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The map label for this gene is mug [H]

Identifier: 38233425

GI number: 38233425

Start: 804154

End: 804705

Strand: Reverse

Name: mug [H]

Synonym: DIP0828

Alternate gene names: 38233425

Gene position: 804705-804154 (Counterclockwise)

Preceding gene: 38233427

Following gene: 38233423

Centisome position: 32.34

GC content: 57.07

Gene sequence:

>552_bases
GTGTCGGATCGAATTCCCAATTCCGACCTCCGATTATTAATCGTGGGCGTCAACCCAGGATTATGGACAGCCGCCGTTAA
CGCACCCTTCGCTCATCCAGGAAACAGATTTTGGCCCTCCCTTGACCGCGCAGGCATTGTCACCCCACGCTTTGACGTCT
CCCACGGAATGAGCGATGAACAAGAAAAACACCTAGCCCACCTCGGAATCGGCATGACAAACCTCGTAGCACGAGCTACT
GCCCGCGCCGACGAACTCACCACACAAGAGCTTATCGACGGCGCCCAACGCGTCATCCACCTCGCCAATGCTTTGCGCCC
GCGCGTAGTCGCCGTGGTAGGAATTACCGCTTATCGCGCCGGGTTTCAACACCGTAAGGCAGTGTTGGGCAAGCAGGATC
CAACCCTCATTGCTGACTGGCCCGAAGATGTTGCGTTGTGGGTTGTGCCCCAACCGAGTGGTCTTAATGCCCATGAAACA
GTGGAGACACTAGCCCAGCGTTGGCGCGACGTCTGGGACGACAGCGCACTATCTTCTCGATCTCCTCACTAG

Upstream 100 bases:

>100_bases
GAGGGGGGTACAAAAGGTAGGTATGAGTACAGCGCATCCTTCCCCAATGGGCGGGGCTAAGCCTACCCGCGATCAGCTTG
CACAGTTTGCCAACGCCACG

Downstream 100 bases:

>100_bases
CGTCGCCCACCAGATTGGAATCCGCCTCGGCGCAGTCGTGGATGCTGCTCCTGCTGATCCTCAAGATCGCTTAGGGCTTG
GCTTAGCCTGCGACCTCGCG

Product: putative DNA repair protein

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 183; Mature: 182

Protein sequence:

>183_residues
MSDRIPNSDLRLLIVGVNPGLWTAAVNAPFAHPGNRFWPSLDRAGIVTPRFDVSHGMSDEQEKHLAHLGIGMTNLVARAT
ARADELTTQELIDGAQRVIHLANALRPRVVAVVGITAYRAGFQHRKAVLGKQDPTLIADWPEDVALWVVPQPSGLNAHET
VETLAQRWRDVWDDSALSSRSPH

Sequences:

>Translated_183_residues
MSDRIPNSDLRLLIVGVNPGLWTAAVNAPFAHPGNRFWPSLDRAGIVTPRFDVSHGMSDEQEKHLAHLGIGMTNLVARAT
ARADELTTQELIDGAQRVIHLANALRPRVVAVVGITAYRAGFQHRKAVLGKQDPTLIADWPEDVALWVVPQPSGLNAHET
VETLAQRWRDVWDDSALSSRSPH
>Mature_182_residues
SDRIPNSDLRLLIVGVNPGLWTAAVNAPFAHPGNRFWPSLDRAGIVTPRFDVSHGMSDEQEKHLAHLGIGMTNLVARATA
RADELTTQELIDGAQRVIHLANALRPRVVAVVGITAYRAGFQHRKAVLGKQDPTLIADWPEDVALWVVPQPSGLNAHETV
ETLAQRWRDVWDDSALSSRSPH

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Escherichia coli, GI1789449, Length=181, Percent_Identity=34.8066298342541, Blast_Score=108, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21356805, Length=146, Percent_Identity=31.5068493150685, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 20124; Mature: 19993

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRIPNSDLRLLIVGVNPGLWTAAVNAPFAHPGNRFWPSLDRAGIVTPRFDVSHGMSDE
CCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
QEKHLAHLGIGMTNLVARATARADELTTQELIDGAQRVIHLANALRPRVVAVVGITAYRA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
GFQHRKAVLGKQDPTLIADWPEDVALWVVPQPSGLNAHETVETLAQRWRDVWDDSALSSR
HHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SPH
CCC
>Mature Secondary Structure 
SDRIPNSDLRLLIVGVNPGLWTAAVNAPFAHPGNRFWPSLDRAGIVTPRFDVSHGMSDE
CCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
QEKHLAHLGIGMTNLVARATARADELTTQELIDGAQRVIHLANALRPRVVAVVGITAYRA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
GFQHRKAVLGKQDPTLIADWPEDVALWVVPQPSGLNAHETVETLAQRWRDVWDDSALSSR
HHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
SPH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA