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The map label for this gene is thrC [H]

Identifier: 38234239

GI number: 38234239

Start: 1701262

End: 1702710

Strand: Reverse

Name: thrC [H]

Synonym: DIP1666

Alternate gene names: 38234239

Gene position: 1702710-1701262 (Counterclockwise)

Preceding gene: 38234241

Following gene: 38234238

Centisome position: 68.42

GC content: 49.21

Gene sequence:

>1449_bases
ATGAAATATATTTCAACGCGCGACGCATCATCAACACCTGCTCATTTTACCGATATCTTGCTTGGTGGACTTGCCCCCGA
TGGTGGTCTTTACCTGCCAGAACAGTATCCACAACTGACCGAAGAGCTGCTTGAGCAGTGGCGTACGTTGTTAGAAGACA
AAGGGTATGCGGCACTCGCTGCTGAAGTATTAAAGCTATTTATCGACGACATCTCCGCGGCCGATATTGAAAAAATCACC
GCCCGTGCGTACACCACGCCCAAGTTTTCTGATGAAGACATCGTTCCAGTGACAAAACTGGAGAACAACATTTATATCGG
TCATCTTTCAGAAGGCCCAACGGCGGCATTTAAAGACATGGCAATGCAGTTGCTCGGCGAACTTTTCGAATATGAGCTAG
GGCGTCGCGGCGAATCCCTGAATATCCTCGGTGCAACCTCCGGTGACACCGGATCGTCTGCGGAATACGCCATGCGTGGC
CGAAAGGGGATCCGCGTTTTTATGCTCACCCCTGCGGGACGTATGACCCCATTCCAACAGGCACAGATGTTCGGTCTTGA
TGACCCAAATATCTTTAATATCGCGCTCGATGGTGTATTCGACGATTGCCAAGATGTAGTTAAAGCAGTGTCGGGGGATT
CGGAATTTAAAAAGAACTACCGAATCGGAGCGGTGAACTCCATTAACTGGGCACGTCTTGTAGCACAAGTTGTGTATTAC
ATTTCTTCTTGGCTTCGCGTTACCGATAGCAACGATCAAAAAGTGAGCTTTTGTGTACCAACCGGCAACTTCGGTGACAT
CTGCGCAGGGCATATTGCAAAACAGATGGGTCTTCCTATCGATCGCCTTATCGTTGCAACGAATGAAAATGATGTGCTCG
ATGAGTTTTTCCGCACCGGCGATTACCGTGTACGCAGCTCTGCAGATACGTATGAAACGTCTTCTCCGTCCATGGACATT
TCGCGTGCTTCTAACTTTGAACGCTTTGTATTTGATCTTCTCGGACGAGATGCAGGCAGAGTAGCTGATCTATTTGGTGT
ACAAGTCAAGCAGGGTGGATTCAGCTTGGCTCAGGACCCAGCATTCGCCGAGGCCGCGAATCGTTACGGATTTGCCTCCG
GTAAATCTACCCATGCTGATCGCGTTGCCACGATTGCAGACTGCTACGAAAATCGTGGCATGATGATCGACCCTCATACC
GCGGACGGTGTGAAAGTAGCACGAGATTGGGCCTGCGATATTGATTCGCCAATTGTCTGCCTTGAAACTGCGCTTCCAGT
TAAGTTCGCTGACACTATCTGCGAAGCAACAGGACGCGAACCTGAGATGCCAGAGCGCTTTGCCAACATCATGGATGCTC
AACGTCGTGTAACTGATCTTCCTAATGACGTATCAGTGGTCAAAGACTTCATTGTGACTAGCATCGAGGAAACCGAAAAA
ACTCAGTAG

Upstream 100 bases:

>100_bases
CTGGGCAGATGAGATGTTCTTCGAATAAAACCTGCAGGATGGGGGTATATGTGGGCGCAATTGTCGTGGTGTGCGCGGTG
TCACCGCTAGGGTAGGAGAG

Downstream 100 bases:

>100_bases
TGCTTTTAGTGGTCATTGACTATGCATACAATCCCCACTTCATCCGGTACTGTGACACACTCACGGATGAAGTGGGGATT
TTTCATAGCTAGACTGACAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKYISTRDASSTPAHFTDILLGGLAPDGGLYLPEQYPQLTEELLEQWRTLLEDKGYAALAAEVLKLFIDDISAADIEKIT
ARAYTTPKFSDEDIVPVTKLENNIYIGHLSEGPTAAFKDMAMQLLGELFEYELGRRGESLNILGATSGDTGSSAEYAMRG
RKGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSGDSEFKKNYRIGAVNSINWARLVAQVVYY
ISSWLRVTDSNDQKVSFCVPTGNFGDICAGHIAKQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTYETSSPSMDI
SRASNFERFVFDLLGRDAGRVADLFGVQVKQGGFSLAQDPAFAEAANRYGFASGKSTHADRVATIADCYENRGMMIDPHT
ADGVKVARDWACDIDSPIVCLETALPVKFADTICEATGREPEMPERFANIMDAQRRVTDLPNDVSVVKDFIVTSIEETEK
TQ

Sequences:

>Translated_482_residues
MKYISTRDASSTPAHFTDILLGGLAPDGGLYLPEQYPQLTEELLEQWRTLLEDKGYAALAAEVLKLFIDDISAADIEKIT
ARAYTTPKFSDEDIVPVTKLENNIYIGHLSEGPTAAFKDMAMQLLGELFEYELGRRGESLNILGATSGDTGSSAEYAMRG
RKGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSGDSEFKKNYRIGAVNSINWARLVAQVVYY
ISSWLRVTDSNDQKVSFCVPTGNFGDICAGHIAKQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTYETSSPSMDI
SRASNFERFVFDLLGRDAGRVADLFGVQVKQGGFSLAQDPAFAEAANRYGFASGKSTHADRVATIADCYENRGMMIDPHT
ADGVKVARDWACDIDSPIVCLETALPVKFADTICEATGREPEMPERFANIMDAQRRVTDLPNDVSVVKDFIVTSIEETEK
TQ
>Mature_482_residues
MKYISTRDASSTPAHFTDILLGGLAPDGGLYLPEQYPQLTEELLEQWRTLLEDKGYAALAAEVLKLFIDDISAADIEKIT
ARAYTTPKFSDEDIVPVTKLENNIYIGHLSEGPTAAFKDMAMQLLGELFEYELGRRGESLNILGATSGDTGSSAEYAMRG
RKGIRVFMLTPAGRMTPFQQAQMFGLDDPNIFNIALDGVFDDCQDVVKAVSGDSEFKKNYRIGAVNSINWARLVAQVVYY
ISSWLRVTDSNDQKVSFCVPTGNFGDICAGHIAKQMGLPIDRLIVATNENDVLDEFFRTGDYRVRSSADTYETSSPSMDI
SRASNFERFVFDLLGRDAGRVADLFGVQVKQGGFSLAQDPAFAEAANRYGFASGKSTHADRVATIADCYENRGMMIDPHT
ADGVKVARDWACDIDSPIVCLETALPVKFADTICEATGREPEMPERFANIMDAQRRVTDLPNDVSVVKDFIVTSIEETEK
TQ

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=459, Percent_Identity=32.8976034858388, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI149193323, Length=471, Percent_Identity=29.723991507431, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1786185, Length=473, Percent_Identity=27.6955602536998, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6319901, Length=466, Percent_Identity=40.5579399141631, Blast_Score=324, Evalue=2e-89,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 53148; Mature: 53148

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYISTRDASSTPAHFTDILLGGLAPDGGLYLPEQYPQLTEELLEQWRTLLEDKGYAALA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHH
AEVLKLFIDDISAADIEKITARAYTTPKFSDEDIVPVTKLENNIYIGHLSEGPTAAFKDM
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHH
AMQLLGELFEYELGRRGESLNILGATSGDTGSSAEYAMRGRKGIRVFMLTPAGRMTPFQQ
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCHHH
AQMFGLDDPNIFNIALDGVFDDCQDVVKAVSGDSEFKKNYRIGAVNSINWARLVAQVVYY
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
ISSWLRVTDSNDQKVSFCVPTGNFGDICAGHIAKQMGLPIDRLIVATNENDVLDEFFRTG
HHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
DYRVRSSADTYETSSPSMDISRASNFERFVFDLLGRDAGRVADLFGVQVKQGGFSLAQDP
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHHHHCCEEECCCCCCCCCC
AFAEAANRYGFASGKSTHADRVATIADCYENRGMMIDPHTADGVKVARDWACDIDSPIVC
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEHHHHCCCCCCCEEE
LETALPVKFADTICEATGREPEMPERFANIMDAQRRVTDLPNDVSVVKDFIVTSIEETEK
EECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
TQ
CC
>Mature Secondary Structure
MKYISTRDASSTPAHFTDILLGGLAPDGGLYLPEQYPQLTEELLEQWRTLLEDKGYAALA
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHH
AEVLKLFIDDISAADIEKITARAYTTPKFSDEDIVPVTKLENNIYIGHLSEGPTAAFKDM
HHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCEEEEECCCCCHHHHHHH
AMQLLGELFEYELGRRGESLNILGATSGDTGSSAEYAMRGRKGIRVFMLTPAGRMTPFQQ
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCHHH
AQMFGLDDPNIFNIALDGVFDDCQDVVKAVSGDSEFKKNYRIGAVNSINWARLVAQVVYY
HHHCCCCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCHHHHHHHHHHHH
ISSWLRVTDSNDQKVSFCVPTGNFGDICAGHIAKQMGLPIDRLIVATNENDVLDEFFRTG
HHHHHEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
DYRVRSSADTYETSSPSMDISRASNFERFVFDLLGRDAGRVADLFGVQVKQGGFSLAQDP
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCHHHHHHCCEEECCCCCCCCCC
AFAEAANRYGFASGKSTHADRVATIADCYENRGMMIDPHTADGVKVARDWACDIDSPIVC
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCEEHHHHCCCCCCCEEE
LETALPVKFADTICEATGREPEMPERFANIMDAQRRVTDLPNDVSVVKDFIVTSIEETEK
EECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
TQ
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2127631; 12948626 [H]