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The map label for this gene is moeZ [H]

Identifier: 38233104

GI number: 38233104

Start: 457757

End: 458800

Strand: Reverse

Name: moeZ [H]

Synonym: DIP0492

Alternate gene names: 38233104

Gene position: 458800-457757 (Counterclockwise)

Preceding gene: 38233105

Following gene: 38233077

Centisome position: 18.44

GC content: 54.12

Gene sequence:

>1044_bases
ATGACTATTGACCACGCACGCTATGCCCGTCAGATCGCGCTCAGTGGTTTTGGTGTAGCTGGGCAAACAGCGCTTTCTGG
TGCGCATGTGGTCTGCATTGGTGCTGGTGGTCTCGGCTCCCCTGCCGCCTTGTACCTTGCTGCAGCAGGTGTTGGCACCA
TTACGATTATCGACGATGATGTGGTCGATCGTTCCAACCTACAACGCCAAATCATGCACTCCGATGAGGCGGTTGGTCAG
CCTAAGGTCGAATCAGCACTGCAGCGTCTGCGCGCATTGAATCCGGATTGCCGTGTTGTGGCGATCAATAAGCGCTGTGT
GTGGCCTGCTTGCCTCGATATGTGCCGCGACGCTGATGTGATTATCGACGGCTCTGATAATTTTGATACCCGTTACGTTG
CCAGCACCACGGCAGCACGCCTTGGTATTCCGCACGTGTGGGGAGCAATTTTGGGGTTCCAAGCACAACTGAGTGTATTC
GATGCTGAGCATGGCCCTGTGTATGAGGATGTATTTCCACAGCCTCCCCTGCCAGGCGATGTACCCAACTGTGCAGAAGC
AGGAGTTCTTGGTCCGCTCGTTGGTGTTGTAGGCTCTGCCATGGCGTTGGAGGCGATCAAGCTCATCACAGGAATTGGGC
AGCCGCTCACCGGAAACATCGGCTATTTCGACGGCATGACTGGATTGTGGGAATATATTCCTATTAGTTCTCATGCCGAT
ACTCGCCGTCAACTGCGTGTAGAACCTCCTCGGCACACCGCCACAGTGCGCGAGACAACAAAGGTAGATTCAAAAAAATA
CACAACCATTATTGATGTGCGAGAACCTGAAGAAACCCACCACGGGACGATCCCGAATGCTCGCCTTGTTCCGTTATCAC
TTATCGAAAACGACCTCAATACGGCACGCTCGCTTATCCCCGATGGTTCGCTGCTCTATTGCGCCGCAGGAATACGCTCG
GCGCGGGCATGTATTCTGCTTTCCCGCGCCGGCGTTAAAGACCTTGTGAGCCTATCAGGTGGCTACAACCAATGGAGTGC
CTAA

Upstream 100 bases:

>100_bases
TTGATGCAGCAAGCGCAGTAGCTGATGAAGTCAAAGCTTCGGTTCCGATCTGGAAAGAGCAGAAAATGGCAGATGGTTCC
ATCCAGTGGGTTGGACTCTG

Downstream 100 bases:

>100_bases
AACAGCGTCTTCGGGTCAGTTTTCGTTGCTAATGCGCAGGCCAGTAGGATTCGTGACTGCCCGGCGCGCAGGATGTCTGC
ACCAATCACGCCTTTGGCGG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTIDHARYARQIALSGFGVAGQTALSGAHVVCIGAGGLGSPAALYLAAAGVGTITIIDDDVVDRSNLQRQIMHSDEAVGQ
PKVESALQRLRALNPDCRVVAINKRCVWPACLDMCRDADVIIDGSDNFDTRYVASTTAARLGIPHVWGAILGFQAQLSVF
DAEHGPVYEDVFPQPPLPGDVPNCAEAGVLGPLVGVVGSAMALEAIKLITGIGQPLTGNIGYFDGMTGLWEYIPISSHAD
TRRQLRVEPPRHTATVRETTKVDSKKYTTIIDVREPEETHHGTIPNARLVPLSLIENDLNTARSLIPDGSLLYCAAGIRS
ARACILLSRAGVKDLVSLSGGYNQWSA

Sequences:

>Translated_347_residues
MTIDHARYARQIALSGFGVAGQTALSGAHVVCIGAGGLGSPAALYLAAAGVGTITIIDDDVVDRSNLQRQIMHSDEAVGQ
PKVESALQRLRALNPDCRVVAINKRCVWPACLDMCRDADVIIDGSDNFDTRYVASTTAARLGIPHVWGAILGFQAQLSVF
DAEHGPVYEDVFPQPPLPGDVPNCAEAGVLGPLVGVVGSAMALEAIKLITGIGQPLTGNIGYFDGMTGLWEYIPISSHAD
TRRQLRVEPPRHTATVRETTKVDSKKYTTIIDVREPEETHHGTIPNARLVPLSLIENDLNTARSLIPDGSLLYCAAGIRS
ARACILLSRAGVKDLVSLSGGYNQWSA
>Mature_346_residues
TIDHARYARQIALSGFGVAGQTALSGAHVVCIGAGGLGSPAALYLAAAGVGTITIIDDDVVDRSNLQRQIMHSDEAVGQP
KVESALQRLRALNPDCRVVAINKRCVWPACLDMCRDADVIIDGSDNFDTRYVASTTAARLGIPHVWGAILGFQAQLSVFD
AEHGPVYEDVFPQPPLPGDVPNCAEAGVLGPLVGVVGSAMALEAIKLITGIGQPLTGNIGYFDGMTGLWEYIPISSHADT
RRQLRVEPPRHTATVRETTKVDSKKYTTIIDVREPEETHHGTIPNARLVPLSLIENDLNTARSLIPDGSLLYCAAGIRSA
RACILLSRAGVKDLVSLSGGYNQWSA

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=319, Percent_Identity=36.0501567398119, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI38045948, Length=103, Percent_Identity=36.8932038834951, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787048, Length=233, Percent_Identity=39.9141630901288, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI87082356, Length=234, Percent_Identity=42.7350427350427, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1789177, Length=87, Percent_Identity=40.2298850574713, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540406, Length=383, Percent_Identity=31.331592689295, Blast_Score=175, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321903, Length=211, Percent_Identity=44.0758293838863, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24582879, Length=377, Percent_Identity=35.8090185676393, Blast_Score=197, Evalue=8e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 36941; Mature: 36809

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIDHARYARQIALSGFGVAGQTALSGAHVVCIGAGGLGSPAALYLAAAGVGTITIIDDD
CCCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECC
VVDRSNLQRQIMHSDEAVGQPKVESALQRLRALNPDCRVVAINKRCVWPACLDMCRDADV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCE
IIDGSDNFDTRYVASTTAARLGIPHVWGAILGFQAQLSVFDAEHGPVYEDVFPQPPLPGD
EEECCCCCCCEEEHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCCHHHCCCCCCCCCC
VPNCAEAGVLGPLVGVVGSAMALEAIKLITGIGQPLTGNIGYFDGMTGLWEYIPISSHAD
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
TRRQLRVEPPRHTATVRETTKVDSKKYTTIIDVREPEETHHGTIPNARLVPLSLIENDLN
CHHHEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHCCCCCCCCEEEEHHHHHHHHH
TARSLIPDGSLLYCAAGIRSARACILLSRAGVKDLVSLSGGYNQWSA
HHHHHCCCCCEEEEEHHHHHHHEEEEEECCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TIDHARYARQIALSGFGVAGQTALSGAHVVCIGAGGLGSPAALYLAAAGVGTITIIDDD
CCCHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECC
VVDRSNLQRQIMHSDEAVGQPKVESALQRLRALNPDCRVVAINKRCVWPACLDMCRDADV
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCE
IIDGSDNFDTRYVASTTAARLGIPHVWGAILGFQAQLSVFDAEHGPVYEDVFPQPPLPGD
EEECCCCCCCEEEHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCCHHHCCCCCCCCCC
VPNCAEAGVLGPLVGVVGSAMALEAIKLITGIGQPLTGNIGYFDGMTGLWEYIPISSHAD
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
TRRQLRVEPPRHTATVRETTKVDSKKYTTIIDVREPEETHHGTIPNARLVPLSLIENDLN
CHHHEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHCCCCCCCCEEEEHHHHHHHHH
TARSLIPDGSLLYCAAGIRSARACILLSRAGVKDLVSLSGGYNQWSA
HHHHHCCCCCEEEEEHHHHHHHEEEEEECCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]