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The map label for this gene is purE [H]

Identifier: 38233271

GI number: 38233271

Start: 641251

End: 641751

Strand: Direct

Name: purE [H]

Synonym: DIP0664

Alternate gene names: 38233271

Gene position: 641251-641751 (Clockwise)

Preceding gene: 38233270

Following gene: 38233272

Centisome position: 25.77

GC content: 56.09

Gene sequence:

>501_bases
ATGACACCACTCGTAGGCCTTATCATGGGCTCCGACTCCGACTGGCCCACCGTTGAACCAGCCGCCGAGGTACTCGCCGA
ATTCGGCATCCCCTTCGAAGTAGGCGTAGTTTCTGCACACCGTACTCCAGAGAAAATGCTGGCATACGCAAAAACCGCAC
ATGAGCGCGGTCTAAAATGTATCATTGCCTGCGCCGGCGGTGCCGCACACCTACCTGGCATGGTCGCAGCAGCCACCCCG
CTACCCGTCATCGGAATCCCACGCGCTCTCAAAGAACTCGACGGCATGGATTCTCTGCTCTCCATCGTCCAAATGCCAGG
CGGGGTTCCCGTTGCTACCGTCTCCATTGGAGGCGCTAAAAACGCAGGACTGTTGGCCGCACGAATTCTTGGCGCCGGTG
ATCCAGAACTAGTAACCAAGATGGCTGACTACCAAGAAAACATGCGCCAAGAAGTTGAGCGCAAAGATGCCAACCTCAAG
AAGAAATTGATGGGCGAGTAA

Upstream 100 bases:

>100_bases
TCGGTCACGTCAACATGGCCGGCACGGATGCAGAAGAACTGAAAACCGCAGCTGAAAACGCCGCCTACTACCTCGTTCAC
GCCGAATGGAAGGAACAATA

Downstream 100 bases:

>100_bases
GTTTTTGTTCCGGAAGGAATCGACGATTCTTGTCTTGGGCTCCAAAGTCAGGGGAGCCCAACCAGGTCACGTGTTGCGCT
GGCGACTCGAGCATGCGCTT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTPLVGLIMGSDSDWPTVEPAAEVLAEFGIPFEVGVVSAHRTPEKMLAYAKTAHERGLKCIIACAGGAAHLPGMVAAATP
LPVIGIPRALKELDGMDSLLSIVQMPGGVPVATVSIGGAKNAGLLAARILGAGDPELVTKMADYQENMRQEVERKDANLK
KKLMGE

Sequences:

>Translated_166_residues
MTPLVGLIMGSDSDWPTVEPAAEVLAEFGIPFEVGVVSAHRTPEKMLAYAKTAHERGLKCIIACAGGAAHLPGMVAAATP
LPVIGIPRALKELDGMDSLLSIVQMPGGVPVATVSIGGAKNAGLLAARILGAGDPELVTKMADYQENMRQEVERKDANLK
KKLMGE
>Mature_165_residues
TPLVGLIMGSDSDWPTVEPAAEVLAEFGIPFEVGVVSAHRTPEKMLAYAKTAHERGLKCIIACAGGAAHLPGMVAAATPL
PVIGIPRALKELDGMDSLLSIVQMPGGVPVATVSIGGAKNAGLLAARILGAGDPELVTKMADYQENMRQEVERKDANLKK
KLMGE

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=150, Percent_Identity=51.3333333333333, Blast_Score=129, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324702, Length=158, Percent_Identity=61.3924050632911, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17312; Mature: 17180

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLVGLIMGSDSDWPTVEPAAEVLAEFGIPFEVGVVSAHRTPEKMLAYAKTAHERGLKC
CCCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEE
IIACAGGAAHLPGMVAAATPLPVIGIPRALKELDGMDSLLSIVQMPGGVPVATVSIGGAK
EEEECCCHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAARILGAGDPELVTKMADYQENMRQEVERKDANLKKKLMGE
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPLVGLIMGSDSDWPTVEPAAEVLAEFGIPFEVGVVSAHRTPEKMLAYAKTAHERGLKC
CCCEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCEE
IIACAGGAAHLPGMVAAATPLPVIGIPRALKELDGMDSLLSIVQMPGGVPVATVSIGGAK
EEEECCCHHHCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCC
NAGLLAARILGAGDPELVTKMADYQENMRQEVERKDANLKKKLMGE
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8998996 [H]