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The map label for this gene is lysI [H]

Identifier: 38233510

GI number: 38233510

Start: 888244

End: 889740

Strand: Reverse

Name: lysI [H]

Synonym: DIP0914

Alternate gene names: 38233510

Gene position: 889740-888244 (Counterclockwise)

Preceding gene: 38233520

Following gene: 38233501

Centisome position: 35.75

GC content: 55.38

Gene sequence:

>1497_bases
ATGACCACCCCGGCCACCATCGTCGAAGCAACTTCTGCCAAAAGCCATAGCGTCCGCATCTGGACACTCATTGGACTCAT
CATCGGCTCTACCGTTGGCTCCGGAATCTTCTCCCTGCCTCAAAACATCGCCTCCGTTGCCGCCCCAGGCGCCATGTTCA
TCGGCTGGCTGATCGCTGGAATCGGCATGCTCGCCGTCGCCTTCGTCTTCCAAATCTTGGCACACCGTAAGCCACACCTC
GATTCCGGCGTCTACTCCTACGTGCGTGCAGGACTTGGCGACTACATCGGATTTACTTCTGGTTGGGGTTACTGGCTCGG
CAGCGTTATAGCACAGGTCGGCTACGCCACCCTGTTTTTCTCCACGCTTGGCCACTACGTTCCGCTGTTTAACAGCGACA
ACCGCGTAGCCTCCGTCATCGGAGTCTCCCTTCTTACATGGGTAATTTTTGGCATTTTGTCCATGGGCGTCAAACAAGCG
GCCTTCATGAATGCCATCACCACAGTCGCTAAGCTCCTCCCCATTTTTGCCTTCATCATCCTCGTCGCCTTCCTAGGCTT
TAGCTGGGACAAACTTACTCTCGACTTCTGGGGCGAATCCACTGGCAGCAGCGTATTCGAACAGATCCAAGGCATTATGC
TGTTCACCGTCTGGGTCTTCATCGGCGTGGAGGGTGCATCGGTCTACTCCAAGCAAGCCCGCACGCGTCGCGACGTCGGC
CGCGCCACCGTCATCGGCTTTTTCACCGTGCTGGTACTCCTCGTCTCGGTTTCTACTCTGTCCTACGGCGTGCTCACACA
AGCCGAACTTGCCGCCCTTCCCGATAACTCCATGGCCAATGTCCTCGAGGCTGTTATCGGCACATGGGGAGCAGCACTAG
TATCCATCGGCCTATGCTTGAGCGTGCTGGGCGCCTATGTGTCATGGCAGATGTTGTGTGCAGAGCCTGTTGCCATGATG
GCTTTCGACGGCCTTTTGCCCCGCAAACTCGGCACCATTAATGCCACAGGCTCCCCTGTTATCGCACAGCTGATTTCCAC
CATTGTGATCCAACTATGGGTCTTCGTGTTTTTCCTCAACGAAACGACCTATATCTCCATGGTGCAATTAGCAACAGTTC
TCTACCTGCTGCCCTATGTGTTCTCCTCGCTCTACCTCATTTTGTTGGCTACCCGCGGCAAAGGAATCTCTCACCCTGCC
GCAGGCACGCGTTTCGACGACTCCGGCCCCGACGTCAGCGCAGCCGACAACCGCCGACACCTCTTTGTCGGTGCAGTCGC
ATTCGTTTACTCCCTGTGGCTGTTTTACGCAGCCGACTTGAAATACGTGCTCTTCGGCGCGCTCGCAGTTCTGCCAGGAT
TGATCCCCTACGTGTGGACTCGCCTGTACACAAAAGAACGAGTATTCAACGCCTTCGAATGGTTTGTTGTTGCACTCATT
ATCATCGCAGCAGGCTATGGTCTTTCGGGGATCATGACAGGATCAATGTCGCTATAA

Upstream 100 bases:

>100_bases
AATTTCTTGTAACCTTTAGCTTTACTTAACCGCGTTTAGAATTACTTCATTTATCTGTATAGAGGTGCACATGGCTGCCG
TTCCTAAGGGGACAGAATCG

Downstream 100 bases:

>100_bases
CCCCGACACCTTAATCCCAAGGGCTTTGGCCAACATCAAAGCCCTCAATATAGCCACGAATCGCCTCAGTTACCGCGTTG
ACTCCAAAAACAACTTCAGC

Product: L-lysine transport protein

Products: NA

Alternate protein names: L-lysine permease [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTTPATIVEATSAKSHSVRIWTLIGLIIGSTVGSGIFSLPQNIASVAAPGAMFIGWLIAGIGMLAVAFVFQILAHRKPHL
DSGVYSYVRAGLGDYIGFTSGWGYWLGSVIAQVGYATLFFSTLGHYVPLFNSDNRVASVIGVSLLTWVIFGILSMGVKQA
AFMNAITTVAKLLPIFAFIILVAFLGFSWDKLTLDFWGESTGSSVFEQIQGIMLFTVWVFIGVEGASVYSKQARTRRDVG
RATVIGFFTVLVLLVSVSTLSYGVLTQAELAALPDNSMANVLEAVIGTWGAALVSIGLCLSVLGAYVSWQMLCAEPVAMM
AFDGLLPRKLGTINATGSPVIAQLISTIVIQLWVFVFFLNETTYISMVQLATVLYLLPYVFSSLYLILLATRGKGISHPA
AGTRFDDSGPDVSAADNRRHLFVGAVAFVYSLWLFYAADLKYVLFGALAVLPGLIPYVWTRLYTKERVFNAFEWFVVALI
IIAAGYGLSGIMTGSMSL

Sequences:

>Translated_498_residues
MTTPATIVEATSAKSHSVRIWTLIGLIIGSTVGSGIFSLPQNIASVAAPGAMFIGWLIAGIGMLAVAFVFQILAHRKPHL
DSGVYSYVRAGLGDYIGFTSGWGYWLGSVIAQVGYATLFFSTLGHYVPLFNSDNRVASVIGVSLLTWVIFGILSMGVKQA
AFMNAITTVAKLLPIFAFIILVAFLGFSWDKLTLDFWGESTGSSVFEQIQGIMLFTVWVFIGVEGASVYSKQARTRRDVG
RATVIGFFTVLVLLVSVSTLSYGVLTQAELAALPDNSMANVLEAVIGTWGAALVSIGLCLSVLGAYVSWQMLCAEPVAMM
AFDGLLPRKLGTINATGSPVIAQLISTIVIQLWVFVFFLNETTYISMVQLATVLYLLPYVFSSLYLILLATRGKGISHPA
AGTRFDDSGPDVSAADNRRHLFVGAVAFVYSLWLFYAADLKYVLFGALAVLPGLIPYVWTRLYTKERVFNAFEWFVVALI
IIAAGYGLSGIMTGSMSL
>Mature_497_residues
TTPATIVEATSAKSHSVRIWTLIGLIIGSTVGSGIFSLPQNIASVAAPGAMFIGWLIAGIGMLAVAFVFQILAHRKPHLD
SGVYSYVRAGLGDYIGFTSGWGYWLGSVIAQVGYATLFFSTLGHYVPLFNSDNRVASVIGVSLLTWVIFGILSMGVKQAA
FMNAITTVAKLLPIFAFIILVAFLGFSWDKLTLDFWGESTGSSVFEQIQGIMLFTVWVFIGVEGASVYSKQARTRRDVGR
ATVIGFFTVLVLLVSVSTLSYGVLTQAELAALPDNSMANVLEAVIGTWGAALVSIGLCLSVLGAYVSWQMLCAEPVAMMA
FDGLLPRKLGTINATGSPVIAQLISTIVIQLWVFVFFLNETTYISMVQLATVLYLLPYVFSSLYLILLATRGKGISHPAA
GTRFDDSGPDVSAADNRRHLFVGAVAFVYSLWLFYAADLKYVLFGALAVLPGLIPYVWTRLYTKERVFNAFEWFVVALII
IAAGYGLSGIMTGSMSL

Specific function: Permease that is involved in the transport across the membrane of lysine [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1787890, Length=468, Percent_Identity=36.5384615384615, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI2367353, Length=474, Percent_Identity=26.1603375527426, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1790575, Length=392, Percent_Identity=25.5102040816327, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786908, Length=474, Percent_Identity=21.7299578059072, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24668806, Length=429, Percent_Identity=25.4079254079254, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21356285, Length=429, Percent_Identity=25.4079254079254, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24668802, Length=429, Percent_Identity=25.4079254079254, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53689; Mature: 53558

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHCCCCCCC
>Mature Secondary Structure 
TTPATIVEATSAKSHSVRIWTLIGLIIGSTVGSGIFSLPQNIASVAAPGAMFIGWLIAG
CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHH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HHHHCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1667221; 12948626 [H]