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The map label for this gene is mprA [H]

Identifier: 38233451

GI number: 38233451

Start: 827685

End: 828377

Strand: Direct

Name: mprA [H]

Synonym: DIP0854

Alternate gene names: 38233451

Gene position: 827685-828377 (Clockwise)

Preceding gene: 38233450

Following gene: 38233452

Centisome position: 33.26

GC content: 55.12

Gene sequence:

>693_bases
ATGAAGATTGTGGTCGTAGATGATGAGCAGGCGGTGCGCGAGTCGCTTTGTCGTTCGTTGTCCTTTAACGGATATGAAGT
GCATCTGGCTCAAGATGGAGTCGAGGCACTTGAAGTAATTGAACGTGAACAACCAGAGCTGGTCATCCTTGACGTGATGA
TGCCACGCATGGATGGTCTTGAGGTTTGCCGCACCTTGCGTGGTAGCGGTGACGACCGTCCGATTTTGGTTCTGACCGCT
CGCGATGGTGTGTCTGATCGTGTTGCCGGCCTTGATGCTGGTGCAGACGACTACCTTCCTAAGCCATTCGCACTTGAGGA
GCTACTAGCTCGTGTGCGTTCCCTGCTTCGCCGTGCCGCTGCAGAGTCCGTCGGCTCCGGCAGCCAAGGGGAGCTTTCCT
TTGAGGATCTTCGCCTAAACCCCGATACGCGCGATGTCACCCGCGGTGGTCGCCCTATTAGCTTGACTCGCACTGAGTTT
GCGCTGCTCCAGTTGCTGATGGCGAATTCTCGTCGCGTACTTTCGCGTGCGTCGATCTTGGAAGAAGTGTGGGGATATGA
CTTCCCAACTTCTGGAAACGCACTGGAAGTCTATATTGGCTATTTGCGTCGCAAGACTGAATCAGAAGGGGAGCCACGTT
TGATCCATACCGTTCGCGGTGTTGGCTACGTGCTGAGGGAAACTGCGCCGTGA

Upstream 100 bases:

>100_bases
CAACGCACTATAAAATTGTTGCATTAAATGTAATTATTCATAGCTGACTCTGGGCGTTGCTTGAGGGTCGGTCTCGGCGG
GACAAGGCAGAATAGACTGA

Downstream 100 bases:

>100_bases
TGCTGCGCCGTTTCCGCGAAAGCCTGCCGGGAGGGGCAGGCTTTTTAGGTATGTCTGGGGATGCCCGCACTTCACACTTT
TCGCGTGCGTCGCTTAAATC

Product: putative two component system response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKIVVVDDEQAVRESLCRSLSFNGYEVHLAQDGVEALEVIEREQPELVILDVMMPRMDGLEVCRTLRGSGDDRPILVLTA
RDGVSDRVAGLDAGADDYLPKPFALEELLARVRSLLRRAAAESVGSGSQGELSFEDLRLNPDTRDVTRGGRPISLTRTEF
ALLQLLMANSRRVLSRASILEEVWGYDFPTSGNALEVYIGYLRRKTESEGEPRLIHTVRGVGYVLRETAP

Sequences:

>Translated_230_residues
MKIVVVDDEQAVRESLCRSLSFNGYEVHLAQDGVEALEVIEREQPELVILDVMMPRMDGLEVCRTLRGSGDDRPILVLTA
RDGVSDRVAGLDAGADDYLPKPFALEELLARVRSLLRRAAAESVGSGSQGELSFEDLRLNPDTRDVTRGGRPISLTRTEF
ALLQLLMANSRRVLSRASILEEVWGYDFPTSGNALEVYIGYLRRKTESEGEPRLIHTVRGVGYVLRETAP
>Mature_230_residues
MKIVVVDDEQAVRESLCRSLSFNGYEVHLAQDGVEALEVIEREQPELVILDVMMPRMDGLEVCRTLRGSGDDRPILVLTA
RDGVSDRVAGLDAGADDYLPKPFALEELLARVRSLLRRAAAESVGSGSQGELSFEDLRLNPDTRDVTRGGRPISLTRTEF
ALLQLLMANSRRVLSRASILEEVWGYDFPTSGNALEVYIGYLRRKTESEGEPRLIHTVRGVGYVLRETAP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=42.6666666666667, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=40.3587443946188, Blast_Score=165, Evalue=2e-42,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=40.5286343612335, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=40.0881057268723, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=36.1607142857143, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=40, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=38.1165919282511, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=37.1681415929204, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=32.8888888888889, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=38.4279475982533, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=33.3333333333333, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=31.8777292576419, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=32.15859030837, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=40.5940594059406, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790299, Length=144, Percent_Identity=30.5555555555556, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=38.2608695652174, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=38.3333333333333, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=35.8490566037736, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=35.3448275862069, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=31.0924369747899, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25542; Mature: 25542

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVVDDEQAVRESLCRSLSFNGYEVHLAQDGVEALEVIEREQPELVILDVMMPRMDGL
CEEEEECCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCEEEEEEHHCCCCHH
EVCRTLRGSGDDRPILVLTARDGVSDRVAGLDAGADDYLPKPFALEELLARVRSLLRRAA
HHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AESVGSGSQGELSFEDLRLNPDTRDVTRGGRPISLTRTEFALLQLLMANSRRVLSRASIL
HHHCCCCCCCCEEHHHEEECCCCHHHHCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHH
EEVWGYDFPTSGNALEVYIGYLRRKTESEGEPRLIHTVRGVGYVLRETAP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIVVVDDEQAVRESLCRSLSFNGYEVHLAQDGVEALEVIEREQPELVILDVMMPRMDGL
CEEEEECCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCCEEEEEEHHCCCCHH
EVCRTLRGSGDDRPILVLTARDGVSDRVAGLDAGADDYLPKPFALEELLARVRSLLRRAA
HHHHHHHCCCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
AESVGSGSQGELSFEDLRLNPDTRDVTRGGRPISLTRTEFALLQLLMANSRRVLSRASIL
HHHCCCCCCCCEEHHHEEECCCCHHHHCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHH
EEVWGYDFPTSGNALEVYIGYLRRKTESEGEPRLIHTVRGVGYVLRETAP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA