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The map label for this gene is cdr [H]

Identifier: 38234319

GI number: 38234319

Start: 1792489

End: 1794102

Strand: Direct

Name: cdr [H]

Synonym: DIP1748

Alternate gene names: 38234319

Gene position: 1792489-1794102 (Clockwise)

Preceding gene: 38234318

Following gene: 38234320

Centisome position: 72.03

GC content: 58.36

Gene sequence:

>1614_bases
ATGACCACCACGATCATCGTCGGCGGCGTTGCCGGCGGCATGTCCACCGCAGCACGTCTACGTCGGCGCGACGAGGACAT
GACCATCCTCGTATTCGAAGCTTCAAACCACGTATCCTTTGCCAACTGTGGCCTTCCCTACCACGTCAGTGGCGTAATCC
CCGAGCGTTCCTCACTTCTGCTGCAAACGCCGGAGTCACTTGCAGCTAGGTTCAACATCGATGTGCGCGTTGACCATCTA
GTTACCGCCATTAACCGCGAAGCTGGCAGCGTCTCCGTGAAAAACCTCGCCACCGGCGAGGTGAGCGAGCATCACTACGA
TCACCTCGTGCTTTCTCCCGGCGCGCGCCCGATCTTGCCACCGCTTCCTGGCATCGAAAAAGCTCTGACGCTCCGCACCG
TCGAAGACGTAGATACCATCATCGAACGCGTTGCTGGCGCTTCTTCATCAGCCATCATCGGCGGCGGTTTTATTGGCATC
GAGCTGGCGGAAAACTTGGCACACCGGGGTATCGCCACCACGATCATCGAGCGTGGTCCACAGATCCTTGGCCCCCTCGA
CATTGAGATGGCAGCGTTTGTGGAGCAGCGCCTTCGTGACAATGGAATCAGCGTGCGTACTAACGCCAACGCTGCGGCGA
TCTCAGACACCGGCGTTGAGCTTGCCGACGGCTCCGTCACCGCCGATGTTGTCGTTGCGGCAGTTGGCGTAGCACCGGCA
AGCGACCTTGCCCGTGCGGCAGGTCTAGCTGTTGGGGAACGCGGCGGTATCGTTGTCGATGACCAGCTGCGGACTAACGA
CCCTCAGATCTTTGCGCTTGGCGATGCTGCTGAAAAACGCGATGCTATTTCCGGTGCCGACACTCTCGTGCCACTCGCAC
AAACCGCTAACCGTCATGGCCGCTTGGTAGCGGACATCATCACTGGACGCGATGTGAAGCGCACCTCTACTTTGGGCACC
GCCATCGTTGGGGTTTTCGGATTGGCAGCTGCCAGTGTTGGGTGGAGCGAAAAGCGTGCGGTAGCTGCGGGCAAGAACAT
TCGCGTTATTCACACGCACCCAGCAAGTCATGCCGGTTACTATCCTGGCGCAGCACAACTGCACCTCAAGCTGGTCGTCG
ACGCTGATACCGACGCTATTCTCGGCGCTCAGGCCGTTGGTGAAGACGGCGCGGACAAGCGTATCGACGTCATCGCCACG
GCCATGCGTGCTGGTCTCAGCGCTACCGATCTCGCAGATCTCGAGCTGGCCTACTCCCCACAGTATGGTTCGGCAAAAGA
TCCAGTGAACCTCATCGGCATGGTCAACGACAATATCCGCTCCGGTGAGCGCAGTGTGCAATGGCACGAGCTTGATGCTC
AGATTGCCGATGGCTGGACCTTGGTAGATGTTCGCACCGCCGGTGAATTCGCCGCCGGCAATATTCCAGGTGCCATCAAT
ATTCCTGTCGATGAGCTACGTGAACACCTCGACGAGCTACAGGGCAAGAATGTGCTGGTGCATTGTCAGGTTGGCCTAAG
GGGCCACGTTGCCGCTACTCTTTTGACTAATAGCGGTATCAACGCCGCCAACCTCGACGGTGGTTATCTCACATGGAAAA
CTGCCACCTCTTAA

Upstream 100 bases:

>100_bases
ACAAGTCAAAGCCCAAGTACCTAAGGGACAGTGGTGCACCTGCAAAAAGCCACAGAAACAAGGACTATTCGCTTCCCTCT
TCGGACGTTAAGGACCAACC

Downstream 100 bases:

>100_bases
GGAGCGACGCCATGAAACTCTCGCCGGAAGAGTCTAAACCAGCCATCACGCGCCTCAAAAGGGCGAAAGGCCAGCTTGAA
GCGGTGATCCGCATGCTGGA

Product: putative oxidase

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MTTTIIVGGVAGGMSTAARLRRRDEDMTILVFEASNHVSFANCGLPYHVSGVIPERSSLLLQTPESLAARFNIDVRVDHL
VTAINREAGSVSVKNLATGEVSEHHYDHLVLSPGARPILPPLPGIEKALTLRTVEDVDTIIERVAGASSSAIIGGGFIGI
ELAENLAHRGIATTIIERGPQILGPLDIEMAAFVEQRLRDNGISVRTNANAAAISDTGVELADGSVTADVVVAAVGVAPA
SDLARAAGLAVGERGGIVVDDQLRTNDPQIFALGDAAEKRDAISGADTLVPLAQTANRHGRLVADIITGRDVKRTSTLGT
AIVGVFGLAAASVGWSEKRAVAAGKNIRVIHTHPASHAGYYPGAAQLHLKLVVDADTDAILGAQAVGEDGADKRIDVIAT
AMRAGLSATDLADLELAYSPQYGSAKDPVNLIGMVNDNIRSGERSVQWHELDAQIADGWTLVDVRTAGEFAAGNIPGAIN
IPVDELREHLDELQGKNVLVHCQVGLRGHVAATLLTNSGINAANLDGGYLTWKTATS

Sequences:

>Translated_537_residues
MTTTIIVGGVAGGMSTAARLRRRDEDMTILVFEASNHVSFANCGLPYHVSGVIPERSSLLLQTPESLAARFNIDVRVDHL
VTAINREAGSVSVKNLATGEVSEHHYDHLVLSPGARPILPPLPGIEKALTLRTVEDVDTIIERVAGASSSAIIGGGFIGI
ELAENLAHRGIATTIIERGPQILGPLDIEMAAFVEQRLRDNGISVRTNANAAAISDTGVELADGSVTADVVVAAVGVAPA
SDLARAAGLAVGERGGIVVDDQLRTNDPQIFALGDAAEKRDAISGADTLVPLAQTANRHGRLVADIITGRDVKRTSTLGT
AIVGVFGLAAASVGWSEKRAVAAGKNIRVIHTHPASHAGYYPGAAQLHLKLVVDADTDAILGAQAVGEDGADKRIDVIAT
AMRAGLSATDLADLELAYSPQYGSAKDPVNLIGMVNDNIRSGERSVQWHELDAQIADGWTLVDVRTAGEFAAGNIPGAIN
IPVDELREHLDELQGKNVLVHCQVGLRGHVAATLLTNSGINAANLDGGYLTWKTATS
>Mature_536_residues
TTTIIVGGVAGGMSTAARLRRRDEDMTILVFEASNHVSFANCGLPYHVSGVIPERSSLLLQTPESLAARFNIDVRVDHLV
TAINREAGSVSVKNLATGEVSEHHYDHLVLSPGARPILPPLPGIEKALTLRTVEDVDTIIERVAGASSSAIIGGGFIGIE
LAENLAHRGIATTIIERGPQILGPLDIEMAAFVEQRLRDNGISVRTNANAAAISDTGVELADGSVTADVVVAAVGVAPAS
DLARAAGLAVGERGGIVVDDQLRTNDPQIFALGDAAEKRDAISGADTLVPLAQTANRHGRLVADIITGRDVKRTSTLGTA
IVGVFGLAAASVGWSEKRAVAAGKNIRVIHTHPASHAGYYPGAAQLHLKLVVDADTDAILGAQAVGEDGADKRIDVIATA
MRAGLSATDLADLELAYSPQYGSAKDPVNLIGMVNDNIRSGERSVQWHELDAQIADGWTLVDVRTAGEFAAGNIPGAINI
PVDELREHLDELQGKNVLVHCQVGLRGHVAATLLTNSGINAANLDGGYLTWKTATS

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=360, Percent_Identity=25.2777777777778, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI226437568, Length=360, Percent_Identity=25.2777777777778, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI65787454, Length=360, Percent_Identity=25.2777777777778, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1789065, Length=280, Percent_Identity=29.6428571428571, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789765, Length=395, Percent_Identity=26.5822784810127, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788892, Length=288, Percent_Identity=30.2083333333333, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1789915, Length=317, Percent_Identity=26.813880126183, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87081717, Length=342, Percent_Identity=28.9473684210526, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1786307, Length=325, Percent_Identity=25.5384615384615, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17559934, Length=260, Percent_Identity=26.9230769230769, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557007, Length=321, Percent_Identity=25.5451713395639, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 56047; Mature: 55916

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTIIVGGVAGGMSTAARLRRRDEDMTILVFEASNHVSFANCGLPYHVSGVIPERSSLL
CCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCEEEEECCCCCCCEE
LQTPESLAARFNIDVRVDHLVTAINREAGSVSVKNLATGEVSEHHYDHLVLSPGARPILP
EECCHHHHHEEEEEEEHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCCCCC
PLPGIEKALTLRTVEDVDTIIERVAGASSSAIIGGGFIGIELAENLAHRGIATTIIERGP
CCCCCCHHEEEHHHHHHHHHHHHHCCCCCCEEEECCEEHHHHHHHHHHCCHHHHHHHCCC
QILGPLDIEMAAFVEQRLRDNGISVRTNANAAAISDTGVELADGSVTADVVVAAVGVAPA
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCEEECCCCHHHHHHHHHCCCCH
SDLARAAGLAVGERGGIVVDDQLRTNDPQIFALGDAAEKRDAISGADTLVPLAQTANRHG
HHHHHHHCCEECCCCCEEEECCCCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHCCCCC
RLVADIITGRDVKRTSTLGTAIVGVFGLAAASVGWSEKRAVAAGKNIRVIHTHPASHAGY
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCEEEEEECCCCCCCC
YPGAAQLHLKLVVDADTDAILGAQAVGEDGADKRIDVIATAMRAGLSATDLADLELAYSP
CCCCEEEEEEEEEECCCCCEECHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECC
QYGSAKDPVNLIGMVNDNIRSGERSVQWHELDAQIADGWTLVDVRTAGEFAAGNIPGAIN
CCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCEECCCEEEEEEEECCCCCCCCCCCEEE
IPVDELREHLDELQGKNVLVHCQVGLRGHVAATLLTNSGINAANLDGGYLTWKTATS
CCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCEEECCCCEEEEEECCC
>Mature Secondary Structure 
TTTIIVGGVAGGMSTAARLRRRDEDMTILVFEASNHVSFANCGLPYHVSGVIPERSSLL
CEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCEEEEECCCCCCCEE
LQTPESLAARFNIDVRVDHLVTAINREAGSVSVKNLATGEVSEHHYDHLVLSPGARPILP
EECCHHHHHEEEEEEEHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEECCCCCCCCC
PLPGIEKALTLRTVEDVDTIIERVAGASSSAIIGGGFIGIELAENLAHRGIATTIIERGP
CCCCCCHHEEEHHHHHHHHHHHHHCCCCCCEEEECCEEHHHHHHHHHHCCHHHHHHHCCC
QILGPLDIEMAAFVEQRLRDNGISVRTNANAAAISDTGVELADGSVTADVVVAAVGVAPA
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCEEECCCCHHHHHHHHHCCCCH
SDLARAAGLAVGERGGIVVDDQLRTNDPQIFALGDAAEKRDAISGADTLVPLAQTANRHG
HHHHHHHCCEECCCCCEEEECCCCCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHCCCCC
RLVADIITGRDVKRTSTLGTAIVGVFGLAAASVGWSEKRAVAAGKNIRVIHTHPASHAGY
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCEEEEEECCCCCCCC
YPGAAQLHLKLVVDADTDAILGAQAVGEDGADKRIDVIATAMRAGLSATDLADLELAYSP
CCCCEEEEEEEEEECCCCCEECHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEECC
QYGSAKDPVNLIGMVNDNIRSGERSVQWHELDAQIADGWTLVDVRTAGEFAAGNIPGAIN
CCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCEECCCEEEEEEEECCCCCCCCCCCEEE
IPVDELREHLDELQGKNVLVHCQVGLRGHVAATLLTNSGINAANLDGGYLTWKTATS
CCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA