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The map label for this gene is ahcY

Identifier: 38233299

GI number: 38233299

Start: 666509

End: 667945

Strand: Direct

Name: ahcY

Synonym: DIP0692

Alternate gene names: 38233299

Gene position: 666509-667945 (Clockwise)

Preceding gene: 38233298

Following gene: 38233300

Centisome position: 26.78

GC content: 53.79

Gene sequence:

>1437_bases
ATGGCTGCTTTTGATTACAACGTGAAAGACCTCAGCTTGGCTGAGGCCGGCCGCCACCAGATTCGTCTAGCCGAGTATGA
AATGCCTGGCCTTATGCAGTTGCGTGAGGAATACCAGCAAGAGCAGCCATTGGCGGGCGCTCGAATCACCGGTTCGATCC
ATATGACGGTTCAGACCGCAGTGCTTATCGAGACTCTAGTTGCCTTGGGTGCTCAGGTGCGTTGGGCTTCCTGCAATATT
TTCTCTACTCAGGACGAGGCTGCCGCAGCTGTCGTCGTTGGTCCGCATGGCACTCCTGAAGACCCCCAAGGTGTCCCAGT
GTTTGCGTGGAAAGGTGAGACGCTCGAAGAGTACTGGGACTGCGTAGATAAGATCTTTAGCTGGGGTGATGAGCTTCCTA
ACATGATCTTGGACGATGGCGGCGATGCCACCATGGCTGTGATCCGTGGTAAGCAGTTCGAGGAAGCTGGCATGGTCCCA
CCAGTCGAAGAAGGCGACTCGGATGAGTACCAAGCATTCCTTGGCATGTTGCGCAAGACCTTGGCAGAGCAGCCTGGTAA
ATGGACCGCCATTGCCGAGTCCGTCAAGGGCGTGACGGAAGAAACCACCACTGGTGTCCACCGTCTCTACCATTTCGCAG
AAGAAGGCGTTTTGCCGTTCCCTGCAATGAACGTCAACGATGCAGTGACCAAGTCCAAGTTTGACAACAAGTACGGCACT
CGCCATTCGCTTATCGACGGAATCAACCGCGCCACCGATATGCTGATGGGCGGAAAGAACGTGCTGATCTGTGGCTATGG
CGATGTGGGCAAGGGCTGTGCAGAAGCCATGGCTGGCCAGGGTGCACGCGTAAAGGTCACCGAAGCTGATCCGATCAATG
CTTTGCAGGCTTTGATGGATGGTTTCCCAGTGGTCCATGTTGATCAAGCTATTGGCGATGCCGACATTGTGATTACTGCG
ACTGGCAACATGGGCATCATCTCCTTTGAGCAGATGCTCGCTATGAAAGATCACGCAGTGTTGGGCAACATCGGCCACTT
TGACAATGAGATCGACATGGCCTCGTTACTGCACCGCGATGATGTTTCGCGTGTGACCATCAAGCCACAAGTTGACGAGT
TCACGTTGCCTAATGGCAAGTCCATTGTGGTGCTGTCGGAAGGCCGCCTTCTGAATTTGGGCAATGCAACCGGACACCCT
AGCTTCGTGATGTCTACCTCCTTTGCTGACCAAACCATCGCGCAGATTGAGCTTTTCCAAAATGATGGCCGATACGTCAA
CGAGGTATACCGCCTGCCAAAGATCTTGGACGAAAAGGTCGCTCGTATCCATGTCGAGGCATTGGGTGGCACGATTACCG
AACTGACAAAGGAGCAAGCCGAATACATCGGAGTTGATGTTGCTGGCCCTTACAAGCCGGAGCATTACCGCTACTAA

Upstream 100 bases:

>100_bases
TTTTCCCAGCTTGTGTGTCACGTGCTACCTGTAGGCTGGGTTCGATTTGTTTCTGCACTCCCTTTTTTGACGCAATTTCC
CCAAGGAGAGAATAGCCACG

Downstream 100 bases:

>100_bases
TGATCATCGCGATTGAGGGTATTGATGGCGCTGGCAAGAACACCTTGGTCAGCGCCATCAAGGAGCGTTTCGACGCCGAT
GTGATCGGTTTCCCACGCTA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MAAFDYNVKDLSLAEAGRHQIRLAEYEMPGLMQLREEYQQEQPLAGARITGSIHMTVQTAVLIETLVALGAQVRWASCNI
FSTQDEAAAAVVVGPHGTPEDPQGVPVFAWKGETLEEYWDCVDKIFSWGDELPNMILDDGGDATMAVIRGKQFEEAGMVP
PVEEGDSDEYQAFLGMLRKTLAEQPGKWTAIAESVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
RHSLIDGINRATDMLMGGKNVLICGYGDVGKGCAEAMAGQGARVKVTEADPINALQALMDGFPVVHVDQAIGDADIVITA
TGNMGIISFEQMLAMKDHAVLGNIGHFDNEIDMASLLHRDDVSRVTIKPQVDEFTLPNGKSIVVLSEGRLLNLGNATGHP
SFVMSTSFADQTIAQIELFQNDGRYVNEVYRLPKILDEKVARIHVEALGGTITELTKEQAEYIGVDVAGPYKPEHYRY

Sequences:

>Translated_478_residues
MAAFDYNVKDLSLAEAGRHQIRLAEYEMPGLMQLREEYQQEQPLAGARITGSIHMTVQTAVLIETLVALGAQVRWASCNI
FSTQDEAAAAVVVGPHGTPEDPQGVPVFAWKGETLEEYWDCVDKIFSWGDELPNMILDDGGDATMAVIRGKQFEEAGMVP
PVEEGDSDEYQAFLGMLRKTLAEQPGKWTAIAESVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
RHSLIDGINRATDMLMGGKNVLICGYGDVGKGCAEAMAGQGARVKVTEADPINALQALMDGFPVVHVDQAIGDADIVITA
TGNMGIISFEQMLAMKDHAVLGNIGHFDNEIDMASLLHRDDVSRVTIKPQVDEFTLPNGKSIVVLSEGRLLNLGNATGHP
SFVMSTSFADQTIAQIELFQNDGRYVNEVYRLPKILDEKVARIHVEALGGTITELTKEQAEYIGVDVAGPYKPEHYRY
>Mature_477_residues
AAFDYNVKDLSLAEAGRHQIRLAEYEMPGLMQLREEYQQEQPLAGARITGSIHMTVQTAVLIETLVALGAQVRWASCNIF
STQDEAAAAVVVGPHGTPEDPQGVPVFAWKGETLEEYWDCVDKIFSWGDELPNMILDDGGDATMAVIRGKQFEEAGMVPP
VEEGDSDEYQAFLGMLRKTLAEQPGKWTAIAESVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGTR
HSLIDGINRATDMLMGGKNVLICGYGDVGKGCAEAMAGQGARVKVTEADPINALQALMDGFPVVHVDQAIGDADIVITAT
GNMGIISFEQMLAMKDHAVLGNIGHFDNEIDMASLLHRDDVSRVTIKPQVDEFTLPNGKSIVVLSEGRLLNLGNATGHPS
FVMSTSFADQTIAQIELFQNDGRYVNEVYRLPKILDEKVARIHVEALGGTITELTKEQAEYIGVDVAGPYKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=473, Percent_Identity=50.9513742071882, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI239937451, Length=451, Percent_Identity=51.219512195122, Blast_Score=437, Evalue=1e-123,
Organism=Homo sapiens, GI298286489, Length=475, Percent_Identity=46.7368421052632, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI195539349, Length=475, Percent_Identity=46.7368421052632, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI24308043, Length=475, Percent_Identity=46.7368421052632, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI195539337, Length=475, Percent_Identity=46.7368421052632, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI21361647, Length=475, Percent_Identity=44.8421052631579, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17506425, Length=477, Percent_Identity=50.314465408805, Blast_Score=452, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6320882, Length=492, Percent_Identity=49.1869918699187, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24642172, Length=479, Percent_Identity=52.1920668058455, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24656245, Length=476, Percent_Identity=45.1680672268908, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553387, Length=475, Percent_Identity=45.4736842105263, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI45553385, Length=474, Percent_Identity=45.3586497890295, Blast_Score=403, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_CORDI (P61456)

Other databases:

- EMBL:   BX248355
- RefSeq:   NP_939066.1
- ProteinModelPortal:   P61456
- SMR:   P61456
- GeneID:   2650626
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP0692
- NMPDR:   fig|257309.1.peg.657
- HOGENOM:   HBG352029
- OMA:   WLNANAV
- PhylomeDB:   P61456
- ProtClustDB:   PRK05476
- BioCyc:   CDIP257309:DIP0692-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52209; Mature: 52078

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 56-56 BINDING 139-139 BINDING 201-201 BINDING 231-231 BINDING 235-235 BINDING 236-236 BINDING 288-288 BINDING 323-323 BINDING 392-392

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAFDYNVKDLSLAEAGRHQIRLAEYEMPGLMQLREEYQQEQPLAGARITGSIHMTVQTA
CCCCCCCCCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECEEEEEHHHH
VLIETLVALGAQVRWASCNIFSTQDEAAAAVVVGPHGTPEDPQGVPVFAWKGETLEEYWD
HHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHH
CVDKIFSWGDELPNMILDDGGDATMAVIRGKQFEEAGMVPPVEEGDSDEYQAFLGMLRKT
HHHHHHHHHHHCCCCEECCCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LAEQPGKWTAIAESVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
HHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCC
RHSLIDGINRATDMLMGGKNVLICGYGDVGKGCAEAMAGQGARVKVTEADPINALQALMD
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHC
GFPVVHVDQAIGDADIVITATGNMGIISFEQMLAMKDHAVLGNIGHFDNEIDMASLLHRD
CCCEEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHC
DVSRVTIKPQVDEFTLPNGKSIVVLSEGRLLNLGNATGHPSFVMSTSFADQTIAQIELFQ
CCCEEEECCCCCCEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCCCHHHHHHEEEEC
NDGRYVNEVYRLPKILDEKVARIHVEALGGTITELTKEQAEYIGVDVAGPYKPEHYRY
CCCHHHHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHEEEECCCCCCCCCCCC
>Mature Secondary Structure 
AAFDYNVKDLSLAEAGRHQIRLAEYEMPGLMQLREEYQQEQPLAGARITGSIHMTVQTA
CCCCCCCCCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECEEEEEHHHH
VLIETLVALGAQVRWASCNIFSTQDEAAAAVVVGPHGTPEDPQGVPVFAWKGETLEEYWD
HHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHH
CVDKIFSWGDELPNMILDDGGDATMAVIRGKQFEEAGMVPPVEEGDSDEYQAFLGMLRKT
HHHHHHHHHHHCCCCEECCCCCEEEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHH
LAEQPGKWTAIAESVKGVTEETTTGVHRLYHFAEEGVLPFPAMNVNDAVTKSKFDNKYGT
HHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCC
RHSLIDGINRATDMLMGGKNVLICGYGDVGKGCAEAMAGQGARVKVTEADPINALQALMD
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHC
GFPVVHVDQAIGDADIVITATGNMGIISFEQMLAMKDHAVLGNIGHFDNEIDMASLLHRD
CCCEEEECCCCCCCCEEEEECCCCCEEEHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHC
DVSRVTIKPQVDEFTLPNGKSIVVLSEGRLLNLGNATGHPSFVMSTSFADQTIAQIELFQ
CCCEEEECCCCCCEECCCCCEEEEEECCCEEECCCCCCCCCEEEECCCCHHHHHHEEEEC
NDGRYVNEVYRLPKILDEKVARIHVEALGGTITELTKEQAEYIGVDVAGPYKPEHYRY
CCCHHHHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910