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The map label for this gene is glyA

Identifier: 38233528

GI number: 38233528

Start: 903498

End: 904787

Strand: Direct

Name: glyA

Synonym: DIP0932

Alternate gene names: 38233528

Gene position: 903498-904787 (Clockwise)

Preceding gene: 38233526

Following gene: 38233530

Centisome position: 36.3

GC content: 55.43

Gene sequence:

>1290_bases
ATGACAGATGACATCCGTTACCAATCGCTAACCGAGCTTGATCCAGAGGTTGCGGCTGCAATCACTGGTGAGCTTGACCG
CCAGCGTTCCACGCTCGAGATGATCGCGTCTGAAAACTTCGTTCCACGCGCAGTTTTGCAGGCACAAGGATCCGTATTCA
CCAACAAATACGCTGAAGGTTACCCAGGGCGTCGCTACTACGGTGGCTGTGAAAACGCCGACATCGTTGAAGATCTAGCG
CGTAACCGTGCCAAAGAGGTCTTCGGTGCTGAGTTTGCCAACGTGCAGCCTCACGCAGGTGCACAGGCTAATGCTGCTGT
GTTGATGGCACTAGCCAACCCCGGCGATAAGATCATGGGCCTGTCCTTGGCTCATGGTGGCCACCTGACCCACGGCATGC
ACTTGAACTTCTCCGGAAAGCTCTATGAAGTTGCAGCCTACGAGGTAGAACCAGATAATTTCCGCTTGGACATGGACAAG
ATCCGTGAACAGGCTTTGAAAGAGAAACCACAGGTTCTGATTGCTGGCTGGTCCGCATACCCACGCCACCAGGACTTCGC
AGCATTCCGTTCTATCGCTGATGAGGTTGACGCTAAGTTGTGGGTCGATATGGCTCACTTCGCTGGTCTTGTGGCTGCTG
GTTTGCACCCATCGCCAGTTCCTTACGCTGATGTTGTGTCCACGACCGTTCACAAGACGTTGGGTGGTCCACGCTCGGGC
ATGATCTTGTCCAAGCAGGAGTATGCTAAGAAGCTGAACTCCGCAGTCTTCCCAGGCCAGCAGGGCGGACCTTTGATGCA
CGCAATTGTTGCTAAGGCTGTTGCCATGAAGATTGCTGCTACTGAGGAGTTCAAGGATCGCCAGCAGCGCACCCTTGATG
GTGCTCAGATTATCGCTGAGCGCTTGACAGGTGCTGATTGCAAAGCTGCAGGTGTAGACGTACTGACCGGTGGCACCGAT
GTCCACTTGGTTCTTGTCGATCTGCGTAATTCCCAGATGGATGGCCAGCAGGCTGAAGATCTCCTCCATGAGGTCGGAAT
CACCGTGAACCGTAACGCGGTTCCATTCGACCCACGTCCTCCAATGGTCACCTCCGGTTTGCGTATCGGTACACCAGCTT
TGGCTACCCGTGGCTTCGATGCTGCAGGTTTCACCGAGGTTGCCGACATCATCGCTACCGCATTGGCACAAGGCGCCGGT
GCTGACACCGAGCAGCTGCGCGCACGCGTCGCTAAGCTTGCCGAGCAGTACCCACTCTACGAGGGCCTTGAGGACTGGAA
GCTCCTCTAA

Upstream 100 bases:

>100_bases
GCAGGTATAACGCAAAAGTCGCTTACTTGCGTTTCGCTCGTTAACATCCATGATGCGCACATATGACCACAAACGATGAA
AGGGTTAGTGGCCTTAAGCC

Downstream 100 bases:

>100_bases
ACCTCAAACAAAAGCCGCACATCGTGAAGGTAAAACTCCTTCAGAATGTGCGGCTTTCGTGTTGTCTTACTTAGTTTTCG
TCGTGATCGTTGCCGGTTTC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTDDIRYQSLTELDPEVAAAITGELDRQRSTLEMIASENFVPRAVLQAQGSVFTNKYAEGYPGRRYYGGCENADIVEDLA
RNRAKEVFGAEFANVQPHAGAQANAAVLMALANPGDKIMGLSLAHGGHLTHGMHLNFSGKLYEVAAYEVEPDNFRLDMDK
IREQALKEKPQVLIAGWSAYPRHQDFAAFRSIADEVDAKLWVDMAHFAGLVAAGLHPSPVPYADVVSTTVHKTLGGPRSG
MILSKQEYAKKLNSAVFPGQQGGPLMHAIVAKAVAMKIAATEEFKDRQQRTLDGAQIIAERLTGADCKAAGVDVLTGGTD
VHLVLVDLRNSQMDGQQAEDLLHEVGITVNRNAVPFDPRPPMVTSGLRIGTPALATRGFDAAGFTEVADIIATALAQGAG
ADTEQLRARVAKLAEQYPLYEGLEDWKLL

Sequences:

>Translated_429_residues
MTDDIRYQSLTELDPEVAAAITGELDRQRSTLEMIASENFVPRAVLQAQGSVFTNKYAEGYPGRRYYGGCENADIVEDLA
RNRAKEVFGAEFANVQPHAGAQANAAVLMALANPGDKIMGLSLAHGGHLTHGMHLNFSGKLYEVAAYEVEPDNFRLDMDK
IREQALKEKPQVLIAGWSAYPRHQDFAAFRSIADEVDAKLWVDMAHFAGLVAAGLHPSPVPYADVVSTTVHKTLGGPRSG
MILSKQEYAKKLNSAVFPGQQGGPLMHAIVAKAVAMKIAATEEFKDRQQRTLDGAQIIAERLTGADCKAAGVDVLTGGTD
VHLVLVDLRNSQMDGQQAEDLLHEVGITVNRNAVPFDPRPPMVTSGLRIGTPALATRGFDAAGFTEVADIIATALAQGAG
ADTEQLRARVAKLAEQYPLYEGLEDWKLL
>Mature_428_residues
TDDIRYQSLTELDPEVAAAITGELDRQRSTLEMIASENFVPRAVLQAQGSVFTNKYAEGYPGRRYYGGCENADIVEDLAR
NRAKEVFGAEFANVQPHAGAQANAAVLMALANPGDKIMGLSLAHGGHLTHGMHLNFSGKLYEVAAYEVEPDNFRLDMDKI
REQALKEKPQVLIAGWSAYPRHQDFAAFRSIADEVDAKLWVDMAHFAGLVAAGLHPSPVPYADVVSTTVHKTLGGPRSGM
ILSKQEYAKKLNSAVFPGQQGGPLMHAIVAKAVAMKIAATEEFKDRQQRTLDGAQIIAERLTGADCKAAGVDVLTGGTDV
HLVLVDLRNSQMDGQQAEDLLHEVGITVNRNAVPFDPRPPMVTSGLRIGTPALATRGFDAAGFTEVADIIATALAQGAGA
DTEQLRARVAKLAEQYPLYEGLEDWKLL

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=432, Percent_Identity=42.5925925925926, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI261862350, Length=432, Percent_Identity=42.5925925925926, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI261862348, Length=432, Percent_Identity=42.5925925925926, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI19923315, Length=432, Percent_Identity=42.5925925925926, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI261862346, Length=427, Percent_Identity=42.8571428571429, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI22547186, Length=413, Percent_Identity=44.3099273607748, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI22547189, Length=398, Percent_Identity=42.4623115577889, Blast_Score=271, Evalue=9e-73,
Organism=Escherichia coli, GI1788902, Length=419, Percent_Identity=51.0739856801909, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI25144732, Length=416, Percent_Identity=43.2692307692308, Blast_Score=316, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI25144729, Length=416, Percent_Identity=43.2692307692308, Blast_Score=316, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6319739, Length=412, Percent_Identity=41.747572815534, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6323087, Length=448, Percent_Identity=38.3928571428571, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24640005, Length=462, Percent_Identity=43.0735930735931, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI221329721, Length=462, Percent_Identity=43.0735930735931, Blast_Score=339, Evalue=2e-93,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_CORDI (Q6NI47)

Other databases:

- EMBL:   BX248356
- RefSeq:   NP_939295.1
- ProteinModelPortal:   Q6NI47
- SMR:   Q6NI47
- GeneID:   2649972
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0932
- NMPDR:   fig|257309.1.peg.886
- HOGENOM:   HBG301263
- OMA:   SINSAVF
- ProtClustDB:   PRK00011
- BioCyc:   CDIP257309:DIP0932-MONOMER
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 46316; Mature: 46185

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDIRYQSLTELDPEVAAAITGELDRQRSTLEMIASENFVPRAVLQAQGSVFTNKYAEG
CCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHCC
YPGRRYYGGCENADIVEDLARNRAKEVFGAEFANVQPHAGAQANAAVLMALANPGDKIMG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCEEEEEECCCCCCEEE
LSLAHGGHLTHGMHLNFSGKLYEVAAYEVEPDNFRLDMDKIREQALKEKPQVLIAGWSAY
EEEECCCCCCCCEEECCCCCEEEEEEEEECCCCEEECHHHHHHHHHHCCCCEEEECCCCC
PRHQDFAAFRSIADEVDAKLWVDMAHFAGLVAAGLHPSPVPYADVVSTTVHKTLGGPRSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
MILSKQEYAKKLNSAVFPGQQGGPLMHAIVAKAVAMKIAATEEFKDRQQRTLDGAQIIAE
CEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLTGADCKAAGVDVLTGGTDVHLVLVDLRNSQMDGQQAEDLLHEVGITVNRNAVPFDPRP
HHCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCC
PMVTSGLRIGTPALATRGFDAAGFTEVADIIATALAQGAGADTEQLRARVAKLAEQYPLY
CCEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHH
EGLEDWKLL
CCCHHHCCC
>Mature Secondary Structure 
TDDIRYQSLTELDPEVAAAITGELDRQRSTLEMIASENFVPRAVLQAQGSVFTNKYAEG
CCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHCC
YPGRRYYGGCENADIVEDLARNRAKEVFGAEFANVQPHAGAQANAAVLMALANPGDKIMG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHCCCCCCCCCCCCCEEEEEECCCCCCEEE
LSLAHGGHLTHGMHLNFSGKLYEVAAYEVEPDNFRLDMDKIREQALKEKPQVLIAGWSAY
EEEECCCCCCCCEEECCCCCEEEEEEEEECCCCEEECHHHHHHHHHHCCCCEEEECCCCC
PRHQDFAAFRSIADEVDAKLWVDMAHFAGLVAAGLHPSPVPYADVVSTTVHKTLGGPRSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCC
MILSKQEYAKKLNSAVFPGQQGGPLMHAIVAKAVAMKIAATEEFKDRQQRTLDGAQIIAE
CEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLTGADCKAAGVDVLTGGTDVHLVLVDLRNSQMDGQQAEDLLHEVGITVNRNAVPFDPRP
HHCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCC
PMVTSGLRIGTPALATRGFDAAGFTEVADIIATALAQGAGADTEQLRARVAKLAEQYPLY
CCEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHH
EGLEDWKLL
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910