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The map label for this gene is uvrD [H]

Identifier: 38233332

GI number: 38233332

Start: 700467

End: 702518

Strand: Direct

Name: uvrD [H]

Synonym: DIP0726

Alternate gene names: 38233332

Gene position: 700467-702518 (Clockwise)

Preceding gene: 38233331

Following gene: 38233334

Centisome position: 28.15

GC content: 54.19

Gene sequence:

>2052_bases
ATGATTAACTTGGATGATCTTGACGATGACCAGCGTGCAGCCGCCGAGGCGCCGCGTGGTCCGGTAGCCATTTTGGCAGG
CGCAGGGACAGGTAAAACTCGTACGATCACCTACCGGATAGCGCACTTGATTGACCGTGGCATGGCAAGCCCTCATCGCG
TGCTCGCAGTTACCTTCACGCGTCGCGCTGCTGGGGAAATGCGGCATCGTCTGGGGTTGATGGGCGTTGGTGGCGTTCAA
GCCCAAACATTTCACTCTGCTGCGCTGCGACAACTACGCTATTTTTGGCCACAGGTAGCCGGGAATTTGCCATGGCGAAT
TGTTGACAACAAATTTTCACTGGTGGGTCGCGCAACTCGTAGCGTCGGGGTGGAATCCTCAACAGAAAATGTTCGAGATC
TACTCAGCGAAATCGAATGGGCCAAAGCAGCACTGATCACTCCTGATAACTATGTGGAACGCCTCAACGGGCGCAAGACC
CCAGTAGCAGCCGAAAAAGTGGCGGAAGTATATCGACGATACGAGCAGTCGAAAACTACACCGGAAGGAATGCTGCTCGA
CTTTGATGACTTGCTGCTTCATACCGCCGGAGCCATCGAGAATTCTGCTGCTATCGCAGAGGAATTTCGGCAACAATACC
GCACGTTCGTTGTCGACGAGTACCAGGACGTGACGCCACTGCAACAGCGGGTCTTAGACGCATGGCTTGGCGAACGCGAT
GATGTGACCGTGGTGGGCGATGCCAATCAGACGATCTACTCGTTTACAGGCGCTTCACCAGACTATTTGCTGGGGTTTTC
ACGCAAATATCCCCATGCCACGGTGGTGAAACTGCAACGAGACTACCGTTCTACACCGCAAATTACAGATCTTGCTAACC
GCGTGATCGACCAAGCAGTAGGGCGGATCGCAGGGACTCGGTTGGAATTAGAAGGCATGCGTACAGCAGGACCGCAACCA
GAATTTCAAGAATTCAGCGACGAACCCGCAGAAGCACACGCCGTAGCCTTGAAAATCAAGCAGCTTCTAGCACAAGGCGT
TCCTGCCTCCGAGATTGCGATTTTGTACCGCATTAATGCCCAATCCGCGACTTTCGAACAAGCCCTCGATGACGCTGGAA
TTGTGTATCAAGTTCGCGGCGGTGAGGAATTCTTCCAGCGTTCGGAAATCAAACAAGCGATGTCAGAGATCATCCGAACT
ACTCAGCGTGATGACCTTCCCGACGCTCGTGGAGTAGACCTAGAACGCATCGTGCGTGCAATATTAGCGCCGCTGGGTTT
GAGCAAACATGAACCAGAAGGCGCCCGCGCACGGGAACGCTGGCAGTCGTTGGAAGCTCTTGCAGAACTGAGCTTGGAAA
TTGGCCAAGCGACACCAGACTTAAACCTTCAAGGGTTATTAGCAGCACTCAACCAGCGAGCAAGCGCCAAGCATCCCCCC
ACCATGCAAGGGGTTACCTTGGCATCCCTCCACGCAGCGAAGGGCTTGGAATGGGACGCCGTATTCCTCGTTGGGCTTGT
CGACGGCACCCTGCCGATCTCTCACGCAATGAAAGCGGGCGATCATGCCATCGAGGAAGAACGCCGCCTGTTTTATGTGG
GCGTGACGCGTGCCCGAGAAATTTTATATTGCTCGTGGGCAAAAGCTCGCCAAGAAGGCGGACGTGCAACACGAAAGCGG
ACTCGTTTTTTGGACAGCATAGTTCCTGAACTCGATGTTTCCTCCGTACCACCACGCTCTAAACGACGCCAGCGCTGTCG
TGTATGCGGCACCACATTGAACAGTCCCGCAGAACGCATCGTGGGACGCTGTGACCAATGCCCCAGCGGAGTTGATGGAG
AAGTGTTTGAAACTCTGCGGAAATGGCGAGCGGATACAGCCCGTGAACTCAACGTTCCGGCCTATATTGTGTTCACCGAT
GCCACCTTGCATGCGATAGCCGAAAATCTTCCGCAATCCGCCGAAGAGCTGATGCAGATTTCTGGAATAGGGCAGGTCAA
AGTAGAACGTTTTGGCCCAGGTCTGCTAGAAACGCTTGTTCCGTTCCAGTAA

Upstream 100 bases:

>100_bases
ATAACGTGGGCGTCGCGAAGCGAACTCCGCGAAGGGGTATTTACCCTGCCACATAGGAATTCTCTAGCGTTCCAATTGAT
CACAGAATGGGTGGGACAAC

Downstream 100 bases:

>100_bases
GCGGATCGCAGTCCCAGCGACTCGACCAACATAATGGGCAACGGGAATGCGGACTCATGATCTCGGATGAAAGCTCCCCA
TCGGAGGAGACGCGGATAAC

Product: putative DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 683; Mature: 683

Protein sequence:

>683_residues
MINLDDLDDDQRAAAEAPRGPVAILAGAGTGKTRTITYRIAHLIDRGMASPHRVLAVTFTRRAAGEMRHRLGLMGVGGVQ
AQTFHSAALRQLRYFWPQVAGNLPWRIVDNKFSLVGRATRSVGVESSTENVRDLLSEIEWAKAALITPDNYVERLNGRKT
PVAAEKVAEVYRRYEQSKTTPEGMLLDFDDLLLHTAGAIENSAAIAEEFRQQYRTFVVDEYQDVTPLQQRVLDAWLGERD
DVTVVGDANQTIYSFTGASPDYLLGFSRKYPHATVVKLQRDYRSTPQITDLANRVIDQAVGRIAGTRLELEGMRTAGPQP
EFQEFSDEPAEAHAVALKIKQLLAQGVPASEIAILYRINAQSATFEQALDDAGIVYQVRGGEEFFQRSEIKQAMSEIIRT
TQRDDLPDARGVDLERIVRAILAPLGLSKHEPEGARARERWQSLEALAELSLEIGQATPDLNLQGLLAALNQRASAKHPP
TMQGVTLASLHAAKGLEWDAVFLVGLVDGTLPISHAMKAGDHAIEEERRLFYVGVTRAREILYCSWAKARQEGGRATRKR
TRFLDSIVPELDVSSVPPRSKRRQRCRVCGTTLNSPAERIVGRCDQCPSGVDGEVFETLRKWRADTARELNVPAYIVFTD
ATLHAIAENLPQSAEELMQISGIGQVKVERFGPGLLETLVPFQ

Sequences:

>Translated_683_residues
MINLDDLDDDQRAAAEAPRGPVAILAGAGTGKTRTITYRIAHLIDRGMASPHRVLAVTFTRRAAGEMRHRLGLMGVGGVQ
AQTFHSAALRQLRYFWPQVAGNLPWRIVDNKFSLVGRATRSVGVESSTENVRDLLSEIEWAKAALITPDNYVERLNGRKT
PVAAEKVAEVYRRYEQSKTTPEGMLLDFDDLLLHTAGAIENSAAIAEEFRQQYRTFVVDEYQDVTPLQQRVLDAWLGERD
DVTVVGDANQTIYSFTGASPDYLLGFSRKYPHATVVKLQRDYRSTPQITDLANRVIDQAVGRIAGTRLELEGMRTAGPQP
EFQEFSDEPAEAHAVALKIKQLLAQGVPASEIAILYRINAQSATFEQALDDAGIVYQVRGGEEFFQRSEIKQAMSEIIRT
TQRDDLPDARGVDLERIVRAILAPLGLSKHEPEGARARERWQSLEALAELSLEIGQATPDLNLQGLLAALNQRASAKHPP
TMQGVTLASLHAAKGLEWDAVFLVGLVDGTLPISHAMKAGDHAIEEERRLFYVGVTRAREILYCSWAKARQEGGRATRKR
TRFLDSIVPELDVSSVPPRSKRRQRCRVCGTTLNSPAERIVGRCDQCPSGVDGEVFETLRKWRADTARELNVPAYIVFTD
ATLHAIAENLPQSAEELMQISGIGQVKVERFGPGLLETLVPFQ
>Mature_683_residues
MINLDDLDDDQRAAAEAPRGPVAILAGAGTGKTRTITYRIAHLIDRGMASPHRVLAVTFTRRAAGEMRHRLGLMGVGGVQ
AQTFHSAALRQLRYFWPQVAGNLPWRIVDNKFSLVGRATRSVGVESSTENVRDLLSEIEWAKAALITPDNYVERLNGRKT
PVAAEKVAEVYRRYEQSKTTPEGMLLDFDDLLLHTAGAIENSAAIAEEFRQQYRTFVVDEYQDVTPLQQRVLDAWLGERD
DVTVVGDANQTIYSFTGASPDYLLGFSRKYPHATVVKLQRDYRSTPQITDLANRVIDQAVGRIAGTRLELEGMRTAGPQP
EFQEFSDEPAEAHAVALKIKQLLAQGVPASEIAILYRINAQSATFEQALDDAGIVYQVRGGEEFFQRSEIKQAMSEIIRT
TQRDDLPDARGVDLERIVRAILAPLGLSKHEPEGARARERWQSLEALAELSLEIGQATPDLNLQGLLAALNQRASAKHPP
TMQGVTLASLHAAKGLEWDAVFLVGLVDGTLPISHAMKAGDHAIEEERRLFYVGVTRAREILYCSWAKARQEGGRATRKR
TRFLDSIVPELDVSSVPPRSKRRQRCRVCGTTLNSPAERIVGRCDQCPSGVDGEVFETLRKWRADTARELNVPAYIVFTD
ATLHAIAENLPQSAEELMQISGIGQVKVERFGPGLLETLVPFQ

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=661, Percent_Identity=30.8623298033283, Blast_Score=235, Evalue=8e-63,
Organism=Escherichia coli, GI48994965, Length=413, Percent_Identity=31.4769975786925, Blast_Score=163, Evalue=4e-41,
Organism=Escherichia coli, GI48994977, Length=61, Percent_Identity=49.1803278688525, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324477, Length=391, Percent_Identity=24.2966751918159, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=439, Percent_Identity=28.4738041002278, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR002121
- InterPro:   IPR014016
- InterPro:   IPR010997 [H]

Pfam domain/function: PF00570 HRDC; PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 75673; Mature: 75673

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINLDDLDDDQRAAAEAPRGPVAILAGAGTGKTRTITYRIAHLIDRGMASPHRVLAVTFT
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCEEEEEEEH
RRAAGEMRHRLGLMGVGGVQAQTFHSAALRQLRYFWPQVAGNLPWRIVDNKFSLVGRATR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
SVGVESSTENVRDLLSEIEWAKAALITPDNYVERLNGRKTPVAAEKVAEVYRRYEQSKTT
HCCCCCCHHHHHHHHHHHHHHHHEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
PEGMLLDFDDLLLHTAGAIENSAAIAEEFRQQYRTFVVDEYQDVTPLQQRVLDAWLGERD
CCCEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
DVTVVGDANQTIYSFTGASPDYLLGFSRKYPHATVVKLQRDYRSTPQITDLANRVIDQAV
CEEEEECCCCEEEEECCCCCHHEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GRIAGTRLELEGMRTAGPQPEFQEFSDEPAEAHAVALKIKQLLAQGVPASEIAILYRINA
HHHHCCEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECC
QSATFEQALDDAGIVYQVRGGEEFFQRSEIKQAMSEIIRTTQRDDLPDARGVDLERIVRA
CCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
ILAPLGLSKHEPEGARARERWQSLEALAELSLEIGQATPDLNLQGLLAALNQRASAKHPP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
TMQGVTLASLHAAKGLEWDAVFLVGLVDGTLPISHAMKAGDHAIEEERRLFYVGVTRARE
CCCCCHHHHHHHHCCCCCHHEEEEEHHCCCCCHHHHHHHCCHHHHHCCEEEEEEHHHHHH
ILYCSWAKARQEGGRATRKRTRFLDSIVPELDVSSVPPRSKRRQRCRVCGTTLNSPAERI
HHEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
VGRCDQCPSGVDGEVFETLRKWRADTARELNVPAYIVFTDATLHAIAENLPQSAEELMQI
HHHHHCCCCCCCHHHHHHHHHHHCCCHHCCCCCEEEEEECHHHHHHHHHCCHHHHHHHHH
SGIGQVKVERFGPGLLETLVPFQ
CCCCCEEHHHCCCHHHHHHCCCC
>Mature Secondary Structure
MINLDDLDDDQRAAAEAPRGPVAILAGAGTGKTRTITYRIAHLIDRGMASPHRVLAVTFT
CCCCCCCCCHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCEEEEEEEH
RRAAGEMRHRLGLMGVGGVQAQTFHSAALRQLRYFWPQVAGNLPWRIVDNKFSLVGRATR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHH
SVGVESSTENVRDLLSEIEWAKAALITPDNYVERLNGRKTPVAAEKVAEVYRRYEQSKTT
HCCCCCCHHHHHHHHHHHHHHHHEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
PEGMLLDFDDLLLHTAGAIENSAAIAEEFRQQYRTFVVDEYQDVTPLQQRVLDAWLGERD
CCCEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
DVTVVGDANQTIYSFTGASPDYLLGFSRKYPHATVVKLQRDYRSTPQITDLANRVIDQAV
CEEEEECCCCEEEEECCCCCHHEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GRIAGTRLELEGMRTAGPQPEFQEFSDEPAEAHAVALKIKQLLAQGVPASEIAILYRINA
HHHHCCEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHEEEEEEECC
QSATFEQALDDAGIVYQVRGGEEFFQRSEIKQAMSEIIRTTQRDDLPDARGVDLERIVRA
CCHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
ILAPLGLSKHEPEGARARERWQSLEALAELSLEIGQATPDLNLQGLLAALNQRASAKHPP
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCC
TMQGVTLASLHAAKGLEWDAVFLVGLVDGTLPISHAMKAGDHAIEEERRLFYVGVTRARE
CCCCCHHHHHHHHCCCCCHHEEEEEHHCCCCCHHHHHHHCCHHHHHCCEEEEEEHHHHHH
ILYCSWAKARQEGGRATRKRTRFLDSIVPELDVSSVPPRSKRRQRCRVCGTTLNSPAERI
HHEEHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
VGRCDQCPSGVDGEVFETLRKWRADTARELNVPAYIVFTDATLHAIAENLPQSAEELMQI
HHHHHCCCCCCCHHHHHHHHHHHCCCHHCCCCCEEEEEECHHHHHHHHHCCHHHHHHHHH
SGIGQVKVERFGPGLLETLVPFQ
CCCCCEEHHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]