Click here to switch to the map view.

The map label for this gene is emrB [C]

Identifier: 38233532

GI number: 38233532

Start: 906600

End: 908165

Strand: Reverse

Name: emrB [C]

Synonym: DIP0936

Alternate gene names: 38233532

Gene position: 908165-906600 (Counterclockwise)

Preceding gene: 38233533

Following gene: 38233529

Centisome position: 36.49

GC content: 53.13

Gene sequence:

>1566_bases
GTGAGCACTCAATTGTCGCCGGAAAAAGTGCGCGAACCGGCCGCACACCATCGCCCTGTGGGCTGGATTATTGCAGCTTT
GATGCTCAGTATGTTGATGGGCTCGTTGGGGCAGATGATTTTTGCTACCGCACTGCCAACTATCGTGGGGGATCTCGGCG
GTGTGGAACACATGTCGTGGGTAATCACAGCATTTTTGCTGGGACAGACGATCGCCATGCCGCTCTTTGGCAAGCTGGGC
GATGTAATAAATCGCAAGCCGCTCTTTATTTTTGCCAACCTGTTGTTCATGTTGGGATCACTCATTGGCGGGTTGGCTAC
GTCGATGTCGATGCTGATTCTTGCGCGTGCCATTCAGGGAGTTGCCGGTGGTGCGTCGATGATTCTTTCGCAGGCAATCA
CTGCCGAGGTCACCACTGCCCGCGAACGCGGTAAATACATGGGCGTGATGGGCACTGTTTTCGGGGTGTCCTCAGTACTA
GGCCCTGTGCTGGGTGGTTGGTTTACCGACGGCCCAGGTTGGCGGTGGGGCCTATGGCTTAATCTCCCACTAGGAGCTGT
CACTGTGATCACCATTTGGCTCTTGTTGTCATTGCCAAGCAAAGACGTGAAGTTCCGACTGGATTGGTGGGGAACGCTCA
CCATGGCCATCGCTACGGCTTCGCTGGTGCTGTTTGTCACTTGGGGCGGTCGCGATTACGCCTGGAGCGATCCCATCATT
GTGGGTCTTATTGCATCGTTTGTGGTCTTCGGTATTATTTTTGTCGCTGTAGAGCTGCGTGTCGACGATCCTTTGATCCC
CATGACTCTTTTCCAAAACCGCAACTTCACGCTCACAACGATCGCGGGACTTGCTATCGGTGTCATCATGTTCGGATCAA
TGGCCTACCTACCAACATATTTGCAGATGGTGCACCATATGAGCCCCACCAAGGCGGGTCTGACCATGATCACGATGATG
TCTGGGCTTATGATCTCCTCAATCGGAGTAGGAAACCTCGTTTCACGCACGGGTCGTTATAAGACATTCCCACTGATCGG
GCAGATCATCACATCCATCGCATTGGTATTGCTCTCTCGGCTGCATTACAACGACTCACTTGTCACCGTTGGAATATACA
TGTTCATCTTCGGCGTGGGCCTTGGCTGCACAATGCAAATCTTGGTCCTGATCGTTCAAAATTCATTCTCACTCGCAATG
GTGGGTACTGCCACTGGATCAAACAACTTCTTCCGCCAAGTAGGAGGCGCTGTAGGTTCAGCATTAATCGGATCGATGTT
CATGACCAATCTCAAGGAACAGATCGGAACGCATCTGCCCACGGCAGTTCAGCAGGCTGTGGCTCAGGGCTACCCGATGG
ATGCCGTCGATAAGCTGCAAAGTGCAAGTAGACTCACGCCGGCATTTGTCAACCACCTGCCCCAAGTGATTCAAGATGCT
ATTGCTGTGTCGTACAACGACGCGCTTACCCCCGTCTTCCTCCTAGTCGCACCGTTGTCGATTCTAGCGGCGATCTTGCT
TGCCCTTGTTCACGAGACTGAGCTAAGCCAGACCATCGAGCGCTAG

Upstream 100 bases:

>100_bases
ACTTTATGGGCAGACAGCCCTTCCGCTAGTTTTTCCACCCTCGAGGAATCGTGCCTCGAGGCCTTGGTCCACCTTCGCAC
GATCAACAAGGGACTATAAC

Downstream 100 bases:

>100_bases
TATTTTAGGGTTCTACAGCTGCTGCCTCATGATCAGCGAGTTCTGGCTTGGGCAGCAGTTTTTCCCAAATATCAGTGTCG
CGCCATTGGCCTGCCATTTC

Product: putative drug transport membrane protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MSTQLSPEKVREPAAHHRPVGWIIAALMLSMLMGSLGQMIFATALPTIVGDLGGVEHMSWVITAFLLGQTIAMPLFGKLG
DVINRKPLFIFANLLFMLGSLIGGLATSMSMLILARAIQGVAGGASMILSQAITAEVTTARERGKYMGVMGTVFGVSSVL
GPVLGGWFTDGPGWRWGLWLNLPLGAVTVITIWLLLSLPSKDVKFRLDWWGTLTMAIATASLVLFVTWGGRDYAWSDPII
VGLIASFVVFGIIFVAVELRVDDPLIPMTLFQNRNFTLTTIAGLAIGVIMFGSMAYLPTYLQMVHHMSPTKAGLTMITMM
SGLMISSIGVGNLVSRTGRYKTFPLIGQIITSIALVLLSRLHYNDSLVTVGIYMFIFGVGLGCTMQILVLIVQNSFSLAM
VGTATGSNNFFRQVGGAVGSALIGSMFMTNLKEQIGTHLPTAVQQAVAQGYPMDAVDKLQSASRLTPAFVNHLPQVIQDA
IAVSYNDALTPVFLLVAPLSILAAILLALVHETELSQTIER

Sequences:

>Translated_521_residues
MSTQLSPEKVREPAAHHRPVGWIIAALMLSMLMGSLGQMIFATALPTIVGDLGGVEHMSWVITAFLLGQTIAMPLFGKLG
DVINRKPLFIFANLLFMLGSLIGGLATSMSMLILARAIQGVAGGASMILSQAITAEVTTARERGKYMGVMGTVFGVSSVL
GPVLGGWFTDGPGWRWGLWLNLPLGAVTVITIWLLLSLPSKDVKFRLDWWGTLTMAIATASLVLFVTWGGRDYAWSDPII
VGLIASFVVFGIIFVAVELRVDDPLIPMTLFQNRNFTLTTIAGLAIGVIMFGSMAYLPTYLQMVHHMSPTKAGLTMITMM
SGLMISSIGVGNLVSRTGRYKTFPLIGQIITSIALVLLSRLHYNDSLVTVGIYMFIFGVGLGCTMQILVLIVQNSFSLAM
VGTATGSNNFFRQVGGAVGSALIGSMFMTNLKEQIGTHLPTAVQQAVAQGYPMDAVDKLQSASRLTPAFVNHLPQVIQDA
IAVSYNDALTPVFLLVAPLSILAAILLALVHETELSQTIER
>Mature_520_residues
STQLSPEKVREPAAHHRPVGWIIAALMLSMLMGSLGQMIFATALPTIVGDLGGVEHMSWVITAFLLGQTIAMPLFGKLGD
VINRKPLFIFANLLFMLGSLIGGLATSMSMLILARAIQGVAGGASMILSQAITAEVTTARERGKYMGVMGTVFGVSSVLG
PVLGGWFTDGPGWRWGLWLNLPLGAVTVITIWLLLSLPSKDVKFRLDWWGTLTMAIATASLVLFVTWGGRDYAWSDPIIV
GLIASFVVFGIIFVAVELRVDDPLIPMTLFQNRNFTLTTIAGLAIGVIMFGSMAYLPTYLQMVHHMSPTKAGLTMITMMS
GLMISSIGVGNLVSRTGRYKTFPLIGQIITSIALVLLSRLHYNDSLVTVGIYMFIFGVGLGCTMQILVLIVQNSFSLAMV
GTATGSNNFFRQVGGAVGSALIGSMFMTNLKEQIGTHLPTAVQQAVAQGYPMDAVDKLQSASRLTPAFVNHLPQVIQDAI
AVSYNDALTPVFLLVAPLSILAAILLALVHETELSQTIER

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=427, Percent_Identity=27.4004683840749, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788710, Length=417, Percent_Identity=26.8585131894484, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081983, Length=409, Percent_Identity=27.1393643031785, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788392, Length=325, Percent_Identity=33.5384615384615, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1790195, Length=382, Percent_Identity=25.3926701570681, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790146, Length=153, Percent_Identity=28.1045751633987, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=307, Percent_Identity=30.2931596091205, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6322958, Length=516, Percent_Identity=23.4496124031008, Blast_Score=119, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6321663, Length=371, Percent_Identity=23.989218328841, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325455, Length=477, Percent_Identity=24.3186582809224, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319770, Length=473, Percent_Identity=22.1987315010571, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319783, Length=409, Percent_Identity=23.2273838630807, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55912; Mature: 55781

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQLSPEKVREPAAHHRPVGWIIAALMLSMLMGSLGQMIFATALPTIVGDLGGVEHMSW
CCCCCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VITAFLLGQTIAMPLFGKLGDVINRKPLFIFANLLFMLGSLIGGLATSMSMLILARAIQG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGGASMILSQAITAEVTTARERGKYMGVMGTVFGVSSVLGPVLGGWFTDGPGWRWGLWL
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
NLPLGAVTVITIWLLLSLPSKDVKFRLDWWGTLTMAIATASLVLFVTWGGRDYAWSDPII
ECCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHH
VGLIASFVVFGIIFVAVELRVDDPLIPMTLFQNRNFTLTTIAGLAIGVIMFGSMAYLPTY
HHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LQMVHHMSPTKAGLTMITMMSGLMISSIGVGNLVSRTGRYKTFPLIGQIITSIALVLLSR
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LHYNDSLVTVGIYMFIFGVGLGCTMQILVLIVQNSFSLAMVGTATGSNNFFRQVGGAVGS
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
ALIGSMFMTNLKEQIGTHLPTAVQQAVAQGYPMDAVDKLQSASRLTPAFVNHLPQVIQDA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
IAVSYNDALTPVFLLVAPLSILAAILLALVHETELSQTIER
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STQLSPEKVREPAAHHRPVGWIIAALMLSMLMGSLGQMIFATALPTIVGDLGGVEHMSW
CCCCCHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
VITAFLLGQTIAMPLFGKLGDVINRKPLFIFANLLFMLGSLIGGLATSMSMLILARAIQG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGGASMILSQAITAEVTTARERGKYMGVMGTVFGVSSVLGPVLGGWFTDGPGWRWGLWL
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
NLPLGAVTVITIWLLLSLPSKDVKFRLDWWGTLTMAIATASLVLFVTWGGRDYAWSDPII
ECCHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHH
VGLIASFVVFGIIFVAVELRVDDPLIPMTLFQNRNFTLTTIAGLAIGVIMFGSMAYLPTY
HHHHHHHHHHHHHHHHHHEECCCCCCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
LQMVHHMSPTKAGLTMITMMSGLMISSIGVGNLVSRTGRYKTFPLIGQIITSIALVLLSR
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LHYNDSLVTVGIYMFIFGVGLGCTMQILVLIVQNSFSLAMVGTATGSNNFFRQVGGAVGS
HCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
ALIGSMFMTNLKEQIGTHLPTAVQQAVAQGYPMDAVDKLQSASRLTPAFVNHLPQVIQDA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
IAVSYNDALTPVFLLVAPLSILAAILLALVHETELSQTIER
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]