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The map label for this gene is mazG [H]

Identifier: 38233511

GI number: 38233511

Start: 889839

End: 890537

Strand: Direct

Name: mazG [H]

Synonym: DIP0915

Alternate gene names: 38233511

Gene position: 889839-890537 (Clockwise)

Preceding gene: 38233509

Following gene: 38233512

Centisome position: 35.76

GC content: 52.5

Gene sequence:

>699_bases
TTGCCGCAGAATCAATATCGCCACGAACACCCAGCACCGGAGCGGGTACCCGCTATCAAAGCCTCTATGATTACTATGTC
AGTCATGACCGTTCTGCTTCTCGACGCCCGTTGGCCATCCATGATCCCCTTTAATTTGGTAGGCAAGCTCGAAGGACAGC
TACGATTCACCGACGAAGTACCCGTAAAAGTTCGCTGGAACCTCGACGACATTGTGCGTTTCGCAACCGATGATCTGCTT
GTAAGCACCAATGAGTTAGATCCGCAAGTGATCGCAGCCATCAACAATGGAGCAAGCGTTATTGAAGTTCCCAGCCGGCA
CGACGCCCTAGGTCAAGCACGTGAAGTGATGCGCCGAGCAGTAGCCCGTGGGGAATGGGAACAAACCCAAACCCACGAAT
CTCTTCTGGAATATCTCGACGAAGAAACCGAAGAATTCGCGCAAGCTGTTGCCCACGGAACCACCGACCACATTGTTTCC
GAGCTTGGCGACGTACTACTCCAAGTGCTCTTTCACGCCGAAATCGGTGCACGACATGGCGAATTCAATCTCGACGATGT
AGCCGCAAGCTTTGTGACCAAAATGCAACAACGCTCGCCCTACCTTTTCGACGGCTCCGACGGAGTAGTACCCATAGAAG
AACAAGAACGTCTCTGGGAGGCCGGAAAACATCGATCTGCACACGCACAAACAAACTAG

Upstream 100 bases:

>100_bases
ATCGATTCTGTCCCCTTAGGAACGGCAGCCATGTGCACCTCTATACAGATAAATGAAGTAATTCTAAACGCGGTTAAGTA
AAGCTAAAGGTTACAAGAAA

Downstream 100 bases:

>100_bases
GGAGTCTTGGGTTGAGAAAAGCCGCAGGGTGCGCGCTAGGAGTAGTGCTGGCAGTCATTATGGTCATTGCCATCGTCGGG
TGGACCCTATCCATTATGAG

Product: hypothetical protein

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MPQNQYRHEHPAPERVPAIKASMITMSVMTVLLLDARWPSMIPFNLVGKLEGQLRFTDEVPVKVRWNLDDIVRFATDDLL
VSTNELDPQVIAAINNGASVIEVPSRHDALGQAREVMRRAVARGEWEQTQTHESLLEYLDEETEEFAQAVAHGTTDHIVS
ELGDVLLQVLFHAEIGARHGEFNLDDVAASFVTKMQQRSPYLFDGSDGVVPIEEQERLWEAGKHRSAHAQTN

Sequences:

>Translated_232_residues
MPQNQYRHEHPAPERVPAIKASMITMSVMTVLLLDARWPSMIPFNLVGKLEGQLRFTDEVPVKVRWNLDDIVRFATDDLL
VSTNELDPQVIAAINNGASVIEVPSRHDALGQAREVMRRAVARGEWEQTQTHESLLEYLDEETEEFAQAVAHGTTDHIVS
ELGDVLLQVLFHAEIGARHGEFNLDDVAASFVTKMQQRSPYLFDGSDGVVPIEEQERLWEAGKHRSAHAQTN
>Mature_231_residues
PQNQYRHEHPAPERVPAIKASMITMSVMTVLLLDARWPSMIPFNLVGKLEGQLRFTDEVPVKVRWNLDDIVRFATDDLLV
STNELDPQVIAAINNGASVIEVPSRHDALGQAREVMRRAVARGEWEQTQTHESLLEYLDEETEEFAQAVAHGTTDHIVSE
LGDVLLQVLFHAEIGARHGEFNLDDVAASFVTKMQQRSPYLFDGSDGVVPIEEQERLWEAGKHRSAHAQTN

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=81, Percent_Identity=35.8024691358025, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 26113; Mature: 25981

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQNQYRHEHPAPERVPAIKASMITMSVMTVLLLDARWPSMIPFNLVGKLEGQLRFTDEV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEECCCC
PVKVRWNLDDIVRFATDDLLVSTNELDPQVIAAINNGASVIEVPSRHDALGQAREVMRRA
CEEEEECHHHHHHHHHHHHEEECCCCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHH
VARGEWEQTQTHESLLEYLDEETEEFAQAVAHGTTDHIVSELGDVLLQVLFHAEIGARHG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EFNLDDVAASFVTKMQQRSPYLFDGSDGVVPIEEQERLWEAGKHRSAHAQTN
CCCHHHHHHHHHHHHHHCCCCEEECCCCEECCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
PQNQYRHEHPAPERVPAIKASMITMSVMTVLLLDARWPSMIPFNLVGKLEGQLRFTDEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEECCCC
PVKVRWNLDDIVRFATDDLLVSTNELDPQVIAAINNGASVIEVPSRHDALGQAREVMRRA
CEEEEECHHHHHHHHHHHHEEECCCCCCCEEEEECCCCCEEECCCHHHHHHHHHHHHHHH
VARGEWEQTQTHESLLEYLDEETEEFAQAVAHGTTDHIVSELGDVLLQVLFHAEIGARHG
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
EFNLDDVAASFVTKMQQRSPYLFDGSDGVVPIEEQERLWEAGKHRSAHAQTN
CCCHHHHHHHHHHHHHHCCCCEEECCCCEECCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]