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The map label for this gene is hemN [H]

Identifier: 38234293

GI number: 38234293

Start: 1758649

End: 1759782

Strand: Reverse

Name: hemN [H]

Synonym: DIP1722

Alternate gene names: 38234293

Gene position: 1759782-1758649 (Counterclockwise)

Preceding gene: 38234294

Following gene: 38234292

Centisome position: 70.71

GC content: 56.17

Gene sequence:

>1134_bases
ATGTCGGATAGTTTTGGAGTTTATGTCCACGTCCCGTTTTGTTCCTCACGTTGCGGGTACTGCGACTTTAATACCTACAC
CCCCGGTGAACTCGGTGGAACAGCATCTCCTGAAAGCTACCTCGATGCACTTGAAAAAGAACTCGAGCTAGCCGCAGCCT
CGGGAACCACACGCCCTGCAACTACCGTGTTTATCGGCGGCGGCACGCCATCGATGCTAGGCGCCAGCGGGCTCACACGC
GTTCTCAGCGCTGTGCGTAACACCATCGGGATTGCACCCGGCGCAGAAGTCACCACTGAATCGAATCCAGAGACAACCTC
CCCAGAATTTTTCTCGGAACTGCTCGATGCCGGTTACAATCGCATTTCTTTGGGAATGCAGTCGGCGTCGTCAAGCGTGC
TGCGCGTATTGGAACGAAAACACACCCCAGGACGTGCCTTCGACGCCGCCCTCGAAGCCATGAACGCTGGGTTCCTGCAC
GTAAACCTCGACATGATCTACGGCACGCCCACCGAGACTGACGACGACGTTCGGCTTACCCTTGAGCGCGCCCTCGACAC
CGGAGTTGACCACATCAGCGCCTATTCGCTGATCGTGGAAGACGGCACCGCCATGGCCCGAAAGGTACACAAAGGCCAGC
TACCTCCTCCGAACGAGGACGTGTACGCTGATCGCTATGGGCTTATCGATACCGCGCTGCGAGCCCAAGGATTTGATTGG
TATGAAGTCTCCAATTGGGCAAAGCCAGGCGGAGAATGCCAGCACAATCTCGGCTATTGGCTCGACGGCGATTGGTGGGG
AGCAGGGCCTGGCGCGCACTCGCACATTGCGTCTCGACGCTTCTTCAACGTGAAACACCCGAGCACGTATGCTCAACACC
TTGCCGACGGGCAGCTGCCGATCAAAGAAGAAGAGCTCCTCGATAGCACTGAGCGCCATGAAGAGTCTGTCATGCTCGGG
TTACGCTTGCGTCAAGGACTTGAATTATCGCGGTTTACCGAAGCGGAGCGTGCCGTCATCGAAAAATATGTAGGCCTAAA
ACTCCTGCATATCTATGATGGTCGCGTTGCTTCCACACTGCAAGGTCGCCTGTTGATCGATGGGATCATCGCCGATATTT
TGGTCGCCTACTAA

Upstream 100 bases:

>100_bases
ACTATGCGCGGTGCGCACCCGCCGCGCTTTCTTAACGAACGCGCACGGATCGACGCCATCGTGGCAAAAGTAGCAGCTAA
ACGCCAAGATTCAGGAAAAT

Downstream 100 bases:

>100_bases
GGTAAATAGGGTAAATCGTCAGCGACCTTAGGGGAGACAATGGCTGGAGCTACCGATCAGCGTAGGCAAGAAGTGCTGCG
TGCGATCGTTGCCGACTACA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MSDSFGVYVHVPFCSSRCGYCDFNTYTPGELGGTASPESYLDALEKELELAAASGTTRPATTVFIGGGTPSMLGASGLTR
VLSAVRNTIGIAPGAEVTTESNPETTSPEFFSELLDAGYNRISLGMQSASSSVLRVLERKHTPGRAFDAALEAMNAGFLH
VNLDMIYGTPTETDDDVRLTLERALDTGVDHISAYSLIVEDGTAMARKVHKGQLPPPNEDVYADRYGLIDTALRAQGFDW
YEVSNWAKPGGECQHNLGYWLDGDWWGAGPGAHSHIASRRFFNVKHPSTYAQHLADGQLPIKEEELLDSTERHEESVMLG
LRLRQGLELSRFTEAERAVIEKYVGLKLLHIYDGRVASTLQGRLLIDGIIADILVAY

Sequences:

>Translated_377_residues
MSDSFGVYVHVPFCSSRCGYCDFNTYTPGELGGTASPESYLDALEKELELAAASGTTRPATTVFIGGGTPSMLGASGLTR
VLSAVRNTIGIAPGAEVTTESNPETTSPEFFSELLDAGYNRISLGMQSASSSVLRVLERKHTPGRAFDAALEAMNAGFLH
VNLDMIYGTPTETDDDVRLTLERALDTGVDHISAYSLIVEDGTAMARKVHKGQLPPPNEDVYADRYGLIDTALRAQGFDW
YEVSNWAKPGGECQHNLGYWLDGDWWGAGPGAHSHIASRRFFNVKHPSTYAQHLADGQLPIKEEELLDSTERHEESVMLG
LRLRQGLELSRFTEAERAVIEKYVGLKLLHIYDGRVASTLQGRLLIDGIIADILVAY
>Mature_376_residues
SDSFGVYVHVPFCSSRCGYCDFNTYTPGELGGTASPESYLDALEKELELAAASGTTRPATTVFIGGGTPSMLGASGLTRV
LSAVRNTIGIAPGAEVTTESNPETTSPEFFSELLDAGYNRISLGMQSASSSVLRVLERKHTPGRAFDAALEAMNAGFLHV
NLDMIYGTPTETDDDVRLTLERALDTGVDHISAYSLIVEDGTAMARKVHKGQLPPPNEDVYADRYGLIDTALRAQGFDWY
EVSNWAKPGGECQHNLGYWLDGDWWGAGPGAHSHIASRRFFNVKHPSTYAQHLADGQLPIKEEELLDSTERHEESVMLGL
RLRQGLELSRFTEAERAVIEKYVGLKLLHIYDGRVASTLQGRLLIDGIIADILVAY

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=267, Percent_Identity=37.0786516853933, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1789325, Length=295, Percent_Identity=35.9322033898305, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI87082341, Length=305, Percent_Identity=26.2295081967213, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41105; Mature: 40974

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSFGVYVHVPFCSSRCGYCDFNTYTPGELGGTASPESYLDALEKELELAAASGTTRPA
CCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
TTVFIGGGTPSMLGASGLTRVLSAVRNTIGIAPGAEVTTESNPETTSPEFFSELLDAGYN
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
RISLGMQSASSSVLRVLERKHTPGRAFDAALEAMNAGFLHVNLDMIYGTPTETDDDVRLT
EEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHH
LERALDTGVDHISAYSLIVEDGTAMARKVHKGQLPPPNEDVYADRYGLIDTALRAQGFDW
HHHHHHCCHHHHHHEEEEEECCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
YEVSNWAKPGGECQHNLGYWLDGDWWGAGPGAHSHIASRRFFNVKHPSTYAQHLADGQLP
EECCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHHCCCCCC
IKEEELLDSTERHEESVMLGLRLRQGLELSRFTEAERAVIEKYVGLKLLHIYDGRVASTL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHH
QGRLLIDGIIADILVAY
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDSFGVYVHVPFCSSRCGYCDFNTYTPGELGGTASPESYLDALEKELELAAASGTTRPA
CCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
TTVFIGGGTPSMLGASGLTRVLSAVRNTIGIAPGAEVTTESNPETTSPEFFSELLDAGYN
EEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCC
RISLGMQSASSSVLRVLERKHTPGRAFDAALEAMNAGFLHVNLDMIYGTPTETDDDVRLT
EEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEEEECCCCCCCCHHHHH
LERALDTGVDHISAYSLIVEDGTAMARKVHKGQLPPPNEDVYADRYGLIDTALRAQGFDW
HHHHHHCCHHHHHHEEEEEECCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
YEVSNWAKPGGECQHNLGYWLDGDWWGAGPGAHSHIASRRFFNVKHPSTYAQHLADGQLP
EECCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHEEECCCCHHHHHHHCCCCCC
IKEEELLDSTERHEESVMLGLRLRQGLELSRFTEAERAVIEKYVGLKLLHIYDGRVASTL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHH
QGRLLIDGIIADILVAY
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]