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The map label for this gene is dcuB [H]

Identifier: 38233788

GI number: 38233788

Start: 1197600

End: 1198985

Strand: Direct

Name: dcuB [H]

Synonym: DIP1198

Alternate gene names: 38233788

Gene position: 1197600-1198985 (Clockwise)

Preceding gene: 38233787

Following gene: 38233790

Centisome position: 48.12

GC content: 45.82

Gene sequence:

>1386_bases
ATGCTCGCTTCAATTCTCGATCCCACGTCTGGTATCGCGCTTTTATTACAAATTGCGGTAATTCTTTCCTGCCTCGTGTT
GGGTACGCGATATGGCGGAATGGGACTAGGTCTTATTTCTGGTATTGGTTTGTTTATCCTTGCCTTTATATTTGGCCTTA
AACCGGGAGAGCCACCGGTGTCGGTGATGCTTACGATTATTGCGGTCATCGGTTGTGCAGCTACTTTGCAACAGGCGCGT
GGTCTTGATGTGATGATGCAATTTGCGGAAAAGATTTTAAGAAAGCATCCCGAGCGAATCACGATTTTGGCTCCGATTAC
TACTTGGCTATTAACCGTATTGTGTGGAACTGGACATGTTGTTTATACAATGTTTCCGATTATTGAAGACATCGCGATTA
AAACAAATATCCGCCCAGAAAGGCCTATGGCTGTCTCTTCTACAGCTGCCCAGATGGGTATCACAGCCTCGCCGGTGTCG
GTAGCTATTGTTTCATTGACTTCTATTTTGGCGGAGCATGCTGGTGTAACTCAATCTGCATACTCTATTCCGCAAATCTT
AGCGGTTGCGATGCCTGCATCGTTATGCGGTGTTTTGGTGGCTGCAGTGTGGTCCCTGCATCGAGGCAAAGACTTGGATA
AAGATGAGGCCTTCCAAGAACGTCTTAAAGATCCAGAGTTTAAAAAGAGTGTATACAGTGAGTCGCATTCTTTGATCGGA
CAACGATTTGAAAAGGGCGCGTATCGTGCCACTGGAATTTTCTTGGGTGCCATTGCGATCGTAGTGTTACTCGGCGCGAT
CGAATGGTTGCGCCCATCATTCCCTAATTCCAATGGTGATCTGAAACCATTGTCTATGAATCTCGTTATCCAGATGATTA
TGTTGGTGGCAGGTGCCCTCATGATGCTGTTGTGCAAGGTTGAACCTGGAAAGATTGCTTCTACAACCGTGTTCAAGGCG
GGAATGACCGCTGTGTTCTCTGTGTTCGGTGTTGCATGGATGGCTGACACATTTTTCCAAGCGCATTTAGATTCTCTCGT
AGATGCGCTCAGCGGTGTGGTGCAAAGTCATGCATGGGCCTATGCGTTAGTTTTACTGCTTGTTTCTAAACTTGTTAACT
CTCAAGGTGCAGCGATCGTAGCGATCGTACCGTTGGGTCTTAAGCTTGGTCTGGATCCTGCAACGGTTATCGGCTTTATC
GGTGCAGCGTATGGCTACTTTATTCTTCCAACGTATCCGTCAGATTTGGCTTGTATTGGATTTGATAAGACTGGTACTAC
CAGAATCGGTAAGTATGTCTTGAACCATTCGTTCATTATTCCTGGCTTTATATGCGTTATTGTTTCTTGCATTGTGGGAA
CTGTATTAGCCCAAGTACTTCTTTAG

Upstream 100 bases:

>100_bases
GGAGATTCGGTTATGGATTTTCAATAATGCGGGAATAGATTGAGAAATGATTGTTAAAAGATTAGGCAATCGGTGGCATT
AATTTGAAAGGCTTCTGCGT

Downstream 100 bases:

>100_bases
AGTAGAAGTGAGTAGGTGCTAGTCAAGCTCTTATTGAGTTTTGACTAGCGCTTTTTTATATAAAAATGCGTCGAAACGAT
AAGGGATTTCCACCAAAGAT

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MLASILDPTSGIALLLQIAVILSCLVLGTRYGGMGLGLISGIGLFILAFIFGLKPGEPPVSVMLTIIAVIGCAATLQQAR
GLDVMMQFAEKILRKHPERITILAPITTWLLTVLCGTGHVVYTMFPIIEDIAIKTNIRPERPMAVSSTAAQMGITASPVS
VAIVSLTSILAEHAGVTQSAYSIPQILAVAMPASLCGVLVAAVWSLHRGKDLDKDEAFQERLKDPEFKKSVYSESHSLIG
QRFEKGAYRATGIFLGAIAIVVLLGAIEWLRPSFPNSNGDLKPLSMNLVIQMIMLVAGALMMLLCKVEPGKIASTTVFKA
GMTAVFSVFGVAWMADTFFQAHLDSLVDALSGVVQSHAWAYALVLLLVSKLVNSQGAAIVAIVPLGLKLGLDPATVIGFI
GAAYGYFILPTYPSDLACIGFDKTGTTRIGKYVLNHSFIIPGFICVIVSCIVGTVLAQVLL

Sequences:

>Translated_461_residues
MLASILDPTSGIALLLQIAVILSCLVLGTRYGGMGLGLISGIGLFILAFIFGLKPGEPPVSVMLTIIAVIGCAATLQQAR
GLDVMMQFAEKILRKHPERITILAPITTWLLTVLCGTGHVVYTMFPIIEDIAIKTNIRPERPMAVSSTAAQMGITASPVS
VAIVSLTSILAEHAGVTQSAYSIPQILAVAMPASLCGVLVAAVWSLHRGKDLDKDEAFQERLKDPEFKKSVYSESHSLIG
QRFEKGAYRATGIFLGAIAIVVLLGAIEWLRPSFPNSNGDLKPLSMNLVIQMIMLVAGALMMLLCKVEPGKIASTTVFKA
GMTAVFSVFGVAWMADTFFQAHLDSLVDALSGVVQSHAWAYALVLLLVSKLVNSQGAAIVAIVPLGLKLGLDPATVIGFI
GAAYGYFILPTYPSDLACIGFDKTGTTRIGKYVLNHSFIIPGFICVIVSCIVGTVLAQVLL
>Mature_461_residues
MLASILDPTSGIALLLQIAVILSCLVLGTRYGGMGLGLISGIGLFILAFIFGLKPGEPPVSVMLTIIAVIGCAATLQQAR
GLDVMMQFAEKILRKHPERITILAPITTWLLTVLCGTGHVVYTMFPIIEDIAIKTNIRPERPMAVSSTAAQMGITASPVS
VAIVSLTSILAEHAGVTQSAYSIPQILAVAMPASLCGVLVAAVWSLHRGKDLDKDEAFQERLKDPEFKKSVYSESHSLIG
QRFEKGAYRATGIFLGAIAIVVLLGAIEWLRPSFPNSNGDLKPLSMNLVIQMIMLVAGALMMLLCKVEPGKIASTTVFKA
GMTAVFSVFGVAWMADTFFQAHLDSLVDALSGVVQSHAWAYALVLLLVSKLVNSQGAAIVAIVPLGLKLGLDPATVIGFI
GAAYGYFILPTYPSDLACIGFDKTGTTRIGKYVLNHSFIIPGFICVIVSCIVGTVLAQVLL

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790565, Length=411, Percent_Identity=54.5012165450122, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1790580, Length=457, Percent_Identity=36.1050328227571, Blast_Score=254, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 48915; Mature: 48915

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLASILDPTSGIALLLQIAVILSCLVLGTRYGGMGLGLISGIGLFILAFIFGLKPGEPPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
SVMLTIIAVIGCAATLQQARGLDVMMQFAEKILRKHPERITILAPITTWLLTVLCGTGHV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHH
VYTMFPIIEDIAIKTNIRPERPMAVSSTAAQMGITASPVSVAIVSLTSILAEHAGVTQSA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
YSIPQILAVAMPASLCGVLVAAVWSLHRGKDLDKDEAFQERLKDPEFKKSVYSESHSLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
QRFEKGAYRATGIFLGAIAIVVLLGAIEWLRPSFPNSNGDLKPLSMNLVIQMIMLVAGAL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MMLLCKVEPGKIASTTVFKAGMTAVFSVFGVAWMADTFFQAHLDSLVDALSGVVQSHAWA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YALVLLLVSKLVNSQGAAIVAIVPLGLKLGLDPATVIGFIGAAYGYFILPTYPSDLACIG
HHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCHHHHHHHHHHHHCCEEECCCCCCEEEEE
FDKTGTTRIGKYVLNHSFIIPGFICVIVSCIVGTVLAQVLL
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MLASILDPTSGIALLLQIAVILSCLVLGTRYGGMGLGLISGIGLFILAFIFGLKPGEPPV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
SVMLTIIAVIGCAATLQQARGLDVMMQFAEKILRKHPERITILAPITTWLLTVLCGTGHV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCHH
VYTMFPIIEDIAIKTNIRPERPMAVSSTAAQMGITASPVSVAIVSLTSILAEHAGVTQSA
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
YSIPQILAVAMPASLCGVLVAAVWSLHRGKDLDKDEAFQERLKDPEFKKSVYSESHSLIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
QRFEKGAYRATGIFLGAIAIVVLLGAIEWLRPSFPNSNGDLKPLSMNLVIQMIMLVAGAL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MMLLCKVEPGKIASTTVFKAGMTAVFSVFGVAWMADTFFQAHLDSLVDALSGVVQSHAWA
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YALVLLLVSKLVNSQGAAIVAIVPLGLKLGLDPATVIGFIGAAYGYFILPTYPSDLACIG
HHHHHHHHHHHHCCCCCEEEEEEECCHHCCCCHHHHHHHHHHHHCCEEECCCCCCEEEEE
FDKTGTTRIGKYVLNHSFIIPGFICVIVSCIVGTVLAQVLL
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]