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The map label for this gene is hrcA

Identifier: 38234292

GI number: 38234292

Start: 1757572

End: 1758609

Strand: Reverse

Name: hrcA

Synonym: DIP1721

Alternate gene names: 38234292

Gene position: 1758609-1757572 (Counterclockwise)

Preceding gene: 38234293

Following gene: 38234291

Centisome position: 70.67

GC content: 53.56

Gene sequence:

>1038_bases
ATGGCTGGAGCTACCGATCAGCGTAGGCAAGAAGTGCTGCGTGCGATCGTTGCCGACTACATCGCATCCCAAGAACCTGT
GGGATCAAAAGCACTGCTGGAACGCCACAACCTTAAGGTCAGCTCGGCGACAATCCGCAACGATATGGCCGTGCTGGAAT
CAGAAGGCTACATCGTTCAGCAACATGCAAGTTCTGGGCGAATCCCCACGGAAAAGGCATATCGCACCTTTGTTGATTCC
ATCAACGACATCAAGCCGCTTTCCGTTGCGGAGCGCCGGGCTATTTTGGGGTTTCTGGAACGAGGCGTTGATCTTGAGGA
CGTACTCAAACGATCTGTGCAGTTGTTGAGTCAGCTCACCCGCCAGGCAGCGGTCATTCAGTTACCAAACCTCAACGTTT
CTCGCGTAAAACACTGCGAGGTCGTACTGCTGAGCCCAGTTCGACTTCTACTCGTGCTTATTACTGATAACGGTAGGGTA
GAGCAACGCAACGTAGAAGTAGACCAGATCTGCGAACCGGAGCATGTGGCAAAAATGCGCGATGTTCTCAACCGCGCACT
GGACAACAAAACCCTTAGCGACGCCTCAGCGTCTCTTGCCGAGCTAGCAGCAGGGGAGATTCTGGTCGATCCCGATATTC
AGCCGATGATCCTGCGCTGTGCCACAGTGTTAATTGAAACATTGGTGGAACAACCCAATGATCGCCTCATATTGGCAGGG
GCTAGCAACCTCACCCACATTGCTCGAGAAATGCCGTCTTCACTTCCGGCCATGTTGGAGGCGCTCGAAGAACAAGTCGT
GGTGCTCAAACTGCTTACTAATGTGCGCGACCTTGGGCATGTGAGCGTGCTCATTGGCGAAGAAAACGAAGACGAACAGC
TCCGTGGTACCTCGGTTGTCACCACCGGCTATGGTGCACAAGGTGCAACCCTCGGTGGACTAGGGGTAGTAGGTCCCACT
TTTATGGACTATTCGGGAACAATGTCCAAGGTCTACGCCGTTGCACACTATGTCAGTCGAGTGCTCAGCGGGGGCTAA

Upstream 100 bases:

>100_bases
CACACTGCAAGGTCGCCTGTTGATCGATGGGATCATCGCCGATATTTTGGTCGCCTACTAAGGTAAATAGGGTAAATCGT
CAGCGACCTTAGGGGAGACA

Downstream 100 bases:

>100_bases
GTTAGGTCTTTGCTCGTAATCTCGATAACATTGTTTGTTTCACTGATCAATTGAGAGGGAAGTTTTTCGCACCGTGGCAC
GTGATTATTACGCAATCTTG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MAGATDQRRQEVLRAIVADYIASQEPVGSKALLERHNLKVSSATIRNDMAVLESEGYIVQQHASSGRIPTEKAYRTFVDS
INDIKPLSVAERRAILGFLERGVDLEDVLKRSVQLLSQLTRQAAVIQLPNLNVSRVKHCEVVLLSPVRLLLVLITDNGRV
EQRNVEVDQICEPEHVAKMRDVLNRALDNKTLSDASASLAELAAGEILVDPDIQPMILRCATVLIETLVEQPNDRLILAG
ASNLTHIAREMPSSLPAMLEALEEQVVVLKLLTNVRDLGHVSVLIGEENEDEQLRGTSVVTTGYGAQGATLGGLGVVGPT
FMDYSGTMSKVYAVAHYVSRVLSGG

Sequences:

>Translated_345_residues
MAGATDQRRQEVLRAIVADYIASQEPVGSKALLERHNLKVSSATIRNDMAVLESEGYIVQQHASSGRIPTEKAYRTFVDS
INDIKPLSVAERRAILGFLERGVDLEDVLKRSVQLLSQLTRQAAVIQLPNLNVSRVKHCEVVLLSPVRLLLVLITDNGRV
EQRNVEVDQICEPEHVAKMRDVLNRALDNKTLSDASASLAELAAGEILVDPDIQPMILRCATVLIETLVEQPNDRLILAG
ASNLTHIAREMPSSLPAMLEALEEQVVVLKLLTNVRDLGHVSVLIGEENEDEQLRGTSVVTTGYGAQGATLGGLGVVGPT
FMDYSGTMSKVYAVAHYVSRVLSGG
>Mature_344_residues
AGATDQRRQEVLRAIVADYIASQEPVGSKALLERHNLKVSSATIRNDMAVLESEGYIVQQHASSGRIPTEKAYRTFVDSI
NDIKPLSVAERRAILGFLERGVDLEDVLKRSVQLLSQLTRQAAVIQLPNLNVSRVKHCEVVLLSPVRLLLVLITDNGRVE
QRNVEVDQICEPEHVAKMRDVLNRALDNKTLSDASASLAELAAGEILVDPDIQPMILRCATVLIETLVEQPNDRLILAGA
SNLTHIAREMPSSLPAMLEALEEQVVVLKLLTNVRDLGHVSVLIGEENEDEQLRGTSVVTTGYGAQGATLGGLGVVGPTF
MDYSGTMSKVYAVAHYVSRVLSGG

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_CORDI (Q6NG13)

Other databases:

- EMBL:   BX248359
- RefSeq:   NP_940059.1
- ProteinModelPortal:   Q6NG13
- SMR:   Q6NG13
- GeneID:   2650314
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1721
- NMPDR:   fig|257309.1.peg.1650
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   CDIP257309:DIP1721-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37528; Mature: 37396

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGATDQRRQEVLRAIVADYIASQEPVGSKALLERHNLKVSSATIRNDMAVLESEGYIVQ
CCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEHHHHHHHHHHHHCCCCEEEE
QHASSGRIPTEKAYRTFVDSINDIKPLSVAERRAILGFLERGVDLEDVLKRSVQLLSQLT
ECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RQAAVIQLPNLNVSRVKHCEVVLLSPVRLLLVLITDNGRVEQRNVEVDQICEPEHVAKMR
HHHHEEECCCCCHHHHHHHHHHHCCHHHHEEEEECCCCCEECCCCCHHHCCCHHHHHHHH
DVLNRALDNKTLSDASASLAELAAGEILVDPDIQPMILRCATVLIETLVEQPNDRLILAG
HHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
ASNLTHIAREMPSSLPAMLEALEEQVVVLKLLTNVRDLGHVSVLIGEENEDEQLRGTSVV
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCEEE
TTGYGAQGATLGGLGVVGPTFMDYSGTMSKVYAVAHYVSRVLSGG
EECCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGATDQRRQEVLRAIVADYIASQEPVGSKALLERHNLKVSSATIRNDMAVLESEGYIVQ
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCEEHHHHHHHHHHHHCCCCEEEE
QHASSGRIPTEKAYRTFVDSINDIKPLSVAERRAILGFLERGVDLEDVLKRSVQLLSQLT
ECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RQAAVIQLPNLNVSRVKHCEVVLLSPVRLLLVLITDNGRVEQRNVEVDQICEPEHVAKMR
HHHHEEECCCCCHHHHHHHHHHHCCHHHHEEEEECCCCCEECCCCCHHHCCCHHHHHHHH
DVLNRALDNKTLSDASASLAELAAGEILVDPDIQPMILRCATVLIETLVEQPNDRLILAG
HHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
ASNLTHIAREMPSSLPAMLEALEEQVVVLKLLTNVRDLGHVSVLIGEENEDEQLRGTSVV
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHCCCEEE
TTGYGAQGATLGGLGVVGPTFMDYSGTMSKVYAVAHYVSRVLSGG
EECCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910