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The map label for this gene is lpd [H]

Identifier: 38232984

GI number: 38232984

Start: 334658

End: 336067

Strand: Direct

Name: lpd [H]

Synonym: DIP0368

Alternate gene names: 38232984

Gene position: 334658-336067 (Clockwise)

Preceding gene: 38232975

Following gene: 38232986

Centisome position: 13.45

GC content: 55.32

Gene sequence:

>1410_bases
GTGACTGAACATTATGACGTAGTAGTACTCGGTGCAGGCCCTGGTGGCTATGTCGCCGCCATCCGCGCAGCCCAGCTTGG
CAAGAAGGTTGCAGTCGTTGAAAAGCAGTACTGGGGAGGTGTCTGTCTCAACGTCGGTTGTATCCCTTCCAAGGCGCTTC
TGAAAAACGCTGAGGTAGCGCACATCTTTAACCATGAGGCAAAGACCTTCGGCATTAGTGGCGACGTGTCCTTTGACTTC
GGTGCTGCTCATAAGCGCTCCCGCCAGGTATCTTCCGGAATCGTCAAGGGTGTCCACTACTTGATGAAGAAGAACAAGAT
CACCGAAATCGACGGCCTCGGCTCCTTTAAAGACGCCAAGACCATCGAGATCACCGAGGGTAACGACGCCGGCAAGGTAG
TTACTTTCGATGACTGCATTATCGCCACCGGTTCCGTCGTGCGTTCCCTGCCTGGTGTGACCATCGGCGGTAACATCGTT
TCCTTCGAAGAGCAGATCCTCAAGGAAGAAGCACCAAAGTCCATGGTGATCGTGGGCGCCGGCGCTATCGGTATGGAGTT
TGCTTACGTTCTCGTTAACTACGGCGTAGACATCACCATCGTGGAATTCATGGACCGCGTACTGCCTAACGAGGATGCAG
ACGTATCCAAGGAGATCGCAAAGCAGTACAAGAAGCTCGGCGTGAAACTGCTGACCGGTTACAAGACCACCGCCATCACC
GATAACGGCGACAACGTCACCGTCGAGGTGGAGTCCAAGGACGGCTCCAAGAAAGACAGCCTCACCGTTGAGCGCTGCAT
GGTGTCCATCGGATTCGCACCACGTGTTGAAGGCTACGGCCTCGAAAACACCGGTGTGAAGCTCACCGAGCGCGGCGCTA
TCGAAATCGACGACTTCATGCGCACCAACGTCGACCACATTTACGCAATTGGCGACGTCACCGCGAAACTGCAGCTGGCA
CACGTTGCAGAAGCACAGGGTGTTGTTGCCGCCGAGGTTATCGCCGGTGCTGAAACCCAAGAACTGGGCGACTACATGAT
GATGCCACGCGCTACCTTCTGTAACCCACAGGTTGCCTCCTTCGGCTACACCGAAGAGCAGGCGAAGGCAAAGTTCGAAG
GCCGTGAGATCAAGACCGCCACCTTCCCATTCTCTGCCAACGGCAAGGCAGCCGGCCTCGCTGAAACTGCAGGCTTTGTC
AAGATCGTTGCAGACGCAGAATTTGGCGAGATCGTCGGTGCACACATGGTTGGCGCAAACGTCTCCGAACTGCTGCCAGA
ACTCACCTTGGCACAGCGTTTCGACCTCACCTGTGAAGAAATCGGACGCAACGTTCATACGCACCCAACCCTGTCTGAGG
CAATGAAGGAAGCCGCAGAAGGAATCATGGGTCACATGATCAACCTCTAA

Upstream 100 bases:

>100_bases
TGGCCTACCCCGAAAGCCACGCTTCGGGGTAGGCCATCTTTTTGTTTAATTTGAGCAGAGGGCACGACAATTTGATGTGA
TGCACGTATCCTAGGAAATT

Downstream 100 bases:

>100_bases
AAACCATGAAGATGCTCCTCGTTGCCGCACCTGGCAGCGGGGAGCGTCGGCGTATCATGTGGCCTATGGCTCATACCCCT
AAGTGCCCCGTGCGGTATGG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of alpha keto acid dehydrogenase complexes [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MTEHYDVVVLGAGPGGYVAAIRAAQLGKKVAVVEKQYWGGVCLNVGCIPSKALLKNAEVAHIFNHEAKTFGISGDVSFDF
GAAHKRSRQVSSGIVKGVHYLMKKNKITEIDGLGSFKDAKTIEITEGNDAGKVVTFDDCIIATGSVVRSLPGVTIGGNIV
SFEEQILKEEAPKSMVIVGAGAIGMEFAYVLVNYGVDITIVEFMDRVLPNEDADVSKEIAKQYKKLGVKLLTGYKTTAIT
DNGDNVTVEVESKDGSKKDSLTVERCMVSIGFAPRVEGYGLENTGVKLTERGAIEIDDFMRTNVDHIYAIGDVTAKLQLA
HVAEAQGVVAAEVIAGAETQELGDYMMMPRATFCNPQVASFGYTEEQAKAKFEGREIKTATFPFSANGKAAGLAETAGFV
KIVADAEFGEIVGAHMVGANVSELLPELTLAQRFDLTCEEIGRNVHTHPTLSEAMKEAAEGIMGHMINL

Sequences:

>Translated_469_residues
MTEHYDVVVLGAGPGGYVAAIRAAQLGKKVAVVEKQYWGGVCLNVGCIPSKALLKNAEVAHIFNHEAKTFGISGDVSFDF
GAAHKRSRQVSSGIVKGVHYLMKKNKITEIDGLGSFKDAKTIEITEGNDAGKVVTFDDCIIATGSVVRSLPGVTIGGNIV
SFEEQILKEEAPKSMVIVGAGAIGMEFAYVLVNYGVDITIVEFMDRVLPNEDADVSKEIAKQYKKLGVKLLTGYKTTAIT
DNGDNVTVEVESKDGSKKDSLTVERCMVSIGFAPRVEGYGLENTGVKLTERGAIEIDDFMRTNVDHIYAIGDVTAKLQLA
HVAEAQGVVAAEVIAGAETQELGDYMMMPRATFCNPQVASFGYTEEQAKAKFEGREIKTATFPFSANGKAAGLAETAGFV
KIVADAEFGEIVGAHMVGANVSELLPELTLAQRFDLTCEEIGRNVHTHPTLSEAMKEAAEGIMGHMINL
>Mature_468_residues
TEHYDVVVLGAGPGGYVAAIRAAQLGKKVAVVEKQYWGGVCLNVGCIPSKALLKNAEVAHIFNHEAKTFGISGDVSFDFG
AAHKRSRQVSSGIVKGVHYLMKKNKITEIDGLGSFKDAKTIEITEGNDAGKVVTFDDCIIATGSVVRSLPGVTIGGNIVS
FEEQILKEEAPKSMVIVGAGAIGMEFAYVLVNYGVDITIVEFMDRVLPNEDADVSKEIAKQYKKLGVKLLTGYKTTAITD
NGDNVTVEVESKDGSKKDSLTVERCMVSIGFAPRVEGYGLENTGVKLTERGAIEIDDFMRTNVDHIYAIGDVTAKLQLAH
VAEAQGVVAAEVIAGAETQELGDYMMMPRATFCNPQVASFGYTEEQAKAKFEGREIKTATFPFSANGKAAGLAETAGFVK
IVADAEFGEIVGAHMVGANVSELLPELTLAQRFDLTCEEIGRNVHTHPTLSEAMKEAAEGIMGHMINL

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=37.9609544468547, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=29.5896328293737, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI22035672, Length=460, Percent_Identity=27.3913043478261, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=25.5274261603376, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=26.0960334029228, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI33519430, Length=481, Percent_Identity=25.987525987526, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI33519428, Length=481, Percent_Identity=25.987525987526, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI33519426, Length=481, Percent_Identity=25.987525987526, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI148277071, Length=479, Percent_Identity=26.0960334029228, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI291045268, Length=470, Percent_Identity=23.6170212765957, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1786307, Length=465, Percent_Identity=36.5591397849462, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=27.8260869565217, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=29.5404814004376, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=26.6811279826464, Blast_Score=141, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=38.2608695652174, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17557007, Length=487, Percent_Identity=25.6673511293634, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=440, Percent_Identity=26.3636363636364, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71983419, Length=440, Percent_Identity=26.3636363636364, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=26.2939958592132, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=213, Percent_Identity=32.8638497652582, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6321091, Length=470, Percent_Identity=38.2978723404255, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=28.2426778242678, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=28.9699570815451, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=39.3939393939394, Blast_Score=308, Evalue=5e-84,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=26.6112266112266, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=26.6112266112266, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=26.6112266112266, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=26.6806722689076, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50154; Mature: 50023

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHYDVVVLGAGPGGYVAAIRAAQLGKKVAVVEKQYWGGVCLNVGCIPSKALLKNAEVA
CCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCCEEEEECCCCCHHHHCCCCEE
HIFNHEAKTFGISGDVSFDFGAAHKRSRQVSSGIVKGVHYLMKKNKITEIDGLGSFKDAK
EEECCCCCEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCC
TIEITEGNDAGKVVTFDDCIIATGSVVRSLPGVTIGGNIVSFEEQILKEEAPKSMVIVGA
EEEEECCCCCCCEEEECCHHHHCCHHHHHCCCEEECCCEEHHHHHHHHHCCCCEEEEEEC
GAIGMEFAYVLVNYGVDITIVEFMDRVLPNEDADVSKEIAKQYKKLGVKLLTGYKTTAIT
CHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCEEEEEE
DNGDNVTVEVESKDGSKKDSLTVERCMVSIGFAPRVEGYGLENTGVKLTERGAIEIDDFM
CCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEHHHH
RTNVDHIYAIGDVTAKLQLAHVAEAQGVVAAEVIAGAETQELGDYMMMPRATFCNPQVAS
HCCCCEEEEECCCEEEEEEEHHHHHCCCEEEHHHCCCCHHHHHHHHHCCCCCCCCCCHHC
FGYTEEQAKAKFEGREIKTATFPFSANGKAAGLAETAGFVKIVADAEFGEIVGAHMVGAN
CCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCHHHHHHHHHCCCC
VSELLPELTLAQRFDLTCEEIGRNVHTHPTLSEAMKEAAEGIMGHMINL
HHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEHYDVVVLGAGPGGYVAAIRAAQLGKKVAVVEKQYWGGVCLNVGCIPSKALLKNAEVA
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCCEEEEECCCCCHHHHCCCCEE
HIFNHEAKTFGISGDVSFDFGAAHKRSRQVSSGIVKGVHYLMKKNKITEIDGLGSFKDAK
EEECCCCCEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCC
TIEITEGNDAGKVVTFDDCIIATGSVVRSLPGVTIGGNIVSFEEQILKEEAPKSMVIVGA
EEEEECCCCCCCEEEECCHHHHCCHHHHHCCCEEECCCEEHHHHHHHHHCCCCEEEEEEC
GAIGMEFAYVLVNYGVDITIVEFMDRVLPNEDADVSKEIAKQYKKLGVKLLTGYKTTAIT
CHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEEEECCEEEEEE
DNGDNVTVEVESKDGSKKDSLTVERCMVSIGFAPRVEGYGLENTGVKLTERGAIEIDDFM
CCCCEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEHHHH
RTNVDHIYAIGDVTAKLQLAHVAEAQGVVAAEVIAGAETQELGDYMMMPRATFCNPQVAS
HCCCCEEEEECCCEEEEEEEHHHHHCCCEEEHHHCCCCHHHHHHHHHCCCCCCCCCCHHC
FGYTEEQAKAKFEGREIKTATFPFSANGKAAGLAETAGFVKIVADAEFGEIVGAHMVGAN
CCCCHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCHHHHHHHHHCCCC
VSELLPELTLAQRFDLTCEEIGRNVHTHPTLSEAMKEAAEGIMGHMINL
HHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]