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The map label for this gene is obgE

Identifier: 38234350

GI number: 38234350

Start: 1822199

End: 1823725

Strand: Reverse

Name: obgE

Synonym: DIP1779

Alternate gene names: 38234350

Gene position: 1823725-1822199 (Counterclockwise)

Preceding gene: 38234351

Following gene: 38234349

Centisome position: 73.28

GC content: 58.61

Gene sequence:

>1527_bases
ATGGCACGTTTCGTAGACCGCGTGGTCCTACACCTTGAAGCAGGCGACGGCGGCAACGGCTGTGCTTCTGTGCACCGCGA
GAAGTTCAAGCCCCTCGGTGGCCCAGATGGTGGCAATGGCGGACACGGCGGCGATATTATCCTCACCGTCTCCCCACAAG
CACATACCCTCCTCGATCTGCATTACCGCCCACACCTGAAAGCCCAGCGTGGCGCCAACGGTGCCGGCGATCACCGCAAC
GGTGCTCGCGGCCAAGACCTCGTGCTGGAGGTCCCCGCTGGCACCGTCGTCATGAGCGAATCAGGTGAGACGCTAGCAGA
CCTCACATCCCCTGGCATGACCTTCATCGCAGCCAAGGGCGGCTTTGGTGGCTTGGGCAACGCTGCGCTGGCCTCCGCTG
CCCGTAAGGCGCCAGGCTTTGCTCTCAAAGGTGAACCCGGCGAACAACACGACGTGATCCTCGAGCTGAAGTCCATGGCA
GACATCGGTTTGGTGGGATTCCCCAGTGCGGGTAAGTCCTCGCTGATTTCTGTGATGTCTGCGGCTAAACCAAAGATCGG
CGATTACCCATTCACCACTTTGCAACCAAACCTCGGCGTGGTGGACATGGGCAATGATGCCTTTACCATCGCAGACGTGC
CAGGTCTTATCCCTGGTGCTTCTCAGGGTAAGGGCCTCGGCCTCGACTTCCTGCGTCATATCGAGCGCACCGCTGTGCTC
GCCCATGTGGTAGACGCTGCAACCCTTGAGCCTGGCCGCGACCCCATTTCCGATATTGAGGCGCTCGAGGAAGAACTCGC
AGCGTATCAGTCGGCGTTGGATGAAGACACCAGCCTTGGTGATCTGCGTGAACGCGCCCGTATCGTTATTTTGAATAAGG
CTGATATCCCCGATGCGCTCGAGCTTGCAGAGTTCCTCAAAGAAGACATTGAGGAGAAGTTCGGCTGGCCGGTGTTTATC
ATCTCTGCGGTTGCCCGCAAAGGCCTTGATCCACTGAAATACGCGATGCTGGATTTGGTGCAGCAATCTCGCAAGAAGCG
CCCGAAGCAAAAAGTGGAAGAGCGTATCGTGGTCCGCCCGCAGGCTGTGGATGCCCGCAAGAAGAACAAAGACTTTGAGA
TCCTGGCGGATCCACAGGTCGAAAACGGCTACCTCGTTGTTGGTGAGAAGCCGGAGCGCTGGATCATCCAAACCGACTTC
GAAAACGACGAAGCCGTAGGCTACCTAGCGGACCGCCTCGCACGCATGGGTGTGGAGGATGCTTTGTGGAAGAAGGGGGC
ACGCGCAGGCTGCACCGTGACCATTGGCGAGGTGTCTTTCGAATGGGAGCCAACCACCGCTGCTGGTGTAGAGGTCCAAA
TGTCTGGCCGTGGTACCGATATGCGCCTTGAACGCAATACGCGTGTCTCGGCACAAGAGCGTAAGCGAGCGTCTCAGGTT
CGCCGTGGTCTTATCGACGAATACGATTTCGGTGATGACCAGAAGGTCACCCGCGAATCCGCAAACCGCGATCGCTGGCA
AGGCTAG

Upstream 100 bases:

>100_bases
GGGTGTTTGTGTTTTTACTCAGCATTTTTTACTAAGCTATGACTCACACATGGGTGAGTAATGCTCCTCGGGGAGCAATA
AAGGAAGGCAACAAACACTA

Downstream 100 bases:

>100_bases
CAGATGATTAAAGCAGCGTGGACGTTGTACGGTGCGGCCGTAGCAGTTTTCCTCCTCGGAGCTGTCTCTGAAGGTTGGTT
ACCTACTTCTGTCCGCGCTG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MARFVDRVVLHLEAGDGGNGCASVHREKFKPLGGPDGGNGGHGGDIILTVSPQAHTLLDLHYRPHLKAQRGANGAGDHRN
GARGQDLVLEVPAGTVVMSESGETLADLTSPGMTFIAAKGGFGGLGNAALASAARKAPGFALKGEPGEQHDVILELKSMA
DIGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVDMGNDAFTIADVPGLIPGASQGKGLGLDFLRHIERTAVL
AHVVDAATLEPGRDPISDIEALEEELAAYQSALDEDTSLGDLRERARIVILNKADIPDALELAEFLKEDIEEKFGWPVFI
ISAVARKGLDPLKYAMLDLVQQSRKKRPKQKVEERIVVRPQAVDARKKNKDFEILADPQVENGYLVVGEKPERWIIQTDF
ENDEAVGYLADRLARMGVEDALWKKGARAGCTVTIGEVSFEWEPTTAAGVEVQMSGRGTDMRLERNTRVSAQERKRASQV
RRGLIDEYDFGDDQKVTRESANRDRWQG

Sequences:

>Translated_508_residues
MARFVDRVVLHLEAGDGGNGCASVHREKFKPLGGPDGGNGGHGGDIILTVSPQAHTLLDLHYRPHLKAQRGANGAGDHRN
GARGQDLVLEVPAGTVVMSESGETLADLTSPGMTFIAAKGGFGGLGNAALASAARKAPGFALKGEPGEQHDVILELKSMA
DIGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVDMGNDAFTIADVPGLIPGASQGKGLGLDFLRHIERTAVL
AHVVDAATLEPGRDPISDIEALEEELAAYQSALDEDTSLGDLRERARIVILNKADIPDALELAEFLKEDIEEKFGWPVFI
ISAVARKGLDPLKYAMLDLVQQSRKKRPKQKVEERIVVRPQAVDARKKNKDFEILADPQVENGYLVVGEKPERWIIQTDF
ENDEAVGYLADRLARMGVEDALWKKGARAGCTVTIGEVSFEWEPTTAAGVEVQMSGRGTDMRLERNTRVSAQERKRASQV
RRGLIDEYDFGDDQKVTRESANRDRWQG
>Mature_507_residues
ARFVDRVVLHLEAGDGGNGCASVHREKFKPLGGPDGGNGGHGGDIILTVSPQAHTLLDLHYRPHLKAQRGANGAGDHRNG
ARGQDLVLEVPAGTVVMSESGETLADLTSPGMTFIAAKGGFGGLGNAALASAARKAPGFALKGEPGEQHDVILELKSMAD
IGLVGFPSAGKSSLISVMSAAKPKIGDYPFTTLQPNLGVVDMGNDAFTIADVPGLIPGASQGKGLGLDFLRHIERTAVLA
HVVDAATLEPGRDPISDIEALEEELAAYQSALDEDTSLGDLRERARIVILNKADIPDALELAEFLKEDIEEKFGWPVFII
SAVARKGLDPLKYAMLDLVQQSRKKRPKQKVEERIVVRPQAVDARKKNKDFEILADPQVENGYLVVGEKPERWIIQTDFE
NDEAVGYLADRLARMGVEDALWKKGARAGCTVTIGEVSFEWEPTTAAGVEVQMSGRGTDMRLERNTRVSAQERKRASQVR
RGLIDEYDFGDDQKVTRESANRDRWQG

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=330, Percent_Identity=38.4848484848485, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI111955139, Length=252, Percent_Identity=38.4920634920635, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI111955063, Length=140, Percent_Identity=42.8571428571429, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI58761500, Length=128, Percent_Identity=32.03125, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789574, Length=361, Percent_Identity=41.8282548476454, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1787454, Length=129, Percent_Identity=34.1085271317829, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=337, Percent_Identity=39.1691394658754, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17552324, Length=318, Percent_Identity=30.188679245283, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17509631, Length=144, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=207, Percent_Identity=38.6473429951691, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321649, Length=181, Percent_Identity=30.3867403314917, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=107, Percent_Identity=38.3177570093458, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129375, Length=259, Percent_Identity=38.2239382239382, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24585318, Length=310, Percent_Identity=34.5161290322581, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24640873, Length=151, Percent_Identity=29.8013245033113, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640877, Length=151, Percent_Identity=29.8013245033113, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24640875, Length=151, Percent_Identity=29.8013245033113, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356473, Length=144, Percent_Identity=37.5, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_CORDI (Q6NFV7)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940117.1
- HSSP:   P20964
- ProteinModelPortal:   Q6NFV7
- SMR:   Q6NFV7
- GeneID:   2649404
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1779
- NMPDR:   fig|257309.1.peg.1708
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- ProtClustDB:   PRK12296
- BioCyc:   CDIP257309:DIP1779-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 54838; Mature: 54706

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFVDRVVLHLEAGDGGNGCASVHREKFKPLGGPDGGNGGHGGDIILTVSPQAHTLLDL
CCHHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEE
HYRPHLKAQRGANGAGDHRNGARGQDLVLEVPAGTVVMSESGETLADLTSPGMTFIAAKG
CCCCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHCCCCEEEEEECC
GFGGLGNAALASAARKAPGFALKGEPGEQHDVILELKSMADIGLVGFPSAGKSSLISVMS
CCCCCCHHHHHHHHHHCCCEEECCCCCCCCHHEEEEHHHCCCCEEECCCCCHHHHHHHHH
AAKPKIGDYPFTTLQPNLGVVDMGNDAFTIADVPGLIPGASQGKGLGLDFLRHIERTAVL
HCCCCCCCCCCCEECCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AHVVDAATLEPGRDPISDIEALEEELAAYQSALDEDTSLGDLRERARIVILNKADIPDAL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEECCCCCHHH
ELAEFLKEDIEEKFGWPVFIISAVARKGLDPLKYAMLDLVQQSRKKRPKQKVEERIVVRP
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEECCC
QAVDARKKNKDFEILADPQVENGYLVVGEKPERWIIQTDFENDEAVGYLADRLARMGVED
CHHHHHHCCCCCEEEECCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHH
ALWKKGARAGCTVTIGEVSFEWEPTTAAGVEVQMSGRGTDMRLERNTRVSAQERKRASQV
HHHHCCCCCCCEEEEECEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHH
RRGLIDEYDFGDDQKVTRESANRDRWQG
HHCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ARFVDRVVLHLEAGDGGNGCASVHREKFKPLGGPDGGNGGHGGDIILTVSPQAHTLLDL
CHHHEEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEE
HYRPHLKAQRGANGAGDHRNGARGQDLVLEVPAGTVVMSESGETLADLTSPGMTFIAAKG
CCCCCCCHHCCCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCHHHHHCCCCEEEEEECC
GFGGLGNAALASAARKAPGFALKGEPGEQHDVILELKSMADIGLVGFPSAGKSSLISVMS
CCCCCCHHHHHHHHHHCCCEEECCCCCCCCHHEEEEHHHCCCCEEECCCCCHHHHHHHHH
AAKPKIGDYPFTTLQPNLGVVDMGNDAFTIADVPGLIPGASQGKGLGLDFLRHIERTAVL
HCCCCCCCCCCCEECCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AHVVDAATLEPGRDPISDIEALEEELAAYQSALDEDTSLGDLRERARIVILNKADIPDAL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCEEEEEECCCCCHHH
ELAEFLKEDIEEKFGWPVFIISAVARKGLDPLKYAMLDLVQQSRKKRPKQKVEERIVVRP
HHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEECCC
QAVDARKKNKDFEILADPQVENGYLVVGEKPERWIIQTDFENDEAVGYLADRLARMGVED
CHHHHHHCCCCCEEEECCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHH
ALWKKGARAGCTVTIGEVSFEWEPTTAAGVEVQMSGRGTDMRLERNTRVSAQERKRASQV
HHHHCCCCCCCEEEEECEEEEECCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHHHHHH
RRGLIDEYDFGDDQKVTRESANRDRWQG
HHCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910