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The map label for this gene is mprB [H]

Identifier: 38233452

GI number: 38233452

Start: 828428

End: 829918

Strand: Direct

Name: mprB [H]

Synonym: DIP0855

Alternate gene names: 38233452

Gene position: 828428-829918 (Clockwise)

Preceding gene: 38233451

Following gene: 38233453

Centisome position: 33.29

GC content: 52.85

Gene sequence:

>1491_bases
ATGTCTGGGGATGCCCGCACTTCACACTTTTCGCGTGCGTCGCTTAAATCACGTATCTCTCTGCTTACTGCATCGATGGT
GGCAATTGCTGTGGGCATGATGCTTATCGTGTCGTATTGGTCCGTTTCTGGCACGCTGCGTAGTTCGATGGACCGCACTT
TGAACGCCAAGGCAACGGCGTTGATTAGTCGGATGGATCAGCCTGATTTTTTCTTCCGTTCTCAGTACGAGATCGACAAG
TTTCGTGAGTATAACGCGGATACCCGTATCTCGTTGCGAATGCCCGGCTGGAACTATTCTGTCGGCGACGATTTGCCGAT
GGTCAAGGGTGGCGGCGACGATGTCGAGGGGTATAGTGCTGCCACGATCAACGGTGAGCGAGTTTTAACTAAGGTGTCGG
ATTCCGGTGCCACCGTCATTTTGGCGCGCGGAATGGAAGCCACCCACAAGATGATTACTAGCTTGGCAATTACGCTGTTG
CTGGTAGCGGGTCTTGGTGTGCTAATGGCGATCGCTACAGGTGTAGCCGTCGCATCTACGGTGCTTCGTCCTTTGCGGCG
GTTGCGCAACCGAGTTCGTTATATTACGGAAACAGACGATCTCAAACCGATCCAAGTAGAAGGTAATGACGAGCTTTCCG
AGCTTACGACTCGTTTCAACGAGATGCTTGAGGCGTTACGACGTTCGCGTCAGCGTCAAACCGAGCTTGTTGCCGATGCC
GGCCATGAGCTGAAGACGCCGCTTACTTCTATGCGCACCAACATTGAATTGTTGATGATGATGCATAACACGGACTCTGC
TTCGATCAGTGAAGAAGATAAGCAGGCATTGCAGTCGGATGTGATTGCACAGATGGAGGAGCTTTCCACGCTGATCGGTG
ATCTTATCGATCTGGCACGTCAAGAAACCTCGGAGAAAACCTTAGAACCTATCGATCTGCTTGATGTGGTCAATTCTTCG
GTCGAGCGCGTGCGGCGGCGTCGTCCCGATGTGCGCTTCGAAATCCAGGCGATTCCGTGGTACCTCGAAGGTGACAGCTT
TGCCTTGGGGCGCGCAATTTTGAACCTCCTTGATAACGCATCAAAGTGGTCACCAGCTGATGGTGTTGTTCGTTTCACCA
TGCAGGTCGTAGAGCGTGAAGACGGCGATCGCGTTTTGCATATGGACATTTCTGATTCTGGTCCAGGTATTCCGGTCGAA
GATCGTGAAAAAGTTTTTGATCGCTTCTATAGATCGGTGAGCGCGCGTTCAACCCCAGGTTCTGGTTTGGGACTTGCCAT
CGTGCATTCCACGATCGTTCGCCACGGGGGAACTGTCACAGCTGGGGAATCCGACGACGGAGGCGCGCGGATGCGTGTCG
AGTTGCCAGGATCTGTTACGGATGAAGAACTCCATTCTTCATCAAAGACCCGTGTGGTTCAGCCAAGCAGCACTGCTGAG
CGCCTTGATCTGGCACGTCAACGTCGTGAGGAGCGTCGTAACGGCAAATAA

Upstream 100 bases:

>100_bases
TCCATACCGTTCGCGGTGTTGGCTACGTGCTGAGGGAAACTGCGCCGTGATGCTGCGCCGTTTCCGCGAAAGCCTGCCGG
GAGGGGCAGGCTTTTTAGGT

Downstream 100 bases:

>100_bases
TACGTTCACAGGAACCTCCCAGCGATTCACGACGCTACCCGCAGTGAGGTTCCAGAACGTCACCAGTATGTGGTCCGATA
GTATTTACTATGACAAATCC

Product: putative two component system sensor kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MSGDARTSHFSRASLKSRISLLTASMVAIAVGMMLIVSYWSVSGTLRSSMDRTLNAKATALISRMDQPDFFFRSQYEIDK
FREYNADTRISLRMPGWNYSVGDDLPMVKGGGDDVEGYSAATINGERVLTKVSDSGATVILARGMEATHKMITSLAITLL
LVAGLGVLMAIATGVAVASTVLRPLRRLRNRVRYITETDDLKPIQVEGNDELSELTTRFNEMLEALRRSRQRQTELVADA
GHELKTPLTSMRTNIELLMMMHNTDSASISEEDKQALQSDVIAQMEELSTLIGDLIDLARQETSEKTLEPIDLLDVVNSS
VERVRRRRPDVRFEIQAIPWYLEGDSFALGRAILNLLDNASKWSPADGVVRFTMQVVEREDGDRVLHMDISDSGPGIPVE
DREKVFDRFYRSVSARSTPGSGLGLAIVHSTIVRHGGTVTAGESDDGGARMRVELPGSVTDEELHSSSKTRVVQPSSTAE
RLDLARQRREERRNGK

Sequences:

>Translated_496_residues
MSGDARTSHFSRASLKSRISLLTASMVAIAVGMMLIVSYWSVSGTLRSSMDRTLNAKATALISRMDQPDFFFRSQYEIDK
FREYNADTRISLRMPGWNYSVGDDLPMVKGGGDDVEGYSAATINGERVLTKVSDSGATVILARGMEATHKMITSLAITLL
LVAGLGVLMAIATGVAVASTVLRPLRRLRNRVRYITETDDLKPIQVEGNDELSELTTRFNEMLEALRRSRQRQTELVADA
GHELKTPLTSMRTNIELLMMMHNTDSASISEEDKQALQSDVIAQMEELSTLIGDLIDLARQETSEKTLEPIDLLDVVNSS
VERVRRRRPDVRFEIQAIPWYLEGDSFALGRAILNLLDNASKWSPADGVVRFTMQVVEREDGDRVLHMDISDSGPGIPVE
DREKVFDRFYRSVSARSTPGSGLGLAIVHSTIVRHGGTVTAGESDDGGARMRVELPGSVTDEELHSSSKTRVVQPSSTAE
RLDLARQRREERRNGK
>Mature_495_residues
SGDARTSHFSRASLKSRISLLTASMVAIAVGMMLIVSYWSVSGTLRSSMDRTLNAKATALISRMDQPDFFFRSQYEIDKF
REYNADTRISLRMPGWNYSVGDDLPMVKGGGDDVEGYSAATINGERVLTKVSDSGATVILARGMEATHKMITSLAITLLL
VAGLGVLMAIATGVAVASTVLRPLRRLRNRVRYITETDDLKPIQVEGNDELSELTTRFNEMLEALRRSRQRQTELVADAG
HELKTPLTSMRTNIELLMMMHNTDSASISEEDKQALQSDVIAQMEELSTLIGDLIDLARQETSEKTLEPIDLLDVVNSSV
ERVRRRRPDVRFEIQAIPWYLEGDSFALGRAILNLLDNASKWSPADGVVRFTMQVVEREDGDRVLHMDISDSGPGIPVED
REKVFDRFYRSVSARSTPGSGLGLAIVHSTIVRHGGTVTAGESDDGGARMRVELPGSVTDEELHSSSKTRVVQPSSTAER
LDLARQRREERRNGK

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=316, Percent_Identity=29.1139240506329, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=282, Percent_Identity=30.4964539007092, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787374, Length=407, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=27.5618374558304, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788279, Length=326, Percent_Identity=25.1533742331288, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789808, Length=307, Percent_Identity=27.3615635179153, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787894, Length=263, Percent_Identity=31.1787072243346, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1789403, Length=358, Percent_Identity=27.0949720670391, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788713, Length=298, Percent_Identity=23.8255033557047, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=27.6, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790551, Length=310, Percent_Identity=26.1290322580645, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=25.974025974026, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=345, Percent_Identity=24.3478260869565, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790861, Length=288, Percent_Identity=25.6944444444444, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=272, Percent_Identity=25.3676470588235, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=28.6885245901639, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=25.6637168141593, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54936; Mature: 54805

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDARTSHFSRASLKSRISLLTASMVAIAVGMMLIVSYWSVSGTLRSSMDRTLNAKATA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISRMDQPDFFFRSQYEIDKFREYNADTRISLRMPGWNYSVGDDLPMVKGGGDDVEGYSA
HHHHCCCCCCHHCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
ATINGERVLTKVSDSGATVILARGMEATHKMITSLAITLLLVAGLGVLMAIATGVAVAST
EEECCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPLRRLRNRVRYITETDDLKPIQVEGNDELSELTTRFNEMLEALRRSRQRQTELVADA
HHHHHHHHHHHHHEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHELKTPLTSMRTNIELLMMMHNTDSASISEEDKQALQSDVIAQMEELSTLIGDLIDLAR
CCHHHCCHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QETSEKTLEPIDLLDVVNSSVERVRRRRPDVRFEIQAIPWYLEGDSFALGRAILNLLDNA
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCC
SKWSPADGVVRFTMQVVEREDGDRVLHMDISDSGPGIPVEDREKVFDRFYRSVSARSTPG
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SGLGLAIVHSTIVRHGGTVTAGESDDGGARMRVELPGSVTDEELHSSSKTRVVQPSSTAE
CCCHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCHHHHHCCCCCEEECCCCHHH
RLDLARQRREERRNGK
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SGDARTSHFSRASLKSRISLLTASMVAIAVGMMLIVSYWSVSGTLRSSMDRTLNAKATA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LISRMDQPDFFFRSQYEIDKFREYNADTRISLRMPGWNYSVGDDLPMVKGGGDDVEGYSA
HHHHCCCCCCHHCCCCCHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEE
ATINGERVLTKVSDSGATVILARGMEATHKMITSLAITLLLVAGLGVLMAIATGVAVAST
EEECCCEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPLRRLRNRVRYITETDDLKPIQVEGNDELSELTTRFNEMLEALRRSRQRQTELVADA
HHHHHHHHHHHHHEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GHELKTPLTSMRTNIELLMMMHNTDSASISEEDKQALQSDVIAQMEELSTLIGDLIDLAR
CCHHHCCHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QETSEKTLEPIDLLDVVNSSVERVRRRRPDVRFEIQAIPWYLEGDSFALGRAILNLLDNA
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHCC
SKWSPADGVVRFTMQVVEREDGDRVLHMDISDSGPGIPVEDREKVFDRFYRSVSARSTPG
CCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SGLGLAIVHSTIVRHGGTVTAGESDDGGARMRVELPGSVTDEELHSSSKTRVVQPSSTAE
CCCHHHHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCHHHHHCCCCCEEECCCCHHH
RLDLARQRREERRNGK
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA