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The map label for this gene is gnd [H]

Identifier: 38233803

GI number: 38233803

Start: 1214868

End: 1216322

Strand: Reverse

Name: gnd [H]

Synonym: DIP1213

Alternate gene names: 38233803

Gene position: 1216322-1214868 (Counterclockwise)

Preceding gene: 38233805

Following gene: 38233802

Centisome position: 48.88

GC content: 52.3

Gene sequence:

>1455_bases
ATGACTGATCAAACACAACTAGCGCAGATCGGCATTGTCGGTCTCGCTGTCATGGGTTCGAACCTCGCACGCAATTTTGC
TCATAAAGGCCACACGGTTGCTGTTTTTAATCGCAGCTTTGAAAAGACCCAAGCGCTCATGGATCAGCACGGAGATGAAG
GCAATTTCATCCCGTCCGCCACAATCGAAGAATTTGTTGCTTCGCTAGAAAAGCCTCGTCGCGCCATCATCATGGTTCAA
GCAGGACCTGCAACTGACGCAGTAATCAACCAACTTGCCGATGCGATGGATGAAGGCGACATCATTATCGATGGCGGCAA
CGCACTCTACACCGACACGATTCGTCGTGAAAGCGAAATTGCTCAACGAGGCCTCAACTTCGTCGGCGCCGGCATTTCCG
GAGGCGAAGAAGGAGCCCTCAACGGTCCTTCTATCATGCCTGGTGGTCCTGATAAATCTTGGGAAGCACTTGGACCGCTG
CTCGAATCCATCGCCGCACAGGTTGGCGGCACACCATGTGTTACTCACATCGGCCCTGACGGCGCAGGCCACTTTGTCAA
GATGGTTCATAATGGAATCGAATATGCCGACATGCAAGTGATCGGCGAGGCATACCAATTGCTTCGATACGCCACCGAAA
TGCAGCCATCTGAGATTGCAGATGTGTTTAAGACATGGAACCAAGGTGACTTGGACTCCTACCTCATTGAGATTACGTCT
GAGGTACTTGCTCAGGTCGATTCTGAAACTGGCACACCACTTATCGATCTCATCGTGGATGAAGCTGGTCAAAAAGGAAC
CGGTCGTTGGACGGTGAAAGCTGCTCTAGACCTTGGTATTGCAACTACTGGAATCGGCGAAGCAGTATTCGCTCGCGCAC
TTTCAGGTGCAACCACTCAGCGCAAGGCAGCCCAAGGTAACTTGCCAGCCGGCACTTTGGAATCATTGGCCTCGTTGAAC
ATCGATAAGGACCAGTTCGTAGAAGATGTCCGTCGCGCACTCTATGCTTCAAAGCTCGTCGCTTATGCGCAGGGCTTCGA
CGAAATTATCGCCGGATCAGCCGAGCACAACTGGGATGTCGATCCTCGCGACCTCGCTACCATCTGGCGCGGTGGCTGCA
TCATTCGCGCAAAGTTCCTTAACCGCATCGTTGAAGCTTACGACGCTAATCCAGAACTCCCGTCCCTCCTACTGGATCCC
TACTTTAAGACTGAGCTGGAATCGCTTATCGATTCATGGCGCCGCGTAGTCGTTGCAGCTACACAACTGGGATTGCCTGT
TCCAGTGTTCGCTTCATCGTTATCCTACTACGACTCTTTGCGAGCCGAACGCCTACCAGCTGCACTTATCCAAGGCCAGC
GTGATTTTTTCGGTGCACACACTTACCGTCGCACGGATAAAGACGGAAGCTTCCACACCTTGTGGTCCGGTGATCGTAGC
GAAGTAGAAGCTTAA

Upstream 100 bases:

>100_bases
TCTCATCGTTGTTACTCATGTTGCCCAATCTAGTCTTTCTCCATGCCCAATCCGCAAGCTGGGTGGGTAAAATTGCTGCA
GTCAGGGTATTGTCACAGTC

Downstream 100 bases:

>100_bases
CGCTTCTTCTCGACGAAACATTCACCTTTATTTTAGAAAACAGGCTGGGCATTTTCGCCCAGCCTGTCTGTTTTTCACGC
AGATTGCAGTAGAATTGTCC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTDQTQLAQIGIVGLAVMGSNLARNFAHKGHTVAVFNRSFEKTQALMDQHGDEGNFIPSATIEEFVASLEKPRRAIIMVQ
AGPATDAVINQLADAMDEGDIIIDGGNALYTDTIRRESEIAQRGLNFVGAGISGGEEGALNGPSIMPGGPDKSWEALGPL
LESIAAQVGGTPCVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYQLLRYATEMQPSEIADVFKTWNQGDLDSYLIEITS
EVLAQVDSETGTPLIDLIVDEAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATTQRKAAQGNLPAGTLESLASLN
IDKDQFVEDVRRALYASKLVAYAQGFDEIIAGSAEHNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANPELPSLLLDP
YFKTELESLIDSWRRVVVAATQLGLPVPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYRRTDKDGSFHTLWSGDRS
EVEA

Sequences:

>Translated_484_residues
MTDQTQLAQIGIVGLAVMGSNLARNFAHKGHTVAVFNRSFEKTQALMDQHGDEGNFIPSATIEEFVASLEKPRRAIIMVQ
AGPATDAVINQLADAMDEGDIIIDGGNALYTDTIRRESEIAQRGLNFVGAGISGGEEGALNGPSIMPGGPDKSWEALGPL
LESIAAQVGGTPCVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYQLLRYATEMQPSEIADVFKTWNQGDLDSYLIEITS
EVLAQVDSETGTPLIDLIVDEAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATTQRKAAQGNLPAGTLESLASLN
IDKDQFVEDVRRALYASKLVAYAQGFDEIIAGSAEHNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANPELPSLLLDP
YFKTELESLIDSWRRVVVAATQLGLPVPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYRRTDKDGSFHTLWSGDRS
EVEA
>Mature_483_residues
TDQTQLAQIGIVGLAVMGSNLARNFAHKGHTVAVFNRSFEKTQALMDQHGDEGNFIPSATIEEFVASLEKPRRAIIMVQA
GPATDAVINQLADAMDEGDIIIDGGNALYTDTIRRESEIAQRGLNFVGAGISGGEEGALNGPSIMPGGPDKSWEALGPLL
ESIAAQVGGTPCVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYQLLRYATEMQPSEIADVFKTWNQGDLDSYLIEITSE
VLAQVDSETGTPLIDLIVDEAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATTQRKAAQGNLPAGTLESLASLNI
DKDQFVEDVRRALYASKLVAYAQGFDEIIAGSAEHNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANPELPSLLLDPY
FKTELESLIDSWRRVVVAATQLGLPVPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYRRTDKDGSFHTLWSGDRSE
VEA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=48.3050847457627, Blast_Score=435, Evalue=1e-122,
Organism=Escherichia coli, GI1788341, Length=474, Percent_Identity=52.7426160337553, Blast_Score=508, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=47.3460721868365, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6321695, Length=481, Percent_Identity=45.5301455301455, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6321977, Length=487, Percent_Identity=45.3798767967146, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24639279, Length=478, Percent_Identity=45.6066945606695, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52212; Mature: 52081

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQTQLAQIGIVGLAVMGSNLARNFAHKGHTVAVFNRSFEKTQALMDQHGDEGNFIPSA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCH
TIEEFVASLEKPRRAIIMVQAGPATDAVINQLADAMDEGDIIIDGGNALYTDTIRRESEI
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHH
AQRGLNFVGAGISGGEEGALNGPSIMPGGPDKSWEALGPLLESIAAQVGGTPCVTHIGPD
HHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
GAGHFVKMVHNGIEYADMQVIGEAYQLLRYATEMQPSEIADVFKTWNQGDLDSYLIEITS
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHH
EVLAQVDSETGTPLIDLIVDEAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATTQ
HHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEHHHHCHHHCCHHHHHHHHHHHCCCHH
RKAAQGNLPAGTLESLASLNIDKDQFVEDVRRALYASKLVAYAQGFDEIIAGSAEHNWDV
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCC
DPRDLATIWRGGCIIRAKFLNRIVEAYDANPELPSLLLDPYFKTELESLIDSWRRVVVAA
CHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
TQLGLPVPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYRRTDKDGSFHTLWSGDRS
HHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHCCHHHCCCCCCCCEEEEECCCHH
EVEA
CCCC
>Mature Secondary Structure 
TDQTQLAQIGIVGLAVMGSNLARNFAHKGHTVAVFNRSFEKTQALMDQHGDEGNFIPSA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCH
TIEEFVASLEKPRRAIIMVQAGPATDAVINQLADAMDEGDIIIDGGNALYTDTIRRESEI
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCEEEHHHHHHHHHH
AQRGLNFVGAGISGGEEGALNGPSIMPGGPDKSWEALGPLLESIAAQVGGTPCVTHIGPD
HHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCC
GAGHFVKMVHNGIEYADMQVIGEAYQLLRYATEMQPSEIADVFKTWNQGDLDSYLIEITS
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHH
EVLAQVDSETGTPLIDLIVDEAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATTQ
HHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEHHHHCHHHCCHHHHHHHHHHHCCCHH
RKAAQGNLPAGTLESLASLNIDKDQFVEDVRRALYASKLVAYAQGFDEIIAGSAEHNWDV
HHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCC
DPRDLATIWRGGCIIRAKFLNRIVEAYDANPELPSLLLDPYFKTELESLIDSWRRVVVAA
CHHHHHHHHCCCCEEHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
TQLGLPVPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYRRTDKDGSFHTLWSGDRS
HHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHCCHHHCCCCCCCCEEEEECCCHH
EVEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]