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The map label for this gene is pyrD

Identifier: 38233852

GI number: 38233852

Start: 1270943

End: 1272034

Strand: Direct

Name: pyrD

Synonym: DIP1264

Alternate gene names: 38233852

Gene position: 1270943-1272034 (Clockwise)

Preceding gene: 38233851

Following gene: 38233854

Centisome position: 51.07

GC content: 50.09

Gene sequence:

>1092_bases
TTGCGAACTAAAGCATACGCACTTGCGCTAAAAGGGATGTTTACGATGTCCCCTGAGCGTATTCACCACATCATCACTCG
TGGCATGCAATTAGTTCAAGCGATTTCACCTCTACGACGCGCAGTGGGGTCAATTCTTCCCGTCAACGATCCCATTCTGA
GACAAGAGGTGTTTGGTGTAACTTTCCCGCAGCCGCTTGGGTTGGCTGCAGGATTTGATAAGAATGGTGAAGCTCCAGAT
GTGTGGGCGGCATTCGGCTTTGGCTATGCAGAATTGGGAACAGTGACGGCATCACCTCAACCTGGTAACCCCACTCCCCG
ACTATTCCGTCTACCTGCAGATAAAGCGATTTTAAATCGTATGGGATTCAATAATTTGGGAGCCGCCGAAGTAGCTAAAA
ATCTTAAACGCCGTAAGTCTGATGCGGTTATCGGCATTAATATCGGCAAGACAAAGGTAGTTGCCTCGAAAGATGCTGTG
AATGATTATCGACGATCAGCACTGCTTCTCGGTAACCTCGCAGACTATCTCGTGATTAATGTTTCTTCCCCAAATACTCC
GGGGCTTCGAGATCTTCAAGCAGTAGAATCACTGCGCCCGATAATTGCAGCAGTTCAAGAATCAACATCTGTGCCAGTGC
TAGTGAAAATAGCGCCAGATTTGTCTGATGATGACATAGACGCAGTAGCGGACCTTGCTGTCGAAATGGGAATTGCCGGC
ATCGTAGCGACTAATACGACCATTTCCCGCAATGGACTGCGCACTCCGCATCAAGATGTTGCAGACATGGGGGCTGGCGG
CATCTCGGGAGCTCCGGTAGCCCAGCGATCTCTGGAAGTTCTAGAACGCCTGTATGCGCACGTAGGGACGGAAATGGTGC
TCATTGGAGTGGGAGGCATTTCAACACCACAGCAAGCATGGGAGCGTATCGCCGCAGGAGCAACCCTTTTGCAGGGGTAC
ACAGGAATGATCTACGGTGGACCAGATTGGATCAGGGATATTCATTTAGGAATTGCAGCGCAATTGCGAGCCCACGACCT
CAGCAGCATTGATCAAGCCGTTGGCTCGAAACTTCCTTGGACACTTCAATAA

Upstream 100 bases:

>100_bases
GCAGGCCTCCAACTTGTTAAAAGCCAAACAGACTAATGCCCCACACACCTTTAAAATAGCGAAAGGCCTATCCACCATGT
CGGATTTTTCATCTCATCCT

Downstream 100 bases:

>100_bases
AGTGTTGTTTTTAATCGCGGCTGAGACTAGGTAGCGTCCTAGACTCTGCCGCTATTTCTAACTTCGAACAGTTAGCATGC
GAGCTAACAAGCTAGCTATG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MRTKAYALALKGMFTMSPERIHHIITRGMQLVQAISPLRRAVGSILPVNDPILRQEVFGVTFPQPLGLAAGFDKNGEAPD
VWAAFGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLKRRKSDAVIGINIGKTKVVASKDAV
NDYRRSALLLGNLADYLVINVSSPNTPGLRDLQAVESLRPIIAAVQESTSVPVLVKIAPDLSDDDIDAVADLAVEMGIAG
IVATNTTISRNGLRTPHQDVADMGAGGISGAPVAQRSLEVLERLYAHVGTEMVLIGVGGISTPQQAWERIAAGATLLQGY
TGMIYGGPDWIRDIHLGIAAQLRAHDLSSIDQAVGSKLPWTLQ

Sequences:

>Translated_363_residues
MRTKAYALALKGMFTMSPERIHHIITRGMQLVQAISPLRRAVGSILPVNDPILRQEVFGVTFPQPLGLAAGFDKNGEAPD
VWAAFGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLKRRKSDAVIGINIGKTKVVASKDAV
NDYRRSALLLGNLADYLVINVSSPNTPGLRDLQAVESLRPIIAAVQESTSVPVLVKIAPDLSDDDIDAVADLAVEMGIAG
IVATNTTISRNGLRTPHQDVADMGAGGISGAPVAQRSLEVLERLYAHVGTEMVLIGVGGISTPQQAWERIAAGATLLQGY
TGMIYGGPDWIRDIHLGIAAQLRAHDLSSIDQAVGSKLPWTLQ
>Mature_363_residues
MRTKAYALALKGMFTMSPERIHHIITRGMQLVQAISPLRRAVGSILPVNDPILRQEVFGVTFPQPLGLAAGFDKNGEAPD
VWAAFGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNRMGFNNLGAAEVAKNLKRRKSDAVIGINIGKTKVVASKDAV
NDYRRSALLLGNLADYLVINVSSPNTPGLRDLQAVESLRPIIAAVQESTSVPVLVKIAPDLSDDDIDAVADLAVEMGIAG
IVATNTTISRNGLRTPHQDVADMGAGGISGAPVAQRSLEVLERLYAHVGTEMVLIGVGGISTPQQAWERIAAGATLLQGY
TGMIYGGPDWIRDIHLGIAAQLRAHDLSSIDQAVGSKLPWTLQ

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=321, Percent_Identity=42.0560747663551, Blast_Score=232, Evalue=3e-61,
Organism=Escherichia coli, GI1787177, Length=348, Percent_Identity=41.3793103448276, Blast_Score=251, Evalue=5e-68,
Organism=Caenorhabditis elegans, GI17509475, Length=323, Percent_Identity=38.0804953560372, Blast_Score=207, Evalue=5e-54,
Organism=Drosophila melanogaster, GI281361352, Length=327, Percent_Identity=38.5321100917431, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI17137316, Length=327, Percent_Identity=38.5321100917431, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_CORDI (Q6NH79)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939619.1
- ProteinModelPortal:   Q6NH79
- GeneID:   2649818
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1264
- NMPDR:   fig|257309.1.peg.1210
- HOGENOM:   HBG351027
- OMA:   AALNRMG
- PhylomeDB:   Q6NH79
- ProtClustDB:   PRK05286
- BioCyc:   CDIP257309:DIP1264-MONOMER
- BRENDA:   1.3.3.1
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 38587; Mature: 38587

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 183-183

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKAYALALKGMFTMSPERIHHIITRGMQLVQAISPLRRAVGSILPVNDPILRQEVFGV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
TFPQPLGLAAGFDKNGEAPDVWAAFGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNR
CCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHCEEECCCCCCCCCCCEEECCCHHHHHHH
MGFNNLGAAEVAKNLKRRKSDAVIGINIGKTKVVASKDAVNDYRRSALLLGNLADYLVIN
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEE
VSSPNTPGLRDLQAVESLRPIIAAVQESTSVPVLVKIAPDLSDDDIDAVADLAVEMGIAG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCE
IVATNTTISRNGLRTPHQDVADMGAGGISGAPVAQRSLEVLERLYAHVGTEMVLIGVGGI
EEEECCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
STPQQAWERIAAGATLLQGYTGMIYGGPDWIRDIHLGIAAQLRAHDLSSIDQAVGSKLPW
CCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLQ
CCC
>Mature Secondary Structure
MRTKAYALALKGMFTMSPERIHHIITRGMQLVQAISPLRRAVGSILPVNDPILRQEVFGV
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCC
TFPQPLGLAAGFDKNGEAPDVWAAFGFGYAELGTVTASPQPGNPTPRLFRLPADKAILNR
CCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHCEEECCCCCCCCCCCEEECCCHHHHHHH
MGFNNLGAAEVAKNLKRRKSDAVIGINIGKTKVVASKDAVNDYRRSALLLGNLADYLVIN
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEE
VSSPNTPGLRDLQAVESLRPIIAAVQESTSVPVLVKIAPDLSDDDIDAVADLAVEMGIAG
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCE
IVATNTTISRNGLRTPHQDVADMGAGGISGAPVAQRSLEVLERLYAHVGTEMVLIGVGGI
EEEECCEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
STPQQAWERIAAGATLLQGYTGMIYGGPDWIRDIHLGIAAQLRAHDLSSIDQAVGSKLPW
CCHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14602910