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The map label for this gene is cobC [C]

Identifier: 38234249

GI number: 38234249

Start: 1715369

End: 1716502

Strand: Reverse

Name: cobC [C]

Synonym: DIP1678

Alternate gene names: 38234249

Gene position: 1716502-1715369 (Counterclockwise)

Preceding gene: 38234250

Following gene: 38234248

Centisome position: 68.97

GC content: 52.91

Gene sequence:

>1134_bases
ATGAAGGTCATCATCGAGGCAGACGGCGGTTCCCGAGGAAACCCCGGAATCGCTGGATCCGGCACACTTATCTACAACGC
CGATCGCTCCCAAGTTCTCAAGGAATACTCCTATGTGGTGGGTAAAGCCACCAATAACGTAGCGGAATACCATGGCCTGC
TCAACGGGCTACGTGGAGCAGCGGAACTCGGAGCCACCGAAGTATCGGTTCGCATGGATTCCAAGCTGGTTGTTGAGCAA
ATGTCGGGGCGGTGGAAGATCAAGCACCCAGACATGAAAGAACTGGCACTGGAGTGTAAGAAAGTTGCCTCGTCGATAGG
TTCCGTAAGCTACGAGTGGATTCCGAGAAGCGAAAACTCTCATGCGGATGCACTTGCTAACAAAGCGATGGATGCTCTAG
CTGAAGGTGCTGCAGTTGGATTTCTTGAATTAGAAGAACCTGCAGCGAAGACTGATTCTGAAGAAAAGGTAGTCGAAACT
GCAACATCTCCTGCGGTGTGGAATGGGGCGACTACCCAGGCGACGCGTTTCGTTTTACTGCGCCACGGTCAAACAGCGAT
GTCGGCGGCCCGCCAATATAGCGGTAGGAGTAACCCCGAGCTCACCAGTGTTGGCCTTGAACAGGCGCGCCGGGCTGCGG
CATTTATTGGGCGTCGTGGCGGAATCGATGCGATCGTGGCCTCGCCTTTGCAGCGTTGCCAGCAGACCGCCCATGAAGTC
TCTGAACAACTGGGTGGTATGCCAGTACGCACTATTGATGGCCTGATTGAGATGGATTTTGGGCAGTGGGATGGACTGTC
GTTTTCTCAGGCACACGAGGCTGATCCAGAACTTCATAGCGCGTGGTTAGATGACTCGCGAACCGCACCACCAGGTGGAG
AATCTTTACAGCAAGTTCACCGCAGGGTGAAGAAAGTTCGTGAAGAATTAGAACGCAAATATGCTGGTAAAACCATCGTC
GTGGTAAGTCACGTGACTCCGATTAAATCCATTTTGCGTCAAGCTTTGGATGCCTCCGCGTCGATGTTTCATCGTATGCA
TTTGGATTTGGCGTCTATTTCGGTCGCTGAGTTTTACTCCGATGGGCCAACGTGCGTGCGAAGCGTGAACGATACGCATT
ATCTCTACGGGTAG

Upstream 100 bases:

>100_bases
TCTTGCCGCCGGCAGATATTTCTATCATTCGTCGTGCGCCAATGAACGTCTTGCCACAATGCCCAGACTGCGGAAGCTAC
TTGGTACGTCAAGGAGATTA

Downstream 100 bases:

>100_bases
CCGGATTGATGTTGGGTGCCTTCTCCTCCGGCCTGTTGAGCATGTACTTCGGCGAAGAATCCAACACGGAAAAGACGGCA
TTTGTTCGTCGCAAAGCGGG

Product: bifunctional RNase H/acid phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKVIIEADGGSRGNPGIAGSGTLIYNADRSQVLKEYSYVVGKATNNVAEYHGLLNGLRGAAELGATEVSVRMDSKLVVEQ
MSGRWKIKHPDMKELALECKKVASSIGSVSYEWIPRSENSHADALANKAMDALAEGAAVGFLELEEPAAKTDSEEKVVET
ATSPAVWNGATTQATRFVLLRHGQTAMSAARQYSGRSNPELTSVGLEQARRAAAFIGRRGGIDAIVASPLQRCQQTAHEV
SEQLGGMPVRTIDGLIEMDFGQWDGLSFSQAHEADPELHSAWLDDSRTAPPGGESLQQVHRRVKKVREELERKYAGKTIV
VVSHVTPIKSILRQALDASASMFHRMHLDLASISVAEFYSDGPTCVRSVNDTHYLYG

Sequences:

>Translated_377_residues
MKVIIEADGGSRGNPGIAGSGTLIYNADRSQVLKEYSYVVGKATNNVAEYHGLLNGLRGAAELGATEVSVRMDSKLVVEQ
MSGRWKIKHPDMKELALECKKVASSIGSVSYEWIPRSENSHADALANKAMDALAEGAAVGFLELEEPAAKTDSEEKVVET
ATSPAVWNGATTQATRFVLLRHGQTAMSAARQYSGRSNPELTSVGLEQARRAAAFIGRRGGIDAIVASPLQRCQQTAHEV
SEQLGGMPVRTIDGLIEMDFGQWDGLSFSQAHEADPELHSAWLDDSRTAPPGGESLQQVHRRVKKVREELERKYAGKTIV
VVSHVTPIKSILRQALDASASMFHRMHLDLASISVAEFYSDGPTCVRSVNDTHYLYG
>Mature_377_residues
MKVIIEADGGSRGNPGIAGSGTLIYNADRSQVLKEYSYVVGKATNNVAEYHGLLNGLRGAAELGATEVSVRMDSKLVVEQ
MSGRWKIKHPDMKELALECKKVASSIGSVSYEWIPRSENSHADALANKAMDALAEGAAVGFLELEEPAAKTDSEEKVVET
ATSPAVWNGATTQATRFVLLRHGQTAMSAARQYSGRSNPELTSVGLEQARRAAAFIGRRGGIDAIVASPLQRCQQTAHEV
SEQLGGMPVRTIDGLIEMDFGQWDGLSFSQAHEADPELHSAWLDDSRTAPPGGESLQQVHRRVKKVREELERKYAGKTIV
VVSHVTPIKSILRQALDASASMFHRMHLDLASISVAEFYSDGPTCVRSVNDTHYLYG

Specific function: Converts N1-(5-Phospho-Alpha-D-Ribosyl)-5,6- Dimethylbenzimidazole Into N1-Alpha-D-Ribosyl-5,6- Dimethylbenzimidazole; Involved In The Assembly Of The Nucleotide Loop Of Cobalamin. [C]

COG id: COG0406

COG function: function code G; Fructose-2,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Escherichia coli, GI1786857, Length=150, Percent_Identity=34, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR012337
- InterPro:   IPR014636
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00300 PGAM; PF00075 RnaseH [H]

EC number: 3.1.3.73 [C]

Molecular weight: Translated: 40860; Mature: 40860

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIIEADGGSRGNPGIAGSGTLIYNADRSQVLKEYSYVVGKATNNVAEYHGLLNGLRGA
CEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AELGATEVSVRMDSKLVVEQMSGRWKIKHPDMKELALECKKVASSIGSVSYEWIPRSENS
HHCCCCEEEEECCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCC
HADALANKAMDALAEGAAVGFLELEEPAAKTDSEEKVVETATSPAVWNGATTQATRFVLL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCEECCCCHHHHHHHHE
RHGQTAMSAARQYSGRSNPELTSVGLEQARRAAAFIGRRGGIDAIVASPLQRCQQTAHEV
ECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SEQLGGMPVRTIDGLIEMDFGQWDGLSFSQAHEADPELHSAWLDDSRTAPPGGESLQQVH
HHHHCCCCHHHHHHHHEECCCCCCCCCCCHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHH
RRVKKVREELERKYAGKTIVVVSHVTPIKSILRQALDASASMFHRMHLDLASISVAEFYS
HHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGPTCVRSVNDTHYLYG
CCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKVIIEADGGSRGNPGIAGSGTLIYNADRSQVLKEYSYVVGKATNNVAEYHGLLNGLRGA
CEEEEECCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
AELGATEVSVRMDSKLVVEQMSGRWKIKHPDMKELALECKKVASSIGSVSYEWIPRSENS
HHCCCCEEEEECCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCC
HADALANKAMDALAEGAAVGFLELEEPAAKTDSEEKVVETATSPAVWNGATTQATRFVLL
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCEECCCCHHHHHHHHE
RHGQTAMSAARQYSGRSNPELTSVGLEQARRAAAFIGRRGGIDAIVASPLQRCQQTAHEV
ECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
SEQLGGMPVRTIDGLIEMDFGQWDGLSFSQAHEADPELHSAWLDDSRTAPPGGESLQQVH
HHHHCCCCHHHHHHHHEECCCCCCCCCCCHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHH
RRVKKVREELERKYAGKTIVVVSHVTPIKSILRQALDASASMFHRMHLDLASISVAEFYS
HHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DGPTCVRSVNDTHYLYG
CCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]