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The map label for this gene is clpP2

Identifier: 38234362

GI number: 38234362

Start: 1839462

End: 1840091

Strand: Reverse

Name: clpP2

Synonym: DIP1791

Alternate gene names: 38234362

Gene position: 1840091-1839462 (Counterclockwise)

Preceding gene: 38234363

Following gene: 38234361

Centisome position: 73.94

GC content: 57.14

Gene sequence:

>630_bases
ATGAATAACAACGGAATGCAGATGCCACAGGCTCGCTACGTACTGCCATCGTTTATTGAGCAGTCCGCGTATGGCACTAA
AGAAACAAACCCTTATGCCAAGTTGTTCGAGGAGCGCATTATTTTCCTCGGCACCCAGGTGGATGACACCTCGGCAAACG
ACATCATGGCGCAGTTGTTGGTGCTCGAGGGCCTCGACCCTGACCGCGACATCACCATGTACATCAACTCCCCAGGTGGC
TCCTTTACCTCGTTGATGGCGATTTACGACACGATGCAGTACGTGCGTCCCGACGTTCGCACTGTCTGCCTTGGCCAAGC
AGCATCCGCAGCGGCTGTGCTGCTTGCCGCAGGAGCACCAGGCAAGCGCGCCTGCCTGCCTAACTCCCGTGTGCTGATTC
ACCAGCCAGCAACCCAAGGCACCCAAGGGCAGGTTTCGGATCTGGAGATCCAAGCAAAAGAAATCGAGCGCATGCGTACC
TTGATGGAGCAAACGCTGGCACGCCACACCGGCCGCAGCGCTGAGCAGGTGCGTATCGACACCGACCGTGACAAGATCCT
CACCGCTGAGGAAGCTGTGGAATACGGCATCGTGGACCAGGTCTTCGATTACCGCAAGCTCAACGGCTAA

Upstream 100 bases:

>100_bases
GCTGGTTTACCGCACAGCAGGCAAAGGAATACGGAATCGTAGACCACGTTATTGAGTCCGCGCAGGGCCCGCTTTCTAAC
TAGGCAGGAGTAACACCGAT

Downstream 100 bases:

>100_bases
CGGCTAAGCTCTCATCCCCGGGCCCCGCAGGAACCTCCGCACGTGTCTGGGGATTTTTGCGTCGATAGGGTGGCACAAGG
AACAATCGGTGGTTATGCAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNNNGMQMPQARYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLVLEGLDPDRDITMYINSPGG
SFTSLMAIYDTMQYVRPDVRTVCLGQAASAAAVLLAAGAPGKRACLPNSRVLIHQPATQGTQGQVSDLEIQAKEIERMRT
LMEQTLARHTGRSAEQVRIDTDRDKILTAEEAVEYGIVDQVFDYRKLNG

Sequences:

>Translated_209_residues
MNNNGMQMPQARYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLVLEGLDPDRDITMYINSPGG
SFTSLMAIYDTMQYVRPDVRTVCLGQAASAAAVLLAAGAPGKRACLPNSRVLIHQPATQGTQGQVSDLEIQAKEIERMRT
LMEQTLARHTGRSAEQVRIDTDRDKILTAEEAVEYGIVDQVFDYRKLNG
>Mature_209_residues
MNNNGMQMPQARYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLLVLEGLDPDRDITMYINSPGG
SFTSLMAIYDTMQYVRPDVRTVCLGQAASAAAVLLAAGAPGKRACLPNSRVLIHQPATQGTQGQVSDLEIQAKEIERMRT
LMEQTLARHTGRSAEQVRIDTDRDKILTAEEAVEYGIVDQVFDYRKLNG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=41.8367346938776, Blast_Score=168, Evalue=4e-42,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=54.1666666666667, Blast_Score=224, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=42.1875, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=41.3612565445026, Blast_Score=167, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_CORDI (Q6NFU5)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940129.1
- ProteinModelPortal:   Q6NFU5
- SMR:   Q6NFU5
- MEROPS:   S14.009
- GeneID:   2649416
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1791
- NMPDR:   fig|257309.1.peg.1720
- HOGENOM:   HBG558421
- OMA:   QDPYTKL
- ProtClustDB:   PRK12553
- BioCyc:   CDIP257309:DIP1791-MONOMER
- BRENDA:   3.4.21.92
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23151; Mature: 23151

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 109-109 ACT_SITE 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNGMQMPQARYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
VLEGLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRPDVRTVCLGQAASAAAVLLAAGAP
HHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHEEEEECCCC
GKRACLPNSRVLIHQPATQGTQGQVSDLEIQAKEIERMRTLMEQTLARHTGRSAEQVRID
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
TDRDKILTAEEAVEYGIVDQVFDYRKLNG
CCCCCEEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNNGMQMPQARYVLPSFIEQSAYGTKETNPYAKLFEERIIFLGTQVDDTSANDIMAQLL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEECCCCCCCHHHHHHHHH
VLEGLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRPDVRTVCLGQAASAAAVLLAAGAP
HHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHEEEEECCCC
GKRACLPNSRVLIHQPATQGTQGQVSDLEIQAKEIERMRTLMEQTLARHTGRSAEQVRID
CCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
TDRDKILTAEEAVEYGIVDQVFDYRKLNG
CCCCCEEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910