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The map label for this gene is atpA

Identifier: 38233644

GI number: 38233644

Start: 1030794

End: 1032422

Strand: Direct

Name: atpA

Synonym: DIP1050

Alternate gene names: 38233644

Gene position: 1030794-1032422 (Clockwise)

Preceding gene: 38233643

Following gene: 38233645

Centisome position: 41.42

GC content: 56.84

Gene sequence:

>1629_bases
ATGGCGGAGCTTACGATCTCCTCCGATGAGATCCGTAGCGCGATTGCGAACTACACCTCGAGCTACTCCGCGGAGGCCTC
CCGTGAGGAGGTCGGCGTGGTCATTTCCGCAGCTGATGGTATTGCCCAAGTTTCGGGCTTGCCTTCAGTTATGGCAAATG
AGCTCCTCGAGTTCCCTAGCGGCGTCATCGGCGTCGCACAGAACCTTGACACCGACCGTATCGGCGTTGTGGTTTTGGGT
AACTACGAAATCCTTAAAGAAGGCGACGAAGTCAAGCGAACCGGCGAGGTCCTCTCGATTCCGGTTGGCGAGAAGTTCCT
TGGTCGCGTCATCAACCCACTAGGCCAGCCAATTGACGGCCTTGGCGCTATCGAGGCTGAGGAACAGCGTGTCCTCGAAC
TGCAGGCACCTTCTGTGCTGCAGCGTCAGCCAGTCGAAGAGCCAATGCAGACCGGCATCAAGGCTATCGATGCAATGACC
CCAATCGGTCGCGGTCAGCGTCAGCTGATCATTGGTGACCGCAAGACTGGTAAGACTGCAGTCTGCATCGACACCATCTT
GAACCAGAAGGCTAACTGGGAGTCCGGCGATAAGAGCAAGCAGGTTCGCTGCATCTATGTTGCAGTCGGCCAGAAGGGCT
CGACCATTGCTGCCGTTCGTCAGACCCTAGAAGAGCACGGTGCGCTGGAGTACACCACCATCGTTGCTGCACCAGCTTCT
GATTCCGCAGGCTTCAAGTGGTTGGCACCTTTCGCAGGTGCTGCATTGGGCCAGCACTGGATGTACCAGGGTAACCACGT
CCTGGTTATCTACGATGATCTGACCAAGCAGGCAGAGGCATACCGTGCCATCTCCTTGCTGCTTCGTCGCCCACCAGGAC
GCGAAGCTTACCCAGGTGACGTCTTCTACCTCCACTCCCGTCTGCTGGAGCGTGCTGCAAAGCTCTCCGACGACATGGGC
GCAGGTTCCATGACGGCACTTCCCATCATCGAGACCAAGGCAAACGACGTTTCTGCCTTCATTCCTACCAACGTGATCTC
CATCACCGATGGTCAGGTATTCCTCGAGTCCGATCTGTTCAACCAGGGTGTTCGCCCGGCTATTAACGTCGGTGTGTCCG
TTTCCCGTGTTGGTGGCGCAGCTCAGACCAAGGGTATGAAGAAGGTTTCCGGTTCGTTGCGTCTGGATCTCGCTGCTTAT
CGCGACCTCGAGGCATTCGCTACCTTCGCATCTGACCTCGATGCTGCTTCCAAGGCTCAGCTTGACCGCGGTGCACGTTT
GGTCGAGTTGCTCAAGCAGGCAGAGAACGCACCTCAGTCTGTTGAGCACCAGATCGTTTCCATCTGGCTTGCAGGCAACG
GCCACTTCGATACCGTTCCCGTCGAAGACATCCGTCGCTTCGAGTTTGATTTGATCGATCACCTGCACGCTGCTGTACCA
CAGGTATTCGAGCAGATTGCCGGCGGCGCTCAGCTGTCTGAGGAATCCCAGGCTGCGCTCGTCGCTGCAACCGAGGATTT
TAAGCGCACCTTCCAGACCACTGATGGCACCCCCGTGATTAACGAGCCAGAGGTCGCGGCATTGTCTGCAGACCAGGTGA
AGAAGAACACGATTTCGGTGAAGAAGTAA

Upstream 100 bases:

>100_bases
CTCGGGCAAGCTCGAGCGTCTCCGCGCGAACCTCGCGTAAGCCAACGCGACAACACAAATAGAAATAATGCTGGAAGAAA
CTACCGAGAGCAGGAAGAAC

Downstream 100 bases:

>100_bases
GACGTTACAGTCTGAAAACGACCATCAAGGAAAAGAAGGGAGGCGAATGAACCATGGCAAATCTTCGTGAGCTGCGCGAC
CGTATCCGGTCAGTGAACTC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MAELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSVMANELLEFPSGVIGVAQNLDTDRIGVVVLG
NYEILKEGDEVKRTGEVLSIPVGEKFLGRVINPLGQPIDGLGAIEAEEQRVLELQAPSVLQRQPVEEPMQTGIKAIDAMT
PIGRGQRQLIIGDRKTGKTAVCIDTILNQKANWESGDKSKQVRCIYVAVGQKGSTIAAVRQTLEEHGALEYTTIVAAPAS
DSAGFKWLAPFAGAALGQHWMYQGNHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDMG
AGSMTALPIIETKANDVSAFIPTNVISITDGQVFLESDLFNQGVRPAINVGVSVSRVGGAAQTKGMKKVSGSLRLDLAAY
RDLEAFATFASDLDAASKAQLDRGARLVELLKQAENAPQSVEHQIVSIWLAGNGHFDTVPVEDIRRFEFDLIDHLHAAVP
QVFEQIAGGAQLSEESQAALVAATEDFKRTFQTTDGTPVINEPEVAALSADQVKKNTISVKK

Sequences:

>Translated_542_residues
MAELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSVMANELLEFPSGVIGVAQNLDTDRIGVVVLG
NYEILKEGDEVKRTGEVLSIPVGEKFLGRVINPLGQPIDGLGAIEAEEQRVLELQAPSVLQRQPVEEPMQTGIKAIDAMT
PIGRGQRQLIIGDRKTGKTAVCIDTILNQKANWESGDKSKQVRCIYVAVGQKGSTIAAVRQTLEEHGALEYTTIVAAPAS
DSAGFKWLAPFAGAALGQHWMYQGNHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDMG
AGSMTALPIIETKANDVSAFIPTNVISITDGQVFLESDLFNQGVRPAINVGVSVSRVGGAAQTKGMKKVSGSLRLDLAAY
RDLEAFATFASDLDAASKAQLDRGARLVELLKQAENAPQSVEHQIVSIWLAGNGHFDTVPVEDIRRFEFDLIDHLHAAVP
QVFEQIAGGAQLSEESQAALVAATEDFKRTFQTTDGTPVINEPEVAALSADQVKKNTISVKK
>Mature_541_residues
AELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSVMANELLEFPSGVIGVAQNLDTDRIGVVVLGN
YEILKEGDEVKRTGEVLSIPVGEKFLGRVINPLGQPIDGLGAIEAEEQRVLELQAPSVLQRQPVEEPMQTGIKAIDAMTP
IGRGQRQLIIGDRKTGKTAVCIDTILNQKANWESGDKSKQVRCIYVAVGQKGSTIAAVRQTLEEHGALEYTTIVAAPASD
SAGFKWLAPFAGAALGQHWMYQGNHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDMGA
GSMTALPIIETKANDVSAFIPTNVISITDGQVFLESDLFNQGVRPAINVGVSVSRVGGAAQTKGMKKVSGSLRLDLAAYR
DLEAFATFASDLDAASKAQLDRGARLVELLKQAENAPQSVEHQIVSIWLAGNGHFDTVPVEDIRRFEFDLIDHLHAAVPQ
VFEQIAGGAQLSEESQAALVAATEDFKRTFQTTDGTPVINEPEVAALSADQVKKNTISVKK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=484, Percent_Identity=54.3388429752066, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI4757810, Length=484, Percent_Identity=54.3388429752066, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI19913428, Length=323, Percent_Identity=30.030959752322, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI19913426, Length=323, Percent_Identity=29.4117647058824, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI32189394, Length=378, Percent_Identity=24.3386243386243, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1790172, Length=521, Percent_Identity=50.4798464491363, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788251, Length=323, Percent_Identity=28.4829721362229, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1790170, Length=315, Percent_Identity=25.3968253968254, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=484, Percent_Identity=55.3719008264463, Blast_Score=565, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71988080, Length=484, Percent_Identity=55.3719008264463, Blast_Score=564, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71988074, Length=484, Percent_Identity=52.0661157024793, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17570191, Length=322, Percent_Identity=30.1242236024845, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17510931, Length=368, Percent_Identity=27.7173913043478, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25144756, Length=451, Percent_Identity=23.2815964523282, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319370, Length=503, Percent_Identity=54.8707753479125, Blast_Score=558, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319603, Length=341, Percent_Identity=30.791788856305, Blast_Score=138, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322581, Length=400, Percent_Identity=24.75, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24658560, Length=508, Percent_Identity=54.5275590551181, Blast_Score=573, Evalue=1e-163,
Organism=Drosophila melanogaster, GI281361666, Length=332, Percent_Identity=30.1204819277108, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646341, Length=332, Percent_Identity=30.1204819277108, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136796, Length=332, Percent_Identity=30.1204819277108, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24638766, Length=326, Percent_Identity=25.4601226993865, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574560, Length=450, Percent_Identity=22, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_CORDI (Q6NHT1)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939411.1
- ProteinModelPortal:   Q6NHT1
- SMR:   Q6NHT1
- GeneID:   2650816
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1050
- NMPDR:   fig|257309.1.peg.1002
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q6NHT1
- ProtClustDB:   PRK09281
- BioCyc:   CDIP257309:DIP1050-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 58216; Mature: 58084

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSVMANELLEFPS
CCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHCCCHHHHHHHHHHCCC
GVIGVAQNLDTDRIGVVVLGNYEILKEGDEVKRTGEVLSIPVGEKFLGRVINPLGQPIDG
CHHHHHCCCCCCCEEEEEECCHHHHHCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCC
LGAIEAEEQRVLELQAPSVLQRQPVEEPMQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTA
CCCCCHHHHHHEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEE
VCIDTILNQKANWESGDKSKQVRCIYVAVGQKGSTIAAVRQTLEEHGALEYTTIVAAPAS
EHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECCC
DSAGFKWLAPFAGAALGQHWMYQGNHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGD
CCCCCEEHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCH
VFYLHSRLLERAAKLSDDMGAGSMTALPIIETKANDVSAFIPTNVISITDGQVFLESDLF
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEECCCCEEEECCCCEEEECHHH
NQGVRPAINVGVSVSRVGGAAQTKGMKKVSGSLRLDLAAYRDLEAFATFASDLDAASKAQ
CCCCCCHHHCCEEEECCCCHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHH
LDRGARLVELLKQAENAPQSVEHQIVSIWLAGNGHFDTVPVEDIRRFEFDLIDHLHAAVP
HHCCHHHHHHHHHHCCCCHHHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QVFEQIAGGAQLSEESQAALVAATEDFKRTFQTTDGTPVINEPEVAALSADQVKKNTISV
HHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHCCCCC
KK
CC
>Mature Secondary Structure 
AELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSVMANELLEFPS
CEEECCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHCCCHHHHHHHHHHCCC
GVIGVAQNLDTDRIGVVVLGNYEILKEGDEVKRTGEVLSIPVGEKFLGRVINPLGQPIDG
CHHHHHCCCCCCCEEEEEECCHHHHHCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCC
LGAIEAEEQRVLELQAPSVLQRQPVEEPMQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTA
CCCCCHHHHHHEEECCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEE
VCIDTILNQKANWESGDKSKQVRCIYVAVGQKGSTIAAVRQTLEEHGALEYTTIVAAPAS
EHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECCC
DSAGFKWLAPFAGAALGQHWMYQGNHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGD
CCCCCEEHHHHHHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCH
VFYLHSRLLERAAKLSDDMGAGSMTALPIIETKANDVSAFIPTNVISITDGQVFLESDLF
HHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCEEECCCCEEEECCCCEEEECHHH
NQGVRPAINVGVSVSRVGGAAQTKGMKKVSGSLRLDLAAYRDLEAFATFASDLDAASKAQ
CCCCCCHHHCCEEEECCCCHHHHCCHHHHCCCEEEEHHHHHHHHHHHHHHHHHCHHHHHH
LDRGARLVELLKQAENAPQSVEHQIVSIWLAGNGHFDTVPVEDIRRFEFDLIDHLHAAVP
HHCCHHHHHHHHHHCCCCHHHHEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
QVFEQIAGGAQLSEESQAALVAATEDFKRTFQTTDGTPVINEPEVAALSADQVKKNTISV
HHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHCCCCC
KK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 14602910