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The map label for this gene is accBC [H]

Identifier: 38233256

GI number: 38233256

Start: 622563

End: 624347

Strand: Reverse

Name: accBC [H]

Synonym: DIP0649

Alternate gene names: 38233256

Gene position: 624347-622563 (Counterclockwise)

Preceding gene: 38233257

Following gene: 38233255

Centisome position: 25.09

GC content: 59.33

Gene sequence:

>1785_bases
GTGTCTGTGGAACAGAAGAAGATCACTAAGGTGCTCATCGCAAACCGCGGTGAGATCGCCGTCCGCGTTATCCGTGCAGC
CCGCGATGCCGGCATCGCCAGCGTCGCCGTGTACGCAGAGCCCGATGCAGACGCTCCTTTCGTCTCCATGGCTGACGAGG
CATTTGCACTAGGTGGCCAAACCTCCGCCGAGTCCTACCTTGTCTTTGACAAGATCCTCGACGCGGCCAAGAAATCCGGC
GCCGACGCCATCCACCCAGGCTATGGCTTCCTCTCTGAAAACGGCGACTTCGCCGAAGCAGTTATCAATGCAGGCCTGAT
CTGGATCGGCCCATCGCCGCAGTCCATCCGCGACCTCGGCGACAAAGTCACTGCACGCCACATCGCGCTTAAAGCCGAAG
CACCTATGGCACCAGGCACCAAAGAGCCAGTCAAAGACGCCTCCGAGGTCGTCGCCTTCGCAGAAGAGCACGGACTTCCC
ATCGCTATTAAGGCAGCATTCGGCGGCGGCGGACGCGGCATGAAAGTTGCCTACACCATGGATGAAGTAGCCGACCTCTA
CGAATCCGCAACCCGCGAGGCAGTGGCAGCCTTCGGTCGCGGCGAATGCTTCGTCGAGCGTTACCTCGACAAAGCACGCC
ACGTCGAGTGCCAAGTCATCGCAGATATGCACGGCAACGTTGTTGTCGCAGGCACCCGCGACTGCTCCCTCCAGCGCCGA
TTCCAAAAGCTCGTCGAAGAAGCACCAGCCCCATTCCTTACCGACGACCAGCGCACCCGCCTTCACGAATCCGCCAAAGC
CATCTGTAAAGAAGCTGGTTACTACGGTGCCGGCACCGTAGAGTACCTCGTCGGCTCCGACGGACTGATCTCCTTCCTTG
AGGTCAACACCCGCCTCCAGGTGGAACACCCCGTCACCGAGGTCACCACCGGCCTCGACTTGGTACGCGAGCAATTCCGC
ATCGCAGAAGGCAAAGAACTCCACATCAAACAAGACCCAACCCCTCGTGGACACGCCTTCGAATTCCGAATCAACGGCGA
AGACGCAGGCTCAAACTTCATGCCCGCACCAGGCAAGGTCACCAAGTACATCGAGCCTTCCGGCCCAGGTGTACGCATGG
ACTCCGGTATCGTCGAAGGCTCCGTCATCGGCGGCCAATTCGACTCCATGCTCGCCAAGCTCATCGTCTTCGGAGAAACC
CGTGACGAAGCACTCCAACGCGCATCCCGCGCTCTTAATGAGTACGTCGTCGAAGGCATGCCCACCGTCTTGCCATTCCA
CCGCCACATCGTGGAAAACCCAGCCTTCATCGGCGACGGCGAAAAATTCGAGGTCTACACCAAGTGGATCGAAGAAGAGT
GGAACAACCCGATCGAGCCATACGTCGACCCAACAGATGTGGATGATGAAGAAGCAGCACTGCCATCCCAGAAAGTTGTC
GTGGAAATCGACGGCCGCCGCGTAGAAATCGCACTACCAGGCGACCTCGCACTCGGCGGCGGCGCAGGTGCACCAAAGAA
GAAAGCCAAGAAGCGCCGCGCAGGTGGCTCCAAGGCTGCCATCTCTGGCGACGCTGTTGCAGCACCAATGCAGGGCACCG
TCATCAAGATCAACGCCGAAGAAGGCGCCGAAGTAGCTGAAGGCGACACCGTCGTCGTCCTCGAAGCAATGAAGATGGAA
AACCCCGTCAAGGCACACAAGTCCGGTGTGGTCACCGGTCTAGCCATCGCCGCTGGCGAAGGCGTAACCAAGGGCCAAGT
ACTCCTCGAGATCAAAGACGCCTAA

Upstream 100 bases:

>100_bases
GACTGACAATGGTGTAGCAACCTATAGCGAGATGTCATGCCACGCCCCTAGAATTGCTACACCAGCCCCAAAAATTTTCA
TCAGAACCAGGAGAGCTTCA

Downstream 100 bases:

>100_bases
ACGCCCTTAAAAAGACTCAGGCTCGTCACCTCGCTGGCTTACTGCCTTACTGCGCTGAAATTACGAGCCTGACGTCACCC
CACCTGGGCCTTCCCGCAGG

Product: acyl coenzyme A carboxylase

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MSVEQKKITKVLIANRGEIAVRVIRAARDAGIASVAVYAEPDADAPFVSMADEAFALGGQTSAESYLVFDKILDAAKKSG
ADAIHPGYGFLSENGDFAEAVINAGLIWIGPSPQSIRDLGDKVTARHIALKAEAPMAPGTKEPVKDASEVVAFAEEHGLP
IAIKAAFGGGGRGMKVAYTMDEVADLYESATREAVAAFGRGECFVERYLDKARHVECQVIADMHGNVVVAGTRDCSLQRR
FQKLVEEAPAPFLTDDQRTRLHESAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEVTTGLDLVREQFR
IAEGKELHIKQDPTPRGHAFEFRINGEDAGSNFMPAPGKVTKYIEPSGPGVRMDSGIVEGSVIGGQFDSMLAKLIVFGET
RDEALQRASRALNEYVVEGMPTVLPFHRHIVENPAFIGDGEKFEVYTKWIEEEWNNPIEPYVDPTDVDDEEAALPSQKVV
VEIDGRRVEIALPGDLALGGGAGAPKKKAKKRRAGGSKAAISGDAVAAPMQGTVIKINAEEGAEVAEGDTVVVLEAMKME
NPVKAHKSGVVTGLAIAAGEGVTKGQVLLEIKDA

Sequences:

>Translated_594_residues
MSVEQKKITKVLIANRGEIAVRVIRAARDAGIASVAVYAEPDADAPFVSMADEAFALGGQTSAESYLVFDKILDAAKKSG
ADAIHPGYGFLSENGDFAEAVINAGLIWIGPSPQSIRDLGDKVTARHIALKAEAPMAPGTKEPVKDASEVVAFAEEHGLP
IAIKAAFGGGGRGMKVAYTMDEVADLYESATREAVAAFGRGECFVERYLDKARHVECQVIADMHGNVVVAGTRDCSLQRR
FQKLVEEAPAPFLTDDQRTRLHESAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEVTTGLDLVREQFR
IAEGKELHIKQDPTPRGHAFEFRINGEDAGSNFMPAPGKVTKYIEPSGPGVRMDSGIVEGSVIGGQFDSMLAKLIVFGET
RDEALQRASRALNEYVVEGMPTVLPFHRHIVENPAFIGDGEKFEVYTKWIEEEWNNPIEPYVDPTDVDDEEAALPSQKVV
VEIDGRRVEIALPGDLALGGGAGAPKKKAKKRRAGGSKAAISGDAVAAPMQGTVIKINAEEGAEVAEGDTVVVLEAMKME
NPVKAHKSGVVTGLAIAAGEGVTKGQVLLEIKDA
>Mature_593_residues
SVEQKKITKVLIANRGEIAVRVIRAARDAGIASVAVYAEPDADAPFVSMADEAFALGGQTSAESYLVFDKILDAAKKSGA
DAIHPGYGFLSENGDFAEAVINAGLIWIGPSPQSIRDLGDKVTARHIALKAEAPMAPGTKEPVKDASEVVAFAEEHGLPI
AIKAAFGGGGRGMKVAYTMDEVADLYESATREAVAAFGRGECFVERYLDKARHVECQVIADMHGNVVVAGTRDCSLQRRF
QKLVEEAPAPFLTDDQRTRLHESAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQVEHPVTEVTTGLDLVREQFRI
AEGKELHIKQDPTPRGHAFEFRINGEDAGSNFMPAPGKVTKYIEPSGPGVRMDSGIVEGSVIGGQFDSMLAKLIVFGETR
DEALQRASRALNEYVVEGMPTVLPFHRHIVENPAFIGDGEKFEVYTKWIEEEWNNPIEPYVDPTDVDDEEAALPSQKVVV
EIDGRRVEIALPGDLALGGGAGAPKKKAKKRRAGGSKAAISGDAVAAPMQGTVIKINAEEGAEVAEGDTVVVLEAMKMEN
PVKAHKSGVVTGLAIAAGEGVTKGQVLLEIKDA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI295821183, Length=642, Percent_Identity=38.006230529595, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI65506442, Length=679, Percent_Identity=36.3770250368188, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI189095269, Length=677, Percent_Identity=36.4844903988183, Blast_Score=376, Evalue=1e-104,
Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=44.0715883668904, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI106049528, Length=457, Percent_Identity=43.3260393873085, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI106049295, Length=457, Percent_Identity=43.3260393873085, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI106049292, Length=457, Percent_Identity=43.3260393873085, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI38679977, Length=496, Percent_Identity=32.0564516129032, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI38679967, Length=496, Percent_Identity=32.0564516129032, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI38679974, Length=496, Percent_Identity=32.0564516129032, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI38679971, Length=496, Percent_Identity=32.0564516129032, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI38679960, Length=496, Percent_Identity=32.0564516129032, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI134142062, Length=509, Percent_Identity=30.6483300589391, Blast_Score=206, Evalue=5e-53,
Organism=Escherichia coli, GI1789654, Length=443, Percent_Identity=46.0496613995485, Blast_Score=358, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71987519, Length=661, Percent_Identity=37.2163388804841, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567343, Length=452, Percent_Identity=43.8053097345133, Blast_Score=368, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17562816, Length=441, Percent_Identity=43.5374149659864, Blast_Score=348, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI133931226, Length=466, Percent_Identity=28.9699570815451, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=27.0428015564202, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=27.0428015564202, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6319695, Length=437, Percent_Identity=45.5377574370709, Blast_Score=358, Evalue=2e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=437, Percent_Identity=45.9954233409611, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=41.3551401869159, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6323863, Length=477, Percent_Identity=29.3501048218029, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=29.3774319066148, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24651757, Length=474, Percent_Identity=42.8270042194093, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652212, Length=441, Percent_Identity=45.3514739229025, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652210, Length=441, Percent_Identity=45.3514739229025, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652214, Length=441, Percent_Identity=45.3514739229025, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI19921944, Length=441, Percent_Identity=45.3514739229025, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652216, Length=441, Percent_Identity=45.3514739229025, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI281363050, Length=441, Percent_Identity=45.3514739229025, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652224, Length=441, Percent_Identity=45.3514739229025, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652222, Length=441, Percent_Identity=45.3514739229025, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652220, Length=441, Percent_Identity=45.3514739229025, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24652218, Length=441, Percent_Identity=45.3514739229025, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24651759, Length=430, Percent_Identity=42.093023255814, Blast_Score=319, Evalue=4e-87,
Organism=Drosophila melanogaster, GI161076409, Length=503, Percent_Identity=30.4174950298211, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24586458, Length=503, Percent_Identity=30.4174950298211, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI161076407, Length=503, Percent_Identity=30.4174950298211, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24586460, Length=503, Percent_Identity=30.4174950298211, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 63476; Mature: 63344

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEQKKITKVLIANRGEIAVRVIRAARDAGIASVAVYAEPDADAPFVSMADEAFALGGQ
CCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCHHHCCCCC
TSAESYLVFDKILDAAKKSGADAIHPGYGFLSENGDFAEAVINAGLIWIGPSPQSIRDLG
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCEEEECCCCHHHHHHH
DKVTARHIALKAEAPMAPGTKEPVKDASEVVAFAEEHGLPIAIKAAFGGGGRGMKVAYTM
HHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEH
DEVADLYESATREAVAAFGRGECFVERYLDKARHVECQVIADMHGNVVVAGTRDCSLQRR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCHHHHH
FQKLVEEAPAPFLTDDQRTRLHESAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEEE
VEHPVTEVTTGLDLVREQFRIAEGKELHIKQDPTPRGHAFEFRINGEDAGSNFMPAPGKV
ECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCE
TKYIEPSGPGVRMDSGIVEGSVIGGQFDSMLAKLIVFGETRDEALQRASRALNEYVVEGM
EEEECCCCCCEEECCCCEECEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PTVLPFHRHIVENPAFIGDGEKFEVYTKWIEEEWNNPIEPYVDPTDVDDEEAALPSQKVV
CHHHHHHHHHHCCCCEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEE
VEIDGRRVEIALPGDLALGGGAGAPKKKAKKRRAGGSKAAISGDAVAAPMQGTVIKINAE
EEECCCEEEEEECCCEEECCCCCCCHHHHHHHHCCCCCEEECCCCEECCCCCEEEEEECC
EGAEVAEGDTVVVLEAMKMENPVKAHKSGVVTGLAIAAGEGVTKGQVLLEIKDA
CCCCCCCCCEEEEEEEHHCCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SVEQKKITKVLIANRGEIAVRVIRAARDAGIASVAVYAEPDADAPFVSMADEAFALGGQ
CCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCHHHCCCCC
TSAESYLVFDKILDAAKKSGADAIHPGYGFLSENGDFAEAVINAGLIWIGPSPQSIRDLG
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCEEEECCCCHHHHHHH
DKVTARHIALKAEAPMAPGTKEPVKDASEVVAFAEEHGLPIAIKAAFGGGGRGMKVAYTM
HHHHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEEH
DEVADLYESATREAVAAFGRGECFVERYLDKARHVECQVIADMHGNVVVAGTRDCSLQRR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCCHHHHH
FQKLVEEAPAPFLTDDQRTRLHESAKAICKEAGYYGAGTVEYLVGSDGLISFLEVNTRLQ
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCEEE
VEHPVTEVTTGLDLVREQFRIAEGKELHIKQDPTPRGHAFEFRINGEDAGSNFMPAPGKV
ECCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCE
TKYIEPSGPGVRMDSGIVEGSVIGGQFDSMLAKLIVFGETRDEALQRASRALNEYVVEGM
EEEECCCCCCEEECCCCEECEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
PTVLPFHRHIVENPAFIGDGEKFEVYTKWIEEEWNNPIEPYVDPTDVDDEEAALPSQKVV
CHHHHHHHHHHCCCCEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEE
VEIDGRRVEIALPGDLALGGGAGAPKKKAKKRRAGGSKAAISGDAVAAPMQGTVIKINAE
EEECCCEEEEEECCCEEECCCCCCCHHHHHHHHCCCCCEEECCCCEECCCCCEEEEEECC
EGAEVAEGDTVVVLEAMKMENPVKAHKSGVVTGLAIAAGEGVTKGQVLLEIKDA
CCCCCCCCCEEEEEEEHHCCCCHHHHHCCCEEEEEEECCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7909542; 11234002 [H]