCGACGACCCGGAGCATACCAAGGCATGGTTGGGCGCATGGACCC
TCTTCTTCTGGGCATGGTGGGTGGCTTGGGCGCCATTCGTGGGCCTGTTCCTCGCCCGTATTTCCCGCGGCCGCACGCTG
CGCCAATTCGTGTTCGGCACCTTGAGCATCCCCTTCCTGTTCATCGTGTTGTGGATGAGTTTCTTTGGTAACTCCGCACT
CGCCATCGTGCGCGGCGGCAACGATGCTTTTGGCCACGAGGCTGCCGCTAACCCCCAGCGTGGCTTCTACGATCTGCTGG
CCACCTACCCAGGTGCGATCTTCCTCGTGGGACTGGCCACCATGATCGGTCTGCTGCTGTACATCACCTCTGCTGACTCC
GGTGCGTTGGTGATGAGTAACTTCACCTCCACCACTCACCACAGCAGTCAAGACGGCCCAGTATGGTCCCGAATTTTCTG
GGCTGTGGTTGTCGGTGCGCTCACCATTGTGATGCTGCAGCTCGACGGTATTGCTACCGTCCAGTCGGCTACCGTGGTGA
TGGGACTGCCGTTTACCATCGTGATCTACTTGGTCATGGCCGGTTTGGTGCGCTGTTTCCGATTGGAGCAAACCCAAAAG
GACGCTCGCGTGGTGTCGGTCCATGCTGCTATGTCGGGGCGTAGCACCATCGGTGAGCAGCAGGGACACTCTATTTCGTG
GCGTCGTCGTCTTAGCCGTGCCAACACTTGGCCGAGCGCTGCTAAGGCGCAGGCGTACATCACCAATGTGGCAACGCCGG
CGCTCACGCAGGTGGCTGAAGAGCTGTGCCGCAAGGGAATCAACGCGCGGTTGGTTACTACAAAGACGCAGGCAGTTGAG
GGCTTGGACCTGATCGTGGAGATGGGTTCCGAACAAAACTTCCGCTACCAGCTGTTCCCTGTGTGCAATCCCGTGCCGCA
GTTCACCCGTAAGGCCAATGCCTCGGAGAAGGAAACCTACTACCGCCTTGAGGTGTGTGACCTGACCGGTTCTTTGGGGT
ACGACATCTACGGCTATACCCAGGAACAGCTCATCGACAACGTGCTGGATTTGTACGAGCGTCACCTCGAATTCCTGCAC
ATGCATAGTGATCTGCCGGGTTCCTCGGATCTGAGCGATGGTGCAACTCCACCGTTGTTCTCCTAA

Upstream 100 bases:

>100_bases
CTAAAAAACCAGTGAGCCAAAACTGCTGTCTCACATGGCGAAACGCCGACTCCAGTAACAGCAATGATGATGAGTAGACG
ATAAGAAGAGGTGACATGGC

Downstream 100 bases:

>100_bases
GATCAGGGGCCCGCTAGGGCACTTTTTAGGTAAACAATCAACACAGTATTAAAGGAGAAAATATATATGACCACATCGAA
CGTAGTATTTGATCCCCAGA

Product: high-affinity choline transport protein

Products: Proton [Cytoplasm]; choline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 741; Mature: 741

Protein sequence:

>741_residues
MKEDAHTDGDASSVDASTSHGGKTQGVKEAAPKVLVGSYKAGAGGVVGESSAGGNDIPEPTTNWPVFGASAVGIIALTLW
AFFAREKAATALGAVTEWISTNLGWFYILTATVVIVFVIGVAVTRTGSIRLGPDHSRPQFKLFSWSAMLFAAGIGVDLMF
FSVAEPVAQYYGPPVGQGETREAAEQAVVWALFHYGMTGWALYCLMGMAFGYYAYRLNMPLAIRSALYPLIGKRIHGAVG
NCVDIAAMLGTVFGIAASLGIGVVQLNYGMKVLFGVEEGLTWQIILVVVSVAVATLSAVSGVDKGIKVLSEINVLLAIAL
MIYVVIAGKTAFLLDGLVMNIGDYVSSLPGMTMDTYAFSDDPEHTKAWLGAWTLFFWAWWVAWAPFVGLFLARISRGRTL
RQFVFGTLSIPFLFIVLWMSFFGNSALAIVRGGNDAFGHEAAANPQRGFYDLLATYPGAIFLVGLATMIGLLLYITSADS
GALVMSNFTSTTHHSSQDGPVWSRIFWAVVVGALTIVMLQLDGIATVQSATVVMGLPFTIVIYLVMAGLVRCFRLEQTQK
DARVVSVHAAMSGRSTIGEQQGHSISWRRRLSRANTWPSAAKAQAYITNVATPALTQVAEELCRKGINARLVTTKTQAVE
GLDLIVEMGSEQNFRYQLFPVCNPVPQFTRKANASEKETYYRLEVCDLTGSLGYDIYGYTQEQLIDNVLDLYERHLEFLH
MHSDLPGSSDLSDGATPPLFS

Sequences:

>Translated_741_residues
MKEDAHTDGDASSVDASTSHGGKTQGVKEAAPKVLVGSYKAGAGGVVGESSAGGNDIPEPTTNWPVFGASAVGIIALTLW
AFFAREKAATALGAVTEWISTNLGWFYILTATVVIVFVIGVAVTRTGSIRLGPDHSRPQFKLFSWSAMLFAAGIGVDLMF
FSVAEPVAQYYGPPVGQGETREAAEQAVVWALFHYGMTGWALYCLMGMAFGYYAYRLNMPLAIRSALYPLIGKRIHGAVG
NCVDIAAMLGTVFGIAASLGIGVVQLNYGMKVLFGVEEGLTWQIILVVVSVAVATLSAVSGVDKGIKVLSEINVLLAIAL
MIYVVIAGKTAFLLDGLVMNIGDYVSSLPGMTMDTYAFSDDPEHTKAWLGAWTLFFWAWWVAWAPFVGLFLARISRGRTL
RQFVFGTLSIPFLFIVLWMSFFGNSALAIVRGGNDAFGHEAAANPQRGFYDLLATYPGAIFLVGLATMIGLLLYITSADS
GALVMSNFTSTTHHSSQDGPVWSRIFWAVVVGALTIVMLQLDGIATVQSATVVMGLPFTIVIYLVMAGLVRCFRLEQTQK
DARVVSVHAAMSGRSTIGEQQGHSISWRRRLSRANTWPSAAKAQAYITNVATPALTQVAEELCRKGINARLVTTKTQAVE
GLDLIVEMGSEQNFRYQLFPVCNPVPQFTRKANASEKETYYRLEVCDLTGSLGYDIYGYTQEQLIDNVLDLYERHLEFLH
MHSDLPGSSDLSDGATPPLFS
>Mature_741_residues
MKEDAHTDGDASSVDASTSHGGKTQGVKEAAPKVLVGSYKAGAGGVVGESSAGGNDIPEPTTNWPVFGASAVGIIALTLW
AFFAREKAATALGAVTEWISTNLGWFYILTATVVIVFVIGVAVTRTGSIRLGPDHSRPQFKLFSWSAMLFAAGIGVDLMF
FSVAEPVAQYYGPPVGQGETREAAEQAVVWALFHYGMTGWALYCLMGMAFGYYAYRLNMPLAIRSALYPLIGKRIHGAVG
NCVDIAAMLGTVFGIAASLGIGVVQLNYGMKVLFGVEEGLTWQIILVVVSVAVATLSAVSGVDKGIKVLSEINVLLAIAL
MIYVVIAGKTAFLLDGLVMNIGDYVSSLPGMTMDTYAFSDDPEHTKAWLGAWTLFFWAWWVAWAPFVGLFLARISRGRTL
RQFVFGTLSIPFLFIVLWMSFFGNSALAIVRGGNDAFGHEAAANPQRGFYDLLATYPGAIFLVGLATMIGLLLYITSADS
GALVMSNFTSTTHHSSQDGPVWSRIFWAVVVGALTIVMLQLDGIATVQSATVVMGLPFTIVIYLVMAGLVRCFRLEQTQK
DARVVSVHAAMSGRSTIGEQQGHSISWRRRLSRANTWPSAAKAQAYITNVATPALTQVAEELCRKGINARLVTTKTQAVE
GLDLIVEMGSEQNFRYQLFPVCNPVPQFTRKANASEKETYYRLEVCDLTGSLGYDIYGYTQEQLIDNVLDLYERHLEFLH
MHSDLPGSSDLSDGATPPLFS

Specific function: High-affinity uptake of choline driven by a proton- motive force [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family [H]

Homologues:

Organism=Escherichia coli, GI1786506, Length=669, Percent_Identity=52.1674140508221, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI1786224, Length=486, Percent_Identity=26.3374485596708, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1788102, Length=467, Percent_Identity=25.9100642398287, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 80036; Mature: 80036

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEDAHTDGDASSVDASTSHGGKTQGVKEAAPKVLVGSYKAGAGGVVGESSAGGNDIPEP
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
TTNWPVFGASAVGIIALTLWAFFAREKAATALGAVTEWISTNLGWFYILTATVVIVFVIG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VAVTRTGSIRLGPDHSRPQFKLFSWSAMLFAAGIGVDLMFFSVAEPVAQYYGPPVGQGET
HHHHCCCCEEECCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCH
REAAEQAVVWALFHYGMTGWALYCLMGMAFGYYAYRLNMPLAIRSALYPLIGKRIHGAVG
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHH
NCVDIAAMLGTVFGIAASLGIGVVQLNYGMKVLFGVEEGLTWQIILVVVSVAVATLSAVS
HHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
GVDKGIKVLSEINVLLAIALMIYVVIAGKTAFLLDGLVMNIGDYVSSLPGMTMDTYAFSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
DPEHTKAWLGAWTLFFWAWWVAWAPFVGLFLARISRGRTLRQFVFGTLSIPFLFIVLWMS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FFGNSALAIVRGGNDAFGHEAAANPQRGFYDLLATYPGAIFLVGLATMIGLLLYITSADS
HHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
GALVMSNFTSTTHHSSQDGPVWSRIFWAVVVGALTIVMLQLDGIATVQSATVVMGLPFTI
CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHH
VIYLVMAGLVRCFRLEQTQKDARVVSVHAAMSGRSTIGEQQGHSISWRRRLSRANTWPSA
HHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCHHCCCCCCCCHHHHHHHHHCCCCCCH
AKAQAYITNVATPALTQVAEELCRKGINARLVTTKTQAVEGLDLIVEMGSEQNFRYQLFP
HHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEE
VCNPVPQFTRKANASEKETYYRLEVCDLTGSLGYDIYGYTQEQLIDNVLDLYERHLEFLH
CCCCCHHHHHHCCCCCCHHEEEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
MHSDLPGSSDLSDGATPPLFS
HHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKEDAHTDGDASSVDASTSHGGKTQGVKEAAPKVLVGSYKAGAGGVVGESSAGGNDIPEP
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
TTNWPVFGASAVGIIALTLWAFFAREKAATALGAVTEWISTNLGWFYILTATVVIVFVIG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VAVTRTGSIRLGPDHSRPQFKLFSWSAMLFAAGIGVDLMFFSVAEPVAQYYGPPVGQGET
HHHHCCCCEEECCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCH
REAAEQAVVWALFHYGMTGWALYCLMGMAFGYYAYRLNMPLAIRSALYPLIGKRIHGAVG
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHH
NCVDIAAMLGTVFGIAASLGIGVVQLNYGMKVLFGVEEGLTWQIILVVVSVAVATLSAVS
HHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
GVDKGIKVLSEINVLLAIALMIYVVIAGKTAFLLDGLVMNIGDYVSSLPGMTMDTYAFSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
DPEHTKAWLGAWTLFFWAWWVAWAPFVGLFLARISRGRTLRQFVFGTLSIPFLFIVLWMS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
FFGNSALAIVRGGNDAFGHEAAANPQRGFYDLLATYPGAIFLVGLATMIGLLLYITSADS
HHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
GALVMSNFTSTTHHSSQDGPVWSRIFWAVVVGALTIVMLQLDGIATVQSATVVMGLPFTI
CCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHH
VIYLVMAGLVRCFRLEQTQKDARVVSVHAAMSGRSTIGEQQGHSISWRRRLSRANTWPSA
HHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCHHCCCCCCCCHHHHHHHHHCCCCCCH
AKAQAYITNVATPALTQVAEELCRKGINARLVTTKTQAVEGLDLIVEMGSEQNFRYQLFP
HHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCEEEEEE
VCNPVPQFTRKANASEKETYYRLEVCDLTGSLGYDIYGYTQEQLIDNVLDLYERHLEFLH
CCCCCHHHHHHCCCCCCHHEEEEEEEECCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHH
MHSDLPGSSDLSDGATPPLFS
HHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; choline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + choline [Periplasm] = Proton [Cytoplasm] + choline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]